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JOURNAL ARTICLE
M V Mnikhovich, P A Akhsanova, T N Sotnikova
Ippolit Vasilyevich Davydovsky was born in 1887 in Danilov, Yaroslavl province, into the family of a clergyman. He received his primary education in a parochial church school. After I.V. Davydovsky's family moved to Yaroslavl, he continued his education in a men's gymnasium. Having successfully graduated from the gymnasium, I.V. Davydovsky in 1905 entered the medical faculty of Moscow State University, where he studied and was influenced by Acad. A.I. Abrikosov formed his first scientific interests. After graduating from the university in 1910, I...
2024: Arkhiv Patologii
#2
JOURNAL ARTICLE
Alma Dauletbekova, Sergey Zvonarev, Sergey Nikiforov, Abdirash Akilbekov, Tatiana Shtang, Natalia Karavannova, Aiman Akylbekova, Alexey Ishchenko, Gulzhanat Akhmetova-Abdik, Zein Baymukhanov, Gulnara Aralbayeva, Guldar Baubekova, Anatoli I Popov
Samples of ZrO2 ceramics with different concentrations of impurity titanium ions were synthesized by mixing zirconium and titanium oxide powders in different mass ratios. The X-ray diffraction analysis was used to determine the phase composition, lattice parameters, and crystallite size of the ceramics with varying dopant concentrations. Upon irradiation of the samples with 220 MeV Xe ions to a fluence of 1010 ions/cm2 , a decrease in the intensity of the pulsed cathodoluminescence band at 2.5 eV was observed...
March 12, 2024: Materials
#3
JOURNAL ARTICLE
Gang Xue, Xin Li, Muhammad Kalim, Jing Fang, Zhiwu Jiang, Ningbo Zheng, Ziyu Wang, Xiaoyin Li, Maen Abdelrahim, Zhiheng He, Mikhail Nikiforov, Guangxu Jin, Yong Lu
Emerging as the most potent and durable combinational immunotherapy, dual anti-PD-1 and CTLA-4 immune checkpoint blockade (ICB) therapy notoriously increases grade 3-5 immune-related adverse events (irAEs) in patients. Accordingly, attempts to improve the antitumor potency of anti-PD-1+CTLA-4 ICB by including additional therapeutics have been largely discouraged due to concerns of further increasing fatal toxicity. Here, we screened ∼3,000 Food and Drug Administration (FDA)-approved drugs and identified clofazimine as a potential third agent to optimize anti-PD-1+CTLA-4 ICB...
March 19, 2024: Cancer Cell
#4
JOURNAL ARTICLE
Jacob R Gissinger, Ilia Nikiforov, Yaser Afshar, Brendon Waters, Moon-Ki Choi, Daniel S Karls, Alexander Stukowski, Wonpil Im, Hendrik Heinz, Axel Kohlmeyer, Ellad B Tadmor
New functionality is added to the LAMMPS molecular simulation package, which increases the versatility with which LAMMPS can interface with supporting software and manipulate information associated with bonded force fields. We introduce the "type label" framework that allows atom types and their higher-order interactions (bonds, angles, dihedrals, and impropers) to be represented in terms of the standard atom type strings of a bonded force field. Type labels increase the human readability of input files, enable bonded force fields to be supported by the OpenKIM repository, simplify the creation of reaction templates for the REACTER protocol, and increase compatibility with external visualization tools, such as VMD and OVITO...
