keyword
https://read.qxmd.com/read/38101248/on-line-concentration-and-separation-of-multiple-derivatized-monosaccharides-from-edible-fruit-with-cyclodextrin-encapsulated-sweeping-by-micellar-electrokinetic-chromatography
#21
JOURNAL ARTICLE
Huang-Fei Jin, Ying Shi, Qian-Xue Shen, Jun Cao, Li-Hong Ye
An on-line enrichment and separation of multiple derivatized monosaccharides with cyclodextrin-encapsulated sweeping (CDES) by micellar electrokinetic chromatography (MEKC) was presented. Five monosaccharides (L-(-)-Mannose, D-(+)-Glucose, D-(-)-Ribose, D-(+)-Xylose, and L-(+)-Rhamnose) were derivatized with 1-phenyl-3-methyl-5-pyrazolone, subsequently concentrated and separated by MEKC. The optimized conditions were as follows: 50 mM phosphoric acid (PA), 100 mM sodium dodecyl sulfate (SDS), and 30 % (v/v) methanol in background solution; 140 s injection of sample solution containing 50 mM CD and 100 mM PA, followed by 90 s injection of 40 mM SDS solution...
December 5, 2023: Journal of Chromatography. A
https://read.qxmd.com/read/38092382/rheological-properties-and-composition-affecting-the-skin-permeation-of-a-model-of-a-hydrophilic-drug-in-lecithin-reverse-wormlike-micelles
#22
JOURNAL ARTICLE
Yoshiyuki Miyasaka, Kaname Hashizaki, Kohsuke Shibasaki, Makiko Fujii, Hiroyuki Taguchi
We investigated the effect of the rheological properties and composition of lecithin reverse wormlike micelles (LRWs) on the skin permeation of a model of a hydrophilic drug to determine whether LRWs support uniform hydrophilic drug/oil-based formulations and good drug penetrate into skin. Here, we prepared LRWs with D (-)-ribose (RI) or glycerol (GL) as polar compounds, liquid paraffin (LP) or isopropyl myristate (IPM) as oils, and 6-carboxyfluorescein (CF) as a model for a hydrophilic drug, and evaluated the rheological properties and skin penetration characteristics of the preparations...
December 14, 2023: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38077440/inhibition-of-non-small-cell-lung-cancer-nsclc-proliferation-through-targeting-g6pd
#23
JOURNAL ARTICLE
Makamas Chanda, Pornchai Anuntasomboon, Komkrit Ruangritchankul, Poonlarp Cheepsunthorn, Chalisa L Cheepsunthorn
BACKGROUND: Mounting evidence has linked cancer metabolic reprogramming with altered redox homeostasis. The pentose phosphate pathway (PPP) is one of the key metabolism-related pathways that has been enhanced to promote cancer growth. The glucose 6-phosphate dehydrogenase (G6PD) of this pathway generates reduced nicotinamide adenine dinucleotide phosphate (NADPH), which is essential for controlling cellular redox homeostasis. OBJECTIVE: This research aimed to investigate the growth-promoting effects of G6PD in non-small cell lung cancer (NSCLC)...
2023: PeerJ
https://read.qxmd.com/read/37979730/design-synthesis-and-antitubercular-assessment-of-1-2-3-triazole-incorporated-thiazolylcarboxylate-derivatives
#24
JOURNAL ARTICLE
Rajubai D Bakale, Shubham M Sulakhe, Sanghratna L Kasare, Bhaurao P Sathe, Sanket S Rathod, Prafulla B Choudhari, Estharla Madhu Rekha, Dharmarajan Sriram, Kishan P Haval
A library of 1, 2, 3-triazole incorporated thiazolylcarboxylate derivatives (7a-q) and (8a-j) were synthesized and evaluated for their in-vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. The two compounds 7 h and 8 h have displayed excellent antitubercular activity with MIC values of 3.12 and 1.56 µg/mL respectively (MIC values of standard drugs; Ciprofloxacin 1.56 μg/mL & Ethambutol 3.12 μg/mL). Whereas, the four compounds 7i, 7n, 7p and 8i displayed noticeable antitubercular activity with a MIC value of 6...
