Manuel Albanese, Hong-Ru Chen, Madeleine Gapp, Maximilian Muenchhoff, Hsiu-Hui Yang, David Peterhoff, Katja Hoffmann, Qianhao Xiao, Adrian Ruhle, Ina Ambiel, Stephanie Schneider, Ernesto Mejías-Pérez, Marcel Stern, Paul R Wratil, Katharina Hofmann, Laura Amann, Linda Jocham, Thimo Fuchs, Alessandro F Ulivi, Simon Besson-Girard, Simon Weidlich, Jochen Schneider, Christoph D Spinner, Kathrin Sutter, Ulf Dittmer, Andreas Humpe, Philipp Baumeister, Andreas Wieser, Simon Rothenfusser, Johannes Bogner, Julia Roider, Percy Knolle, Hartmut Hengel, Ralf Wagner, Vibor Laketa, Oliver T Fackler, Oliver T Keppler
Immune cell phenotyping frequently detects lineage-unrelated receptors. Here, we report that surface receptors can be transferred from primary macrophages to CD4 T cells and identify the Fcγ receptor CD32 as driver and cargo of this trogocytotic transfer. Filamentous CD32+ nanoprotrusions deposit distinct plasma membrane patches onto target T cells. Transferred receptors confer cell migration and adhesion properties, and macrophage-derived membrane patches render resting CD4 T cells susceptible to infection by serving as hotspots for HIV-1 binding...
March 28, 2024: Cell reports medicine