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functional connectivity under anesthesia

https://read.qxmd.com/read/38477595/the-promise-mystery-and-perils-of-stenting-for-symptomatic-internal-jugular-vein-stenosis-a-case-series
#1
JOURNAL ARTICLE
Kyle M Fargen, Jackson P Midtlien, Katherine Belanger, Edward J Hepworth, Ferdinand K Hui
BACKGROUND AND OBJECTIVES: Cerebral venous outflow disorders (CVDs) secondary to internal jugular vein (IJV) stenosis are becoming an increasingly recognized cause of significant cognitive and functional impairment in patients. There are little published data on IJV stenting for this condition. This study aims to report on procedural success. METHODS: A single-center retrospective analysis was performed on patients with CVD that underwent IJV stenting procedures...
March 13, 2024: Neurosurgery
https://read.qxmd.com/read/38419667/study-protocol-cerebral-characterization-of-sensory-gating-in-disconnected-dreaming-states-during-propofol-anesthesia-using-fmri
#2
JOURNAL ARTICLE
Benedetta Cecconi, Javier Montupil, Sepehr Mortaheb, Rajanikant Panda, Robert D Sanders, Christophe Phillips, Naji Alnagger, Emma Remacle, Aline Defresne, Melanie Boly, Mohamed Ali Bahri, Laurent Lamalle, Steven Laureys, Olivia Gosseries, Vincent Bonhomme, Jitka Annen
BACKGROUND: Disconnected consciousness describes a state in which subjective experience (i.e., consciousness) becomes isolated from the external world. It appears frequently during sleep or sedation, when subjective experiences remain vivid but are unaffected by external stimuli. Traditional methods of differentiating connected and disconnected consciousness, such as relying on behavioral responsiveness or on post-anesthesia reports, have demonstrated limited accuracy: unresponsiveness has been shown to not necessarily equate to unconsciousness and amnesic effects of anesthesia and sleep can impair explicit recollection of events occurred during sleep/sedation...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38398468/utilization-of-tenting-pole-abutments-for-the-reconstruction-of-severely-resorbed-alveolar-bone-technical-considerations-and-case-series-reports
#3
Dong-Seok Sohn, Albert Lui, Hyunsuk Choi
INTRODUCTION: Although various surgical techniques have been utilized in the reconstruction of severely resorbed alveolar bone, its regeneration is still regarded as a major challenge. Most of the surgical techniques used in advanced ridge augmentation have the disadvantages of prolonging the patient's edentulous healing and increasing the need for surgical revisits because simultaneous implant placement is not allowed. This report presents a new and simplified method for advanced ridge augmentation, which utilizes a vertical tenting device...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38378942/longitudinal-monitoring-of-the-mouse-brain-reveals-heterogenous-network-trajectories-during-aging
#4
JOURNAL ARTICLE
Özgün Özalay, Tomas Mediavilla, Bruno Lima Giacobbo, Robin Pedersen, Daniel Marcellino, Greger Orädd, Anna Rieckmann, Fahad Sultan
The human aging brain is characterized by changes in network efficiency that are currently best captured through longitudinal resting-state functional MRI (rs-fMRI). These studies however are challenging due to the long human lifespan. Here we show that the mouse animal model with a much shorter lifespan allows us to follow the functional network organization over most of the animal's adult lifetime. We used a longitudinal study of the functional connectivity of different brain regions with rs-fMRI under anesthesia...
February 20, 2024: Communications Biology
https://read.qxmd.com/read/38349236/growth-hormone-secreting-pituitary-adenoma-combined-with-graves-disease-retrospective-case-series-and-literature-review
#5
JOURNAL ARTICLE
Caiyan Mo, Tao Tong, Ying Guo, Zheng Li, Liyong Zhong
PURPOSE: The coexistence of growth hormone-secreting pituitary adenoma (GHPA) and Graves' disease (GD) is rare. This study aimed to investigate the relationship between growth hormone (GH)/insulin-like growth factor-1 (IGF-1) levels and thyroid function in patients with GHPA combined with GD and to explore the underlying mechanisms. METHODS: Eleven patients with GHPA combined with GD during 2015-2022 were collected by searching the medical record system of Beijing Tiantan Hospital, Capital Medical University...
