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Ivana Stojanovic, John E Schneider, Jacie Cooper
AIMS: The purpose of this study is to assess the economic cost differences and the associated treatment resource changes between the developing coronary artery disease (CAD) diagnostic tool fast strain-encoded cardiac imaging (Fast-SENC) and the current commonly used stress test single-photon emission computed tomography (SPECT). MATERIALS AND METHODS: We first created a 'payer perspective' model consisting of long-term and short-term components that used a hypothetical cohort of patients of average age (60...
February 7, 2019: Journal of Medical Economics
Sarah J Hoffman, Jaci Stich, Sidhra Musani, Cheryl L Robertson
Sociopolitical discourses surrounding refugee migration and resettlement are characterized by divisiveness, assumptions, and fear. When these discussions are grounded in the narratives of women refugees a deeper understanding of issues impacting health, family, and resilience emerges. We examine how 26 Karen women living in camps along the Thai-Burma border construct meaning around health, in relation to livelihoods. Through directed content analysis, themes emerged: precursors to achieving health, health and livelihoods, and position and agency...
February 6, 2019: Health Care for Women International
Lynne Williams, Tracey Cooper, Lisa Bradford, Beryl Cooledge, Francesca Elner, Denise Fisher, Jaci C Huws, Louise Jones, Stephanie Morris, Natasha Rowe, Robson Sengwe, Catherine Roberts, Karen Roberts, Jane Wright, Heledd Owen Griffiths
Background: Little evidence exists to show the exact impact of the link nurse role in promoting best practice in infection prevention. This paper is a report of the implementation and evaluation of a link nurse programme for community hospitals across one NHS organisation. Aim/objectives: The main aim of the study was to implement and evaluate an infection prevention link programme. The study objectives were: 1) to develop materials for a bespoke infection prevention programme which incorporated education, behaviour change, reward and recognition and 2) to evaluate the implementation of the programme, and to learn about barriers and enablers to implementation...
January 2019: Journal of Infection Prevention
Paul G Thomes, Karuna Rasineni, Li Yang, Terrence M Donohue, Jacy L Kubik, Mark A McNiven, Carol A Casey
BACKGROUND: We are investigating the changes in hepatic lipid catabolism that contribute to alcohol-induced fatty liver. Following chronic ethanol exposure, abstinence from alcohol resolves steatosis. Here, we investigated the hepatocellular events that lead to this resolution by quantifying specific catabolic parameters that returned to control levels after EtOH was withdrawn. We hypothesized that after its chronic consumption ethanol withdrawal reactivates lipid catabolic processes that restore lipostasis...
February 4, 2019: American Journal of Physiology. Gastrointestinal and Liver Physiology
Helen Jessop, Dominique Farge, Riccardo Saccardi, Tobias Alexander, Montserrat Rovira, Basil Sharrack, Raffaella Greco, Nico Wulffraat, John Moore, Majid Kazmi, Manuela Badoglio, Gillian Adams, Bregje Verhoeven, John Murray, John A Snowden
Over the last 20 years, haematopoietic stem cell transplantation (HSCT) has been used to treat patients with severe autoimmune and inflammatory diseases whose response to standard treatment options has been limited, resulting in a poor long-term prognosis in terms of survival or disability. The vast majority of patients have received autologous HSCT where an increasing evidence-base supports its use in a wide range of autoimmune diseases, particularly relapsing remitting MS, systemic sclerosis and Crohn's disease...
January 31, 2019: Bone Marrow Transplantation
Karuna Rasineni, Paul G Thomes, Jacy L Kubik, Edward Noel Harris, Kusum K Kharbanda, Carol A Casey
Fatty liver is the earliest response of the liver to excessive ethanol consumption. Central in the development of alcoholic steatosis is increased mobilization of non-esterified free fatty acids (NEFA) to the liver from the adipose tissue. In this study, we hypothesized that ethanol-induced increase in ghrelin by impairing insulin secretion, could be responsible for the altered lipid metabolism observed in adipose and liver tissue. Male Wistar rats were fed for 5 to 8 weeks with control or ethanol Lieber-DeCarli diet, followed by biochemical analyses in serum and liver tissues...
