keyword
https://read.qxmd.com/read/38507655/updated-analysis-of-comparative-toxicity-of-proton-and-photon-radiation-for-prostate-cancer
#1
JOURNAL ARTICLE
James B Yu, David M DeStephano, Brian Jeffers, David P Horowitz, Pamela R Soulos, Cary P Gross, Simon K Cheng
PURPOSE: Previous comparative effectiveness studies have not demonstrated a benefit of proton beam therapy (PBT) compared with intensity-modulated radiation therapy (IMRT) for prostate cancer. An updated comparison of GI and genitourinary (GU) toxicity is needed. METHODS: We investigated the SEER-Medicare linked database, identifying patients with localized prostate cancer diagnosed from 2010 to 2017. Procedure and diagnosis codes indicative of treatment-related toxicity were identified...
March 20, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38405309/a-comparison-of-field-in-field-and-intensity-modulated-radiation-therapy-in-delivering-hypofractionated-radiation-therapy-for-prostate-cancer
#2
JOURNAL ARTICLE
Hawbir Ghafour, Jalil S Ali, Ronak Taher Ali, Elhussien Sirelkhatim
PURPOSE: This study compares the dosimetric performance of the field-in-field (FIF) technique with intensity modulated radiation therapy (IMRT) for delivering hypofractionated radiation therapy to prostate patients with cancer. The FIF technique uses 6 beams, whereas IMRT uses 9 beams. METHODS AND MATERIALS: This study was conducted on 15 patients with prostate cancer treated with step-and-shoot IMRT. The prescribed dose was 60 Gy in 20 fractions. The FIF plans contained 6 photon beams, and IMRT plans were designed using a 9-field step-and-shoot technique...
February 2024: Advances in Radiation Oncology
https://read.qxmd.com/read/38392056/quality-of-life-longitudinal-evaluation-in-prostate-cancer-patients-from-radiotherapy-start-to-5-years-after-imrt-igrt
#3
JOURNAL ARTICLE
Angelo Maggio, Tiziana Rancati, Marco Gatti, Domenico Cante, Barbara Avuzzi, Cinzia Bianconi, Fabio Badenchini, Bruno Farina, Paolo Ferrari, Tommaso Giandini, Giuseppe Girelli, Valeria Landoni, Alessandro Magli, Eugenia Moretti, Edoardo Petrucci, Paolo Salmoiraghi, Giuseppe Sanguineti, Elisa Villa, Justyna Magdalena Waskiewicz, Alessia Guarneri, Riccardo Valdagni, Claudio Fiorino, Cesare Cozzarini
PURPOSE: The purpose of this study is to study the evolution of quality of life (QoL) in the first 5 years following Intensity-modulated radiation therapy (IMRT) for prostate cancer (PCa) and to determine possible associations with clinical/treatment data. MATERIAL AND METHODS: Patients were enrolled in a prospective multicentre observational trial in 2010-2014 and treated with conventional (74-80 Gy, 1.8-2 Gy/fr) or moderately hypofractionated IMRT (65-75.2 Gy, 2...
February 1, 2024: Current Oncology
https://read.qxmd.com/read/38386171/systemic-interrogation-of-immune-oncology-related-proteins-in-patients-with-locally-advanced-prostate-cancer-undergoing-androgen-deprivation-and-intensity-modulated-radiotherapy
#4
JOURNAL ARTICLE
Ingrid Jenny Guldvik, Håkon Ramberg, Gitte Kristensen, Andreas Røder, Ian G Mills, Wolfgang Lilleby, Kristin Austlid Taskén
PURPOSE: The primary objective was to establish whether blood-based leucine-rich alpha-2-glycoprotein (LRG1) can predict outcomes in patients with locally advanced prostate cancer undergoing androgen-deprivation therapy (ADT) and radiotherapy (RT) and to determine how it may relate to 92 immune-oncology (I-O)-related proteins in this setting. METHODS: Baseline blood level of LRG1 from patients treated with ADT and RT enrolled in the CuPCa (n = 128) and IMRT (n = 81) studies was measured using ELISA...
