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Multiple sclerosis cognitive

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https://read.qxmd.com/read/30877926/caregiver-strain-among-life-partners-of-persons-with-mild-disability-due-to-relapsing-remitting-multiple-sclerosis
#1
K van der Hiele, D A M van Gorp, M A P Heerings, P J Jongen, J J L van der Klink, E A C Beenakker, J J J van Eijk, S T F M Frequin, B M van Geel, G J D Hengstman, E Hoitsma, J P Mostert, W I M Verhagen, K de Gans, D Zemel, H A M Middelkoop, L H Visser
BACKGROUND: Multiple sclerosis (MS) is a chronic disorder of the central nervous system with an unpredictable disease course. Life partners often become caregivers, which can be both rewarding and challenging, as the caregiver's physical and mental health is often negatively affected. Previous studies on caregiver strain focused on caregivers of persons with MS with relatively high disability levels, while caregiver strain may already be experienced by life partners living with mildly disabled persons with MS...
March 6, 2019: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/30877732/robust-regional-cerebral-blood-flow-perfusion-deficits-in-relapsing-remitting-multiple-sclerosis-patients-with-executive-function-impairment
#2
Lambros Messinis, Dimitris Apostolopoulos, Tryfon Spiridonidis, Grigorios Nasios, Aikaterini Giazkoulidou, Magda Tsolaki, Vasilis Panagiotopoulos
OBJECTIVES: Cognitive impairment is present in up to 65% of Relapsing Remitting Multiple sclerosis (RRMS) patients and can be extremely debilitating. Although deficits in episodic memory and processing speed occur more frequently than executive deficits, executive dysfunction tends to have a significant impact on MS patients' ability to generate strategies, think divergently, solve and estimate problems, and reason in abstract terms with substantial negative impacts on activities of daily living...
January 2019: Hellenic Journal of Nuclear Medicine
https://read.qxmd.com/read/30877728/cognitive-functions-and-social-cognition-in-multiple-sclerosis-an-overview
#3
Aikaterini Giazkoulidou, Lampros Messinis, Grigorios Nasios
Cognitive decline has been widely reported in patients with multiple sclerosis (MS) despite its clinical heterogeneity, at all stages and in all subtypes of the disease. Deficits are most commonly present in attention, processing speed, working memory, verbal fluency and executive function. However, MS patients also show decreased performance in tasks related to social cognition, i.e. mental operations thatdrive interpersonal skills such as social perception, empathy and theory of mind. Social cognitive deficits are an underestimated but important aspect of impairment in MS, reflecting how people process, store, and apply information in social interactions...
January 2019: Hellenic Journal of Nuclear Medicine
https://read.qxmd.com/read/30877725/cognitive-decline-in-multiple-sclerosis-patients
#4
Euphrosyni Koutsouraki, Thaleia Kalatha, Effrosyni Grosi, Theodoros Koukoulidis, Dimitrios Michmizos
Cognitive impairment is a common phenomenon in multiple sclerosis (MS), occurring at all stages of the disease, even at the earliest, and can be a major source of disability, social impairment, and impoverished quality of life. Cognitive dysfunction is mainly focused on working memory, conceptual reasoning, verbal fluency, speed of information processing, attention and executive function. Additional clinical factors, including disease course, fatigue and affective disturbance, can impact the degree of MS-related cognitive impairment...
