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JOURNAL ARTICLE
Giovanna Polcaro, Luigi Liguori, Valentina Manzo, Annalisa Chianese, Giuliana Donadio, Alessandro Caputo, Giosuè Scognamiglio, Federica Dell'Annunziata, Maddalena Langella, Graziamaria Corbi, Alessandro Ottaiano, Marco Cascella, Francesco Perri, Margot De Marco, Jessica Dal Col, Giovanni Nassa, Giorgio Giurato, Pio Zeppa, Amelia Filippelli, Gianluigi Franci, Fabrizio Dal Piaz, Valeria Conti, Stefano Pepe, Francesco Sabbatino
Efficient predictive biomarkers are needed for immune checkpoint inhibitor (ICI)-based immunotherapy in non-small cell lung cancer (NSCLC). Testing the predictive value of single nucleotide polymorphisms (SNPs) in programmed cell death 1 (PD-1) or its ligand 1 (PD-L1) has shown contrasting results. Here, we aim to validate the predictive value of PD-L1 SNPs in advanced NSCLC patients treated with ICIs as well as to define the molecular mechanisms underlying the role of the identified SNP candidate. rs822336 efficiently predicted response to anti-PD-1/PD-L1 immunotherapy in advanced non-oncogene addicted NSCLC patients as compared to rs2282055 and rs4143815...
March 25, 2024: Molecular Cancer
#2
JOURNAL ARTICLE
Pooja Goyal, Gajinder K Goyal, Kriti Yadav, Anshuman Bhatt, Khushboo Nassa, Suman K Raushan, Dhairya Aggarwal, Rakesh Dagar
CONTEXT: There has been an increasing prevalence of hypertension (HTN) affecting all populations of the world including the special occupational groups and industries workers. AIMS: To estimate the prevalence of hypertension and to determine the associated factors among industrial workers in the Haryana state of India. SETTINGS AND DESIGN: A cross-sectional study was conducted among 323 industrial workers of Faridabad, Haryana. MATERIALS AND METHODS: A semi-structured and validated questionnaire was used to collect information regarding sociodemographic characteristics of the workers, their personal habits, and occupational history...
January 2024: Journal of Family Medicine and Primary Care
#3
JOURNAL ARTICLE
Veronica Folliero, Carlo Ferravante, Valentina Iovane, Annamaria Salvati, Laura Crescenzo, Rossella Perna, Giusy Corvino, Maria T Della Rocca, Vittorio Panetta, Alessandro Tranfa, Giuseppe Greco, Teresa Baldoni, Ugo Pagnini, Emiliana Finamore, Giorgio Giurato, Giovanni Nassa, Mariagrazia Coppola, Luigi Atripaldi, Rita Greco, Annamaria D'Argenio, Maria Grazia Foti, Rosamaria Abate, Annalisa Del Giudice, Bruno Sarnelli, Alessandro Weisz, Giuseppe Iovane, Renato Pinto, Gianluigi Franci, Massimiliano Galdiero
Tuberculosis (TB) is one of the deadliest infectious disorders in the world. To effectively TB manage, an essential step is to gain insight into the lineage of Mycobacterium tuberculosis (MTB) and the distribution of drug resistance. Although the Campania region is declared a cluster area for the infection, to contribute to the effort to understand TB evolution and transmission, still poorly known, we have generated a dataset of 159 genomes of MTB strains, from Campania region collected during 2018-2021, obtained from the analysis of whole genome sequence...
February 19, 2024: Scientific Data
#4
JOURNAL ARTICLE
Chantal Hampf, Maike Scherf-Clavel, Carolin Weiß, Catherina Klüpfel, Saskia Stonawski, Leif Hommers, Katharina Lichter, Angelika Erhardt-Lehmann, Stefan Unterecker, Katharina Domschke, Sarah Kittel-Schneider, Andreas Menke, Jürgen Deckert, Heike Weber
Anxious depression represents a subtype of major depressive disorder and is associated with increased suicidality, severity, chronicity and lower treatment response. Only a few studies have investigated the differences between anxious depressed (aMDD) and non-anxious depressed (naMDD) patients regarding treatment dosage, serum-concentration and drug-specific treatment response. In our naturalistic and prospective study, we investigated whether the effectiveness of therapy including antidepressants (SSRI, SNRI, NaSSA, tricyclics and combinations) in aMDD patients differs significantly from that in naMDD patients...