February 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38346111/mri-based-prostate-cancer-classification-using-3d-efficient-capsule-network
#6
JOURNAL ARTICLE
Yuheng Li, Jacob Wynne, Jing Wang, Justin Roper, Chih-Wei Chang, Ashish B Patel, Joseph Shelton, Tian Liu, Hui Mao, Xiaofeng Yang
BACKGROUND: Prostate cancer (PCa) is the most common cancer in men and the second leading cause of male cancer-related death. Gleason score (GS) is the primary driver of PCa risk-stratification and medical decision-making, but can only be assessed at present via biopsy under anesthesia. Magnetic resonance imaging (MRI) is a promising non-invasive method to further characterize PCa, providing additional anatomical and functional information. Meanwhile, the diagnostic power of MRI is limited by qualitative or, at best, semi-quantitative interpretation criteria, leading to inter-reader variability...
February 12, 2024: Medical Physics
https://read.qxmd.com/read/38228393/intraoperative-pediatric-electroencephalography-monitoring-an-updated-review
#7
JOURNAL ARTICLE
Ian Yuan, Choon L Bong, Jerry Y Chao
Intraoperative electroencephalography (EEG) monitoring under pediatric anesthesia has begun to attract increasing interest, driven by the availability of pediatric-specific EEG monitors and the realization that traditional dosing methods based on patient movement or changes in hemodynamic response often lead to imprecise dosing, especially in younger infants who may experience adverse events (e.g., hypotension) due to excess anesthesia. EEG directly measures the effects of anesthetics on the brain, which is the target end-organ responsible for inducing loss of consciousness...
January 17, 2024: Korean Journal of Anesthesiology
https://read.qxmd.com/read/38083516/latent-dynamical-model-to-characterize-brain-network-level-rhythmic-dynamics
#8
JOURNAL ARTICLE
Reza Saadati Fard, Navid Ziaei, Ali Yousefi
Characterizing network-level rhythmic dynamics over multiple spatio-temporal scales can significantly advance our understanding of brain cognitive function and information processing. In this research, we propose a new switching state space model called latent dynamical coherence model or briefly LDCM. In the LDCM, we develop model inference and parameter estimation solutions that facilitate studying network-level rhythmic dynamics at scales. In the proposed framework, we incorporate both continuous and discrete state processes, helping us to capture dynamics of functional connectivity at various rates, such as slow, rapid, or a combination of both...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/38063007/differential-effect-of-global-signal-regression-between-awake-and-anesthetized-conditions-in-mice
#9
JOURNAL ARTICLE
Da Wang, Hui Li, Mengyang Xu, Binshi Bo, Mengchao Pei, Zhifeng Liang, Garth J Thompson
In resting-state functional MRI (rs-fMRI) studies, global signal regression (GSR) is a controversial preprocessing strategy. It effectively eliminates global noise driven by motion and respiration but also can introduce artifacts and remove functionally relevant metabolic information. Most preclinical rs-fMRI studies are performed in anesthetized animals, and anesthesia will alter both metabolic and neuronal activity. In this study, we explored the effect of GSR on rs-fMRI data collected under anesthetized and awake state in mice...
December 8, 2023: Brain Connectivity
https://read.qxmd.com/read/38030651/characteristic-dynamic-functional-connectivity-during-sevoflurane-induced-general-anesthesia
#10
JOURNAL ARTICLE
Jingya Miao, Mohamed Tantawi, Mahdi Alizadeh, Sara Thalheimer, Faezeh Vedaei, Victor Romo, Feroze B Mohamed, Chengyuan Wu
General anesthesia (GA) during surgery is commonly maintained by inhalational sevoflurane. Previous resting state functional MRI (rs-fMRI) studies have demonstrated suppressed functional connectivity (FC) of the entire brain networks, especially the default mode networks, transitioning from the awake to GA condition. However, accuracy and reliability were limited by previous administration methods (e.g. face mask) and short rs-fMRI scans. Therefore, in this study, a clinical scenario of epilepsy patients undergoing laser interstitial thermal therapy was leveraged to acquire 15 min of rs-fMRI while under general endotracheal anesthesia to maximize the accuracy of sevoflurane level...
