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Natalie B Riblet, Brian Shiner, Bradley V Watts, Peter Britton
INTRODUCTION: In order to address the problem of suicide, healthcare providers and researchers must be able to accurately identify suicide deaths. Common approaches to detecting suicide in the healthcare setting include the National Death Index (NDI) and Root-Cause Analysis (RCA) methodology. No study has directly compared these two methods. MATERIALS AND METHODS: Suicide reporting was evaluated within the Veterans Affairs (VA) healthcare system. All suicides were included that occurred within 7 days of discharge from an inpatient mental health unit and were reported to the VA through the NDI record linkage and/or RCA database between 2002 and 2014...
March 16, 2019: Military Medicine
David Ying, Milena A Gianfrancesco, Laura Trupin, Jinoos Yazdany, Eric Greidinger, Gabriela Schmajuk
OBJECTIVE: Previously thought to involve primarily the microvasculature, systemic sclerosis (SSc) has been increasingly linked to macrovascular disease. Cardiovascular and cerebrovascular disease are responsible for 20-30% of mortality in SSc, but few studies have shown an independent association between SSc and stroke. In this study, we assessed whether SSc was an independent risk factor for ischemic stroke. METHODS: We conducted a retrospective cohort study using the national Veterans Affairs administrative database containing records from 1999 to 2014...
March 15, 2019: Journal of Rheumatology
Tiffany Cy Eng, Wenxuan Chen, Kazuhide S Okuda, June P Misa, Yvonne Padberg, Kathryn E Crosier, Philip S Crosier, Christopher J Hall, Stefan Schulte-Merker, Benjamin M Hogan, Jonathan W Astin
Lymphatic vessels are known to be derived from veins; however, recent lineage-tracing experiments propose that specific lymphatic networks may originate from both venous and non-venous sources. Despite this, direct evidence of a non-venous lymphatic progenitor is missing. Here, we show that the zebrafish facial lymphatic network is derived from three distinct progenitor populations that add sequentially to the developing facial lymphatic through a relay-like mechanism. We show that while two facial lymphatic progenitor populations are venous in origin, the third population, termed the ventral aorta lymphangioblast (VA-L), does not sprout from a vessel; instead, it arises from a migratory angioblast cell near the ventral aorta that initially lacks both venous and lymphatic markers, and contributes to the facial lymphatics and the hypobranchial artery...
March 15, 2019: EMBO Reports
Henry Ho-Lung Chan, Hang-I Lam, Kai-Yip Choi, Serena Zhe-Chuang Li, Yamunadevi Lakshmanan, Wing-Yan Yu, Raymond Chuen-Chung Chang, Jimmy Lai, Kwok-Fai So
ETHNOPHARMACOLOGICAL RELEVANCE: Lycium barbarum L. (also known as "Goji berry"), a traditional Chinese herbal medicine, has been a common herb in the traditional Chinese pharmacopoeia for centuries. The main active component is the Lycium barbarum polysaccharides and its antioxidative effect has been widely shown to provide neuroprotection to the eye, and it would, therefore, be interesting to determine if Lycium barbarum help delay vision deterioration in patients with retinitis pigmentosa...
March 12, 2019: Journal of Ethnopharmacology
Kristine T Hanson, Kathleen F Carlson, Greta Friedemann-Sanchez, Laura A Meis, Courtney H Van Houtven, Agnes C Jensen, Sean M Phelan, Joan M Griffin
INTRODUCTION: Informal family caregivers play an increasingly important role in healthcare. Despite their role in ongoing management and coordination of care, caregiver satisfaction with the healthcare services care recipients receive has been understudied. We sought to assess what influences caregiver satisfaction with inpatient care provided to their care recipient among caregivers of veterans with traumatic brain injury (TBI) and polytrauma. METHODS: Data from the Family and Caregiver Experience Survey, a national survey of caregivers of veterans with TBI and polytrauma, was used to explore factors associated with caregiver satisfaction with the care his/her care recipient received while an inpatient at a US Department of Veterans Affairs (VA) Polytrauma Rehabilitation Center...
2019: PloS One
Kathryn J Azevedo, Jeremy C Ramirez, Anusha Kumar, Ann LeFevre, Adam Factor, Elon Hailu, Steven E Lindley, Shaili Jain
PURPOSE: Access to mental health care and programs that address violence prevention can be a challenge for veterans residing in rural and underserved areas. A growing number of trauma-affected veterans are now returning to rural areas upon completion of military service. The Palo Alto VA Health Care System has piloted a program known as the Peer Support Program (PSP) where certified peer support specialists hold group sessions for their fellow veterans in remote, community-based outpatient clinics...
