keyword
https://read.qxmd.com/read/38155503/cardiovascular-diseases-after-high-dose-chemotherapy-and-autologous-stem-cell-transplant-for-lymphoma-a-danish-population-based-study
#21
JOURNAL ARTICLE
Joachim Baech, Simon Husby, Trine Trab, Kristian Kragholm, Peter Brown, Jette S Gørløv, Judit M Jørgensen, Sif Gudbrandsdottir, Marianne Tang Severinsen, Kirsten Grønbaek, Thomas Stauffer Larsen, Tove Wästerlid, Sandra Eloranta, Knut B Smeland, Lasse Hjort Jakobsen, Tarec C El-Galaly
Cardiovascular diseases, especially congestive heart failure (CHF), are known complications of anthracyclines, but the risk for patients undergoing high-dose chemotherapy and autologous stem cell transplant (HDT-ASCT) is not well established. With T-cell therapies emerging as alternatives, studies of long-term complications after HDT-ASCT are warranted. Danish patients treated with HDT-ASCT for aggressive lymphoma between 2001 and 2017 were matched 1:5 on sex, birth year and Charlson comorbidity score to the general population...
December 28, 2023: British Journal of Haematology
https://read.qxmd.com/read/38148855/stress-induced-graves-disease-spontaneous-recovery-after-stress-relief
#22
JOURNAL ARTICLE
Jeresa I A Willems, Daan J L van Twist, Robin P Peeters, Guy J M Mostard, Roderick F A Tummers-de Lind van Wijngaarden
PURPOSE: Emotional stress is a precipitating factor for Graves disease (GD). However, the influence of stress relief on the course of GD is unknown. Here, we present a series of patients diagnosed with stress-induced GD in whom stress relief alone led to remission of GD. CASES: We report on 11 patients in whom hyperthyroid symptoms started just after severe emotional stress. All patients had suppressed thyroid-stimulating hormone (TSH) levels and elevated free thyroxine (FT4; 22...
December 1, 2023: Journal of the Endocrine Society
https://read.qxmd.com/read/38147013/unusual-onset-of-graves-disease-associated-with-thymic-hyperplasia-in-a-5-year-old-girl-with-congenital-bilateral-clinical-anophthalmia-diagnostic-and-therapeutic-challenges
#23
Rania Ben Rabeh, Ahmed Bouzidi, Rim Hamdi, Nada Missaoui, Olfa Bouyahia, Sonia Mazigh, Samir Boukthir
OBJECTIVES: Graves' disease (GD) is a rare auto-immune disorder in pediatric population. The association between GD and thymic hyperplasia was rarely reported in children. Diagnosis and management of GD are challenging in children. CASE PRESENTATION: This report presents the case of a 5-year-old girl with a personal history of asthma and congenital bilateral isolated clinical anophthalmia who presented with acute congestive heart failure, sinus tachycardia and atypical signs of orbitopathy with edema and erythema of the lower right eyelid and excessive tearing...
December 27, 2023: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38127192/igg4-serum-levels-in-graves-orbitopathy
#24
JOURNAL ARTICLE
S Comi, G Lanzolla, G Cosentino, M N Maglionico, C Posarelli, F Menconi, F Santini, R Elisei, M Marinò
OBJECTIVE: IgG4-related disease (IgG4-RD) can involve many organs, including thyroid and orbital tissues. A link between IgG4, Graves' disease (GD) and Graves' orbitopathy (GO) has been proposed, but results are conflicting. Here we investigated the possible association between IgG4 and GO. METHODS: Retrospective investigation in 297 patients with Graves' disease (GD), 152 with GO. PRIMARY OUTCOME: prevalence of IgG4 ≥ 135 mg/dL (cut-off for IgG4-RD)...
December 21, 2023: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38117453/transition-from-hashimoto-thyroiditis-to-graves-s-disease-an-unpredictable-change
#25
JOURNAL ARTICLE
Alberto Vassallo, Francesca Ferrari, Luigi di Filippo, Andrea Giustina, Paola Loli
PURPOSE: Hashimoto thyroiditis and Graves's disease are two related autoimmune disorders, representing the leading causes of hypothyroidism and hyperthyroidism. Autoimmune hypothyroidism is generally irreversible but very rarely, some patients would shift to hyperthyroidism. The aim of the study was to seek for possible clinical predictors of the transition from hypo to hyperthyroidism in patients with Hashimoto thyroiditis and to outline their clinical phenotype. METHODS: Twelve patients with overt autoimmune hypothyroidism who had at least one transition from hypothyroidism to autoimmune hyperthyroidism were compared with 294 consecutive patients with autoimmune hypothyroidism and 69 consecutive patients with autoimmune hyperthyroidism that accessed the outpatient clinic over six months...