November 16, 2023: Bioorganic & Medicinal Chemistry Letters
https://read.qxmd.com/read/37977213/generation-of-autoantibodies-against-glycated-fibrinogen-role-in-diabetic-nephropathy-and-retinopathy
#25
JOURNAL ARTICLE
Afreen Khanam, Sultan Alouffi, Amjad R Alyahyawi, Arbab Husain, Saif Khan, Talal Alharazi, Rihab Akasha, Hamda Khan, Uzma Shahab, Saheem Ahmad
The process of glycation, characterized by the non-enzymatic reaction between sugars and free amino groups on biomolecules, is a key contributor to the development and progression of both microvascular and macrovascular complications associated with diabetes, particularly due to persistent hyperglycemia. This glycation process gives rise to advanced glycation end products (AGEs), which play a central role in the pathophysiology of diabetes complications, including nephropathy. The d-ribose-mediated glycation of fibrinogen plays a central role in the pathogenesis of diabetes nephropathy (DN) and retinopathy (DR) by the generation and accumulation of advanced glycation end products (AGEs)...
November 15, 2023: Analytical Biochemistry
https://read.qxmd.com/read/37886810/complete-composition-analysis-of-polysaccharides-based-on-hpaec-pad-coupled-with-quantitative-analysis-of-multi-components-by-single-marker
#26
JOURNAL ARTICLE
Xiao-Hui Yan, Xue-Qing Liu, Jun Liang, Hai-Xue Kuang, Yong-Gang Xia
INTRODUCTION: Monosaccharide compositions analysis (MCA) is indispensable for structural characterisations and structure-activity relationships of plant polysaccharides. OBJECTIVES: To develop a concise and direct MCA method, we established a quantitative analysis of the multi-monosaccharaides by single marker (QAMS) by high-performance anion-exchange chromatography with pulsed-amperometric detection (HPAEC-PAD) method. METHODOLOGY: A stable and reproducible HPAEC-PAD method for simultaneous determination of aldoses, ketoses and uronic acids (i...
October 27, 2023: Phytochemical Analysis: PCA
https://read.qxmd.com/read/37820454/x-ray-structures-of-enterobacter-cloacae-allose-binding-protein-in-complexes-with-monosaccharides-demonstrate-its-unique-recognition-mechanism-for-high-affinity-to-allose
#27
JOURNAL ARTICLE
Shigehiro Kamitori
d-Allose is an aldohexose of the C3-epimer of d-glucose, existing in very small amounts in nature, called a rare sugar. The operon responsible for d-allose metabolism, the allose operon, was found in several bacteria, which consists of seven genes: alsR, alsB, alsA, alsC, alsE, alsK, and rpiB. To understand the biological implication of the allose operon utilizing a rare sugar of d-allose as a carbon source, it is important to clarify whether the allose operon functions specifically for d-allose or also functions for other ligands...
October 5, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37810713/design-and-synthesis-of-l-1-homologated-adenosine-derivatives-as-potential-anti-inflammatory-agents
#28
JOURNAL ARTICLE
Mai Nguyen, Muhammad Arif Aslam, Yen Nguyen, Hafiz Muhammad Ahmad Javaid, Linh Pham, Joo Young Huh, Gyudong Kim
Inflammatory responses are fundamental protective warning mechanisms. However, in certain instances, they contribute significantly to the development of several chronic diseases such as cancer. Based on previous studies of truncated 1'-homologated adenosine derivatives, l-nucleosides and their nucleobase-modified quinolone analogues were designed, synthesized, and evaluated for anti-inflammatory activities. The target molecules were synthesized via the key intramolecular cyclization of monotosylate and Mitsunobu condensation from the natural product, d-ribose...