December 5, 2023: International Journal of Molecular Sciences
#5
JOURNAL ARTICLE
Yuliya Piatkova, Matthieu Doyen, Sébastien Heyer, Ayaz Tahmazov, Solene Frismand, Lucie Hopes, Laetitia Imbert, Antoine Verger
PURPOSE: Dopamine transporter (DAT) imaging is used to support the diagnosis of neurodegenerative parkinsonian disorders. Specific medications have been reported to confound the interpretation of [123 I]I-FP-CIT SPECT scans, but there is limited data. The aim of the current study is to identify potential medication effects on the interpretation of [123 I]I-FP-CIT SPECT scans in routine practice. MATERIALS AND METHODS: Consecutive patients undergoing a [123 I]I-FP-CIT SPECT/CT scan on a 360° CZT camera between September 2019 and December 2022 were included...
December 20, 2023: European Journal of Nuclear Medicine and Molecular Imaging
#6
JOURNAL ARTICLE
Genome-wide DNA methylation changes upon DOT1L inhibition in hormone-responsive breast cancer cells.
Giorgio Giurato, Ilaria Terenzi, Francesco Chiuso, Annamaria Salvati, Francesca Rizzo, Roberta Tarallo, Alessandro Weisz, Giovanni Nassa
No abstract text is available yet for this article.
2023: Frontiers in Cell and Developmental Biology
#7
JOURNAL ARTICLE
Emma M Harding-Esch, Clara R Burgert-Brucker, Cristina Jimenez, Ana Bakhtiari, Rebecca Willis, Michael Dejene Bejiga, Caleb Mpyet, Jeremiah Ngondi, Sarah Boyd, Mariamo Abdala, Amza Abdou, Yilikal Adamu, Addisu Alemayehu, Wondu Alemayehu, Tawfik Al-Khatib, Sue-Chen Apadinuwe, Naomie Awaca, Marcel S Awoussi, Gilbert Baayendag, Mouctar Dieng Badiane, Robin L Bailey, Wilfrid Batcho, Zulficar Bay, Assumpta Bella, Nassirou Beido, Yak Yak Bol, Clarisse Bougouma, Christopher J Brady, Victor Bucumi, Robert Butcher, Risiate Cakacaka, Anaseini Cama, Mamoudou Camara, Eunice Cassama, Shorai Grace Chaora, Amel Chenaoui Chebbi, Alvin Blessings Chisambi, Brian Chu, Abdulai Conteh, Sidi Mohamed Coulibaly, Paul Courtright, Abdi Dalmar, Tran Minh Dat, Thully Davids, Mohamed El Amine Djaker, Maria de Fátima Costa Lopes, Djore Dézoumbé, Sarity Dodson, Philip Downs, Stephanie Eckman, Bilghis Elkhair Elshafie, Mourad Elmezoghi, Ange Aba Elvis, Paul Emerson, Emilienne Ee Epée, Daniel Faktaufon, Mawo Fall, Aréty Fassinou, Fiona Fleming, Rebecca Flueckiger, Koizan Kadjo Gamael, Mackline Garae, Jambi Garap, Katie Gass, Genet Gebru, Michael M Gichangi, Emanuele Giorgi, André Goépogui, Daniela Vaz