March 20, 2024: Journal of Physical Chemistry. B
#5
JOURNAL ARTICLE
A I Ahmadov, Sh M Nagiyev, A N Ikot, V A Tarverdiyeva
In this study, we have successfully obtained the analytical solutions for the Klein-Gordon equation with new proposed a non-central exponential potential <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>V</mml:mi> <mml:mfenced><mml:mi>r</mml:mi></mml:mfenced> <mml:mo>=</mml:mo> <mml:mi>D</mml:mi> <mml:msup> <mml:mfenced><mml:mrow><mml:mn>1</mml:mn> <mml:mo>-</mml:mo> <mml:msub><mml:mi>σ</mml:mi> <mml:mn>0</mml:mn></mml:msub> <mml:mo>coth</mml:mo> <mml:mrow><mml:mo>(</mml:mo> <mml:mi>α</mml:mi> <mml:mi>r</mml:mi> <mml:mo>)</mml:mo></mml:mrow> </mml:mrow> </mml:mfenced> <mml:mn>2</mml:mn></mml:msup> <mml:mo>+</mml:mo> <mml:mrow><mml:mo>(</mml:mo> <mml:msub><mml:mi>η</mml:mi> <mml:mn>1</mml:mn></mml:msub> <mml:mo>+</mml:mo> <mml:msub><mml:mi>η</mml:mi> <mml:mn>2</mml:mn></mml:msub> <mml:mo>cos</mml:mo> <mml:mi>θ</mml:mi> <mml:mo>)</mml:mo></mml:mrow> <mml:mo>/</mml:mo> <mml:msup><mml:mi>r</mml:mi> <mml:mn>2</mml:mn></mml:msup> <mml:msup><mml:mo>sin</mml:mo> <mml:mn>2</mml:mn></mml:msup> <mml:mi>θ</mml:mi></mml:mrow> </mml:math> ...
March 6, 2024: Scientific Reports
#6
JOURNAL ARTICLE
Alexander N Orekhov, Alexander D Zhuravlev, Andrey Y Vinokurov, Nikita G Nikiforov, Andrey V Omelchenko, Vasily N Sukhorukov, Vasily V Sinyov, Igor A Sobenin
BACKGROUND AND AIMS: The role of mitophagy in atherosclerosis has been extensively studied during the last few years. It was shown that mitophagy is involved in the regulation of macrophages, which are important players as immune cells in atherosclerosis development. In this study, we investigated the relationship between mitophagy and response to inflammatory stimulation of macrophage-like cells. Six cybrid cell lines with normal mitophagy, that is, increasing in response to stimulation, and 7 lines with defective mitophagy not responding to stimulation were obtained...
March 1, 2024: Current Medicinal Chemistry
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JOURNAL ARTICLE
Vasily N Sukhorukov, Victoria A Khotina, Daria D Borodko, Mariam Bagheri Ekta, Yumiko Oishi, Andrey V Omelchenko, Kira I Kolmychkova, Nikita G Nikiforov, Igor A Sobenin, Alexander N Orekhov
BACKGROUND: The relationship between the cellular pro-inflammatory response and intracellular lipid accumulation in atherosclerosis is not sufficiently studied. Transcriptomic analysis is one way to establish such a relationship. Previously, we identified 10 potential key genes (IL-15, CXCL8, PERK, IL-7, IL-7R, DUSP1, TIGIT, F2RL1, TSPYL2, and ANXA1) involved in cholesterol accumulation in macrophages. It should be noted that all these genes do not directly participate in cholesterol metabolism, but encode molecules related to inflammation...
February 19, 2024: Current Medicinal Chemistry
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JOURNAL ARTICLE
Sheida Aliakbarshirazi, Rouba Ghobeira, Mahtab Asadian, Mehrnoush Narimisa, Anton Nikiforov, Ives De Baere, Wim Van Paepegem, Nathalie De Geyter, Heidi Declercq, Rino Morent
Despite all recent progresses in nerve tissue engineering, critical-sized nerve defects are still extremely challenging to repair. Therefore, this study targets the bridging of critical nerve defects and promoting an oriented neuronal outgrowth by engineering innovative nerve guidance conduits (NGCs) synergistically possessing exclusive topographical, chemical, and mechanical cues. To do so, a mechanically adequate mixture of polycaprolactone (PCL) and polylactic- co -glycolic acid (PLGA) was first carefully selected as base material to electrospin nanofibrous NGCs simulating the extracellular matrix...