November 29, 2023: Scientific Reports
https://read.qxmd.com/read/38029397/type-2-diabetes-alters-hippocampal-neural-oscillations-and-disrupts-synchrony-between-the-hippocampus-and-cortex
#11
JOURNAL ARTICLE
Gratianne Rabiller, Zachary Ip, Shahram Zarrabian, Hongxia Zhang, Yoshimichi Sato, Azadeh Yazdan-Shahmorad, Jialing Liu
Type 2 diabetes mellitus (T2DM) increases the risk of neurological diseases, yet how brain oscillations change as age and T2DM interact is not well characterized. To delineate the age and diabetic effect on neurophysiology, we recorded local field potentials with multichannel electrodes spanning the somatosensory cortex and hippocampus (HPC) under urethane anesthesia in diabetic and normoglycemic control mice, at 200 and 400 days of age. We analyzed the signal power of brain oscillations, brain state, sharp wave associate ripples (SPW-Rs), and functional connectivity between the cortex and HPC...
November 15, 2023: Aging and Disease
https://read.qxmd.com/read/37981636/high-density-exploration-of-activity-states-in-a-multi-area-brain-model
#12
JOURNAL ARTICLE
David Aquilué-Llorens, Jennifer S Goldman, Alain Destexhe
To simulate whole brain dynamics with only a few equations, biophysical, mesoscopic models of local neuron populations can be connected using empirical tractography data. The development of mesoscopic mean-field models of neural populations, in particular, the Adaptive Exponential (AdEx mean-field model), has successfully summarized neuron-scale phenomena leading to the emergence of global brain dynamics associated with conscious (asynchronous and rapid dynamics) and unconscious (synchronized slow-waves, with Up-and-Down state dynamics) brain states, based on biophysical mechanisms operating at cellular scales (e...
November 20, 2023: Neuroinformatics
https://read.qxmd.com/read/37974577/propofol-modulates-neural-dynamics-of-thalamo-cortical-system-associated-with-anesthetic-levels-in-rats
#13
JOURNAL ARTICLE
Xuliang Jiang, Xin Wen, Guoyao Ou, Shitong Li, Yali Chen, Jun Zhang, Zhenhu Liang
UNLABELLED: The thalamocortical system plays an important role in consciousness. How anesthesia modulates the thalamocortical interactions is not completely known.  We simultaneously recorded local field potentials(LFPs) in thalamic reticular nucleus(TRN) and ventroposteromedial thalamic nucleus(VPM), and electrocorticographic(ECoG) activities in frontal and occipital cortices in freely moving rats ( n  = 11). We analyzed the changes in thalamic and cortical local spectral power and connectivities, which were measured with phase-amplitude coupling (PAC), coherence and multivariate Granger causality, at the states of baseline, intravenous infusion of propofol 20, 40, 80 mg/kg/h and after recovery of righting reflex...
December 2023: Cognitive Neurodynamics
https://read.qxmd.com/read/37733058/alterations-in-rat-brain-modular-organization-during-unconsciousness-are-dependent-on-communication-efficiency-and-metabolic-cost
#14
JOURNAL ARTICLE
Siyang Li, Yali Chen, Peng Ren, Zhipeng Li, Jun Zhang, Xia Liang
Spontaneous brain activity exhibits a highly structured modular organization that varies across individuals and reconfigures over time. Although it has been proposed that brain organization is shaped by an economic trade-off between minimizing costs and facilitating efficient information transfer, it remains untested whether modular variability and its changes during unconscious conditions might be constrained by the economy of brain organization. We acquired functional MRI and FDG-PET in rats under three different levels of consciousness induced by propofol administration...
September 21, 2023: Brain Structure & Function
https://read.qxmd.com/read/37718817/malignant-brain-aging-the-formidable-link-between-dysregulated-signaling-through-mechanistic-target-of-rapamycin-pathways-and-alzheimer-s-disease-type-3-diabetes
#15
REVIEW
Suzanne M de la Monte
Malignant brain aging corresponds to accelerated age-related declines in brain functions eventually derailing the self-sustaining forces that govern independent vitality. Malignant brain aging establishes the path toward dementing neurodegeneration, including Alzheimer's disease (AD). The full spectrum of AD includes progressive dysfunction of neurons, oligodendrocytes, astrocytes, microglia, and the microvascular systems, and is mechanistically driven by insulin and insulin-like growth factor (IGF) deficiencies and resistances with accompanying deficits in energy balance, increased cellular stress, inflammation, and impaired perfusion, mimicking the core features of diabetes mellitus...