March 15, 2019: Journal of Rural Health
Maciej M Bartuzel, D Robert Iskander, Iván Marín-Franch, Norberto López-Gil
Experimental visual acuity (VA) of eight subjects was measured using the Freiburg vision test in a custom-made adaptive optics system. Measurements were conducted under one control and five defocus-induced conditions. In the defocus-induced conditions, 1 diopter of myopic defocus was added to the system using the Badal stage, and defocus vibrations with five different levels of amplitude were generated by a deformable mirror at 50 Hz. Computational simulations of the visual Strehl ratio (VSOTF) were performed using average aberrations of each subject recorded in the control condition...
March 1, 2019: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Lu Xiao, Baolin Chen, Di Feng, Ting Yang, Tingyu Li, Jie Chen
Objectives: To investigate the specific role of Toll-like receptor 4 (TLR4) in the regulation of the intestinal mucosa-associated microbiota by vitamin A (VA). Methods: Both TLR4-/- (knockout, KO) and wild-type (WT) female mice were randomly fed a VA normal (VAN) or VA deficient (VAD) diet for 4 weeks to establish the following four mouse model groups: TLR4-/- mice fed a VAN diet (KO VAN), TLR4-/- mice fed a VAD diet (KO VAD), WT mice fed a VAN diet (WT VAN), and WT mice fed a VAD diet (WT VAD). Then, the mice from each experimental group were mated with male mice with the same genetic background...
2019: Frontiers in Microbiology
Shanshan Jin, David S Friedman, Kai Cao, Mayinuer Yusufu, Jingshang Zhang, Jinda Wang, Simeng Hou, Guyu Zhu, Bingsong Wang, Ying Xiong, Jing Li, Xiaoxia Li, Hailong He, Xiuhua Wan
BACKGROUND: To compare the clinical performance of bifocal and trifocal intraocular lenses (IOLs) in cataract surgery, a meta-analysis on randomized controlled trials was conducted. METHODS: A comprehensive literature retrieval of PubMed, Science Direct and EMBASE was performed in this systematic review. Clinical outcomes included visual acuity (VA), contrast sensitivity (CS), spectacle independence, postoperative refraction and surgical satisfaction. RESULTS: There were 8 RCTs included in this study...
March 14, 2019: BMC Ophthalmology
Qing Shi
BACKGROUND: Several abundant proteins have been identified in lipid body of an alkenone-producing marine haptophyte alga Tisochrysis lutea. The gene expression patterns of these proteins were investigated to better understand their roles in alkenone biosynthesis. For this purpose, T. lutea was first cultured in nitrogen-sufficient medium for biomass production and then shifted to nitrogen-deprived medium to induce lipid body formation. RESULTS: There were remarkable increases in the volume of alkenone body (AB) and alkenone content in the alga after they were exposed to nitrogen depletion medium...
March 11, 2019: BMC Microbiology
Steve Hankey, Peter Sforza, Matt Pierson
Most empirical air quality models (e.g., land use regression) focus on urban areas. Mobile monitoring for model development offers the opportunity to explore smaller, rural communities - an understudied population. We use mobile monitoring to systematically sample all daylight hours (7am-7pm) to develop empirical models capable of estimating hourly concentrations in Blacksburg, VA - a small town in rural Appalachia (population: 182,635). We collected ~120 hours of mobile monitoring data for Particle Number (PN) and Black Carbon (BC)...
March 15, 2019: Environmental Science & Technology
Samuel Jacob, Brian Lima, Gonzalo V Gonzalez-Stawinski, Magdy M El-Sayed Ahmed, Parag C Patel, Erol V Belli, Ian A Makey, Mathew Thomas, Kevin Landolfo, Carolyn Landolfo, Juan Carlos Leoni Moreno, Daniel S Yip, Si M Pham
BACKGROUND: Severe primary graft dysfunction (PGD) is the leading cause of early death after heart transplant. AIM: To examine the outcomes of heart transplant recipients who received venoarterial extracorporeal membrane oxygenation (VA-ECMO) for severe PGD. METHODS: We reviewed electronic health records of adult patients who underwent heart transplant from November 2005 through June 2015. We defined severe PGD according to International Society for Heart and Lung Transplantation consensus statements...
