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https://read.qxmd.com/read/30770985/investigation-of-urinary-sestrin2-in-patients-with-obstructive-sleep-apnea
#1
Lu Bai, Chunying Sun, Huifen Zhai, Chen Chen, Xiaotian Hu, Xiulin Ye, Min Li, Yan Fang, Weimin Yang, Haoyan Wang, Shibo Sun
BACKGROUND: Obstructive sleep apnea (OSA) is a disease seriously threatening individual health, which results in serious complications such as hypertension and stroke. These complications are associated with oxidative stress triggered by intermittent hypoxia in OSA. Sestrin2 is a crucial factor involved in oxidative stress. The goal of this study was to investigate if a relationship exists between OSA and Sestrin2. METHODS: We prospectively enrolled 71 subjects, and 16 patients of them with severe OSA completed 4 weeks of nasal continuous positive airway pressure (nCPAP) therapy...
February 15, 2019: Lung
https://read.qxmd.com/read/30768487/insomnia-as-an-independent-predictor-of-incident-cardiovascular-disease-in-hiv-data-from-the-veterans-aging-cohort-study
#2
Brittanny M Polanka, Suman Kundu, Kaku A So-Armah, Matthew S Freiberg, Samir K Gupta, Roger J Bedimo, Matthew J Budoff, Adeel A Butt, Chung-Chou H Chang, Stephen S Gottlieb, Vincent C Marconi, Julie A Womack, Jesse C Stewart
BACKGROUND: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown. METHODS: Using the Veterans Aging Cohort Study-Survey Cohort, insomnia symptoms were measured and dummy coded with the item, "Difficulty falling or staying asleep?" (5-point scale from no difficulty to bothers a lot). Incident CVD event ICD-9 codes (acute myocardial infarction, stroke, or coronary artery revascularization) were identified with VA and Medicare administrative data and VA fee-for-service data...
February 7, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/30765992/wake-up-sleepyhead-unilateral-diencephalic-stroke-presenting-with-excessive-sleepiness
#3
R Pradeep, Dhananjay Gupta, Anish Mehta, R Srinivasa, Mahendra Javali, P T Acharya
Altered sleep architecture and stroke share a reciprocal relationship. More than half of the stroke patients display sleep abnormalities including hypersomnia, insomnia, parasomnia, periodic limb movements, or sleep-disordered breathing. Conversely, one of the major causes of severe organic hypersomnia is acute brainstem strokes, involving thalamic infarctions, which may be reversible over 6-12 months. Here, we report a patient with increased lethargy and drowsiness who was diagnosed to have a right thalamic and hypothalamic ischemic stroke...
January 2019: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/30764637/symptom-subtypes-of-obstructive-sleep-apnea-predict-incidence-of-cardiovascular-outcomes
#4
Diego R Mazzotti, Brendan T Keenan, Diane C Lim, Daniel J Gottlieb, Jinyoung Kim, Allan I Pack
RATIONALE: Symptom subtypes have been described in clinical and population samples of obstructive sleep apnea (OSA) patients. It is unclear whether these subtypes have different cardiovascular consequences. OBJECTIVES: This study aimed to characterize OSA symptom subtypes and assess their association with prevalent and incident cardiovascular disease in the Sleep Heart Health Study. METHODS: Data from 1,207 OSA patients (apnea-hypopnea index [AHI]≥15 events/hour) were used to evaluate the existence of symptom subtypes using latent class analysis...
February 15, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30758735/stroke-during-sleep-and-obstructive-sleep-apnea-there-is-a-link
#5
Yousef Mohammad, Ahmed Almutlaq, Abdullah Al-Ruwaita, Amjad Aldrees, Abdulaziz Alsubaie, Fawaz Al-Hussain
OBJECTIVES: The onset of ischemic stroke symptoms has been established to have a diurnal variation, with a sizeable proportion (8-28%) occurring during sleep. Obstructive sleep apnea (OSA) has been established as an important risk factor for ischemic stroke. However, data on the relationship between OSA and wake-up stroke (WUS) has been scarce. The aim of our study is to determine the relationship between OSA and WUS. METHODS: This is a case-control study conducted on acute stroke patients who presented to one of two major medical centers in Riyadh of Saudi Arabia...