Ferreira Gómez, Diana Paola Gómez Forero, Emily W Gower, Anna Harte, Rob Henry, Harvy Alberto Honorio-Morales, Dunera R Ilako, Amadou Alfa Bio Issifou, Ellen Jones, George Kabona, Martin Kabore, Boubacar Kadri, Khumbo Kalua, Sarjo Kebba Kanyi, Shambel Kebede, Fikreab Kebede, Jeremy D Keenan, Amir B Kello, Asad Aslam Khan, Houria Khelifi, Janvier Kilangalanga, Sung Hye Kim, Robert Ko, Susan Lewallen, Thomas Lietman, Makoy Samuel Yibi Logora, Yuri A Lopez, Chad MacArthur, Colin Macleod, Felix Makangila, Brehima Mariko, Diana L Martin, Michael Masika, Patrick Massae, Marilia Massangaie, Hadley S Matendechero, Tsedeke Mathewos, Siobhain McCullagh, Aboulaye Meite, Elsa Palma Mendes, Hirpa M Abdi, Hollman Miller, Abdellahi Minnih, Sailesh Kumar Mishra, Tuduetso Molefi, Aryc Mosher, Nerkoua M'Po, Francis Mugume, Robson Mukwiza, Consity Mwale, Stephen Mwatha, Upendo Mwingira, Scott D Nash, Christophe Nassa, Nebiyu Negussu, Cece Nieba, Jean Claude Noah Noah, Christian O Nwosu, Nicholas Olobio, Rapheal Opon, Alexandre Pavluck, Isaac Phiri, Merelesita Rainima-Qaniuci, Kristen K Renneker, Martha Idalí Saboyá-Díaz, Fatoumata Sakho, Salimato Sanha, Virginia Sarah, Boubacar Sarr, Celia L Szwarcwald, Ahmad Shah Salam, Shekhar Sharma, Fikre Seife, Gloria Marina Serrano Chavez, Mactar Sissoko, Henis Mior Sitoe, Oliver Sokana, Fentahun Tadesse, Fasiah Taleo, Sandra Liliana Talero, Youcef Tarfani, Amsayaw Tefera, Rabebe Tekeraoi, Andeberhan Tesfazion, Abubaker Traina, Lamine Traoré, Julián Trujillo-Trujillo, Edridah M Tukahebwa, Praveen Vashist, Ernest B Wanyama, Supriya D P Warusavithana, Titus K Watitu, Sheila West, Ye Win, Geordie Woods, Aya Yajima, Georges Yaya, Alem Zecarias, Solomon Zewengiel, Akoi Zoumanigui, Pamela J Hooper, Tom Millar, Lisa Rotondo, Anthony W Solomon
PURPOSE: Population-based prevalence surveys are essential for decision-making on interventions to achieve trachoma elimination as a public health problem. This paper outlines the methodologies of Tropical Data, which supports work to undertake those surveys. METHODS: Tropical Data is a consortium of partners that supports health ministries worldwide to conduct globally standardised prevalence surveys that conform to World Health Organization recommendations. Founding principles are health ministry ownership, partnership and collaboration, and quality assurance and quality control at every step of the survey process...