February 22, 2024: World Journal of Urology
https://read.qxmd.com/read/38304655/intensifying-the-hormonal-and-radiation-treatment-in-prostate-cancer-presenting-with-bulky-pelvic-lymph-nodes-an-opportunity-for-a-new-paradigm
#5
Agha H Khan, Nadeem Pervez, Muhammad S Usmani, Houda S Almusalhi, Munjid Al Harthy, Layth Mula-Hussain
Locally advanced prostate cancer may rarely present with bulky pelvic lymph nodes without distant metastasis. Patients may be treated with curative intent. Dual hormonal therapy including luteinizing hormone-releasing hormone agonist in combination with abiraterone or enzalutamide can be utilized neoadjuvantly to shrink bulky disease. This can be followed by radical doses of radiotherapy. This intensified treatment is tolerable. Prostate-specific membrane antigen scan can be utilized to assess staging and treatment response...
January 2024: Curēus
https://read.qxmd.com/read/38263831/dosiomics-for-intensity-modulated-radiotherapy-in-patients-with-prostate-cancer-survival-analysis-stratified-by-baseline-prostate-specific-antigen-and-gleason-grade-group-in-a-2-institutional-retrospective-study
#6
JOURNAL ARTICLE
Yu Murakami, Daisuke Kawahara, Takashi Soyano, Takuyo Kozuka, Yuka Takahashi, Konatsu Miyake, Kenichi Kashihara, Tairo Kashihara, Tatsuya Kamima, Masahiko Oguchi, Yuji Murakami, Yasuo Yoshioka, Yasushi Nagata
OBJECTIVE: This study evaluated the prognostic impact of the quality of dose distribution using dosiomics in patients with prostate cancer, stratified by pretreatment prostate-specific antigen (PSA) levels and Gleason grade (GG) group. METHODS: A total of 721 patients (Japanese Foundation for Cancer Research [JFCR] cohort: N = 489 and Tokyo Radiation Oncology Clinic [TROC] cohort: N = 232) with localized prostate cancer treated by intensity-modulated radiation therapy were enrolled...
January 23, 2024: British Journal of Radiology
https://read.qxmd.com/read/38241733/simulation-and-pre-planning-omitted-radiotherapy-sport-a-feasibility-study-for-prostate-cancer
#7
JOURNAL ARTICLE
Tingliang Zhuang, David Parsons, Neil Desai, Grant Gibbard, Dana Keilty, Mu-Han Lin, Bin Cai, Dan Nguyen, Tsuicheng D Chiu, Andrew Godley, Arnold Pompos, Steve B Jiang
This study explored the feasibility of on-couch intensity modulated radiotherapy (IMRT) planning for prostate cancer (PCa) on a cone-beam CT (CBCT)-based online adaptive RT platform without an individualized pre-treatment plan and contours. Ten patients with PCa previously treated with image-guided IMRT (60Gy/20 fractions) were selected. In contrast to the routine online adaptive RT workflow, a novel approach was employed in which the same preplan that was optimized on one reference patient was adapted to generate individual on-couch/initial plans for the other nine test patients using Ethos emulator...
January 19, 2024: Biomedical Physics & Engineering Express
https://read.qxmd.com/read/38193565/does-intensity-modulated-radiation-therapy-by-helical-tomotherapy-for-prostate-cancer-increase-the-subsequent-risk-of-bladder-cancer-a-propensity-score-matched-analysis
#8
JOURNAL ARTICLE
Fumio Tsukuda, Yasunari Tanaka, Shuichiro Narita, Toshihiro Shimizu, Shu Nakasuka, Kiichi Hagiwara, Noboru Sakamoto, Kawano Toshihiro, Yutaka Horiguchi, Shoji Koga
OBJECTIVES: This study aimed to evaluate the risk of bladder cancer after intensity-modulated radiation therapy (IMRT) using helical tomotherapy for prostate cancer in comparison to the risk post-radical prostatectomy (RP) using propensity score-matched analysis and to assess the risk factors for bladder cancer. METHODS: This retrospective study included 2067 patients with non-metastatic prostate cancer treated at our institution between June 2007 and December 2016...