December 20, 2023: Endocrine
https://read.qxmd.com/read/38111941/evaluation-of-macular-choroidal-and-microvascular-network-changes-by-activity-scores-and-serum-antibodies-in-thyroid-eye-patients-and-healthy-subjects
#26
JOURNAL ARTICLE
Mehmet Erkan Dogan, Ibrahim Basol, Hatice Deniz Ilhan, Yusuf Ayaz, Olgar Ocal
AIM: To investigate the choroidal thickness and the microvascular network changes around the macula in thyroid eye disease (TED) patients at different stages and the relationship of those changes with risk factors, serum antibodies and the severity of TED. METHODS: A total of 85 participants were enrolled. All participants underwent ophthalmology and endocrinology examinations. Subfoveal choroidal thickness (SFCT), superficial (s) and deep (d) foveal avascular zone (FAZ) area, mean (m) and central (c) superficial vascular density (SVD), deep vascular density (DVD) measurements of the enrolled cases were performed with Topcon swept source optical coherence tomography (OCT)/OCT angiography (OCTA) DRI OCT Triton...
2023: International Journal of Ophthalmology
https://read.qxmd.com/read/38107298/comparison-of-two-different-tsh-receptor-antibody-assays-a-clinical-practice-study
#27
JOURNAL ARTICLE
Mathé van Balkum, Marco W J Schreurs, W Edward Visser, Robin P Peeters, Willem A Dik
BACKGROUND: Graves' disease (GD) is caused by the production of TSH-receptor (TSHR) stimulating auto-antibodies. Over the years various TSHR-antibody (TRAb) detection assays have been developed. Most clinical laboratories use competitive TSH-binding inhibitory immunoglobulin (TBII) assays, which measure the total amount of stimulating and blocking auto-antibodies. Selective detection of TSHR stimulating auto-antibodies (TSI) was previously only possible with functional cell-based bioassays...
December 2023: Heliyon
https://read.qxmd.com/read/38101466/interference-against-a-newly-labeled-substance-with-ruthenium-sulfonate-complexes-showing-discrepant-thyroid-function-test-results
#28
Sawako Takahashi, Mitsushige Nishikawa, Eijun Nishihara, Hanna Deguchi, Kazuyoshi Kohsaka, Hiroyuki Yamaoka, Mako Hisakado, Shuji Fukata, Mitsuru Ito, Akira Miyauchi, Takashi Akamizu
We report here two patients exhibiting a combination of falsely elevated serum levels of free thyroxine (FT4), free triiodothyronine (FT3), and thyrotropin receptor antibodies (TRAb), measured using Elecsys assay kits (Roche Diagnostics GmbH). The first patient was a 74-year-old man misdiagnosed with Graves' disease and treated with methimazole. The second patient was a 48-year-old woman whose serum FT4 and FT3 concentrations were found to be high during a blood test. These patients denied taking biotin or any other supplements...
December 13, 2023: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38068542/primary-thyroid-dysfunction-is-prevalent-in-hidradenitis-suppurativa-and-marked-by-a-signature-of-hypothyroid-graves-disease-a-case-control-study
#29
JOURNAL ARTICLE
Nessr Abu Rached, Johannes W Dietrich, Lennart Ocker, Daniel R Quast, Christina Scheel, Thilo Gambichler, Falk G Bechara
Hidradenitis suppurativa (HS) is a chronic skin disease that can have an association with endocrine disorders. There is conflicting information in the literature regarding the role of the thyroid gland in HS. This study aimed to close this knowledge gap and investigate how thyroid disease is involved in patients with HS. We carried out a case-control study with a total of 160 patients, of whom 108 were patients with HS and 52 were controls matched for age and sex. Parametric and non-parametric methods were used to analyze the results...
December 4, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38056708/comparing-outcomes-of-trabeculectomy-with-mitomycin-c-to-45-%C3%AE-m-gelatin-stent-placed-ab-externo-with-open-conjunctiva
#30
JOURNAL ARTICLE
Ernesto Sabogal, Zoë Ingram, Nino Odishelidze, Hani El Helwe, Henisk K Falah, Jonathan Trzcnski, Nathan Hall, David Solá-Del Valle
PURPOSE: To compare trabeculectomy with mitomycin C (trab-MMC) and XEN®45 Gel Stent placed ab externo with open conjunctiva (XGS AEO) with or without cataract surgery in patients with glaucoma. DESIGN: Nonrandomized, retrospective comparative study. SUBJECTS: A total of 204 eyes from 204 glaucoma patients who received XGS placed AEO or underwent trab-MMC with or without cataract surgery between July 2018 and August 2021 at Massachusetts Eye and Ear...