December 2023: Ophthalmic Epidemiology
#8
JOURNAL ARTICLE
Kristin M Sullivan, Emma M Harding-Esch, Wilfrid E Batcho, Amadou A Bio Issifou, Maria de Fátima Costa Lopes, Celia Landmann Szwarcwald, Daniela Vaz Ferreira Gomez, Clarisse Bougouma, Nassa Christophe, Martin Kabore, Victor Bucumi, Assumpta L Bella, Emilienne Epee, Georges Yaya, Julian Trujillo-Trujillo, Michael Dejene, Fikre Seife Gebretsadik, Genet Gebru, Fikreab Kebede, Tsedeke Mathewos, Eunice Texiera de Silva Cassama, Salimato Sanha, Ernest Barasa, Hadley Matendechero Sultani, Titus Watitu, Rabebe Tekeraoi, Khumbo M Kalua, Michael P Masika, Lamine Traoré, Abdallahi O Minnih, Mariamo Abdala, Marília E Massangaie, Ye Win, Sue-Chen Apadinuwe, Sailesh Kumar Mishra, Shekhar Sharma, Abdou Amza, Boubacar Kadri, Beido Nassirou, Caleb D Mpyet, Nicholas Olobio, Arif Hussain, Asad Aslam Khan, Garap Jambi, Robert Ko, Amir B Kello, Mouctar D Badiane, Boubacar Sarr, Abdi Dalmar, Balgesa E Elshafie, George E Kabona, Oscar Kaitaba, Upendo Mwingira, Alistidia Simon, Sarjo Kanyi, Marcel S Awoussi, Kwamy Togbey, Gilbert Baayenda, Mugume Francis, Edridah M Tukahebwa, Ana Bakhtiari, Alexander P Keil, Joanna Maselko, Daniel Westreich, Mackline Garae, Fasiah Taleo, Tawfik Q Al-Khateeb, Consity Mwale, Anthony W Solomon, Emily W Gower
BACKGROUND: Trachomatous trichiasis (TT) is a painful, potentially blinding eye condition that can be managed through epilation or surgery. Women are affected by TT approximately twice as often as men and are believed to face gendered barriers to receiving surgical care to prevent vision loss. METHODS: We used data from 817 cross-sectional surveys conducted during 2015-2019 in 20 African countries to estimate the prevalence difference (PD) between female and male eyes for four outcomes potentially indicating gender-related differences in TT management: (1) received surgery and developed postoperative TT (PTT), (2) never offered surgery, (3) offered surgery but declined it, and (4) offered epilation but never offered surgery...
December 4, 2023: International Health
#9
REVIEW
Qingyang Zhan, Fanyi Kong
Stroke is one of the most common cerebrovascular diseases, which is the cause of long-term mental illness and physical disability, Post-stroke depression (PSD) is the most common neuropsychiatric complication after stroke, and its mechanisms are characterized by complexity, plurality, and diversity, which seriously affects the quality of survival and prognosis of patients. Studies have focused on and recognized neurotransmitter-based mechanisms and selective serotonin-reuptake inhibitors (SSRIs) can be used to treat PSD...
2023: Frontiers in Neurology
#10
JOURNAL ARTICLE
Pasquale Saggese, Aparamita Pandey, Martín Alcaraz, Eileen Fung, Abbie Hall, Jane Yanagawa, Erika F Rodriguez, Tristan R Grogan, Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Orian S Shirihai, Alessandro Weisz, Steven M Dubinett, Claudio Scafoglio
Increased utilization of glucose is a hallmark of cancer. Sodium-glucose transporter 2 (SGLT2) is a critical player in glucose uptake in early-stage and well-differentiated lung adenocarcinoma (LUAD). SGLT2 inhibitors, which are FDA-approved for diabetes, heart failure, and kidney disease, have been shown to significantly delay LUAD development and prolong survival in murine models and in retrospective studies in diabetic patients, suggesting that they may be re-purposed for lung cancer. Despite the anti-tumor effects of SGLT2 inhibition, tumors eventually escape treatment...
November 7, 2023: Cancer Research
#11
JOURNAL ARTICLE
Marzia Di Donato, Erika Di Zazzo, Annamaria Salvati, Carmela Sorrentino, Giorgio Giurato, Donatella Fiore, Maria Chiara Proto, Monica Rienzo, Amelia Casamassimi, Patrizia Gazzerro, Maurizio Bifulco, Gabriella Castoria, Alessandro Weisz, Giovanni Nassa, Ciro Abbondanza
BACKGROUND: Colorectal cancer (CRC) is the third most deadly and fourth most diagnosed cancer worldwide. Despite the progress in early diagnosis and advanced therapeutic options, CRC shows a poor prognosis with a 5 year survival rate of ~ 45%. PRDM2/RIZ, a member of PR/SET domain family (PRDM), expresses two main molecular variants, the PR-plus isoform (RIZ1) and the PR-minus (RIZ2). The imbalance in their expression levels in favor of RIZ2 is observed in many cancer types...
