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chronic thromboembolism

Mai Kimura, Takashi Kohno, Takashi Kawakami, Masaharu Kataoka, Takahiro Hiraide, Hidenori Moriyama, Sarasa Isobe, Toshimitsu Tsugu, Yuji Itabashi, Mitsushige Murata, Shinsuke Yuasa, Keiichi Fukuda
BACKGROUND: There is no consensus on the length of hospital stay (LOHS) and post-interventional management after balloon pulmonary angioplasty (BPA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). We examined temporal trends with respect to LOHS and requirement for intensive care for BPA and their relationship with the incidence of BPA-related complications. METHODS: From November 2012 to September 2017, a total of 123 consecutive patients with CTEPH who underwent BPA were enrolled (age: 66...
February 2019: Canadian Journal of Cardiology
Isabelle Opitz, Michaela B Kirschner
Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a debilitating disease, for which the underlying pathophysiological mechanisms have yet to be fully elucidated. Occurrence of a pulmonary embolism (PE) is a major risk factor for the development of CTEPH, with non-resolution of the thrombus being considered the main cause of CTEPH. Polymorphisms in the α-chain of fibrinogen have been linked to resistance to fibrinolysis in CTEPH patients, and could be responsible for development and disease progression...
February 12, 2019: International Journal of Molecular Sciences
Akira Naito, Takaki Hiwasa, Nobuhiro Tanabe, Takayuki Jujo Sanada, Toshihiko Sugiura, Ayako Shigeta, Jiro Terada, Hirotaka Takizawa, Koichi Kashiwado, Seiichiro Sakao, Koichiro Tatsumi
While circulating autoantibodies have been detected in patients with several cardiovascular diseases, such studies have not been performed for chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Here we investigated the production of certain auto-antibodies in CTEPH patients. Initial screening was performed in 5 CTEPH patients and 5 healthy donors (HDs) using a ProtoArray Human Protein Microarray v5.1 containing 9,375 human proteins, and we selected 34 antigens recognized by IgG antibodies more strongly in the sera of CTEPH patients than in the sera of HDs...
2019: PloS One
Yolanda C Bryce, Rocio Perez-Johnston, Errol B Bryce, Behrang Homayoon, Ernesto G Santos-Martin
Pulmonary embolus (PE) is the third most common cause of cardiovascular death with more than 600,000 cases occurring in the USA per year. About 45% of patients with acute PE will have acute right ventricular failure, and up to 3.8% of patients will develop chronic thromboembolic pulmonary hypertension (CTEPH) with progressive, severe, chronic heart failure. The right ventricle (RV) is constructed to accommodate a low-resistance afterload. Increases in afterload from acute massive and submassive PE and CTEPH may markedly compromise the RV function leading to hemodynamic collapse and death...
February 13, 2019: Insights Into Imaging
Pierluigi Merella, Gavino Casu, Patrizio Mazzone, Giovanni Lorenzoni, Giuseppe D'Angelo, Simonetta Genovesi
Non-valvular atrial fibrillation (AF) is the most frequent arrhythmia in the general population and its prevalence increases with age. The prevalence and incidence of AF is high in patients with chronic kidney failure (CKD). The most important complication associated with AF, both in the general population and in that with CKD, is thromboembolic stroke. For this reason, in patients with AF, the Guidelines indicate oral anticoagulant therapy (OAT) with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) for thromboembolic risk prevention...
February 2019: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Meghan May Cirulis, John J Ryan, Stephen Archer
No abstract text is available yet for this article.
February 12, 2019: Pulmonary Circulation
Naomi K Tepper, Gary Jeng, Kathryn M Curtis, Maegan E Boutot, Sheree L Boulet, Maura K Whiteman
OBJECTIVE: To estimate the absolute and relative risk of venous thromboembolism (VTE) among women who initiate depot medroxyprogesterone acetate (DMPA) immediately postpartum compared with those who do not initiate hormonal contraception. METHODS: The IBM MarketScan Commercial Claims and Encounters databases were used to identify delivery hospitalizations among women aged 15-44 years during 2005 through 2014. Diagnosis, procedure, and drug codes were used to identify contraception, VTE, and potential confounding chronic or pregnancy-related conditions...
February 4, 2019: Obstetrics and Gynecology
Huyen A Tran, Harry Gibbs, Eileen Merriman, Jennifer L Curnow, Laura Young, Ashwini Bennett, Tan Chee Wee, Sanjeev D Chunilal, Chris M Ward, Ross Baker, Harshal Nandurkar
INTRODUCTION: Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common cardiovascular disease and, globally, more than an estimated 10 million people have it yearly. It is a chronic and recurrent disease. The symptoms of VTE are non-specific and the diagnosis should actively be sought once considered. The mainstay of VTE treatment is anticoagulation, with few patients requiring additional intervention. A working group of experts in the area recently completed an evidence-based guideline for the diagnosis and management of DVT and PE on behalf of the Thrombosis and Haemostasis Society of Australia and New Zealand (www...
