Samantha Henry, Steven Macauley Lewis, Samantha Leeanne Cyrill, Mackenzie Kate Callaway, Deeptiman Chatterjee, Amritha Varshini Hanasoge Somasundara, Gina Jones, Xue-Yan He, Giuseppina Caligiuri, Michael Francis Ciccone, Isabella Andrea Diaz, Amelia Aumalika Biswas, Evelyn Hernandez, Taehoon Ha, John Erby Wilkinson, Mikala Egeblad, David Arthur Tuveson, Camila Oresco Dos Santos
Exposure to pathogens throughout a lifetime influences immunity and organ function. Here, we explore how the systemic host-response to bacterial urinary tract infection (UTI) induces tissue-specific alterations to the mammary gland. Utilizing a combination of histological tissue analysis, single cell transcriptomics, and flow cytometry, we identify that mammary tissue from UTI-bearing mice displays collagen deposition, enlarged ductal structures, ductal hyperplasia with atypical epithelial transcriptomes and altered immune composition...
April 16, 2024: Nature Communications