February 13, 2019: Neurological Sciences
https://read.qxmd.com/read/30756321/self-reported-snoring-and-incident-cardiovascular-disease-events-results-from-the-jackson-heart-study
#6
David M Rosen, Vaishnavi Kundel, Michael Rueschman, Robert Kaplan, Na Guo, James G Wilson, Yuan-I Min, Susan Redline, Neomi Shah
PURPOSE: Evidence suggests that snoring is associated with increased risk for cardiovascular disease (CVD) events such as myocardial infarction and stroke. Limited data exists pertaining to this association among African Americans. We therefore examined the association between self-reported habitual snoring and incident CVD in the Jackson Heart Study (JHS), a population-based cohort study of African Americans. METHODS: Self-reported data on snoring and risk factors for CVD were collected at baseline (2000-2004)...
February 13, 2019: Sleep & Breathing, Schlaf & Atmung
https://read.qxmd.com/read/30756119/factors-associated-with-alzheimer-s-disease-an-overview-of-reviews
#7
M Rochoy, V Rivas, E Chazard, E Decarpentry, G Saudemont, P-A Hazard, F Puisieux, S Gautier, R Bordet
Alzheimer's disease (AD) is a frequent pathology, with a poor prognosis, for which no curative treatment is available in 2018. AD prevention is an important issue, and is an important research topic. In this manuscript, we have synthesized the literature reviews and meta-analyses relating to modifiable risk factors associated with AD. Smoking, diabetes, high blood pressure, obesity, hypercholesterolemia, physical inactivity, depression, head trauma, heart failure, bleeding and ischemic strokes, sleep apnea syndrome appeared to be associated with an increased risk of AD...
2019: Journal of Prevention of Alzheimer's Disease
https://read.qxmd.com/read/30746039/sleep-duration-lifestyles-and-chronic-diseases-a-cross-sectional-population-based-study
#8
Cátia Reis, Sara Dias, Ana Maria Rodrigues, Rute Dinis Sousa, Maria João Gregório, Jaime Branco, Helena Canhão, Teresa Paiva
Background: Adequate sleep is essential for health. Both, short and long sleep durations are associated to worse quality of life and poor health outcomes. Portugal represents a specific population model, since according to European statistics it has high rates of chronic diseases like depression, hypertension, diabetes and stroke; and low quality of life as well as low index of physical activity, while in parallel it has some other good health indicators such as: low age-standardized mortality for both genders, nutrition in terms of energy and fruit consumption, smoking and alcohol, obesity and overweight prevalence...
July 2018: Sleep Science
https://read.qxmd.com/read/30744905/how-reliable-is-cerebral-blood-flow-to-map-changes-in-neuronal-activity
#9
REVIEW
Clotilde Lecrux, Miled Bourourou, Edith Hamel
Neuroimaging techniques, such as functional MRI, map brain activity through hemodynamic-based signals, and are invaluable diagnostic tools in several neurological disorders such as stroke and dementia. Hemodynamic signals are normally precisely related to the underlying neuronal activity through neurovascular coupling mechanisms that ensure the supply of blood, glucose and oxygen to neurons at work. The knowledge of neurovascular coupling has greatly advanced over the last 30 years, it involves multifaceted interactions between excitatory and inhibitory neurons, astrocytes, and the microvessels...
March 2019: Autonomic Neuroscience: Basic & Clinical
https://read.qxmd.com/read/30744545/sleep-disordered-breathing-is-associated-with-recurrent-ischemic-stroke
#10
Devin L Brown, Fatema Shafie-Khorassani, Sehee Kim, Ronald D Chervin, Erin Case, Lewis B Morgenstern, Azadeh Yadollahi, Susan Tower, Lynda D Lisabeth
Background and Purpose- Limited data are available about the relationship between sleep-disordered breathing (SDB) and recurrent stroke and mortality, especially from population-based studies, large samples, or ethnically diverse populations. Methods- In the BASIC project (Brain Attack Surveillance in Corpus Christ), we identified patients with ischemic stroke (2010-2015). Subjects were offered screening for SDB with the ApneaLink Plus device, from which a respiratory event index (REI) ≥10 defined SDB. Demographics and baseline characteristics were determined from chart review and interview...
February 12, 2019: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/30743206/sleep-quality-correlates-with-the-carotid-intima-media-thickness-in-stroke-free-community-dwelling-adults-living-in-rural-ecuador-the-atahualpa-project
#11
Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano, Leslie V Simon, Gautam V Matcha, Pablo R Castillo
BACKGROUND/OBJECTIVES: Evidence of an association between sleep disorders and extracranial atherosclerosis is limited and has not been studied in remote rural settings, where living conditions and cardiovascular risk factors are different than in urban centers. We assessed the relationship between the carotid intima-media thickness (cIMT) and sleep quality in stroke-free individuals aged ≥40 years living in rural Ecuador. METHODS: Applying a population-based study design, participants underwent face-to-face interviews using the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality, and sonographic examinations for measurement of the carotid intima-media thickness (cIMT)...
