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Diane Hurd, Eric Arzubi, Mariela Rojas Herrera, Nicholas Coombs, Jeannine Brant
OBJECTIVE: This pilot study aims to explore the feasibility and proof of concept of triple chronotherapy (TCT) as a non-pharmacological, adjunctive intervention in the treatment of acute depression and suicidality in the adolescent population. METHOD: Thirty-one adolescents with moderate to severe depression were included in the study. Each participant underwent a 4-day intervention (TCT) which consisted of one night of sleep deprivation followed by three days of sleep phase advancement and daily bright light therapy...
February 2019: CNS Spectrums
Jannicke Fjæra Laskemoen, Carmen Simonsen, Camilla Büchmann, Elizabeth Ann Barrett, Thomas Bjella, Trine Vik Lagerberg, Trude Jahr Vedal, Ole A Andreassen, Ingrid Melle, Monica Aas
BACKGROUND: Sleep disturbances are prevalent in severe mental disorders but their type and frequency across diagnostic categories has not been investigated in large scale studies. METHODS: Participants with Schizophrenia spectrum disorders (SCZ, (N = 617)), Bipolar disorders (BD, (N = 440)), and Healthy Controls (HC, (N = 173)) were included in the study. Sleep disturbances (insomnia, hypersomnia and delayed sleep phase) were identified based on items from the Inventory of Depressive Symptoms - Clinician rated scale...
February 22, 2019: Comprehensive Psychiatry
Senthil Kumaran Satyanarayanan, Yu-Chuan Chien, Jane Pei-Chen Chang, Shih-Yi Huang, Ta-Wei Guu, Huanxing Su, Kuan-Pin Su
OBJECTIVE: Circadian dysfunction is a core manifestation and a risk factor for psychiatric disorders. Ramelteon (RMT), a melatonin receptor agonist, has been shown to induce sleep phase shifts and has been used to normalize sleep onset time. RMT has been used in sleep disorders, depression and anxiety. In this study, we aimed to investigate the effects of RMT in regulating gene expression profiles of the circadian clock and peripheral markers of inflammation and neuroplasticity. METHODS: Sixteen patients with a diagnosis of primary insomnia comorbid with depression and anxiety and ten healthy controls were recruited in an 8-week open-label trial...
March 6, 2019: Brain, Behavior, and Immunity
Geraldo Jose Ferrari Junior, Diego Grasel Barbosa, Rubian Diego Andrade, Andreia Pelegrini, Thais Silva Beltrame, Érico Pereira Gomes Felden
OBJECTIVE: To analyze the contribution of subjective sleep need for daytime sleepiness in adolescents, and to compare questions about sleep, age and body mass index between adolescents who considered to sleep enough and those who reported the need for more sleep. METHODS: This is a descriptive, epidemiological and cross-sectional study. Data collection was performed in August 2016, with 773 adolescents aged 14-19 years old, from Paranaguá, Paraná, Southern Brazil...
February 25, 2019: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Eleonore L Huang, Ingo G Steffen, Mathias Lukas, Kai Huang, Joerg R Aschenbach, Janet F Eary, Winfried Brenner, Nicola Beindorff
AIM: The aim of this study was to establish normal values for parotid gland (PG) and submandibular-sublingual salivary gland complex (SSC) uptake of 99m technetium pertechnetate (99m TcO4 ) as a function of age, sex and circadian rhythm in mice. METHODS: In 12 female (F) and 12 male (M) C57BL/6N mice, nine consecutive SPECT images of 10 min each were acquired as dynamic acquisitions beginning 5 min after intravenous injection of 80 MBq 99m TcO4 . Each mouse was imaged in follow-up studies at 1, 3, 6, 12 and 24 months of age...
February 2019: Nuklearmedizin. Nuclear Medicine
Javier Gracia-Tabuenca, Ville-Pekka Seppä, Milla Jauhiainen, Anne Kotaniemi-Syrjänen, Kristiina Malmström, Anna Pelkonen, Mika J Mäkelä, Jari Viik, Leo Pekka Malmberg
Overnight analysis of tidal breathing flow volume loops (TBFV), recorded by impedance pneumography (IP), has been successfully applied in the home monitoring of children with wheezing disorders. However, little is known on how sleep physiology modifies the relationship between TBFV profiles and wheeze. We studied such interactions in wheezing infants. 43 infants recruited due to recurrent lower airway symptoms were divided into 3 groups based on their risk of asthma, i.e. high (HR), intermediate (IR) or low (LR)...