January 2019: Hellenic Journal of Nuclear Medicine
https://read.qxmd.com/read/30873106/development-of-cortical-lesion-volumes-on-double-inversion-recovery-mri-in-patients-with-relapse-onset-multiple-sclerosis
#5
Tobias D Faizy, Gabriel Broocks, Christian Thaler, Geraldine Rauch, Pimrapat Gebert, Klarissa H Stürner, Fabian Flottmann, Hannes Leischner, Helge C Kniep, Jan-Patrick Stellmann, Christoph Heesen, Jens Fiehler, Susanne Gellißen, Uta Hanning
Background and Objective: In multiple sclerosis (MS) patients, Double Inversion Recovery (DIR) magnetic resonance imaging (MRI) can be used to detect cortical lesions (CL). While the quantity and distribution of CLs seems to be associated with patients' disease course, literature lacks frequent assessments of CL volumes (CL-V) in this context. We investigated the reliability of DIR for the longitudinal assessment of CL-V development with frequent follow-up MRIs and examined the course of CL-V progressions in relation to white-matter lesions (WML), contrast enhancing lesions (CEL) and clinical parameters in patients with Relapsing-Remitting Multiple Sclerosis (RRMS)...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30871594/role-of-cerebral-hypoperfusion-in-multiple-sclerosis-rochims-study-protocol-for-a-proof-of-concept-randomized-controlled-trial-with-bosentan
#6
Stéphanie Hostenbach, Ayla Pauwels, Veronique Michiels, Hubert Raeymaekers, Anne-Marie Van Binst, Annick Van Merhaeghen-Wieleman, Peter Van Schuerbeek, Jacques De Keyser, Miguel D'Haeseleer
BACKGROUND: Axonal degeneration is related to long-term disability in patients with multiple sclerosis (MS). The underlying mechanism remains ill understood but appears to involve axonal energetic dysfunction. A globally impaired cerebral blood flow (CBF) has been observed in the normal-appearing white matter (NAWM) of patients with MS, which is probably related to astrocytic overexpression of endothelin-1 (ET-1). Cerebral hypoperfusion has been associated with reduced mitochondrial activity and disabling symptoms (e...
March 14, 2019: Trials
https://read.qxmd.com/read/30870707/very-long-term-outcome-in-resected-and-non-resected-patients-with-temporal-lobe-epilepsy-with-medial-temporal-lobe-sclerosis-a-multiple-case-study
#7
P Grewe, R Schulz, F G Woermann, C Brandt, A Doll, M Hoppe, M Tomka-Hoffmeister, C G Bien
PURPOSE: To investigate the very long-term (i.e., ≥15 years) seizure, cognitive and psycho-social outcomes in resected patients (RP) with TLE compared to control patients not having undergone epilepsy surgery. METHODS: We applied a multiple case-study design including three non-resected patients (NRP) who were compared to a group of six RP. The latter were matched to the NRP according to clinical-demographic data. Outcome measures were various seizure, cognitive, and psycho-social variables...
February 24, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/30865313/a-model-of-different-cognitive-processes-during-spontaneous-and-intentional-coupling-to-music-in-multiple-sclerosis
#8
Lousin Moumdjian, Bart Moens, Ellen Vanzeir, Beatrijs De Klerck, Peter Feys, Marc Leman
Evidence for using auditory-motor coupling in neurological rehabilitation to facilitate walking is increasing. However, the distinction between spontaneous and intended coupling and its underlying mechanisms is yet to be investigated. In this study, we include 30 persons with multiple sclerosis and 30 healthy controls (HCs) in an experiment with two sessions in which participants were asked to walk to music with various tempi, matching their preferred walking cadence (PWC) up to 10% above in incremental steps of 2%...
March 13, 2019: Annals of the New York Academy of Sciences
https://read.qxmd.com/read/30863016/adherence-to-disease-modifying-treatments-in-patients-with-multiple-sclerosis-in-spain
#9
Ramón Morillo Verdugo, Esther Ramírez Herráiz, Raquel Fernández-Del Olmo, Montserrat Roig Bonet, María Valdivia García
Purpose: Adherence to disease-modifying treatments is essential in order to maximize the beneficial effects of treatment for multiple sclerosis (MS). There are numerous treatments that have been approved. Treatment selection is essential in patient adherence. In addition, patient preference plays an increasingly significant role in treatment decision-making. This study aims to evaluate the degree of adherence, along with other variables that may influence this adherence, in Spain. Methods: A cross-sectional study was conducted with 157 MS patients with disease-modifying treatments...
2019: Patient Preference and Adherence
https://read.qxmd.com/read/30858445/cognitive-impairment-in-an-animal-model-of-multiple-sclerosis-and-its-amelioration-by-glatiramer-acetate
#10
Rina Aharoni, Nofar Schottlender, Dekel D Bar-Lev, Raya Eilam, Michael Sela, Michael Tsoory, Ruth Arnon
The severe motor impairment in the MS animal model experimental autoimmune encephalomyelitis (EAE) obstructs the assessment of cognitive functions. We developed an experimental system that evaluates memory faculties in EAE-affected mice, irrespective of their motor performance, enabling the assessment of cognitive impairments along the disease duration, the associated brain damage, and the consequences of glatiramer acetate (GA) treatment on these manifestations. The delayed-non-matching to sample (DNMS) T-maze task, testing working and long term memory was adapted and utilized...