February 27, 2024: Biomacromolecules
#9
JOURNAL ARTICLE
Peter Y F Zeng, Stephenie D Prokopec, Stephen Y Lai, Nicole Pinto, Michelle A Chan-Seng-Yue, Roderick Clifton-Bligh, Michelle D Williams, Christopher J Howlett, Paul Plantinga, Matthew J Cecchini, Alfred K Lam, Iram Siddiqui, Jianxin Wang, Ren X Sun, John D Watson, Reju Korah, Tobias Carling, Nishant Agrawal, Nicole Cipriani, Douglas Ball, Barry Nelkin, Lisa M Rooper, Justin A Bishop, Cathie Garnis, Ken Berean, Norman G Nicolson, Paul Weinberger, Ying C Henderson, Christopher M Lalansingh, Mao Tian, Takafumi N Yamaguchi, Julie Livingstone, Adriana Salcedo, Krupal Patel, Frederick Vizeacoumar, Alessandro Datti, Liu Xi, Yuri E Nikiforov, Robert Smallridge, John A Copland, Laura A Marlow, Martin D Hyrcza, Leigh Delbridge, Stan Sidhu, Mark Sywak, Bruce Robinson, Kevin Fung, Farhad Ghasemi, Keith Kwan, S Danielle MacNeil, Adrian Mendez, David A Palma, Mohammed I Khan, Mushfiq Shaikh, Kara M Ruicci, Bret Wehrli, Eric Winquist, John Yoo, Joe S Mymryk, James W Rocco, David Wheeler, Steve Scherer, Thomas J Giordano, John W Barrett, William C Faquin, Anthony J Gill, Gary Clayman, Paul C Boutros, Anthony C Nichols
Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroid cancer, including 213 from patients with primary anaplastic thyroid carcinomas. We also whole genome sequenced 9 patients using multi-region sequencing of both differentiated and anaplastic thyroid cancer components. Using these data, we demonstrate thatanaplastic thyroid carcinomas have a higher burden of mutations than other thyroid cancers, with distinct mutational signatures and molecular subtypes...
February 26, 2024: Cell Reports
#10
JOURNAL ARTICLE
E Omugbe, E S Eyube, C A Onate, I J Njoku, A Jahanshir, E P Inyang, K O Emeje
CONTEXT: In this paper, the approximate analytical energy equations for the deformed hyperbolic potential have been obtained for arbitrary parameters of the potential. The potential function was transformed to a molecular potential by subjecting it to the Varshni conditions which allows for the determination of the energy levels of diatomic molecules. The molecular vibrational energy spectra for [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text], and [Formula: see text] diatomic molecules were obtained and found to match with the results obtained with another analytical approach, potential functions, and experimental data...
February 19, 2024: Journal of Molecular Modeling
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JOURNAL ARTICLE
Samantha Peiling Yang, Min En Nga, Manish Mahadeorao Bundele, Simion I Chiosea, Sze Hwa Tan, Jeffrey H Y Lum, Rajeev Parameswaran, Ming Yann Lim, Hao Li, Wei Keat Cheah, Kathleen Su-Yen Sek, Andre Teck Huat Tan, Thomas Kwok Seng Loh, Kee Yuan Ngiam, Wee Boon Tan, Xinyong Huang, Thomas Wai Thong Ho, Keng Hua Lim, Chwee Ming Lim, Reyaz M Singaporewalla, Anil Dinkar Rao, Nandini C L Rao, Dennis Yu Kim Chua, David Chao-Wu Chin, Abigail I Wald, Virginia A LiVolsi, Yuri E Nikiforov, E Shyong Tai
BACKGROUND: Most thyroid nodules are benign. It is important to determine the likelihood of malignancy in such nodules to avoid unnecessary surgery. The primary objective of this study was to characterize the genetic landscape and the performance of a multigene genomic classifier in fine-needle aspiration (FNA) biopsies of cytologically indeterminate thyroid nodules in a Southeast Asian cohort. The secondary objective was to assess the predictive contribution of clinical characteristics to thyroid malignancy...
