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C A Onate, O Adebimpe, A F Lukman, I J Adama, J O Okoro, E O Davids
The approximate analytical solutions of the non-relativistic Schrӧdinger equation for the Attractive potential model with the centrifugal term are investigated using the elegant methodology of the parametric Nikiforov-Uvarov. The energy equation and the corresponding un-normalized radial wave functions are obtained in a close and compact form after a proper Greene-Aldrich approximation scheme is applied. By changing the numerical values of some potential strengths, special cases of the Attractive potential are investigated in detail...
November 2018: Heliyon
Alejandro Torres-Hernandez, Wei Wang, Yuri Nikiforov, Karla Tejada, Luisana Torres, Aleksandr Kalabin, Yue Wu, Muhammad Israr Ul Haq, Mohammed Y Khan, Zhen Zhao, Wenyu Su, Jimmy Camargo, Mautin Hundeyin, Brian Diskin, Salma Adam, Juan A Kochen Rossi, Emma Kurz, Berk Aykut, Sorin A A Shadaloey, Joshua Leinwand, George Miller
Liver fibrosis and fibrosis-associated hepatocarcinogenesis are driven by chronic inflammation and are leading causes of morbidity and death worldwide. SYK signaling regulates critical processes in innate and adaptive immunity, as well as parenchymal cells. We discovered high SYK expression in the parenchymal hepatocyte, hepatic stellate cell (HSC), and the inflammatory compartments in the fibrotic liver. We postulated that targeting SYK would mitigate hepatic fibrosis and oncogenic progression. We found that inhibition of SYK with the selective small molecule inhibitors Piceatannol and PRT062607 markedly protected against toxin-induced hepatic fibrosis, associated hepatocellular injury and intra-hepatic inflammation, and hepatocarcinogenesis...
February 11, 2019: Oncogene
Nicholas G Smith, Rekha Gyanchandani, Osama S Shah, Grzegorz T Gurda, Peter C Lucas, Ryan J Hartmaier, Adam M Brufsky, Shannon Puhalla, Amir Bahreini, Karthik Kota, Abigail I Wald, Yuri E Nikiforov, Marina N Nikiforova, Steffi Oesterreich, Adrian V Lee
BACKGROUND: Breast cancer is the most common invasive cancer among women worldwide. Next-generation sequencing (NGS) has revolutionized the study of cancer across research labs around the globe; however, genomic testing in clinical settings remains limited. Advances in sequencing reliability, pipeline analysis, accumulation of relevant data, and the reduction of costs are rapidly increasing the feasibility of NGS-based clinical decision making. METHODS: We report the development of MammaSeq, a breast cancer-specific NGS panel, targeting 79 genes and 1369 mutations, optimized for use in primary and metastatic breast cancer...
February 8, 2019: Breast Cancer Research: BCR
Archis Bagati, Sudha Moparthy, Emily E Fink, Anna Bianchi-Smiraglia, Dong Hyun Yun, Masha Kolesnikova, Olga O Udartseva, David W Wolff, Matthew V Roll, Brittany C Lipchick, Zhannan Han, Nadezhda I Kozlova, Peter Jowdy, Albert E Berman, Neil F Box, Cesar Rodriguez, Wiam Bshara, Eugene S Kandel, Maria S Soengas, Gyorgy Paragh, Mikhail A Nikiforov
Although antioxidants promote melanoma metastasis, the role of reactive oxygen species (ROS) in other stages of melanoma progression is controversial. Moreover, genes regulating ROS have not been functionally characterized throughout the entire tumor progression in mouse models of cancer. To address this question, we crossed mice-bearing knock-out of Klf9, an ubiquitous transcriptional regulator of oxidative stress, with two conditional melanocytic mouse models: BrafCA mice, where BrafV600E causes premalignant melanocytic hyperplasia, and BrafCA /Pten-/- mice, where BrafV600E and loss of Pten induce primary melanomas and metastases...
January 21, 2019: Oncogene
Marina N Nikiforova, Alyaksandr V Nikitski, Federica Panebianco, Cihan Kaya, Linwah Yip, Michelle D Williams, Simion I Chiosea, Raja Seethala, Somak Roy, Vincenzo Condello, Lucas Santana-Santos, Abigail I Wald, Sally E Carty, Robert L Ferris, Adel K El-Naggar, Yuri E Nikiforov
BACKGROUND: Hyalinizing trabecular tumor (HTT) is a rare thyroid neoplasm with a characteristic trabecular growth pattern and hyalinization. This lesion has been a subject of long-term controversy surrounding its genetic mechanisms, relationship to papillary thyroid carcinoma, and malignant potential. Due to the presence of nuclear features shared with papillary carcinoma, HTT frequently contribute to false-positive cytology which hampers patient management. The goal of this study was to apply genome-wide sequencing analyses to elucidate the genetic mechanisms of HTT and its relationship to papillary carcinoma...