March 11, 2019: Scientific Reports
https://read.qxmd.com/read/30858063/effects-of-sulforaphane-in-the-central-nervous-system
#11
REVIEW
Dongjian Chen, Chao Huang, Jie Jin, Yue Wu, Zhuo Chen
Sulforaphane (SFN) is an active component extracted from vegetables like cauliflower and broccoli. Activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling is a common mechanism for the anti-oxidative and anti-inflammatory activity of some herb-derived compounds, such as icariin and berberine. However, due to its peculiar ability in Nrf2 activation, SFN is recognized as an activator of Nrf2 and recommended as a supplementation for prevention and/or treatment of disorders like neoplasm and heart failure...
March 8, 2019: European Journal of Pharmacology
https://read.qxmd.com/read/30853896/default-mode-network-structural-integrity-and-cerebellar-connectivity-predict-information-processing-speed-deficit-in-multiple-sclerosis
#12
Giovanni Savini, Matteo Pardini, Gloria Castellazzi, Alessandro Lascialfari, Declan Chard, Egidio D'Angelo, Claudia A M Gandini Wheeler-Kingshott
Cognitive impairment affects about 50% of multiple sclerosis (MS) patients, but the mechanisms underlying this remain unclear. The default mode network (DMN) has been linked with cognition, but in MS its role is still poorly understood. Moreover, within an extended DMN network including the cerebellum (CBL-DMN), the contribution of cortico-cerebellar connectivity to MS cognitive performance remains unexplored. The present study investigated associations of DMN and CBL-DMN structural connectivity with cognitive processing speed in MS, in both cognitively impaired (CIMS) and cognitively preserved (CPMS) MS patients...
2019: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/30852305/assessing-the-effects-of-post-acute-rehabilitation-services-on-health-care-outcomes-for-people-with-multiple-sclerosis
#13
Tingting Zhang, Bianca Jambhekar, Amit Kumar, Syed A Rizvi, Linda Resnik, Theresa I Shireman
BACKGROUND: The impact of post-acute rehabilitative services provided in skilled nursing facilities (SNF) on a particularly vulnerable, disabled subgroup, namely persons with multiple sclerosis (PwMS), is unknown. OBJECTIVE: The objectives of this study were to (1) describe the use of post-acute rehabilitative services in SNFs, and (2) examine the association between the use of physical and occupational therapy (PT/OT) and (a) successful community discharge and (b) functional improvement for PwMS...
March 5, 2019: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/30852304/does-cognitive-reserve-play-any-role-in-multiple-sclerosis-a-meta-analytic-study
#14
Gabriella Santangelo, Manuela Altieri, Antonio Gallo, Luigi Trojano
BACKGROUND: Inconsistent evidence is available about the possibility that cognitive reserve (CR) moderates the impact of disease progression, evaluated by MRI biomarkers (lesion load, white matter or gray matter volumes) or clinical proxies of physical disability (i.e. the Expanded Disability Status Scale, EDSS) on cognition in Multiple Sclerosis (MS). A meta-analytic study with a meta-regression approach was performed to investigate the possible role of CR as moderator of the impact of brain damage and physical disability on cognition...
February 14, 2019: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/30851485/spirituality-and-quality-of-life-in-epilepsy-and-other-chronic-neurological-disorders
#15
Anna Rita Giovagnoli, Chiara Paterlini, Rute Flavia Meneses, Antonio Martins da Silva
PURPOSE: The patients with neurological disorders often report a different quality of life (QoL), which is in part explained by clinical-pathological or psychosocial variables. This study evaluated spirituality in patients with chronic brain pathologies, aiming to clarify its specificity and position to a multidimensional model of QoL. METHODS: A hundred and ninety-nine adult patients with epilepsy (E) (n = 88), mild cognitive impairment (MCI) (n = 32), ischemic vascular disorders (n = 29), tumors (n = 28), or multiple sclerosis (MS) (n = 22), and 66 healthy subjects were assessed using the World Health Organization Quality of Life (WHOQoL) 100, Spiritual, Religious and Personal Beliefs (SRPB), Beck Depression Inventory (BDI), and State-Trait Anxiety Inventory (STAI) for the QoL, spirituality, depression, and anxiety...