February 6, 2024: Cancer Cytopathology
#12
JOURNAL ARTICLE
Khalid Reggab
CONTEXT: To determine the properties of diatomic molecules, studying their chemical bond energy spectrum is essential since it enables the assessment of their characteristics. This research presents diatomic molecules spectroscopic characteristics and rovibrational energy (H2 , CO, I2 , NO). The Schrodinger equation is solved to determine these energies, considering the presence of a combination of two distinct potentials. the inverse quadratic Yukawa potential in combination with the screened modified Kratzer...
January 29, 2024: Journal of Molecular Modeling
#13
JOURNAL ARTICLE
Palak Patel, Ivan Richard, Giuseppe Filice, Ivan Nikiforov, Priyaranjan Kata, Anish Kumar Kanukuntla, Arthur Okere, Christopher S Hollenbeak, Pramil Cheriyath
BACKGROUND: Heart failure affects over 6 million people in the United States (US) with limited evidence to support the use of cardiac catheterization. The benefit of its use remains mostly as expert opinion. This study intends to assess the benefits and risks of cardiac catheterization in elderly patients admitted for heart failure. METHODS: This was a retrospective study using data from the National Inpatient Sample, including admissions 65 years and older hospitalized for heart failure, between 2008 and 2016...
2024: Health Services Insights
#14
JOURNAL ARTICLE
Ivan V Nikiforov, Dmitry A Spassky, Nataliya R Krutyak, Roman Yu Shendrik, Evgenia S Zhukovskaya, Sergey M Aksenov, Dina V Deyneko
A new series of Sr-based phosphates, Sr9- x Mn x Eu(PO4 )7 , were synthesized using the high-temperature solid-state method in air. It was found that these compounds have the same structure as strontiowhitlockite, which is a β-Ca3 (PO4 )2 (or β-TCP) structure. The concentration of Mn2+ ions required to form a pure strontiowhitlockite phase was determined. An unusual partial reduction of Eu3+ to Eu2+ in air was observed and confirmed by photoluminescence (PL) and electron spin resonance (ESR) spectra measurements...
December 24, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#15
JOURNAL ARTICLE
V V Nikiforov, V A Petrov, A A Stremoukhov, M G Avdeeva, Y G Shvarts, I E Kravchenko, I V Nikolaeva, S E Ushakova, O N Belousova, N A Eremina, S V Teplykh, E V Mel'nikova, N E Kostinа
AIM: The search for etiopathogenetic agents to prevent the development of severe and extremely severe COVID-19 remains relevant. A placebo-controlled randomized clinical trial was conducted to evaluate the efficacy and safety of the antibody-based biological drug (Raphamin). MATERIALS AND METHODS: 785 outpatients 18-75 y.o. with laboratory confirmed mild COVID-19 were included within 24 hours from the disease onset. 771 patients were randomized to the group Raphamin (n=382) and the Placebo group (n=389)...
December 22, 2023: Terapevticheskiĭ Arkhiv
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JOURNAL ARTICLE
Svetlana Smorodinskaya, Nikita Kochetkov, Kirill Gavrilin, Dmitry Nikiforov-Nikishin, Diana Reznikova, Aleksey Vatlin, Anastasia Klimuk, Maya Odorskaya, Alexei Nikiforov-Nikishin, Andrey Ponomarev, Maria Marsova, Valery Danilenko
In this study, the results of evaluating the acute toxicity of Bisphenol A on Danio rerio are presented, encompassing peripheral blood parameters, the composition of hematopoietic cells of erythroid and myeloid lines in the head kidney, and data from histological studies. The LC50 values of Bisphenol A for adult zebrafish individuals for 12, 24, and 48-96 h were determined, which were 18.04, 7.55, and 6.22 mg/L, respectively. The study includes data on the morphology and quantitative frequency of specific cells in the hematopoietic tissue of the head kidney, along with the consideration of adaptive mechanisms in hematopoiesis under BPA exposure...