January 16, 2019: Thyroid: Official Journal of the American Thyroid Association
Andrey P Vasilev, Tatyana S Struchkova, Leonid A Nikiforov, Aitalina A Okhlopkova, Petr N Grakovich, Ee Le Shim, Jin-Ho Cho
Mixtures of layered silicates (vermiculite and kaolinite) and carbon fibers were investigated as filler materials for polytetrafluoroethylene. The supramolecular structure and the tribological and mechanical properties of the resulting polymer composite materials were evaluated. The yield strength and compressive strength of the polymer increased by 55% and 60%, respectively, when a mixed filler was used, which was attributed to supramolecular reinforcement of the composites. In addition, the wear resistance increased by 850 times when using vermiculite/kaolinite fillers, which was due to protection of the surface by the formation of hard tribofilms...
January 9, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Øyvind Strømland, Marc Niere, Andrey A Nikiforov, Magali R VanLinden, Ines Heiland, Mathias Ziegler
Research over the last few decades has extended our understanding of nicotinamide adenine dinucleotide (NAD) from a vital redox carrier to an important signalling molecule that is involved in the regulation of a multitude of fundamental cellular processes. This includes DNA repair, cell cycle regulation, gene expression and calcium signalling, in which NAD is a substrate for several families of regulatory proteins, such as sirtuins and ADP-ribosyltransferases. At the molecular level, NAD-dependent signalling events differ from hydride transfer by cleavage of the dinucleotide into an ADP-ribosyl moiety and nicotinamide...
January 9, 2019: Biochemical Society Transactions
Konstantin Shabalin, Kirill Nerinovski, Alexander Yakimov, Veronika Kulikova, Maria Svetlova, Ljudmila Solovjeva, Mikhail Khodorkovskiy, Stepan Gambaryan, Richard Cunningham, Marie E Migaud, Mathias Ziegler, Andrey Nikiforov
Nicotinamide adenine dinucleotide (NAD) and its phosphorylated form, NADP, are the major coenzymes of redox reactions in central metabolic pathways. Nicotinamide adenine dinucleotide is also used to generate second messengers, such as cyclic ADP-ribose, and serves as substrate for protein modifications including ADP-ribosylation and protein deacetylation by sirtuins. The regulation of these metabolic and signaling processes depends on NAD availability. Generally, human cells accomplish their NAD supply through biosynthesis using different forms of vitamin B3: Nicotinamide (Nam) and nicotinic acid as well as nicotinamide riboside (NR) and nicotinic acid riboside (NAR)...
December 6, 2018: International Journal of Molecular Sciences
N Paul Ohori, Michael S Landau, Sally E Carty, Linwah Yip, Shane O LeBeau, Pooja Manroa, Raja R Seethala, Karen E Schoedel, Marina N Nikiforova, Yuri E Nikiforov
BACKGROUND: The benign call rate (BCR) is the percentage of cytomorphologically indeterminate cases with subsequent benign or negative molecular results. For rule-out tests, the BCR is an important parameter because these molecular "negative" cases may be managed similarly to those with a benign cytology diagnosis. Although earlier versions of ThyroSeq molecular tests were less effective in excluding malignancy, the extensively expanded v3 version with a high negative predictive value is considered to represent a rule-out test...
December 18, 2018: Cancer Cytopathology
E A Kornyushova, A V Kashevskii, K Y Arsent'ev, B G Pushkarev, S B Nikiforov, A Y Safronov
Titanium and platinum samples as components of bimetallic implants for the osteoregeneration process have been modified in solutions modeling biological systems and studied by means of cyclic voltammetry, electrochemical impedance spectroscopy and scanning probe microscopy. While aspartic and glutamic acids did not adsorb significantly on platinum in the potential region investigated, the presence of the amino acids affects oxide layer growth on the titanium surface under anodic polarization. The two studied amino acids behave differently on the titanium electrode surface due to differences in adsorption modes of these substances...
