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https://read.qxmd.com/read/30771589/powered-two-wheeler-crash-scenario-development
#1
Deniz Atalar, Pete Thomas
Powered two wheeler (PTW) riders are a group of vulnerable road users that are overrepresented compared to other road user groups with regards to crash injury outcomes. The understanding of the dynamics that occur before a crash benefits in providing suitable countermeasures for said crashes. A clearer interpretation of which factors interact to cause collisions allows an understanding of the mechanisms that produce higher risk in specific situations in the roadway. Real world in-depth crash data provides detailed data which includes human, vehicular and environmental factors collected on site for crash analysis purposes...
February 13, 2019: Accident; Analysis and Prevention
https://read.qxmd.com/read/30771269/zika-transmission-patterns-a-meta-review
#2
REVIEW
S Runge-Ranzinger, A C Morrison, P Manrique-Saide, O Horstick
OBJECTIVE: To assesses what is known and identify knowledge gaps for Zika virus (ZIKV) transmission patterns. METHODS: Meta-review searching the databases BioSys; Cochrane Infectious Diseases Group Specialised Register and Cochrane Central Register of Controlled Trials; EMBASE; Google Scholar; LILACS; MEDLINE (PubMed); Web of Science; and WHOLIS with the term "ZIKA". Systematic reviews and reviews specifying the search methods and describing potential modes of transmission were eligible for analysis...
February 16, 2019: Tropical Medicine & International Health: TM & IH
https://read.qxmd.com/read/30770421/ultrasound-guided-percutaneous-peripheral-nerve-stimulation-neuromodulation-of-the-suprascapular-nerve-and-brachial-plexus-for-postoperative-analgesia-following-ambulatory-rotator-cuff-repair-a-proof-of-concept-study
#3
Brian M Ilfeld, John J Finneran, Rodney A Gabriel, Engy T Said, Patrick L Nguyen, Wendy B Abramson, Bahareh Khatibi, Jacklynn F Sztain, Matthew W Swisher, Pia Jaeger, Dana C Covey, Matthew J Meunier, Eric R Hentzen, Catherine M Robertson
BACKGROUND AND OBJECTIVES: Percutaneous peripheral nerve stimulation (PNS) is an analgesic modality involving the insertion of a lead through an introducing needle followed by the delivery of electric current. This modality has been reported to treat chronic pain as well as postoperative pain following knee and foot surgery. However, it remains unknown if this analgesic technique may be used in ambulatory patients following upper extremity surgery. The purpose of this proof-of-concept study was to investigate various lead implantation locations and evaluate the feasibility of using percutaneous brachial plexus PNS to treat surgical pain following ambulatory rotator cuff repair in the immediate postoperative period...
February 15, 2019: Regional Anesthesia and Pain Medicine
https://read.qxmd.com/read/30770392/trans-splicing-of-the-c-elegans-let-7-primary-transcript-developmentally-regulates-let-7-microrna-biogenesis-and-let-7-family-microrna-activity
#4
Charles Nelson, Victor Ambros
let-7 is a microRNA whose sequence and roles in developmental progression are conserved Generally, transcription of let-7 primary transcript ( pri-let- 7) occurs early in development, whilst processing of the mature let-7 microRNA arises during cellular differentiation. In C. elegans and other animals, the RNA binding protein LIN-28 post-transcriptionally inhibits let-7 biogenesis at early developmental stages, but the mechanisms by which LIN-28 does this are not fully understood. Nor is it understood how the developmental regulation of let-7 might influence the expression or activities of other microRNAs of the same seed family...
February 15, 2019: Development
https://read.qxmd.com/read/30769160/a-thermodynamically-constrained-mathematical-model-for-the-kinetics-and-regulation-of-nadph-oxidase-2-complex-mediated-electron-transfer-and-superoxide-production
#5
Namrata Tomar, Shima Sadri, Allen W Cowley, Chun Yang, Nabeel Quryshi, Venkat R Pannala, Said H Audi, Ranjan K Dash
Reactive oxygen species (ROS) play an important role in cell signaling, growth, and immunity. However, when produced in excess, they are toxic to the cell and lead to premature aging and a myriad of pathologies, including cardiovascular and renal diseases. A major source of ROS in many cells is the family of NADPH oxidase (NOX), comprising of membrane and cytosolic components. NOX2 is among the most widely expressed and well-studied NOX isoform. Although details on the NOX2 structure, its assembly and activation, and ROS production are well elucidated experimentally, there is a lack of a quantitative and integrative understanding of the kinetics of NOX2 complex, and the various factors such as pH, inhibitory drugs, and temperature that regulate the activity of this oxidase...