January 31, 2019: American Journal of Physiology. Gastrointestinal and Liver Physiology
Hélène A Poirel, Marijke Vanspauwen, Gilles Macq, Anke De Geyndt, Johan Maertens, Evelyne Willems, Dominik Selleslag, Xavier Poiré, Koen Theunissen, Carlos Graux, Tessa Kerre, Pierre Zachée, Nathalie Meuleman, Ann De Becker, Anke Verlinden, Florence Van Obbergh, Christine Schuermans, Virginie De Wilde, Aurélie Jaspers, Delphine Pranger, Dries Deeren, Ivan Van Riet, Evelien Vaes, Yves Beguin
While performance since the introduction of the JACIE quality management system has been shown to be improved for allogeneic hematopoietic stem cell transplants (HSCT), impact on autologous-HSCT remains unclear in Europe. Our study on 2697 autologous-HSCT performed in adults in 17 Belgian centres (2007-2013) aims at comparing the adjusted 1 and 3-yr survival between the different centres & investigating the impact of 3 centre-related factors on performance (time between JACIE accreditation achievement by the centre and the considered transplant, centre activity volume and type of HSCT performed by centres: exclusively autologous vs both autologous & allogeneic)...
January 29, 2019: Bone Marrow Transplantation
Julie E Sutton, Jaci C Huws, Christopher R Burton
This qualitative study develops a programme theory demonstrating the complexity embedded in sleep hygiene education (SHE) as an intervention to improve sleep problems in children with developmental disabilities. In co-design workshops, eight parents and six sleep practitioners deliberated themes developed from findings of an earlier exploratory study of stakeholder perceptions of SHE. A SHE tool underpinned by programme theory was developed evidenced by mid-range theories of change. Analytical themes were developed to explain the programme theory and the complexities of a successful SHE intervention: the need to legitimize children's sleep problems and consider the nature of customization, knowledge sharing, health expectation and impact of sleep service rationing and gaming strategies on implementation success...
January 17, 2019: Journal of Intellectual Disabilities: JOID
Rosie K A Bunton-Stasyshyn, Jacy L Wagnon, Eric R Wengert, Bryan S Barker, Alexa Faulkner, Pravin K Wagley, Kritika Bhatia, Julie M Jones, Marissa R Maniaci, Jack M Parent, Howard P Goodkin, Manoj K Patel, Miriam H Meisler
De novo mutations of the sodium channel gene SCN8A result in an epileptic encephalopathy with refractory seizures, developmental delay, and elevated risk of sudden death. p.Arg1872Trp is a recurrent de novo SCN8A mutation reported in 14 unrelated individuals with epileptic encephalopathy that included seizure onset in the prenatal or infantile period and severe verbal and ambulatory comorbidities. The major biophysical effect of the mutation was previously shown to be impaired channel inactivation accompanied by increased current density...
January 2, 2019: Brain: a Journal of Neurology
Pedro L Katayama, Jaci A Castania, Rubens Fazan, Helio C Salgado
Electrical stimulation of the carotid baroreflex has been thoroughly investigated for treating drug-resistant hypertension in humans. However, a previous study from our laboratory, performed in conscious rats, has demonstrated that electrical stimulation of the carotid sinus/nerve (CS) activated both the carotid baroreflex as well as the carotid chemoreflex, resulting in hypotension. Additionally, we also demonstrated that the carotid chemoreceptor deactivation potentiated this hypotensive response. Therefore, to further investigate this carotid baroreflex/chemoreflex interaction, besides the hemodynamic responses, we evaluated the respiratory responses to the electrical stimulation of the CS in both intact (CONT) and carotid chemoreceptors deactivated (CHEMO-X) conscious rats...
January 2019: Autonomic Neuroscience: Basic & Clinical
Catherine Faucher, Catherine Adam, Nelly Bancillon, Elisabeth Bertrand, Fabienne Colledani, Eva de Berranger, Virginie Denis, Isabelle Girard, Fati Hamzy, Noureddine Loukili, Lionel Mannone, Lara Mercier, Agnes Perrin, Alyette Vasseur, Quessar Asma, Caroline Bompoint, Nabil Yafour, Ibrahim Yakoub-Agha, Edgar Jost
Allogeneic hematopoietic cell transplantation (HCT) is part of the standard of care for many hematological diseases. Over the last decades, significant advances in patient and donor selection, conditioning regimens as well as supportive care of patients undergoing allogeneic HCT leading to improved overall survival have been made. In view of many new treatment options in cellular and molecular targeted therapies, the place of allogeneic transplantation in therapy concepts must be reviewed. Most aspects of HCT are well standardized by national guidelines or laws as well as by certification labels such as FACT-JACIE...