January 9, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
https://read.qxmd.com/read/38191958/impact-of-prostate-position-based-image-guidance-in-intensity-modulated-radiation-therapy-for-localized-prostate-cancer
#9
JOURNAL ARTICLE
Rihito Aizawa, Haruo Inokuchi, Itaru Ikeda, Kiyonao Nakamura, Takashi Ogata, Shusuke Akamatsu, Takayuki Goto, Kimihiko Masui, Takayuki Sumiyoshi, Yuki Kita, Takashi Kobayashi, Takashi Mizowaki
BACKGROUND/PURPOSE: The long-term clinical impact of prostate position-based image-guided radiotherapy (IGRT) for localized prostate cancer remains unclear. MATERIALS AND METHODS: We retrospectively compared clinical outcomes following intensity-modulated radiation therapy (IMRT) with cone-beam computed tomography-based prostate position-based IGRT (P-IGRT) or without P-IGRT (non-P-IGRT). From June 2011, we applied P-IGRT in IMRT for intermediate-risk (IR) prostate cancer (PCa) (D'Amico risk classification) (76 Gy in 38 fractions, with smaller margins)...
January 8, 2024: International Journal of Clinical Oncology
https://read.qxmd.com/read/38146764/urologist-practice-divestment-from-radiation-vault-ownership-and-treatment-patterns-for-prostate-cancer
#10
JOURNAL ARTICLE
Kassem S Faraj, Samuel R Kaufman, Lindsey A Herrel, Avinash Maganty, Mary K Oerline, Megan E V Caram, Vahakn B Shahinian, Brent K Hollenbeck
BACKGROUND: Urologists practicing in single-specialty groups with ownership in radiation vaults are more likely to treat men with prostate cancer. The effect of divestment of vault ownership on treatment patterns is unclear. METHODS: A 20% sample of national Medicare claims was used to perform a retrospective cohort study of men with prostate cancer diagnosed between 2010 and 2019. Urology practices were categorized by radiation vault ownership as nonowners, continuous owners, and divested owners...
December 26, 2023: Cancer
https://read.qxmd.com/read/38146130/a-new-predictive-parameter-for-dose-volume-metrics-in-intensity-modulated-radiation-therapy-planning-for-prostate-cancer-initial-phantom-study
#11
JOURNAL ARTICLE
Yuki Saito, Ryusuke Suzuki, Naoki Miyamoto, Kenneth Lee Sutherland, Takahiro Kanehira, Masaya Tamura, Takashi Mori, Kentaro Nishioka, Takayuki Hashimoto, Hidefumi Aoyama
BACKGROUND: Organ-at-risk (OAR) sparing is often assessed using an overlap volume-based parameter, defined as the ratio of the volume of OAR that overlaps the planning target volume (PTV) to the whole OAR volume. However, this conventional overlap-based predictive parameter (COPP) does not consider the volume relationship between the PTV and OAR. PURPOSE: We propose a new overlap-based predictive parameter that consider the PTV volume. The effectiveness of proposed overlap-based predictive parameter (POPP) is evaluated compared with COPP...
December 25, 2023: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/38146119/outcomes-in-patients-with-high-and-very-high-risk-localized-prostate-cancer-treated-with-definitive-imrt-and-long-term-hormone-therapy
#12
JOURNAL ARTICLE
Norihiko Kawamura, Takuji Hayashi, Akira Nagahara, Yasutomo Nakai, Masashi Nakayama, Toshiki Ikawa, Naoyuki Kanayama, Masahiro Morimoto, Koji Konishi, Kazuo Nishimura
BACKGROUND: The aim of this study was to evaluate the effectiveness of intensity-modulated radiation therapy in combination with long-term androgen deprivation therapy for high-risk and very high-risk localized prostate cancer while also investigating factors associated with the therapeutic effect. METHODS: Men who fulfilled criteria for the National Comprehensive Cancer Network high-risk or very high-risk localized prostate cancer and were treated with definitive intensity-modulated radiation therapy (74-78 Gy) of the prostate and the seminal vesicle combined with androgen deprivation therapy in our institution from 2007 to 2016 were identified (n = 197)...