February 10, 2019: Medical Journal of Australia
Janne Brouckaert, Stijn E Verleden, Tom Verbelen, Willy Coosemans, Herbert Decaluwé, Paul De Leyn, Lieven Depypere, Philippe Nafteux, Hans Van Veer, Bart Meyns, Filip Rega, Marc Van De Velde, Gert Poortmans, Steffen Rex, Arne Neyrinck, Greet Van den Berghe, Dirk Vlasselaers, Johan Van Cleemput, Werner Budts, Robin Vos, Rozenn Quarck, Catharina Belge, Marion Delcroix, Geert M Verleden, Dirk Van Raemdonck
BACKGROUND: Transplant type for end-stage pulmonary vascular disease remains debatable. We compared recipient outcome after heart-lung(HLT) versus double-lung(DLT) transplantation. METHODS: Single-center analysis (38HLT-30DLT; 1991-2014] for different causes of pre-capillary pulmonary hypertension(PH): idiopathic(22); heritable(2); drug-induced(9); hepato-portal(1); connective tissue disease(4); congenital heart disease(CHD)(24); chronic thromboembolic PH(6). RESULTS: HLT decreased from 91...
February 8, 2019: Transplant International: Official Journal of the European Society for Organ Transplantation
Diana-Maria Bunu, Cristian-Eugen Timofte, Manuela Ciocoiu, Mariana Floria, Claudia-Cristina Tarniceriu, Oana-Bogdana Barboi, Daniela-Maria Tanase
Inflammatory bowel disease (IBD) refers to a group of chronic inflammatory diseases that targets mainly the gastrointestinal tract. The clinical presentation of IBD includes both gastrointestinal manifestations and extraintestinal manifestations (EIM). The reported cardiovascular manifestations in IBD patients include pericarditis, myocarditis, venous and arterial thromboembolism, arrhythmias, atrioventricular block, heart failure, endocarditis, valvulopathies, and Takayasu arteritis. The aim of this article is to review the available literature about the possible pathogenic mechanisms and determine preventive measures capable of reducing the incidence and severity of the cardiovascular manifestations...
2019: Gastroenterology Research and Practice
Mark W Dodson, Kristina Allen-Brady, Lynette M Brown, C Gregory Elliott, Lisa A Cannon-Albright
BACKGROUND: Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious sequela of pulmonary embolism (PE) and occurs in about 3% of acute PE survivors. Common inherited thrombophilias, including the Factor V Leiden mutation, are not associated with increased risk of CTEPH, even though they increase the risk for VTE. Whether other inherited genetic factors contribute to the risk of developing CTEPH remains unknown. Familial clustering of a disease can indicate inherited genetic risk for that disease...
February 2019: Chest
Ronald A Ligon, Christopher J Petit
We describe a patient with chronic thromboembolic pulmonary hypertension who presented to the pediatric cardiac catheterization laboratory for peripheral pulmonary artery recanalization and angioplasty. This case report outlines serial pulmonary arterial rehabilitation via a retrograde approach through intrapulmonary collateral arterial connections.
February 5, 2019: Catheterization and Cardiovascular Interventions
Stefano Albani, Federico Biondi, Davide Stolfo, Francesco Lo Giudice, Gianfranco Sinagra
: Chronic thromboembolic disease (CTED), especially when associated with pulmonary hypertension (CTEPH), is a fearsome and under-diagnosed but potentially curable complication of pulmonary embolism, thanks to recent therapeutic options. Aspecific symptoms and signs make its diagnosis challenging, requiring clinicians to be ready to suspect its presence in patients with dyspnea of unknown origin or persistent symptoms after acute pulmonary embolism. The aim of this review is to provide an update to the general practitioner or the specialist physician on the state of the art regarding the epidemiology, pathophysiology and clinical management of chronic thromboembolic syndromes...
January 31, 2019: Journal of Cardiovascular Medicine
Alan D Kaye, Laxmaiah Manchikanti, Matthew B Novitch, Imran N Mungrue, Muhammad Anwar, Mark R Jones, Erik M Helander, Elyse M Cornett, Matthew R Eng, Jay S Grider, Michael E Harned, Ramsin M Benyamin, John R Swicegood, Thomas T Simopoulos, Salahadin Abdi, Richard D Urman, Timothy R Deer, Cyrus Bakhit, Mahendra Sanapati, Sairam Atluri, Ramarao Pasupuleti, Amol Soin, Sudhir Diwan, Ricardo Vallejo, Kenneth D Candido, Nebojsa Nick Knezevic, Douglas Beall, Sheri L Albers, Richard E Latchaw, Hari Prabhakar, Joshua A Hirsch
BACKGROUND: Interventional pain management involves diagnosis and treatment of chronic pain. This specialty utilizes minimally invasive procedures to target therapeutics to the central nervous system and the spinal column. A subset of patients encountered in interventional pain are medicated using anticoagulant or antithrombotic drugs to mitigate thrombosis risk. Since these drugs target the clotting system, bleeding risk is a consideration accompanying interventional procedures. Importantly, discontinuation of anticoagulant or antithrombotic drugs exposes underlying thrombosis risk, which can lead to significant morbidity and mortality especially in those with coronary artery or cerebrovascular disease...