October 18, 2023: Journal of Translational Medicine
#12
Annamaria Salvati, Carlo Ferravante, Jessica Lamberti, Teresa Rocco, Elena Alexandrova, Ylenia D'Agostino, Maksim Sorokin, Victor Efimov, Anton Buzdin, Oriana Strianese, Giovanni Nassa, Roberta Tarallo, Alessandro Weisz, Francesca Rizzo, Giorgio Giurato
No abstract text is available yet for this article.
September 7, 2023: Scientific Data
#13
JOURNAL ARTICLE
Bernhards Ogutu, Adoke Yeka, Sylvia Kusemererwa, Ricardo Thompson, Halidou Tinto, Andre Offianan Toure, Chirapong Uthaisin, Amar Verma, Afizi Kibuuka, Moussa Lingani, Carlos Lourenço, Ghyslain Mombo-Ngoma, Videlis Nduba, Tiacoh Landry N'Guessan, Guétawendé Job Wilfried Nassa, Mary Nyantaro, Lucas Otieno Tina, Piyoosh K Singh, Myriam El Gaaloul, Anne Claire Marrast, Havana Chikoto, Katalin Csermak, Ivan Demin, Dheeraj Mehta, Rashidkhan Pathan, Celine Risterucci, Guoqin Su, Cornelis Winnips, Grace Kaguthi, Bakary Fofana, Martin Peter Grobusch
BACKGROUND: Emergence of drug resistance demands novel antimalarial drugs with new mechanisms of action. We aimed to identify effective and well tolerated doses of ganaplacide plus lumefantrine solid dispersion formulation (SDF) in patients with uncomplicated Plasmodium falciparum malaria. METHODS: This open-label, multicentre, parallel-group, randomised, controlled, phase 2 trial was conducted at 13 research clinics and general hospitals in ten African and Asian countries...
June 13, 2023: Lancet Infectious Diseases
#14
JOURNAL ARTICLE
Annamaria Salvati, Carlo Ferravante, Jessica Lamberti, Teresa Rocco, Elena Alexandrova, Ylenia D'Agostino, Maksim Sorokin, Victor Efimov, Anton Buzdin, Oriana Strianese, Giovanni Nassa, Roberta Tarallo, Alessandro Weisz, Francesca Rizzo, Giorgio Giurato
The ongoing COVID-19 pandemic caused by SARS-CoV-2 has affected millions of people worldwide and has significant implications for public health. Host transcriptomics profiling provides comprehensive understanding of how the virus interacts with host cells and how the host responds to the virus. COVID-19 disease alters the host transcriptome, affecting cellular pathways and key molecular functions. To contribute to the global effort to understand the virus's effect on host cell transcriptome, we have generated a dataset from nasopharyngeal swabs of 35 individuals infected with SARS-CoV-2 from the Campania region in Italy during the three outbreaks, with different clinical conditions...
June 14, 2023: Scientific Data
#15
Ilaria Secci, Lucie Petigas, Alexandra Cuenod, Paul Klauser, Carole Kapp, Audrey Novatti, Marco Armando
High rates of co-occurring depression are commonly reported in youth with Autism Spectrum Disorder (ASD), especially in individuals without intellectual disability (ID). Depression in ASD undermines adaptive behavior and is associated with a higher risk of suicidality. Females with ASD may be particularly vulnerable due to their greater use of camouflaging strategies. Indeed, in comparison to males, ASD is underdiagnosed in females, despite higher rates of internalizing symptoms and suicidality. Trauma exposure may also play a role in the development of depressive symptoms in this population...
