Kuniko Kusama-Eguchi, Yuki Tokui, Ai Minoura, Yuta Yanai, Dai Hirose, Megumi Furukawa, Yasuhiro Kosuge, Motofumi Miura, Emika Ohkoshi, Mitsuko Makino, Kimino Minagawa, Keiichi Matsuzaki, Yoshio Ogawa, Kazuko Watanabe, Ayumi Ohsaki
Amyotrophic lateral sclerosis (ALS) is a devastating motor disease with limited treatment options. A domestic fungal extract library was screened using three assays related to the pathophysiology of ALS with the aim of developing a novel ALS drug. 2(3H)-dihydrofuranolactones 1 and 2, and five known compounds 3-7 were isolated from Pleosporales sp. NUH322 culture media, and their protective activity against the excitotoxicity of β-N-oxalyl-L-α,β-diaminopropionic acid (ODAP), an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamatergic agonist, was evaluated under low mitochondrial glutathione levels induced by ethacrynic acid (EA) and low sulfur amino acids using our developed ODAP-EA assay...
October 7, 2023: Journal of Natural Medicines