December 4, 2023: Ophthalmology Glaucoma
https://read.qxmd.com/read/38044176/autoimmune-thyroid-diseases
#31
REVIEW
Petra Petranović Ovčariček, Rainer Görges, Luca Giovanella
Autoimmune thyroid diseases (AITDs) include a wide spectrum of thyroid diseases affecting more commonly women than men. The most frequent forms are Graves' Disease (GD) and Hashimoto's thyroiditis / Autoimmune Thyroiditis (AIT), but there are also other immunogenic destructive forms of thyroiditis, that is, silent and postpartum thyroiditis. In the last decade, AITDs and other inflammatory thyroid diseases related to anti-tumor molecular drugs are more frequently seen due to the widespread use of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICPIs)...
December 2, 2023: Seminars in Nuclear Medicine
https://read.qxmd.com/read/38028251/therapeutic-plasma-exchange-as-a-bridging-therapy-for-the-definitive-treatment-of-a-patient-with-graves-disease-and-methimazole-induced-liver-injury
#32
Dyah Purnamasari, Ardy Wildan, Juferdy Kurniawan, Nadia Ayu Mulansari, Birry Karim, Erwin Danil Yulian
INTRODUCTION: Graves' disease (GD) is an autoimmune condition affecting the thyroid gland. The aim of treating GD is to control the symptoms of hyperthyroidism and achieve long-term remission. Antithyroid drugs (ATDs) are the medications of choice among newly-diagnosed GD patients as they are easy to be delivered and cause remission in more than 50% of patients. However, ATDs increase the risk of hepatotoxicity, especially among patients with liver abnormalities. Patients who cannot tolerate ATDs should receive definitive therapy such as radioactive iodine (RAI) or surgery...
July 2023: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38022226/cut-off-value-of-thyrotropin-receptor-antibodies-in-grave-s-disease-in-basrah
#33
JOURNAL ARTICLE
Maher A Radhi, Nassar T Alibrahim, Abbas A Mansour
BACKGROUND: The diagnosis of Grave's disease (GD) poses a challenge. Thyrotropin-receptor antibodies (TRAb) are the key diagnostic feature of GD, as the American and European Thyroid Associations suggested. AIM OF THE STUDY: This study aims to find a cut-off level of TRAb in GD in Basrah. METHODS: This is a retrospective study that included 617 patients with hyperthyroidism (530 GD and 87 non-Grave's disease (NGD) (thyroiditis or subclinical hyperthyroidism))...
October 2023: Curēus
https://read.qxmd.com/read/37982569/radioactive-iodine-treatment-for-graves-hyperthyroidism-incidence-of-graves-orbitopathy
#34
JOURNAL ARTICLE
Nicole Q X Quah, Manvi M Sobti, Alison M Wren, Richard Scawn, Eleni Kalogianni, James Cleland, Annelies Maenhout
PURPOSE: There are limited recent data on the effect of radioactive iodine (RAI) for Graves' disease on Graves' orbitopathy (GO) development or reactivation. This audit investigates the GO incidence in patients with Graves' disease after RAI treatment, and explores risk factors present, and steroid prophylaxis use. METHODS: A retrospective audit of Graves' disease patients treated with RAI over a 5-year period. Data collected: smoking status, thyroid-stimulating hormone receptor antibody (TRAb) status, GO history, Graves' disease duration, eye features pre- and post-treatment, prophylactic corticosteroids, RAI dose given, post-RAI thyroid status, duration until hypothyroid...
February 1, 2024: Nuclear Medicine Communications
https://read.qxmd.com/read/37943331/management-of-experimental-trabeculectomy-filtering-blebs-via-crosslinking-of-the-scleral-flap-inhibited-vascularization
#35
JOURNAL ARTICLE
Ling Ying Ge, Tian Hong Wu, Yue Qi Liu, Chun Jiang, Xue Yin
PURPOSE: The aim of this study was to evaluate whether UVA-light-activated riboflavin-induced collagen crosslinking (UVA-CXL) can maintain the function of filtering blebs after trabeculectomy (TRAB) in rabbits. METHODS: Thirty-six healthy rabbits were randomized to one of the following groups with 12 rabbits in each group: Trabeculectomy group (TRAB group), trabeculectomy combined with CXL group (CXL group), and trabeculectomy combined with MMC group (MMC group)...