January 2019: Pain Physician
Kelly C Rogers, Daniel W Neu, Melanie C Jaeger, Rahman Shah, Shannon W Finks
A poorly understood significant drug-drug interaction compounded by ineffective communication among providers at times of care transition most likely contributed to multiple thromboembolic events in an 81-year-old patient. Increased awareness of drug interactions with direct oral anticoagulants (DOACs), as well as improved communication among inpatient and outpatient providers at the time of discharge is essential in maximizing efficacy and safety outcomes in patients requiring chronic anticoagulation. When rifampin is coadministered with apixaban, a reduction in apixaban exposure results in decreased efficacy and increased risk for thromboembolic events...
February 2019: Southern Medical Journal
David Jiménez, Alvar Agustí, Manuel Monreal, Remedios Otero, Menno V Huisman, José Luis Lobo, Andrés Quezada, Luis Jara-Palomares, Ascensión Hernando, Eva Tabernero, Pedro Marcos, Pedro Ruiz-Artacho, Aitor Ballaz, Laurent Bertoletti, Francis Couturaud, Roger Yusen
INTRODUCTION: Some previous studies have suggested a high prevalence of pulmonary embolism (PE) during exacerbations of chronic obstructive pulmonary disease (ECOPD). The SLICE trial aims to assess the efficacy and safety of an active strategy for the diagnosis and treatment of PE (vs. usual care) in patients hospitalized because of ECOPD. METHODS AND ANALYSES: SLICE is a phase III, prospective, international, multicenter, randomized, open-label, parallel-group trial...
February 1, 2019: Clinical Cardiology
Natalya A Koziolova, E A Polyanskaya, M V Surovtseva, P G Karavaev
In this review we present data on prevalence of atrial fibrillation (AF) among patients with type 2 diabetes (T2D), diabetic nephropathy and chronic kidney disease (CKD). Patients with nonvalvular AF and T2D combined with CKD have elevated risk of both bleeding and thromboembolic complications, as well as of all cause death. Efficacy and safety of novel oral anticoagulants (NOAC) depend on comorbidities and can be determined by the presence of T2D and/or diabetic nephropathy. Use of warfarin in CKD in some cases provides no preventive effect relative to risk of stroke and is characterized by increased risk of bleeding because of poor INR control, and possibly development of calcification of arteries...
November 18, 2018: Kardiologiia
Z S Valieva, I N Taran, T V Martynyuk, I Ye Chazova
Current research is aimed at studying the fundamental therapeutic targets and discovering new drugs acting on previously set targets. Until recently, the only therapeutic strategy to influence the molecular pathway of nitric oxide (NO) - soluble guanylate cyclase (sGC) - cyclic guanosine monophosphate (cGMP) was the use of phosphodiesterase type 5 inhibitors (PDE-5 inhibitors), such as sildenafil. In September 2014, the first member of sGC stimulators riociguat was licensed in Russia. In the paper, the results of 5 multicenter studies (CHEST-1 and PATENT-1, CHEST-2 and PATENT-2, RESPITE), which reflect the effectiveness and safety of mono - and combination therapy with riociguat in patients suffer from some forms of pulmonary arterial hypertension, and patients with inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTPH), as well as the possibility of optimizing therapy in patients with PAH using iPDE-5 -> riociguat switching was reviewed...
April 19, 2018: Terapevticheskiĭ Arkhiv
R I Stryuk, C A Burns, M P Filippov, Ya V Brytkova, I V Borisov, E L Barkova, T A Gomova, E A Kozina, O A Nagirnyak
AIM: the Aim of the BEREG Registry was to analyze the prevalence and structure of cardiovascular diseases, associated comorbid conditions and assess their effects on pregnancy and perinatal outcomes in real clinical practice. MATERIALS AND METHODS: In Tula city regional perinatal center the observation study named "Assessment of the clinical condition of the pregnant women with cardiovascular disease during gestation, at child delivery, at the early postpartum period and at twelve months after childbirth and assesment of perinatal outcomes, condition of the fetus and the newborn and the quality of treatment of these patients groups...
February 14, 2018: Terapevticheskiĭ Arkhiv
I E Chazova, T V Martynyuk, Z S Valieva, S N Nakonechnikov, S V Nedogoda, A S Salasyuk, I N Taran, S E Gratsianskaya
AIM: The aim of current study was to estimate the economic burden of the chronic thromboembolic pulmonary hypertension (CTEPH) in Russia based on patient registry. MATERIALS AND METHODS: Cost of illness study was based on data derived from CTEPH patient registry that was developed at the Division of hypertension of FSBI "National Medical Research Center of Cardiology". Demographic and clinical patient characteristics were analyzed with descriptive statistic methods...
September 20, 2018: Terapevticheskiĭ Arkhiv
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