George Luo, Kristin Aldridge, Toby Chen, Vivek Aslot, Byung-Gyu Kim, Eun Hyang Han, Neelima Singh, Sai Li, Tsan Sam Xiao, Michael B Sporn, John J Letterio
Synthetic oleanane triterpenoids (SOTs) are small molecules with broad anti-cancer properties. A recently developed SOT, 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4(-pyridin-2-yl)-1H-imidazole (CDDO-2P-Im or '2P-Im'), exhibits enhanced activity and improved pharmacokinetics over CDDO-Im, a previous generation SOT. However, the mechanisms leading to these properties are not defined. Here we show synergy of 2P-Im and the proteasome inhibitor ixazomib in human multiple myeloma (MM) cells, and 2P-Im activity in a murine model of plasmacytoma...
May 7, 2023: Molecular Oncology