March 6, 2019: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/30850505/dynamic-11-c-pib-pet-shows-cerebrospinal-fluid-flow-alterations-in-alzheimer-s-disease-and-multiple-sclerosis
#16
Julia J Schubert, Mattia Veronese, Livia Marchitelli, Benedetta Bodini, Matteo Tonietto, Bruno Stankoff, David J Brooks, Alessandra Bertoldo, Paul Edison, Federico Turkheimer
Cerebrospinal fluid (CSF) plays an important role in the clearance of solutes and maintenance of brain homeostasis. 11 C-PiB PET was recently proposed as a tool for detection of CSF clearance alterations in Alzheimer's disease. The current study seeks to investigate the magnitude of 11 C-PiB PET signal in the lateral ventricles of an independent group of Alzheimer's and mild cognitive impairment subjects. We have also evaluated multiple sclerosis as a model of disease with CSF clearance alterations without amyloid-beta tissue accumulation...
March 8, 2019: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://read.qxmd.com/read/30849952/influence-of-different-rehabilitative-aerobic-exercise-programs-on-anti-inflammatory-immune-signalling-cognitive-and-functional-capacity-in-persons-with-ms-study-protocol-of-a-randomized-controlled-trial
#17
Niklas Joisten, Annette Rademacher, Wilhelm Bloch, Alexander Schenk, Max Oberste, Ulrik Dalgas, Dawn Langdon, Daniel Caminada, Mette-Triin Purde, Roman Gonzenbach, Jan Kool, Philipp Zimmer, Jens Bansi
BACKGROUND: Studies have shown positive effects of therapeutic exercise on motor- and cognitive function as well as on psychosocial outcomes in persons with multiple sclerosis (MS). A reduction of inflammatory stress through physical exercise has been suspected as one key mechanism, mediating the positive effects of exercise in the context of MS. The primary objective of this trial is to investigate the acute and chronic effects of different exercise modalities on (anti-)inflammatory immune signalling as well as on cognitive and functional capacity in persons with MS...
March 8, 2019: BMC Neurology
https://read.qxmd.com/read/30825477/will-behavioral-treatments-for-cognitive-impairment-in-multiple-sclerosis-become-standards-of-care
#18
REVIEW
Brian M Sandroff, John DeLuca
Cognitive impairment is common and debilitating in persons with multiple sclerosis (MS), and further is poorly-managed by pharmacotherapy. Cognitive rehabilitation and exercise training have been identified as promising behavioral approaches for managing MS-related cognitive impairment based on systematic reviews and meta-analyses. However, each body of literature is associated with similar sets of methodological shortcomings, as has been identified by periodic systematic reviews and meta-analyses. Thus, there is little generalizability or transportability research supporting either behavioral approach for managing cognitive dysfunction in this population under real-world conditions (i...
February 27, 2019: International Journal of Psychophysiology
https://read.qxmd.com/read/30824631/factors-associated-with-and-long-term-outcome-of-benign-multiple-sclerosis-a-nationwide-cohort-study
#19
Loes Crielaard, Andrius Kavaliunas, Ryan Ramanujam, Tomas Olsson, Jan Hillert, Pernilla Stridh, Ingrid Kockum, Ali Manouchehrinia
OBJECTIVE: Benign multiple sclerosis (BMS) is often defined by the Expanded Disability Status Scale (EDSS) score of ≤3.0 after ≥15 years of disease duration. This classification's clinical relevance remains unclear as benign patients may suffer other impairments and advance towards a progressive course, prompting our objective to holistically investigate factors associated with BMS and its long-term prognosis. METHODS: Benign cases were identified in the Swedish Multiple Sclerosis registry...
March 1, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/30822617/highly-active-multiple-sclerosis-an-update
#20
REVIEW
Cindy Díaz, Luis Alfonso Zarco, Diego M Rivera
Multiple sclerosis (MS) is the most prevalent chronic inflammatory disease of the central nervous system (CNS), affecting more than 2 million people worldwide. It is characterized by brain and spinal cord involvement. There are the relapsing remitting MS (RRMS), primary progressive MS (PPMS), and secondary progressive MS (SPMS) phenotypes. There is a subgroup of RRMS patients who have a more aggressive disease course marked by a rapid accumulation of physical and cognitive deficit, despite treatment with 1 or more disease modifying drugs (DMTs)...
January 24, 2019: Multiple Sclerosis and related Disorders
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