December 23, 2023: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38108113/a-pooled-patient-reported-outcomes-analysis-of-moderately-hypofractionated-proton-beam-therapy-and-photon-based-intensity-modulated-radiation-therapy-for-low-or-intermediate-risk-prostate-cancer
#13
JOURNAL ARTICLE
Alexander Lukez, Elizabeth Handorf, Nancy P Mendenhall, Randal H Henderson, Bradley J Stish, Brian J Davis, Mark Hallman, Eric M Horwitz, Neha Vapiwala, Jessica Karen Wong
BACKGROUND: We sought to characterize and compare late patient-reported outcomes (PROs) after moderately hypofractionated intensity modulated radiation therapy (IMRT) and proton beam therapy (PBT) for localized prostate cancer (PC). METHODS: This multi-institutional analysis included low- or intermediate-risk group PC patients treated with moderately hypofractionated radiation to an intact prostate stratified by treatment modality: IMRT or PBT. The primary outcomes were prospectively collected patient-reported late gastrointestinal (GI) and genitourinary (GU) toxicity assessed by International Prostate Symptom Score (IPSS) and Expanded PC Index Composite (EPIC)...
December 18, 2023: Prostate
https://read.qxmd.com/read/38107703/dosimetric-comparison-between-intensity-modulated-radiation-therapy-and-volumetric-modulated-arc-therapy-to-enhance-bladder-and-bowel
#14
JOURNAL ARTICLE
May Zeki Saddik, Fatihea Fatihalla Hassan
Prostate cancer is the second most common cancer in men. Two common radiotherapy techniques, intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc radiotherapy (VMAT), are used for treatment. This study aimed to compare the two techniques for sparing the bladder and bowel. Computed tomography data from prostate cancer patients were analyzed to define the clinical target volume (CTV) and planning target volume (PTV). Treatment plans were generated with Monte Carlo algorithms, and dosimetric analysis was performed using the Monaco Treatment Planning System (TPS)...
September 2023: Journal of Medicine and Life
https://read.qxmd.com/read/38092835/long-term-findings-of-rectal-endoscopy-and-rectal-bleeding-after-moderately-hypofractionated-intensity-modulated-radiotherapy-for-prostate-cancer
#15
JOURNAL ARTICLE
Bong Kyung Bae, Ji Eun Kim, Hongryull Pyo, Sung Noh Hong, Won Park
To present rectal endoscopic findings and toxicity after definitive moderately hypofractionated, intensity-modulated radiotherapy (IMRT) for prostate cancer. We retrospectively reviewed patients who underwent IMRT for prostate cancer and underwent post-radiotherapy endoscopies between 2008 and 2018. Endoscopic findings were reviewed and graded using Vienna Rectoscopy Score (VRS). We have analyzed the association between endoscopic findings and rectal bleeding, and investigated risk factors for rectal bleeding...
December 13, 2023: Scientific Reports
https://read.qxmd.com/read/38074646/intensity-modulated-radiation-therapy-with-stereotactic-body-radiation-therapy-boost-for-unfavorable-prostate-cancer-five-year-outcomes
#16
JOURNAL ARTICLE
Michael Carrasquilla, Tamir Sholklapper, Abigail N Pepin, Nicole Hodgins, Siyuan Lei, Abdul Rashid, Malika Danner, Alan Zwart, Grecia Bolanos, Marilyn Ayoob, Thomas Yung, Nima Aghdam, Brian Collins, Simeng Suy, Deepak Kumar, Ryan Hankins, Keith Kowalczyk, Nancy Dawson, Sean Collins
PURPOSE: Intensity-modulated radiation therapy (IMRT) with brachytherapy boost for unfavorable prostate cancer has been shown to improve biochemical relapse-free survival compared to IMRT alone. Stereotactic body radiation therapy (SBRT) is a less-invasive alternative to brachytherapy. Early outcomes utilizing SBRT boost suggest low rates of high-grade toxicity with a maintained patient-reported quality of life. Here, we report the 5-year progression-free survival (PFS) and prostate cancer-specific survival (PCSS) of patients treated with IMRT plus SBRT boost...