February 14, 2019: Journal of Applied Physiology
Andras Bikov, Zsofia Lazar, Peter Horvath, David Laszlo Tarnoki, Adam Domonkos Tarnoki, Luca Fesus, Marton Horvath, Martina Meszaros, Gyorgy Losonczy, Laszlo Kunos
PURPOSE: Obstructive sleep apnoea (OSA) represents a risk for dyslipidaemia. Obstructive respiratory events during rapid eye movement (REM) sleep are more strongly related to the development of hypertension and diabetes than in non-REM. However, the relationship between sleep phases and serum lipid profile is unclear. We aimed to analyse the relationship between obstructive respiratory events in REM and non-REM sleep as well as serum lipid profile. METHODS: Polysomnography was performed in 94 adult subjects who did not take any lipid-modifying medications...
February 2, 2019: Lung
D G Gubin, Т N Malishevskaya, Y S Astakhov, S Y Astakhov, G Cornelissen, V A Kuznetsov, D Weinert
Advanced primary open-angle glaucoma (POAG) is characterized by progressive retinal ganglion cell complex (RGCC) damage that may cause subsequent disruption of the circadian rhythms. Therefore, we evaluated circadian body temperature (BT) rhythm and sleep characteristics of 115 individuals (38 men and 77 women) diagnosed with POAG. GLV (global loss volume; %), a measure of RGCC damage, was estimated by high-definition optical coherence tomography, and RGC functional ability was assessed by pattern electroretinogram amplitude (PERGA)...
January 21, 2019: Chronobiology International
Hans Reinke, Gad Asher
Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest (sleep) phases that differ largely in their metabolic requirements. The circadian clock evolved as an autonomous timekeeping system that aligns behavioural patterns with the solar day and supports the body functions by anticipating and coordinating the required metabolic programmes. The key component of this synchronization is a master clock in the brain, which responds to light-darkness cues from the environment...
January 11, 2019: Nature Reviews. Molecular Cell Biology
Mariana G Figueiro, Philip D Sloane, Kimberly Ward, David Reed, Sheryl Zimmerman, John S Preisser, Seema Garg, Christopher J Wretman
OBJECTIVE: This study investigated whether light delivered through the eyelids of sleeping persons might create phase delay in older adults who are adversely affected by advanced sleep phase disorder. PARTICIPANTS: Thirty-two cognitively intact, community-dwelling participants aged ≥ 50 years (20 females, 12 males) with Pittsburgh Sleep Quality Index scores ≥ 5 (poor sleep) completed the study. METHODS: This within-subjects, randomized, two-treatment crossover design study exposed participants to an active "blue" (λmax   =  480 nm) lighting intervention or a placebo "red" (λmax  = 640 nm) control through closed eyelids during sleep for 8 weeks...
December 27, 2018: Behavioral Sleep Medicine
Kai Huang, Mathias Lukas, Ingo G Steffen, Catharina Lange, Eleonore L Huang, Viktoria Dorau, Winfried Brenner, Nicola Beindorff
AIM: The aim of this study is to present normal values for 99m technetium mercaptoacetyltriglycine renal uptake kinetics as a function of age, sex and circadian rhythm in mice using multi-pinhole SPECT. METHODS: Dynamic multi-pinhole SPECT semistationary acquisitions consisting of 10 20 s frames followed by 25 50 s frames began prior to intravenous injection of 50 MBq in 12 female (F) and 12 male (M) C57BL/6N mice. Each mouse had follow-up imaging at 1, 3, 6, 12 and 22 months of age...
December 2018: Nuklearmedizin. Nuclear Medicine
Bao-Luen Chang, Marco Leite, Albert Snowball, Andreas Lieb, Elodie Chabrol, Matthew C Walker, Dimitri M Kullmann, Stephanie Schorge, Robert C Wykes
Focal neocortical epilepsy is a common form of epilepsy and there is a need to develop animal models that allow the evaluation of novel therapeutic strategies to treat this type of epilepsy. Tetanus toxin (TeNT) injection into rat visual cortex induces focal neocortical epilepsy without preceding status epilepticus. The latency to first seizure ranged from 3 to 7 days. Seizure duration was bimodal, with both short (approximately 30s) and long-lasting (>100s) seizures occurring in the same animals. Seizures were accompanied by non-motor features such as behavioural arrest, or motor seizures with or without evolution to generalized tonic-clonic seizures...
November 22, 2018: Disease Models & Mechanisms
Arcady A Putilov, Evgeniy G Verevkin
The term "social jet lag" was introduced for defining the conflict between social and biological clocks due to the general practice of shifting weekday risetime on early morning hours. The phase delay of the sleep-wake cycle during adolescence is one of the most remarkable features of the ontogenesis of sleep that is incompatible with early school start times. It was previously proposed that the process of accumulation of sleep pressure during wakefulness is slowing down in post-pubertal teens to allow them to stay awake for a longer period of time thus causing the delay of their bedtime...