February 12, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30769016/activation-of-the-calcium-sensing-receptor-in-human-valvular-interstitial-cells-promotes-calcification
#6
Hawraa Issa, Lucie Hénaut, Jeanne Bou Abdallah, Cédric Boudot, Gaëlle Lenglet, Carine Avondo, Aida Ibrik, Thierry Caus, Michel Brazier, Romuald Mentaverri, Kazem Zibara, Saïd Kamel
INTRODUCTION AND AIMS: Calcific aortic valve disease (CAVD) is the most common heart valve disease in western countries. It has been reported that activation of the calcium-sensing receptor(CaSR) expressed by vascular smooth muscle cells prevents vascular calcification. However, to date, the CaSR's expression and function in cardiac valves have not been studied. The present study sought to evaluate the presence of the CaSR within human valvular interstitial cells (hVICs), assess the CaSR's functionality, and ascertain its involvement in hVIC calcification...
February 12, 2019: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/30768685/determination-of-peptide-profile-consistency-and-safety-of-collagen-hydrolysates-as-quality-attributes
#7
Carlos A López-Morales, Said Vázquez-Leyva, Luis Vallejo-Castillo, Gregorio Carballo-Uicab, Leslie Muñoz-García, José Enrique Herbert-Pucheta, L Gerardo Zepeda-Vallejo, Marco Velasco-Velázquez, Lenin Pavón, Sonia M Pérez-Tapia, Emilio Medina-Rivero
Collagen hydrolysates are dietary supplements used for nutritional and medical purposes. They are complex mixtures of low-molecular-weight peptides obtained from the enzymatic hydrolysis of collagen, which provide intrinsic batch-to-batch heterogeneity. In consequence, the quality of these products, which is related to the reproducibility of their mass distribution pattern, should be addressed. Here, we propose an analytical approach to determine the peptide pattern as a quality attribute of Colagenart®, a product containing collagen hydrolysate...
February 15, 2019: Journal of Food Science
https://read.qxmd.com/read/30768629/association-between-commercial-funding-of-canadian-patient-groups-and-their-views-about-funding-of-medicines-an-observational-study
#8
Joel Lexchin
BACKGROUND: Patient groups represent the interest of their members when it comes to drug funding. Many patient groups receive grants from pharmaceutical companies that make products being considered for funding. This research examines whether there is an association between the positions that Canadian groups take about the products and conflicts of interest with the companies. METHODS: The Common Drug Review (CDR) and panCanadian Oncology Drug Review (pCODR) make recommendations to Canadian provincial and federal drug plans about funding particular drug-indications...
2019: PloS One
https://read.qxmd.com/read/30768596/inadequate-knowledge-about-snakebite-envenoming-symptoms-and-application-of-harmful-first-aid-methods-in-the-community-in-high-snakebite-incidence-areas-of-myanmar
#9
Mohammad Afzal Mahmood, Dale Halliday, Robert Cumming, Khin Thida Thwin, Mya Myitzu, Julian White, Sam Alfred, David A Warrell, David Bacon, Win Naing, Htay Aung, Myat Myat Thein, Nyein Nyein Chit, Sara Serhal, Myat Thet Nwe, Pyae Phyo Aung, Chen Au Peh
INTRODUCTION: Every year millions of people in developing countries suffer from snakebite, causing a large number of deaths and long term complications. Prevention and appropriate first aid could reduce the incidence and improve the health outcomes for those who suffer bites. However, many communities where snakebite is a major issue suffer from a lack of information about prevention and first aid measures that a family or community member could take to prevent severe envenoming, complications and poor outcomes...