2023: Frontiers in Oncology
https://read.qxmd.com/read/38021091/comparative-effectiveness-of-new-treatment-modalities-for-localized-prostate-cancer-through-patient-reported-outcome-measures
#17
JOURNAL ARTICLE
Víctor Zamora, Olatz Garin, José Francisco Suárez, Cristina Gutiérrez, Ferran Guedea, Patricia Cabrera, Manuel Castells, Ismael Herruzo, Lluis Fumadó, Pilar Samper, Carlos Ferrer, Lucas Regis, Àngels Pont, Montse Ferrer
PURPOSE: There is scarce comparative effectiveness research on the new treatment modalities for localized prostate cancer. We aim to compare through Patient-Reported Outcome Measures (PROMs) the impact of active surveillance, robot-assisted radical prostatectomy (RARP), intensity-modulated radiotherapy (IMRT), and real-time brachytherapy, considering side effects (incontinence, irritative/obstructive urinary symptoms, sexual dysfunction and bowel symptoms) and physical and mental health...
January 2024: Clinical and Translational Radiation Oncology
https://read.qxmd.com/read/38013636/the-impact-of-margin-reduction-on-radiation-dose-distribution-of-ultra-hypofractionated-prostate-radiotherapy-utilizing-a-1-5-t-mr-linac
#18
JOURNAL ARTICLE
Cem Onal, Esma Efe, Recep Bozca, Cagdas Yavas, Guler Yavas, Gungor Arslan
BACKGROUND: We examined the effects of reducing the planning target volume (PTV) margin in MR-guided radiotherapy (MRgRT) on the distribution of radiation dose to target volumes and organs-at-risk (OARs). Thus, we compared MR-Linac (MRL) plans with and without reduced margin and intensity-modulated radiotherapy (IMRT) plan with conventional linac for low-risk prostate cancer patients receiving 36.25 Gy in five fractions of ultra-hypofractionated radiation therapy. MATERIALS AND METHODS: Twenty low-risk prostate cancer patients treated with 1...
November 27, 2023: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/37979707/randomized-trial-of-concomitant-hypofractionated-imrt-boost-versus-conventional-fractionated-imrt-boost-for-localized-high-risk-prostate-cancer-phart2-rct
#19
JOURNAL ARTICLE
Rachel M Glicksman, Andrew Loblaw, Gerard Morton, Danny Vesprini, Ewa Szumacher, Hans T Chung, William Chu, Stanley K Liu, Chia-Lin Tseng, Rohann Correa, Andrea Deabreu, Alexandre Mamedov, Liying Zhang, Patrick Cheung
BACKGROUND: To report on the results of a phase II randomized trial of moderately hypofractionated (MH) versus conventionally fractionated (CF) radiotherapy to the prostate with elective nodal irradiation (ENI). MATERIALS AND METHODS: This was a single-centre prospective phase II randomized study. Patients with high-risk disease (cT3, PSA >20 ng/mL, or Gleason score 8-10) were eligible. Patients were randomized to either MH using a simultaneous integrated boost (68 Gy in 25 fractions to prostate; 48 Gy to pelvis) or CF (46 Gy in 23 fractions with a sequential boost to the prostate of 32 Gy in 16 fractions), with long-term androgen deprivation therapy (ADT)...
November 16, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37979544/economical-evaluation-of-prostate-cancer-treatment-using-intensity-modulated-radiation-therapy-3-dimensional-conformal-radiation-therapy-and-radical-prostatectomy-a-systematic-review
#20
JOURNAL ARTICLE
Amin Adel, Aziz Rezapour, Ali Aboutorabi, Ali Taghizadeh Kermani, Hamidreza Ghorbani
OBJECTIVES: Prostate cancer is a common form of cancer among men worldwide. The objective of this study was to conduct a systematic review of the economic evaluations of prostate cancer treatment strategies. METHODS: This systematic review was conducted using multiple electronic databases up to May 2021. English-language economic evaluation studies that compared intensity-modulated radiation therapy (IMRT), 3-dimensional conformal radiation therapy (3DCRT), and radical prostatectomy (RP) were included...
January 2024: Value in Health Regional Issues
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