2018: Frontiers in Physiology
Barbara L Parry, Charles J Meliska, Ana M Lopez, Diane L Sorenson, L Fernando Martinez, Henry J Orff, Richard L Hauger, Daniel F Kripke
BACKGROUND: Peripartum major depression (MD) disables mothers and impairs emotional and neurocognitive development of offspring. We tested the hypothesis that critically-timed wake therapy (WT) relieves peripartum MD by altering melatonin and sleep timing, differentially, in antepartum vs. postpartum depressed patients (DP). METHODS: In a university clinical research center, we initially randomized 50 women - 26 antepartum (17 healthy comparison-HC, 9 DP) and 24 postpartum (8 HC, 16 DP) - to a cross-over trial of one night of early-night wake therapy (EWT: sleep 3:00-7:00 am) vs...
November 5, 2018: Journal of Affective Disorders
H Craig Heller, Norman F Ruby
The propensity for sleep is timed by the circadian system. Many studies have shown that learning and memory performance is affected by circadian phase. And, of course it is well established that critical processes of memory consolidation occur during and depend on sleep. This chapter presents evidence that sleep and circadian rhythms do not just have separate influences on learning and memory that happen to coincide because of the circadian timing of sleep, but rather sleep and circadian systems have a critical functional interaction in the processes of memory consolidation...
November 16, 2018: Handbook of Experimental Pharmacology
Diane Hurd, Mariela Herrera, Jeannine M Brant, Nicholas C Coombs, Eric Arzubi
OBJECTIVE: The aim of this pilot study was to explore the feasibility and proof of concept of triple chronotherapy (TCT) as a nonpharmacological adjunctive treatment in the acute management of depression in the adolescent population. METHODS: Thirty-one adolescents with nonpsychotic moderate-to-severe depression were included in the study. The 4-day TCT intervention comprised one night of sleep deprivation followed by 3 days of sleep phase advancement and daily bright light therapy...
November 2, 2018: Journal of Child and Adolescent Psychopharmacology
Thien Nguyen, Olajide Babawale, Tae Kim, Hang Joon Jo, Hanli Liu, Jae Gwan Kim
This study investigates the brain functional connectivity in the rest and sleep states. We collected EEG, EOG, and fNIRS signals simultaneously during rest and sleep phases. The rest phase was defined as a quiet wake-eyes open (w_o) state, while the sleep phase was separated into three states; quiet wake-eyes closed (w_c), non-rapid eye movement sleep stage 1 (N1), and non-rapid eye movement sleep stage 2 (N2) using the EEG and EOG signals. The fNIRS signals were used to calculate the cerebral hemodynamic responses (oxy-, deoxy-, and total hemoglobin)...
November 1, 2018: Scientific Reports
A Della Volpe, L Dipietro, G Ricci, V Pastore, M Paccone, C Pirozzi, A Di Stadio
OBJECTIVES: Previous studies have shown that tryptophan and vitamin B6 used in conjunction with melatonin induce sleep more effectively than melatonin alone. This study aims at evaluating the efficacy of different dosages and timings of administration of a solution containing melatonin, tryptophan, and vitamin B6 for inducing sleep in children undergoing ABR testing. METHODS: 294 children scheduled for Auditory Brain Response (ABR) evaluation were administered a solution containing melatonin, tryptophan, and vitamin B6 to induce sleep before the exam...
December 2018: International Journal of Pediatric Otorhinolaryngology
Maciej Śmietanowski, Jarosław Wysocki, Jarosław Balcerzak, Agnieszka Cudnoch-Jędrzejewska, Maryla Śmietanowska, Kazimierz Niemczyk
Obstructive sleep apnea syndrome (OSA) is a form of sleep disordered breathing. The key phenomena are multiple repetitive pauses or restriction of airflow in the airway, defined as apnea and hypopnea. This study was based on a retrospective analysis of the results of polysomnographic (PSG) recordings of 230 adult patients (62 women and 168 men), being evaluated for OSA. The mean age, body mass index (BMI), apnea-hypopnea index (AHI), and pulse oximetry (SO2 nadir) of all patients were 50.4 ± 12.7 years, 30...
October 25, 2018: Advances in Experimental Medicine and Biology
A V Rosinskaya, E E Vasenina, T N Khaybullin, O S Levin
AIM: To optimize therapy with levodopa preparations in relation to the rate of disease progression. MATERIAL AND METHODS: Eighty-six patients with Parkinson's disease (PD) were studied. Rate of progression was assessed by time of developing the 3rd stage of the disease. Patient state was assessed using MDS-UPDRS, MMSE, verbal activity test, clock drawing test, Beck depression scale, apathy scale and scale of autonomic disorders. RESULTS AND CONCLUSION: In 37 patients, early prescription of levodopa preparations (on average 1,7 years after disease onset) facilitates a decrease in the rate of progression assessed by time of developing the 3rd stage of the disease (7,3±4,4 vs 5,8±2,8 years)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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