February 15, 2019: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/30768328/strong-quantum-nonlocality-without-entanglement
#10
Saronath Halder, Manik Banik, Sristy Agrawal, Somshubhro Bandyopadhyay
Quantum nonlocality is usually associated with entangled states by their violations of Bell-type inequalities. However, even unentangled systems, whose parts may have been prepared separately, can show nonlocal properties. In particular, a set of product states is said to exhibit "quantum nonlocality without entanglement" if the states are locally indistinguishable; i.e., it is not possible to optimally distinguish the states by any sequence of local operations and classical communication. Here, we present a stronger manifestation of this kind of nonlocality in multiparty systems through the notion of local irreducibility...
February 1, 2019: Physical Review Letters
https://read.qxmd.com/read/30768311/observation-of-transverse-%C3%AE-%C3%AE-over-%C3%A2-hyperon-polarization-in-e-e-annihilation-at-belle
#11
Y Guan, A Vossen, I Adachi, K Adamczyk, J K Ahn, H Aihara, S Al Said, D M Asner, H Atmacan, V Aulchenko, T Aushev, R Ayad, V Babu, I Badhrees, A M Bakich, V Bansal, P Behera, C Beleño, M Berger, V Bhardwaj, B Bhuyan, T Bilka, J Biswal, A Bobrov, G Bonvicini, A Bozek, M Bračko, T E Browder, L Cao, D Červenkov, P Chang, V Chekelian, A Chen, B G Cheon, K Chilikin, K Cho, S-K Choi, Y Choi, D Cinabro, S Cunliffe, N Dash, S Di Carlo, J Dingfelder, Z Doležal, T V Dong, Z Drásal, S Eidelman, D Epifanov, J E Fast, T Ferber, B G Fulsom, R Garg, V Gaur, N Gabyshev, A Garmash, M Gelb, A Giri, P Goldenzweig, B Golob, E Guido, J Haba, K Hayasaka, H Hayashii, S Hirose, W-S Hou, T Iijima, K Inami, G Inguglia, A Ishikawa, R Itoh, M Iwasaki, Y Iwasaki, W W Jacobs, I Jaegle, H B Jeon, S Jia, Y Jin, D Joffe, K K Joo, T Julius, K H Kang, T Kawasaki, C Kiesling, D Y Kim, H J Kim, J B Kim, K T Kim, S H Kim, K Kinoshita, P Kodyš, S Korpar, D Kotchetkov, P Križan, R Kroeger, P Krokovny, T Kuhr, R Kulasiri, A Kuzmin, Y-J Kwon, J S Lange, I S Lee, S C Lee, L K Li, Y B Li, L Li Gioi, J Libby, D Liventsev, M Lubej, T Luo, M Masuda, T Matsuda, D Matvienko, M Merola, H Miyata, R Mizuk, G B Mohanty, H K Moon, T Mori, R Mussa, M Nakao, T Nanut, K J Nath, Z Natkaniec, M Nayak, M Niiyama, N K Nisar, S Nishida, S Ogawa, S Okuno, H Ono, P Pakhlov, G Pakhlova, B Pal, S Pardi, H Park, S Paul, T K Pedlar, R Pestotnik, L E Piilonen, V Popov, E Prencipe, A Rabusov, A Rostomyan, G Russo, D Sahoo, Y Sakai, M Salehi, S Sandilya, L Santelj, T Sanuki, V Savinov, O Schneider, G Schnell, C Schwanda, R Seidl, Y Seino, K Senyo, O Seon, M E Sevior, V Shebalin, C P Shen, T-A Shibata, J-G Shiu, F Simon, A Sokolov, E Solovieva, M Starič, J F Strube, M Sumihama, T Sumiyoshi, W Sutcliffe, K Suzuki, M Takizawa, U Tamponi, K Tanida, F Tenchini, M Uchida, T Uglov, Y Unno, S Uno, P Urquijo, Y Usov, S E Vahsen, C Van Hulse, R Van Tonder, G Varner, A Vinokurova, V Vorobyev, E Waheed, B Wang, C H Wang, M-Z Wang, P Wang, X L Wang, S Watanuki, E Widmann, E Won, H Ye, J Yelton, J H Yin, C Z Yuan, Y Yusa, Z P Zhang, V Zhilich, V Zhukova, V Zhulanov, A Zupanc
We report the first observation of the spontaneous polarization of Λ and Λ[over ¯] hyperons transverse to the production plane in e^{+}e^{-} annihilation, which is attributed to the effect arising from a polarizing fragmentation function. For inclusive Λ/Λ[over ¯] production, we also report results with subtracted feed-down contributions from Σ^{0} and charm. This measurement uses a dataset of 800.4  fb^{-1} collected by the Belle experiment at or near a center-of-mass energy of 10.58 GeV. We observe a significant polarization that rises with the fractional energy carried by the Λ/Λ[over ¯] hyperon...