December 20, 2018: Bulletin du Cancer
Juliano Palacios-Abrantes, Juliana Herrera-Correal, Salvador Rodríguez, Jacy Brunkow, Renato Molina
Small-scale fisheries are large contributors to regional economies and livelihoods in coastal communities of Latin America. While Mexico is one of the cases where small-scale fisheries play an important role, overfishing and poor management strategies have led to the collapse of many of its fisheries. The callo de hacha scallop fishery of the Ensenada de La Paz in Baja California Sur is an example of such a fishery which, after years of mismanagement, was closed by the Mexican authorities in 2009. The present study evaluated the recovery efforts in the cove and the potential outcomes of a collaboration between a non-governmental organization and a fishing community working towards the restoration of this pen-shell fishery...
2018: PloS One
Michael Schatz, Scott H Sicherer, David Khan, Robert S Zeiger
A large number of clinically impactful studies and reviews were published in this Journal in 2018. This article provides highlights of the original research published in 2018 issues of JACI: In Practice on the subjects of anaphylaxis, asthma, dermatitis, drug allergy, eosinophilic disorders, food allergy, immune deficiency, rhinitis/upper respiratory disease, and urticaria/angioedema. Within each topic, practical aspects of diagnosis and management are emphasized. Treatments discussed include lifestyle modifications, allergen avoidance therapy, positive and negative effects of pharmacologic therapy, and various forms of immunologic and desensitization management...
December 14, 2018: Journal of Allergy and Clinical Immunology in Practice
Rita de C M Miranda, Jaci Vilanova Neta, Luiz Fernando Romanholo Ferreira, Walter Alves Gomes, Carina Soares do Nascimento, Edelvio de B Gomes, Silvana Mattedi, Cleide M F Soares, Álvaro S Lima
Pineapple fibre was treated with protic ionic liquids (PILs) and the effects on the structure, composition, and properties of the fibres were evaluated. Treatment with PILs efficiently exposed the fibre surface, as confirmed by scanning electron microscopy. The chemical composition analysis revealed reductions in the lignin and hemicellulose contents in the treated fibres, promoting exposure of cellulose. The results correlated with the crystallinity index, which was greater in the treated fibres compared with that in the untreated fibres...
February 15, 2019: Carbohydrate Polymers
Sylvie Tarillon, Christelle Andrianne, Sandie Balcaen, Sarah Bole, Carole Genty, Sandrine Godin, Eva Lemarchand, Jérôme Mouchebeuf, Isabelle Mussot, Anne Wallart, Tamim Alsuliman, Yohann Desbrosses, Jean El Cheikh, Marie Agnès Guerout-Verite, John De Vos, Laure Tardieu, Ibrahim Yakoub-Agha, Sophie Porcheron
JACIE (Joint Accreditation Committee ISTC EBMT) regulations and standards impose a quality and safety requirement for graft reinjection by nurses. However, the standards do not provide a step-by-step graft reinjection procedure. Because of high medical team turnover, the opening of new transplant centers, and continual questions from colleagues trying to decipher the JACIE standards, the need for a specific procedure goes without saying. We collected graft reinjection procedures from each SFGM-TC center that participated in our survey, thus creating an inventory of the different steps that make up graft reinjection...
December 7, 2018: Bulletin du Cancer
Zuhair K Ballas
No abstract text is available yet for this article.
April 2018: Journal of Allergy and Clinical Immunology
Zuhair K Ballas
No abstract text is available yet for this article.
December 2018: Journal of Allergy and Clinical Immunology
Jaci SuLynn Mester
No abstract text is available yet for this article.
December 2018: Nursing Management
Edouard Forcade, Agnès Bonnin, Judith Desoutter, Francisca Nacimento, Isabelle Roch-Torreilles, Flore Vigneron, Jean-Michel Boiron, Ibrahim Yakoub-Agha, Nicolas Simon
Since, several years the integration of a clinical pharmacist in medical units led to improve the patients' care in France. In the frame of stem cell engraftment, patients belong to a particularly complex population, notably due to pediatric patients or because the age to engraft adult patients is higher. Moreover, because of many reasons, such as numerous medications intake or long-term immunosuppression, these patients are very fragile and at risk of complications. Since the 6th edition, the JACIE standard gives a definition of the role of clinical pharmacist with its competence area and its place in the medical ward...
November 16, 2018: Bulletin du Cancer
Ethan Chernivec, Jacie Cooper, Kari Naylor
Current treatments for Parkinson's disease (PD) only alleviate symptoms doing little to inhibit the onset and progression of the disease, thus we must research the mechanism of Parkinson's. Rotenone is a known inducer of parkinsonian conditions in rats; we use rotenone to induce parkinsonian cellular conditions in Dictyostelium discoideum . In our model we primarily focus on mitochondrial dynamics. We found that rotenone disrupts the actin and microtubule cytoskeleton but mitochondrial morphology remains intact...
November 8, 2018: Cells
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