October 3, 2023: ACS Omega
https://read.qxmd.com/read/37804412/2-3h-dihydrofranolactone-metabolites-from-pleosporales-sp-nuh322-as-anti-amyotrophic-lateral-sclerosis-drugs
#29
JOURNAL ARTICLE
Kuniko Kusama-Eguchi, Yuki Tokui, Ai Minoura, Yuta Yanai, Dai Hirose, Megumi Furukawa, Yasuhiro Kosuge, Motofumi Miura, Emika Ohkoshi, Mitsuko Makino, Kimino Minagawa, Keiichi Matsuzaki, Yoshio Ogawa, Kazuko Watanabe, Ayumi Ohsaki
Amyotrophic lateral sclerosis (ALS) is a devastating motor disease with limited treatment options. A domestic fungal extract library was screened using three assays related to the pathophysiology of ALS with the aim of developing a novel ALS drug. 2(3H)-dihydrofuranolactones 1 and 2, and five known compounds 3-7 were isolated from Pleosporales sp. NUH322 culture media, and their protective activity against the excitotoxicity of β-N-oxalyl-L-α,β-diaminopropionic acid (ODAP), an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamatergic agonist, was evaluated under low mitochondrial glutathione levels induced by ethacrynic acid (EA) and low sulfur amino acids using our developed ODAP-EA assay...
October 7, 2023: Journal of Natural Medicines
https://read.qxmd.com/read/37791784/drug-distribution-and-efficacy-of-the-dpre1-inhibitor-btz-043-in-the-c3heb-fej-mouse-tuberculosis-model
#30
JOURNAL ARTICLE
Michelle E Ramey, Firat Kaya, Allison A Bauman, Lisa M Massoudi, Jansy P Sarathy, Matthew D Zimmerman, Dashick W L Scott, Alyx M Job, Jake A Miller-Dawson, Brendan K Podell, Michael A Lyons, Véronique Dartois, Anne J Lenaerts, Gregory T Robertson
BTZ-043, a suicide inhibitor of the Mycobacterium tuberculosis cell wall synthesis decaprenylphosphoryl-beta-D-ribose 2' epimerase, is under clinical development as a potential new anti-tuberculosis agent. BTZ-043 is potent and bactericidal in vitro but has limited activity against non-growing bacilli in rabbit caseum. To better understand its behavior in vivo , BTZ-043 was evaluated for efficacy and spatial drug distribution as a single agent in the C3HeB/FeJ mouse model presenting with caseous necrotic pulmonary lesions upon Mycobacterium tuberculosis infection...
October 4, 2023: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/37764256/chiral-recognition-of-d-l-ribose-by-visual-and-sers-assessments
#31
JOURNAL ARTICLE
Guohua Yao, Chao Liu, Shereen M Elsherbiny, Qing Huang
Ribose is the central molecular unit in ribose nucleic acid (RNA). Ribose is a key molecule in the study of many persistent scientific mysteries, such as the origin of life and the chiral homogeneity of biological molecules. Therefore, the chiral recognition of ribose is of great significance. The traditional method of chiral recognition of ribose is HPLC, which is time-consuming, expensive, and can only be operated in the laboratory. There is no report on optical analytical techniques that can quickly detect the chirality of ribose...
September 7, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37748222/gut-microbiota-derived-autoinducer-2-regulates-lung-inflammation-through-the-gut-lung-axis
#32
JOURNAL ARTICLE
Xianghao Zeng, Huawen Yue, Ling Zhang, Guimei Chen, Qiao Zheng, Qing Hu, Xinhao Du, Qian Tian, Xinyu Zhao, Lanfan Liang, Ziyi Yang, Hang Bai, Yanqin Liu, Ming Zhao, Xiangsheng Fu
OBJECTIVE: This study aimed to determine whether autoinducer-2 (AI-2), a crucial bacterial metabolite and quorum sensing molecule, is involved in lung immunity through the gut-lung axis. METHODS: The level of AI-2 and the gut microbiome composition were analysed in the stools from pneumonic patients and the mouse model of acute lung injury. The effect of AI-2 on lung inflammation was further investigated in the mouse model. RESULTS: The diversity of the faecal microbiota was reduced in pneumonic patients treated with antibiotics compared with healthy volunteers...