February 1, 2019: Physical Review Letters
https://read.qxmd.com/read/30767967/2019-congress-poster-abstracts
#12
(no author information available yet)
Each abstract has been indexed according to the first author. Abstracts appear as they were submitted and have not undergone editing or the Oncology Nursing Forum's review process. Only abstracts that will be presented appear here. Poster numbers are subject to change. For updated poster numbers, visit congress.ons.org or check the Congress guide. Data published in abstracts presented at the ONS 44th Annual Congress are embargoed until the conclusion of the presentation. Coverage and/or distribution of an abstract, poster, or any of its supplemental material to or by the news media, any commercial entity, or individuals, including the authors of said abstract, is strictly prohibited until the embargo is lifted...
March 1, 2019: Oncology Nursing Forum
https://read.qxmd.com/read/30767966/2019-congress-podium-abstracts
#13
(no author information available yet)
Each abstract has been indexed according to first author. Abstracts appear as they were submitted and have not undergone editing or the Oncology Nursing Forum's review process. Only abstracts that will be presented appear here. For Congress scheduling information, visit congress.ons.org or check the Congress guide. Data published in abstracts presented at the ONS 44th Annual Congress are embargoed until the conclusion of the presentation. Coverage and/or distribution of an abstract, poster, or any of its supplemental material to or by the news media, any commercial entity, or individuals, including the authors of said abstract, is strictly prohibited until the embargo is lifted...
March 1, 2019: Oncology Nursing Forum
https://read.qxmd.com/read/30767705/description-and-initial-experience-with-the-lift-less-incisions-but-four-trocars-technique-for-laparoscopic-cholecystectomy
#14
Joaquín-Salvelio Picazo-Yeste, Serge El-Khoury, Ali Yahya Alansi, Muhammad Asghar Malik, Ashwyn Anand Nelson, Said Islam Mallaev, Praveen Reddy
BACKGROUND: Modifications to conventional laparoscopic cholecystectomy (LC) aim to reduce trauma to the abdominal wall and improve cosmetic outcomes. Although single-incision laparoscopic surgery (SILS) provides excellent cosmetic results, the procedure is technically demanding. Herein, we describe the LIFT technique ("Less Incisions but Four Trocars"), with four trocars but only one 3-mm visible incision, using conventional instruments. METHODS: Retrospective study with the LIFT technique for cholecystectomy during 2017...
February 15, 2019: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/30767698/partial-characterization-of-bacillus-pumilus-catalase-partitioned-in-poly-ethylene-glycol-sodium-sulfate-aqueous-two-phase-systems
#15
Yonca Yuzugullu Karakus, Semih Isik
Aqueous two-phase partitioning system (ATPS) was used to extract and purify catalase from Bacillus pumilus. The system parameters for effective purification of catalase were optimized. The best catalase recovery (123%) with a 4.6-fold purification was obtained in the bottom phase of ATPS including the mixture of 15% (w/w) PEG4000, 10% (w/w) Na2 SO4 and 3% (w/w) NaCl at pH 5.0. The purified enzyme was characterized regarding its activity and stability. The highest enzyme activity was observed at pH 7.0 and 37 °C on hydrogen peroxide...
