Michal Schäfer, Neil Wilson, D Dunbar Ivy, Richard Ing, Steven Abman, Lorna P Browne, Gareth Morgan, Michael Ross, Daniel McLennan, Alex J Barker, Brian Fonseca, Michael Di Maria, Kendall S Hunter, Uyen Truong
The purpose of the present study was to characterize pulmonary vascular stiffness using wave intensity analysis (WIA) in children with pulmonary arterial hypertension (PAH), compare the WIA indexes with catheterization- and MRI-derived hemodynamics, and assess the prognostic ability of WIA-derived biomarkers to predict the functional worsening. WIA was performed in children with PAH ( n = 40) and healthy control subjects ( n = 15) from phase-contrast MRI-derived flow and area waveforms in the main pulmonary artery (MPA)...
October 1, 2018: American Journal of Physiology. Heart and Circulatory Physiology