December 4, 2018: Bioelectrochemistry
David L Steward, Sally E Carty, Rebecca S Sippel, Samantha Peiling Yang, Julie A Sosa, Jennifer A Sipos, James J Figge, Susan Mandel, Bryan R Haugen, Kenneth D Burman, Zubair W Baloch, Ricardo V Lloyd, Raja R Seethala, William E Gooding, Simion I Chiosea, Cristiane Gomes-Lima, Robert L Ferris, Jessica M Folek, Raheela A Khawaja, Priya Kundra, Kwok Seng Loh, Carrie B Marshall, Sarah Mayson, Kelly L McCoy, Min En Nga, Kee Yuan Ngiam, Marina N Nikiforova, Jennifer L Poehls, Matthew D Ringel, Huaitao Yang, Linwah Yip, Yuri E Nikiforov
Importance: Approximately 20% of fine-needle aspirations (FNA) of thyroid nodules have indeterminate cytology, most frequently Bethesda category III or IV. Diagnostic surgeries can be avoided for these patients if the nodules are reliably diagnosed as benign without surgery. Objective: To determine the diagnostic accuracy of a multigene classifier (GC) test (ThyroSeq v3) for cytologically indeterminate thyroid nodules. Design, Setting, and Participants: Prospective, blinded cohort study conducted at 10 medical centers, with 782 patients with 1013 nodules enrolled...
November 8, 2018: JAMA Oncology
Aaron Dickenson, Nikolay Britun, Anton Nikiforov, Christophe Leys, Mohammad I Hasan, James L Walsh
The reactive chemical species generated by non-equilibrium plasma under atmospheric pressure conditions are key enablers for many emerging applications spanning the fields of biomedicine, manufacturing and agriculture. Despite showing great application potential, insight in to the underpinning reactive species generation and transport mechanisms remains scarce. This contribution focuses on the spatiotemporal behaviour of reactive nitrogen species (RNS) created and transported by an atmospheric pressure air surface barrier discharge (SBD) using both laser induced fluorescence and particle imaging velocimetry measurements combined with experimentally validated numerical modelling...
November 21, 2018: Physical Chemistry Chemical Physics: PCCP
A Kostic, R Dux, K Crombé, A Nikiforov, R Ochoukov, I Shesterikov, E H Martin, J-M Noterdaeme
IShTAR, Ion cyclotron Sheath Test ARrangement, is a linear device dedicated to the investigation of the edge plasma-ICRF (Ion Cyclotron Range of Frequencies) antenna interactions in tokamak edge-like conditions and serves as a platform for a diagnostic development for measuring the electric fields in the vicinity of ICRF antennas. We present here our progress in the development of an optical emission spectroscopy method for measuring the electric fields which concentrates on the changes in the helium spectral line profiles introduced by the external electrical field, i...
October 2018: Review of Scientific Instruments
Jens Bitzer, Thomas Henkel, Andrey I Nikiforov, Marisa O Rihner, C M Verspeek-Rip, Birol Usta, Michèle van den Wijngaard
A series of in vitro studies were conducted to assess the genetic toxicity of jelly mushroom glycolipids from Dacryopinax spathularia (herein referred to as "AM-1"). In the bacterial reverse mutation assay (Ames test), there was no evidence of mutagenic activity in any Salmonella typhimurium strains tested or in Escherichia coli strain WP2uvrA, at dose levels up to 5000 μg/plate. In the micronucleus (MN) test using human lymphocytes, AM-1 did not show a statistically significant increase in the number of binucleated cells containing micronuclei when compared to concurrent control cultures at all time points and at any of the concentrations analyzed (up to 900 μg/ml of culture medium)...
October 25, 2018: Food and Chemical Toxicology
Emily E Fink, Sudha Moparthy, Archis Bagati, Anna Bianchi-Smiraglia, Brittany C Lipchick, David W Wolff, Matthew V Roll, Jianmin Wang, Song Liu, Andrei V Bakin, Eugene S Kandel, Ann-Hwee Lee, Mikhail A Nikiforov
Transcription factor XBP1s, activated by endoplasmic reticulum (ER) stress in a dose-dependent manner, plays a central role in adaptive unfolded protein response (UPR) via direct activation of multiple genes controlling protein refolding. Here, we report that elevation of ER stress above a critical threshold causes accumulation of XBP1s protein sufficient for binding to the promoter and activation of a gene encoding a transcription factor KLF9. In comparison to other XBP1s targets, KLF9 promoter contains an evolutionary conserved lower-affinity binding site that requires higher amounts of XBP1s for activation...