September 23, 2023: International Immunopharmacology
https://read.qxmd.com/read/37741485/protective-effect-of-thymoquinone-on-glycation-of-human-myoglobin-induced-by-d-ribose
#33
JOURNAL ARTICLE
Jing-Jing Liu, Zhan-Yi Wang, Bin-Bin Jiang, Shu-Qin Gao, Ying-Wu Lin
Nonenzymatic glycation and the subsequent accumulation of advanced glycation end-products (AGEs) in proteins are factors underlying long-term pathogenesis in diabetes. The study of protein glycation is crucial for elucidating their relationship with diabetes mellitus and related disorders. This study explores the interaction between d-ribose and human myoglobin (HMb), as well as the protective effect of thymoquinone (TQ) on glycation. A time-dependent in-vitro glycation study was performed to investigate the mechanism of d-ribose-induced structural interference of HMb in the absence and presence of TQ...
September 21, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37736177/synthesis-and-structure-activity-relationships-of-a-new-class-of-oxadiazoles-targeting-dpre1-as-antitubercular-agents
#34
JOURNAL ARTICLE
Veena D Yadav, Helena I Boshoff, Lena Trifonov, Jose Santinni O Roma, Thomas R Ioerger, Clifton E Barry, Sangmi Oh
The continuing prevalence of drug-resistant tuberculosis threatens global TB control programs, highlighting the need to discover new drug candidates to feed the drug development pipeline. In this study, we describe a high-throughput screening hit (4-benzylpiperidin-1-yl)(1-(5-phenyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl)methanone ( P1 ) as a potent antitubercular agent. Structure-activity guided synthesis led to the discovery of several analogs with high in vitro potency. P1 was found to have promising potency against many drug-resistant strains, as well as drug-susceptible clinical isolates...
September 14, 2023: ACS Medicinal Chemistry Letters
https://read.qxmd.com/read/37723955/a-rational-approach-to-antitubercular-drug-design-molecular-docking-prediction-of-adme-properties-and-evaluation-of-antitubercular-activity-of-novel-isonicotinamide-scaffold
#35
JOURNAL ARTICLE
Paramita Das, Sharanakummar R Gumma, Anjali Nayak, Sunil Menghani, Jithendar Reddy Mandhadi, Padmavathi P Prabhu
INTRODUCTION: One of the most devastating and leading diseases is Tuberculosis (TB), caused by Mycobacterium tuberculosis. Even though many synthetic drugs are available in the market, to increase the therapeutic efficacy and reduce toxicity. Isoniazid is the primary drug used in the treatment of tuberculosis. METHODS: The main objective of the study is to perform molecular docking studies and synthesize the derivatives of isonicotinamide along with the anti-tubercular activity...
August 22, 2023: Recent Adv Antiinfect Drug Discov
https://read.qxmd.com/read/37698416/discovery-of-novel-reversible-inhibitor-of-dpre1-based-on-benzomorpholine-for-the-treatment-of-tuberculosis
#36
JOURNAL ARTICLE
Wang Xiang, Hualong He, Xianjie Duan, Zhiqun He, Xinyue Xu, Mengya Liao, Fei Teng, Xiao Li, Tianwen Luo, Jumei Zeng, Luoting Yu, Chao Gao
About a quarter of the world's population is infected with Mycobacterium tuberculosis , equivalent to about two billion people. With the emergence of multidrug-resistant tuberculosis, those existing anti-tuberculosis drugs no longer meet the demand for cure anymore; there is an urgent need for the development of new anti-tuberculosis drugs. Decaprenylphosphoryl-β-D-ribose 2´-epimerase (DprE1) has been proven to be a potential antimycobacterial target, and several inhibitors have entered clinical trial...