2023: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/37434363/analogous-cortical-reorganization-accompanies-entry-into-states-of-reduced-consciousness-during-anesthesia-and-sleep
#16
JOURNAL ARTICLE
Bryan M Krause, Declan I Campbell, Christopher K Kovach, Rashmi N Mueller, Hiroto Kawasaki, Kirill V Nourski, Matthew I Banks
Theories of consciousness suggest that brain mechanisms underlying transitions into and out of unconsciousness are conserved no matter the context or precipitating conditions. We compared signatures of these mechanisms using intracranial electroencephalography in neurosurgical patients during propofol anesthesia and overnight sleep and found strikingly similar reorganization of human cortical networks. We computed the "effective dimensionality" of the normalized resting state functional connectivity matrix to quantify network complexity...
August 23, 2023: Cerebral Cortex
https://read.qxmd.com/read/37380958/dose-related-adaptive-reconstruction-of-dmn-in-isoflurane-administration-a-study-in-the-rat
#17
JOURNAL ARTICLE
Fengru Guo, Yuqin Li, Zhaoxin Jian, Yan Cui, Wenhui Gong, Airui Li, Wei Jing, Peng Xu, Ke Chen, Daqing Guo, Dezhong Yao, Yang Xia
BACKGROUND: The anesthetic states are accompanied by functional alterations. However, the dose-related adaptive alterations in the higher-order network under anesthesia, e. g. default mode network (DMN), are poorly revealed. METHODS: We implanted electrodes in brain regions of the rat DMN to acquire local field potentials to investigate the perturbations produced by anesthesia. Relative power spectral density, static functional connectivity (FC), fuzzy entropy of dynamic FC, and topological features were computed from the data...
June 28, 2023: BMC Anesthesiology
https://read.qxmd.com/read/37377015/transcranial-direct-current-stimulation-reverses-stroke-induced-network-alterations-in-mice
#18
JOURNAL ARTICLE
Stefan J Blaschke, Susan Vlachakis, Niklas Pallast, Helene L Walter, Lukas J Volz, Dirk Wiedermann, Gereon R Fink, Mathias Hoehn, Markus Aswendt, Michael Schroeter, Maria A Rueger
BACKGROUND: Beyond focal effects, stroke lesions impact the function of distributed networks. We here investigated (1) whether transcranial direct current stimulation (tDCS) alters the network changes induced by cerebral ischemia and (2) whether functional network parameters predict the therapeutic efficacy of tDCS in a mouse model of focal photothrombotic stroke. METHODS: Starting 3 days after stroke, cathodal tDCS (charge density=39.6 kC/m²) was applied over 10 days in male C57Bl/6J mice under light anesthesia over the lesioned sensory-motor cortex...
August 2023: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/37335799/the-characteristics-of-electroencephalogram-signatures-in-minimally-conscious-state-patients-induced-by-general-anesthesia
#19
JOURNAL ARTICLE
Xing Jin, Zhenhu Liang, Xin Wen, Yong Wang, Yang Bai, Xiaoyu Xia, Jianghong He, Jamie Sleigh, Xiaoli Li
OBJECTIVE: General anesthesia (GA) is necessary for surgery, even for patients in a minimally conscious state (MCS). The characteristics of the electroencephalogram (EEG) signatures of the MCS patients under GA are still unclear. METHODS: The EEG during GA were recorded from 10 MCS patients undergoing spinal cord stimulation surgery. The power spectrum, phase-amplitude coupling (PAC), the diversity of connectivity, and the functional network were investigated. Long term recovery was assessed by the Coma Recovery Scale-Revised at one year after the surgery, and the characteristics of the patients with good or bad prognosis status were compared...
June 19, 2023: IEEE Transactions on Bio-medical Engineering
https://read.qxmd.com/read/37332854/post-ischemic-reorganization-of-sensory-responses-in-cerebral-cortex
#20
JOURNAL ARTICLE
P Hayley, C Tuchek, S Dalla, J Borrell, M D Murphy, R J Nudo, D J Guggenmos
INTRODUCTION: Sensorimotor integration is critical for generating skilled, volitional movements. While stroke tends to impact motor function, there are also often associated sensory deficits that contribute to overall behavioral deficits. Because many of the cortico-cortical projections participating in the generation of volitional movement either target or pass-through primary motor cortex (in rats, caudal forelimb area; CFA), any damage to CFA can lead to a subsequent disruption in information flow...
2023: Frontiers in Neuroscience
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