Aleksandra Mamchur, Elena Zelenova, Irina Dzhumaniiazova, Veronika Erema, Daria Kashtanova, Mikhail Ivanov, Maria Bruttan, Mariia Gusakova, Mikhail Terekhov, Vladimir Yudin, Antonina Rumyantseva, Lorena Matkava, Irina Strazhesko, Ruslan Isaev, Anna Kruglikova, Lilit Maytesyan, Irina Tarasova, Olga Beloshevskaya, Elen Mkhitaryan, Sergey Kraevoy, Olga Tkacheva, Sergey Yudin
Previous studies examining the molecular and genetic basis of cognitive impairment, particularly in cohorts of long-living adults, have mainly focused on associations at the genome or transcriptome level. Dozens of significant dementia-associated genes have been identified, including APOE, APOC1, and TOMM40. However, most of these studies did not consider the intergenic interactions and functional gene modules involved in cognitive function, nor did they assess the metabolic changes in individual brain regions...
March 15, 2024: International Journal of Molecular Sciences