March 14, 2019: Clinical Transplantation
Linda Resnik, Sarah Ekerholm, Matthew Borgia, Melissa A Clark
INTRODUCTION: A comprehensive study to assess quality and outcomes of care for Veterans with upper limb amputation is needed. This paper presents methods and summary findings from a national survey of Veterans with upper limb amputation. METHODS: After completion of a pilot study to develop and refine methods, computer-assisted telephone interviews were conducted with 808 Veterans with upper limb amputation (response rate = 47.7%; cooperation rate = 63.3%). RESULTS: Respondents were 776 unilateral and 32 bilateral amputees, 97...
2019: PloS One
Mark Bounthavong, Marcos K Lau, Sarah J Popish, Chad L Kay, Daina L Wells, Julianne E Himstreet, Michael A Harvey, Melissa L D Christopher
BACKGROUND: Benzodiazepine use in the US Veterans Administration (VA) has been decreasing; however, a small number of veterans with posttraumatic stress disorder (PTSD) continue to receive benzodiazepine. Academic detailing, a targeted-educational outreach intervention, was implemented at VA to help reduce the disparity between existing and evidence-based practices, including the reduction in benzodiazepine use in veterans with PTSD. Since evidence to support the national implementation of academic detailing in this clinical scenario was scarce, we performed a quality improvement evaluation on academic detailing's impact on benzodiazepine use in veterans with PTSD...
March 14, 2019: Substance Abuse
Stephanie L Taylor, Rendelle Bolton, Alexis Huynh, Kelly Dvorin, A Rani Elwy, Barbara G Bokhour, Allison Whitehead, Benjamin Kligler
OBJECTIVES: Health care systems are increasingly interested in becoming whole health systems that include complementary and integrative health (CIH) approaches. The nation's largest health care system, the Veterans Health Administration (VA), has been transforming to such a system. However, anecdotal evidence suggested that many VA medical centers have faced challenges in implementing CIH approaches, whereas others have flourished. We report on a large-scale, research-operations partnered effort to understand the challenges faced by VA sites and the strategies used to address these to better support VAs implementation of CIH nationally...
March 2019: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Daniel J Reis, Michael S Namekata, Mary E Oehlert, Nancy King
The Beck Depression Inventory-II (BDI-II) is used within the Veterans Health Administration (VHA) to measure depression symptom severity. This naturalistic study aimed to examine VHA-specific BDI-II use and establish normative data and psychometric properties. Initial BDI-II data for 152,260 individual veterans were extracted from preexisting medical records using the VA Informatics and Computing Infrastructure. BDI-II scores were compared against Beck, Steer, and Brown (1996)'s original sample, as well as across veteran subgroups...
March 14, 2019: Psychological Services
Vijay Ganapathy, Chellappa Vijayakumar, Vilvapathy Senguttuvan Karthikeyan, J Srinivas, Sadhanandham Shrinuvasan
The common causes of irritative voiding symptoms in women include cystitis, vesical calculi, carcinoma bladder and neurologic disorders. Isolated primary vesical amyloidosis (VA) is a rare cause of irritative voiding symptoms. A 50-year-old female, a known case of retroviral disease but not on anti-retroviral therapy, presented with right flank and suprapubic pain for six months, worsening over the past 15 days with dysuria. She also presented with increased frequency of micturition with nocturia and urgency for the same duration...
January 4, 2019: Curēus
Katherine Czarnowski, Chirlie Silver, Bryan Wood, Patricia Underwood, Dhiren Patel
Clinical pharmacists in VA primary care pharmacy clinics can effectively and safely use liraglutide to reduce hemoglobin A1c and insulin requirements in veterans.
February 2019: Federal Practitioner
Emiliya Khazan, Augustus Hough, David Parra, Julie Groppi
Integration of CPSs into an ambulatory cardiology clinic may translate to cost avoidance and a reduction in workload burden for other cardiology health care providers.
February 2019: Federal Practitioner
Tivadar Feczkó, Gabriella Merza, György Babos, Bernadett Varga, Eszter Gyetvai, László Trif, Ervin Kovács, Robert Tuba
Vinyl alcohol (VA) copolymers having fine tunable polarities are emerging materials in drug delivery applications. VA copolymers rendering well-defined molecular architecture (C/OH ratio = 2, 4, 5 and 8) were used as carriers for model drug compound, fluorescein exhibited significantly different release characteristics depending on the polarity of the polymers. Based on the preliminary drug release tests the well-defined VA copolymer having C/OH = 5 ratio, poly(vinyl alcohol alt-propenylene) copolymer (PVA-5) was selected for nanocomposite synthesis...
March 10, 2019: International Journal of Pharmaceutics
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