November 9, 2023: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/37930957/significance-of-thyroperoxydase-and-thyroglobulin-antibodies-in-medically-treated-graves-disease
#36
JOURNAL ARTICLE
Stefan Matei Constantinescu, Julien Hospel, Chantal Daumerie, Orsalia Alexopoulou, Dominique Maiter, Maria-Cristina Burlacu
Objective Thyroperoxidase (TPOAb) and thyroglobulin (TgAb) antibodies are highly prevalent in Graves' disease (GD), but their significance is controversial. Methods We retrospectively analyzed TPOAb and TgAb levels and evolution in 136 patients with newly diagnosed GD between 2000 and 2022, treated with anti-thyroid drugs (ATD) in a block-and-replace (B+R) regimen for at least 12 months and followed-up for at least one year after ATD discontinuation or until disease relapse. Results At diagnosis, 98/136 (72%) of patients were TPOAb positive and 73/136 (54%) of patients were TgAb positive...
November 1, 2023: European Thyroid Journal
https://read.qxmd.com/read/37929347/correlation-between-serum-beta-human-chorionic-gonadotropin-levels-and-thyroid-metabolic-function-in-pregnant-women-with-hyperemesis-gravidarum
#37
JOURNAL ARTICLE
Haiyan Zheng, Qian Wang, Feng Chen
As previously demonstrated, serum beta-human chorionic gonadotropin (β-hCG) is linked to identifying early gestational abnormalities. This research was aimed at investigating the correlation between serum β-hCG levels and thyroid metabolic function in pregnant women with hyperemesis gravidarum (HG). Ninety-one pregnant women with HG were selected as the study group and divided into early pregnancy (EP), mid-pregnancy (MP), and late pregnancy (LP) groups according to their gestational weeks, while 84 normal pregnant women were selected as the control group...
2023: Chinese Journal of Physiology
https://read.qxmd.com/read/37908889/effect-of-the-c-terminus-of-tshr-on-t4-and-trab-expression-in-balb-c-mice
#38
JOURNAL ARTICLE
R H Yue, B Hui, H Chen
CONTEXT: The expression of TSHR-C on the serum tetraiodothyronine (T4) and TSH receptor antibody (TRAb) levels are rarely studied. OBJECTIVE: The effect of TSHR-c on T4 and TRAb levels and concomitant thyroid histological changes in mice was investigated. DESIGN: Animal experimental study. SUBJECTS AND METHODS: Female BALB/c mice at 6-8 weeks of age were immunized with the thyroid stimulating hormone receptor antigen C-terminus (TSHR-C), and randomly divided into control group (treated with the corresponding concentrations of normal saline) and four experimental subgroups: TSHR-c1 subgroup (4 µg), TSHR-c2 subgroup (6 µg), TSHR-c3 subgroup (8 µg) and TSHR-c4 subgroup (10 µg)...
2023: Acta endocrinologica: the international journal of the Romanian Society of Endocrinology
https://read.qxmd.com/read/37898434/effects-of-wholegrain-compared-to-refined-grain-intake-on-cardiometabolic-risk-markers-gut-microbiota-and-gastrointestinal-symptoms-in-children-a-randomized-crossover-trial
#39
JOURNAL ARTICLE
Marie Terese Barlebo Madsen, Rikard Landberg, Dennis Sandris Nielsen, Yichang Zhang, Olivia Mariella Rosie Anneberg, Lotte Lauritzen, Camilla Trab Damsgaard
BACKGROUND: Wholegrain intake is associated with lower risk of cardiometabolic diseases in adults, potentially via changes in the gut microbiota. Although cardiometabolic prevention should start early, we lack evidence on the effects in children. OBJECTIVE: To investigate the effects of wholegrain oats and rye intake on serum low-density lipoprotein (LDL) cholesterol and plasma insulin (co-primary outcomes), other cardiometabolic markers, body composition, gut microbiota composition and metabolites, and gastrointestinal symptoms in children with high body mass index (BMI)...
October 26, 2023: American Journal of Clinical Nutrition
https://read.qxmd.com/read/37870639/tsh-receptor-autoantibody-levels-post-total-thyroidectomy-in-graves-ophthalmopathy-a-meta-analysis
#40
JOURNAL ARTICLE
Arsalan Anees, Femi E Ayeni, Guy D Eslick, Senarath Edirimanne
BACKGROUND: TSH receptor autoantibodies (TRAbs) are pathognomonic for Graves' disease and are thought to also underly the pathogenesis of Graves' ophthalmopathy (GO). A decline in TRAb levels has been documented post-total thyroidectomy (TTx) in GO, however with conflicting correlations with disease outcomes. The aim of the study was to compare the effectiveness of TTx to other treatment modalities of Graves' disease and examine whether the lowering of TRAbs is associated with GO improvements...
October 23, 2023: Langenbeck's Archives of Surgery
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