2023: Frontiers in Psychiatry
#16
JOURNAL ARTICLE
Serge Ouoba, Ko Ko, Moussa Lingani, Shintaro Nagashima, Alice N Guingané, E Bunthen, Md Razeen Ashraf Hussain, Aya Sugiyama, Tomoyuki Akita, Masayuki Ohisa, Moussa Abdel Sanou, Ousmane Traore, Job Wilfried Nassa, Maimouna Sanou, Kazuaki Takahashi, Halidou Tinto, Junko Tanaka
In highly endemic countries for hepatitis B virus (HBV) infection, childhood infection, including mother-to-child transmission (MTCT), represents the primary transmission route. High maternal DNA level (viral load ≥ 200,000 IU/mL) is a significant factor for MTCT. We investigated the prevalence of HBsAg, HBeAg, and high HBV DNA among pregnant women in three hospitals in Burkina Faso and assessed the performance of HBeAg to predict high viral load. Consenting pregnant women were interviewed on their sociodemographic characteristics and tested for HBsAg by a rapid diagnostic test, and dried blood spot (DBS) samples were collected for laboratory analyses...
April 14, 2023: Scientific Reports
#17
JOURNAL ARTICLE
Mamadou Serme, Adama Zida, Roland Bougma, Appolinaire Kima, Christophe Nassa, Micheline Ouedraogo, Cathérine Kabre, Harouna Zoromé, Issa Guire, Dieudonné Nare, Clarisse Bougouma
BACKGROUND & RATIONALE: Burkina Faso has been implementing preventive chemotherapy against lymphatic filariasis since 2001. While 61 health districts (HDs) have stopped mass drug administration (MDA), transmission persists in 9 HDs despite good reported MDA coverage. To validate the reported coverage, an independent post-MDA survey was conducted in Tenkodogo and Fada N'Gourma HDs in September 2018. MATERIALS & METHODS: The study population consisted of all persons in the visited communities...
December 31, 2022: Med Trop Sante Int
#18
Pasquale Saggese, Aparamita Pandey, Eileen Fung, Abbie Hall, Jane Yanagawa, Erika F Rodriguez, Tristan R Grogan, Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Alessandro Weisz, Steven M Dubinett, Claudio Scafoglio
Increased utilization of glucose is a hallmark of cancer. Several studies are investigating the efficacy of glucose restriction by glucose transporter blockade or glycolysis inhibition. However, the adaptations of cancer cells to glucose restriction are unknown. Here, we report the discovery that glucose restriction in lung adenocarcinoma (LUAD) induces cancer cell de-differentiation, leading to a more aggressive phenotype. Glucose deprivation causes a reduction in alpha-ketoglutarate (αKG), leading to attenuated activity of αKG-dependent histone demethylases and histone hypermethylation...
February 1, 2023: bioRxiv
#19
REVIEW
Viola Melone, Annamaria Salvati, Noemi Brusco, Elena Alexandrova, Ylenia D'Agostino, Domenico Palumbo, Luigi Palo, Ilaria Terenzi, Giovanni Nassa, Francesca Rizzo, Giorgio Giurato, Alessandro Weisz, Roberta Tarallo
In the complex and articulated machinery of the human genome, less than 2% of the transcriptome encodes for proteins, while at least 75% is actively transcribed into non-coding RNAs (ncRNAs). Among the non-coding transcripts, those ≥200 nucleotides long (lncRNAs) are receiving growing attention for their involvement in human diseases, particularly cancer. Genomic studies have revealed the multiplicity of processes, including neoplastic transformation and tumor progression, in which lncRNAs are involved by regulating gene expression at epigenetic, transcriptional, and post-transcriptional levels by mechanism(s) that still need to be clarified...
January 6, 2023: International Journal of Molecular Sciences
#20
JOURNAL ARTICLE
Jan-Ole Brütt, Stanislav N Gorb, Wencke Krings
The molluscan phylum is characterized by the radula, used for the gathering and processing of food. This structure can consist of a chitinous membrane with embedded rows of teeth, which show structural, chemical, and biomechanical adaptations to the preferred ingesta. With regard to the chemical composition of teeth, some taxa (Polyplacophora and Patellogastropoda) were extensively studied, and high proportions of incorporated iron, calcium, and silicon were previously reported. However, outside these two groups, there is an immense lack of knowledge about the elemental composition of radular teeth...
December 1, 2022: Die Naturwissenschaften
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