October 2, 2018: Cell Reports
Niels Wardenier, Patrick Vanraes, Anton Nikiforov, Stijn W H Van Hulle, Christophe Leys
The emergence of micropollutants into our aquatic resources is regarded as an issue of increasing environmental concern. To protect the aquatic environment against further contamination with micropollutants, treatment with advanced oxidation processes (AOPs) is put forward as a promising technique. In this work, an innovative AOP based on electrical discharges in a continuous-flow pulsed dielectric barrier discharge (DBD) reactor with falling water film over activated carbon textile is examined for its potential application in water treatment...
January 15, 2019: Journal of Hazardous Materials
Juan Ignacio García, Meritxell Sabidó, Mikhail Nikiforov, Adriana Smith, Gabriela Hernández, Rudy Ortiz, Luis Ardani, Alba Cajas, Elsy Camey, Jordi B Torrelles, Shu-Hua Wang, Colin N J Campbell, Cinta Folch, Jordi Casabona
OBJECTIVE: To describe and compare trends in prevalence, sexual behaviour and HIV transmission knowledge data related to sexually transmitted infections (STI) and HIV in patients attending three STI clinics over an 8-year period in Escuintla Department, Guatemala. METHODS: STI clinic attendees were classified into transmission groups as follows: female sex workers (FSW), men who have sex with men (MSM) and 'high-risk heterosexuals' (HRH). Annual cross-sectional analysis and multivariable Poisson regression adjusted for sociodemographic variables were used for prevalence comparisons and adjusted prevalence trends for HIV/STI outcomes and used for adjusted trends in proportions in sexual behaviour and HIV transmission knowledge outcomes...
September 19, 2018: BMJ Open
Anna Bianchi-Smiraglia, Archis Bagati, Emily E Fink, Hayley C Affronti, Brittany C Lipchick, Sudha Moparthy, Mark D Long, Spencer R Rosario, Shivana M Lightman, Kalyana Moparthy, David W Wolff, Dong Hyun Yun, Zhannan Han, Anthony Polechetti, Matthew V Roll, Ilya I Gitlin, Katerina I Leonova, Aryn M Rowsam, Eugene S Kandel, Andrei V Gudkov, P Leif Bergsagel, Kelvin P Lee, Dominic J Smiraglia, Mikhail A Nikiforov
Polyamine inhibition for cancer therapy is, conceptually, an attractive approach but has yet to meet success in the clinical setting. The aryl hydrocarbon receptor (AHR) is the central transcriptional regulator of the xenobiotic response. Our study revealed that AHR also positively regulates intracellular polyamine production via direct transcriptional activation of 2 genes, ODC1 and AZIN1, which are involved in polyamine biosynthesis and control, respectively. In patients with multiple myeloma (MM), AHR levels were inversely correlated with survival, suggesting that AHR inhibition may be beneficial for the treatment of this disease...
October 1, 2018: Journal of Clinical Investigation
S V Nikiforov, I G Avdyushin, D V Ananchenko, A N Kiryakov, A F Nikiforov
New Al2 O3 -BeO ceramics were synthesized from alumina nanopowder in BeO crucibles by high-temperature treatment in reducing conditions. It was found that the TL curve of these ceramics is characterized by a dosimetric peak at 520-530 K for a heating rate of 2 K/s. The integrated TL of the peak is not influenced by the heating rate of the samples, unlike that in anion-defective alumina and beryllia crystals. The presence of an energy distribution of the traps which cause dosimetric TL peak is verified by Tm-Tstop and initial rise methods...
November 2018: Applied Radiation and Isotopes
Alyaksandr V Nikitski, Susan L Rominski, Mamta Wankhede, Lindsey M Kelly, Federica Panebianco, Guillermo Barila, Daniel L Altschuler, Yuri E Nikiforov
Chromosomal rearrangements of the ALK gene, which lead to constitutive activation of ALK tyrosine kinase, are found in various cancers. In thyroid cancers, ALK fusions, most commonly the STRN-ALK fusion, are detected in papillary thyroid cancer and with higher frequency in poorly differentiated and anaplastic thyroid cancers. Our aim was to establish a mouse model of thyroid-specific expression of STRN-ALK and to test whether this fusion drives the development of thyroid cancer with a propensity for dedifferentiation...
November 2018: American Journal of Pathology
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