November 28, 2023: Animals: An Open Access Journal From MDPI
#17
REVIEW
Mariia Stepanova, Alexey Nikiforov, Tatiana Tennikova, Evgenia Korzhikova-Vlakh
Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition and architecture can vary over a wide range. Their unique ability to form secondary structures, as well as different pathways of modification and biofunctionalization due to the diversity of amino acids, provide variation in the physicochemical and biological properties of polypeptide-containing materials. In this review article, we summarize the advances in the synthesis of polypeptides and their copolymers and the application of these systems for drug delivery in the form of (nano)particles or hydrogels...
November 20, 2023: Pharmaceutics
#18
JOURNAL ARTICLE
Krishan Kanhaiya, Michael Nathanson, Pieter J In 't Veld, Cheng Zhu, Ilia Nikiforov, Ellad B Tadmor, Yeol Kyo Choi, Wonpil Im, Ratan K Mishra, Hendrik Heinz
The simulation of metals, oxides, and hydroxides can accelerate the design of therapeutics, alloys, catalysts, cement-based materials, ceramics, bioinspired composites, and glasses. Here we introduce the INTERFACE force field (IFF) and surface models for α-Al2 O3 , α-Cr2 O3 , α-Fe2 O3 , NiO, CaO, MgO, β-Ca(OH)2 , β-Mg(OH)2 , and β-Ni(OH)2 . The force field parameters are nonbonded, including atomic charges for Coulomb interactions, Lennard-Jones (LJ) potentials for van der Waals interactions with 12-6 and 9-6 options, and harmonic bond stretching for hydroxide ions...
November 14, 2023: Journal of Chemical Theory and Computation
#19
JOURNAL ARTICLE
Jordanka Semkova, Rositza Koleva, Victor Benghin, Krasimir Krastev, Yuri Matviichuk, Borislav Tomov, Stephan Maltchev, Tsvetan Dachev, Nikolay Bankov, Igor Mitrofanov, Alexey Malakhov, Dmitry Golovin, Maxim Litvak, Anton Sanin, Alexander Kozyrev, Maxim Mokrousov, Sergey Nikiforov, Denis Lisov, Artem Anikin, Vyacheslav Shurshakov, Sergey Drobyshev, Nat Gopalswamy
The dosimeter Liulin-MO for measuring the radiation environment onboard the ExoMars Trace Gas Orbiter (TGO) is a module of the Fine Resolution Epithermal Neutron Detector (FREND). Here we present results from measurements of the charged particle fluxes, dose rates and estimation of dose equivalent rates at ExoMars TGO Mars science orbit, provided by Liulin-MO from May 2018 to June 2022. The period of measurements covers the declining and minimum phases of the solar activity in 24th solar cycle and the rising phase of the 25th cycle...
November 2023: Life Sciences in Space Research
#20
JOURNAL ARTICLE
Dania Zhivaki, Emily A Gosselin, Debrup Sengupta, Holly Concepcion, Chisom Arinze, Jonathan Chow, Anastasia Nikiforov, Veronica Komoroski, Carolyn MacFarlane, Caitlin Sullivan, Jonathan C Kagan
Lipid nanoparticle (LNP)-encapsulated mRNAs have emerged as effective vaccination tools to stimulate immunity. The most common application of this technology is to deliver mRNAs that encode antigenic proteins to dendritic cells (DCs), which then stimulate antigen-specific lymphocyte responses. It is unclear whether other immunostimulatory DC activities necessary for vaccine efficacy, beyond antigen presentation, can be induced via mRNA-encoded proteins. Herein, we report an mRNA encoding a self-DNA reactive variant of the enzyme cyclic GMP-AMP synthase (cGAS), known as cGAS∆N...
November 8, 2023: MBio
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