September 12, 2023: Microbiology Spectrum
https://read.qxmd.com/read/37668878/correction-to-d%C3%A2-ribose%C3%A2-l%C3%A2-cysteine-improves-glutathione-levels-neuronal-and-mitochondrial-ultrastructural-damage-caspase%C3%A2-3-and-gfap-expressions-following-manganese%C3%A2-induced-neurotoxicity
#37
Grace T Akingbade, Omamuyovwi M Ijomone, Aminu Imam, Michael Aschner, Moyosore S Ajao
No abstract text is available yet for this article.
December 2023: Neurotoxicity Research
https://read.qxmd.com/read/37659699/2-deoxy-d-ribose-induces-ferroptosis-in-renal-tubular-epithelial-cells-via-ubiquitin-proteasome-system-mediated-xct-protein-degradation
#38
JOURNAL ARTICLE
Miyeon Kim, Ju Young Bae, Soyeon Yoo, Hyun Woo Kim, Sang Ah Lee, Eui Tae Kim, Gwanpyo Koh
Ferroptosis is a novel form of cell death triggered by iron-dependent lipid peroxidation. Recent findings suggest that inhibiting system χc-induces ferroptosis by reducing intracellular cystine levels, and that ferroptosis in renal tubular epithelial cells (RTECs) contributes to acute kidney injury (AKI) and diabetic nephropathy. Moreover, 2-deoxy-d-ribose (dRib) has been shown to inhibit cystine uptake through xCT, the functional unit of system χc-, in β-cells. This study aimed to investigate if dRib induces ferroptosis in RTECs and identify the underlying mechanisms...
September 1, 2023: Free Radical Biology & Medicine
https://read.qxmd.com/read/37655680/design-synthesis-biological-evaluation-and-molecular-dynamics-of-some-novel-3-phenylpyrazolo-1-5-a-pyrimidine-2-7-1-h-4-h-dione-based-compounds-as-anti-tubercular-agents
#39
JOURNAL ARTICLE
Monica Chauhan, Chintu Prajapati, Sadaf Mirza, Rahul Barot, Rasana Yadav, Mahesh Barmade, Dhruvi Kakadiya, Ravi Vijayvargia, Bijaya Haobam, Anurag Tk Baidya, Rajnish Kumar, M R Yadav, Prashant Murumkar
Decaprenylphosphoryl-β-d-ribose-2'-epimerase (DprE1) is a druggable target which is being exploited for the development of new anti-TB agents. In the present work, we report developing a pharmacophore model and performing virtual screening of Asinex database using the developed pharmacophore model to get eight hits as potential DprE1 inhibitors. The hits were used as leads to design new 3-phenylpyrazolo[1,5- a ]pyrimidine-2,7(1 H ,4 H )-dione based potential anti-TB agents. On the basis of the identified lead molecules, a total of 18 compounds were synthesized and evaluated for their anti-TB activity by using MABA...
September 1, 2023: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/37592767/metabolomic-profile-of-seminal-plasma-from-guzer%C3%A3-bulls-bos%C3%A2-indicus-with-contrasting-sperm-freezability-phenotypes
#40
JOURNAL ARTICLE
Eduardo Rodrigues Pessoa, Fábio Roger Vasconcelos, Stelamaris de Oliveira Paula-Marinho, Danilo de Menezes Daloso, Denise Damasceno Guerreiro, Jorge André Matias Martins, Enéas Gomes-Filho, Arlindo Alencar Moura
The present study evaluated the seminal plasma metabolome of Bos indicus Guzerá bulls with good (n = 4) and poor (n = 5) sperm freezability. Animals were raised in natural pasture of a 'Caatinga' ecosystem, in the semi-arid region of Brazil. Seminal plasma samples were subjected to gas chromatography coupled to mass spectrometry and data, analysed using bioinformatics tools (Cytoscape with the MetScape plug-in). Sixty-two metabolites were identified in the bovine seminal plasma...
August 17, 2023: Reproduction in Domestic Animals
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