February 15, 2019: Preparative Biochemistry & Biotechnology
https://read.qxmd.com/read/30767466/de-la-clinique-%C3%A3-la-recherche%C3%A2-l-auto-ethnographie-comme-outil-d-analyse-des-transitions-identitaires-du-chercheur-en-sciences-infirmi%C3%A3-res
#16
Pierre Pariseau-Legault
The scientific legitimacy of nursing research depends on its adherence to different scientific criteria. Despite the lack of consensus on predetermined criteria, reflexivity is widely discussed as a strategy to establish rigour in qualitative research. Unfortunately, with the exception of tools such as the reflexive journal, little is said about how reflexivity can be completed. Several recent studies suggest the relevance of autoethnography to support the reflexive approach of nurse researchers. Inspired by the findings of an autoethnography and a narrative literature review, this article examines how this approach can contribute to the reflexivity of the nurse researcher...
January 18, 2019: Recherche en Soins Infirmiers
https://read.qxmd.com/read/30766425/comparative-evaluation-of-cytotoxic-antimicrobial-and-antioxidant-activities-of-the-crude-extracts-of-three-plectranthus-species-grown-in-saudi-arabia
#17
Ramzi A Mothana, Jamal M Khaled, Ali A El-Gamal, Omar M Noman, Ashok Kumar, Mohamed F Alajmi, Adnan J Al-Rehaily, Mansour S Al-Said
Natural products from medicinal plants represent major resource of novel therapeutic substances for combating serious diseases including cancers and microbial infections. The genus Plectranthus (Family: Labiatae) represents a large and widespread group of species with a diversity of traditional uses in treatment of various ailments. Therefore, this research study aimed to evaluate the cytotoxic, antimicrobial and antioxidant activities of three Plectranthus species growing in Saudi Arabia namely P. cylindraceus Hocst...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30765973/the-pattern-of-psychiatric-morbidity-in-chronic-obstructive-pulmonary-disease-a-cross-sectional-case-control-study-from-a-tertiary-care-hospital-in-kashmir-north-india
#18
Shabir Ahmad Dar, Bilal Ahmad Bhat, Naveed Nazir Shah, Syed Bushra Imtiyaz
Introduction: Psychiatric morbidity has an increased prevalence in chronic obstructive pulmonary disease (COPD). Patients overall psychosocial status plays an important role in the development of depression which, when major, is said to occur in 19%-42% of cases of COPD. We aimed to study patterns of psychosocial issues in patients with COPD. Materials and Methods: This study was conducted over a period of 6 months in an Outpatient Department of Government Chest Disease Hospital Srinagar...
January 2019: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/30765860/regulation-of-the-bi-directional-cross-talk-between-ovarian-cancer-cells-and-adipocytes-by-sparc
#19
Bincy John, Christine Naczki, Chirayu Patel, Alia Ghoneum, Shadi Qasem, Ziyan Salih, Neveen Said
Ovarian cancer (OvCa) exhibits a specific predilection for metastasis to the omentum. Our earlier studies highlighted the tumour-suppressor effect of secreted protein acidic and rich in cysteine (SPARC) in OvCa through multi-faceted roles inhibiting cancer cell interactions within the peritoneal milieu. The goal of this study is to investigate the role of SPARC in OvCa interactions with omental adipocytes and its role in OvCa colonization in the omentum. We employed multi-pronged approach using primary omental adipocytes from Sparc knockout mice, genetically engineered human omental adipocytes in 3D co-cultures with OvCa cells, as well as treatment with recombinant SPARC protein...
February 14, 2019: Oncogene
https://read.qxmd.com/read/30765782/the-development-of-white-matter-structural-changes-during-the-process-of-deterioration-of-the-visual-field
#20
Shir Hofstetter, Norman Sabbah, Saddek Mohand-Saïd, José-Alain Sahel, Christophe Habas, Avinoam B Safran, Amir Amedi
Emerging evidence suggests that white matter plasticity in the adult brain is preserved after sensory and behavioral modifications. However, little is known about the progression of structural changes during the process of decline in visual input. Here we studied two groups of patients suffering from advanced retinitis pigmentosa with specific deterioration of the visual field: patients who had lost their peripheral visual field, retaining only central ("tunnel") vision, and blind patients with complete visual field loss...
February 14, 2019: Scientific Reports
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