December 15, 2018: Sleep Medicine
https://read.qxmd.com/read/30741949/the-association-between-physical-and-mental-chronic-conditions-and-napping
#12
Damien Léger, Marion J Torres, Virginie Bayon, Serge Hercberg, Pilar Galan, Mounir Chennaoui, Valentina A Andreeva
The objectives of this study were to assess the associations among various physical and mental chronic conditions and napping. A cross-sectional epidemiological survey was proposed within the NutriNet-Santé population-based e-cohort launched in France in 2009. Participants were 43,060 French volunteers aged 18 y and over with Internet access. A self-report questionnaire assessing sleep characteristics was administered in 2014. The main outcome (dependent) variable was weekday or weekend napping (yes/no)...
February 11, 2019: Scientific Reports
https://read.qxmd.com/read/30741774/analysis-of-influencing-factors-of-poststroke-depression-is-higher-body-mass-index-always-a-risk-factor-of-poststroke-depression
#13
Zhiqiang Xue, Yanjun Wang, Lijuan Wang, Li Shen, Anning Zhang, Pan Pan, Hongjie Wang, Jing Dou, Xin Guo, Yaogai Lv, Lina Jin, Yan Yao
Poststroke depression (PSD) is a common complication of stroke. We sought to investigate the influencing factors of PSD and explored the association between body mass index (BMI) and PSD. A total of 397 stroke patients in a hospital in Qiqihar City, China, were included in this study in 2016. The order of independent variable importance was the score of the National Institute of Health Stroke Scale, frequency of stroke, age, BMI, and sleep duration. Sleep duration of 7 hours or more (compared with <7 hours) was negatively associated with the Self-Rating Depression Scale (SDS) score in all quantiles...
February 6, 2019: Journal of Nervous and Mental Disease
https://read.qxmd.com/read/30741039/amplatzer-patent-foramen-ovale-occluder-safety-and-efficacy
#14
Raouf Madhkour, Andreas Wahl, Fabien Praz, Bernhard Meier
The patent foramen ovale (PFO) is a common anatomical variant in humans (prevalence 25%). Most often asymptomatic, it may engender paradoxically embolic strokes, myocardial infarctions, or visceral or peripheral ischemia. It is causatively related to migraine, positional or exertional hypoxemia with dyspnea, diving incidents, high altitude edema, and sleep apnea. Percutaneous closure of atrial septal defects was first performed in the seventies. A dedicated PFO occluder (Amplatzer PFO Occluder) was first used on September 10, 1997 by Kurt Amplatz and Bernhard Meier...
February 9, 2019: Expert Review of Medical Devices
https://read.qxmd.com/read/30740838/use-of-targeted-memory-reactivation-enhances-skill-performance-during-a-nap-and-enhances-declarative-memory-during-wake-in-healthy-young-adults
#15
Brian P Johnson, Steven M Scharf, Avelino C Verceles, Kelly P Westlake
Sleep is an important component of motor memory consolidation and learning, providing a critical tool to enhance training and rehabilitation. Following initial skill acquisition, memory consolidation is largely a result of non-rapid eye movement sleep over either a full night or a nap. Targeted memory reactivation is one method used to enhance this critical process, which involves the pairing of an external cue with task performance at the time of initial motor skill acquisition, followed by replay of the same cue during sleep...
February 11, 2019: Journal of Sleep Research
https://read.qxmd.com/read/30736877/obstructive-sleep-apnea-in-children-and-adolescents-and-the-risk-of-major-adverse-cardiovascular-events-a-nationwide-cohort-study-in-taiwan
#16
Nian-Sheng Tzeng, Chi-Hsiang Chung, Hsin-An Chang, Chuan-Chia Chang, Ru-Band Lu, Hui-Wen Yeh, Wei-Shan Chiang, Yu-Chen Kao, Shan-Yueh Chang, Wu-Chien Chien
STUDY OBJECTIVES: This study has investigated the risk of major adverse cardiovascular events (MACEs), including acute myocardial infarction, coronary artery disease, peripheral artery disease, and acute stroke, among children and adolescents (age younger than 20 years) with obstructive sleep apnea (OSA). METHODS: In this study, the population-based National Health Insurance Research Database of Taiwan was used to identify patients in whom OSA had been first diagnosed between 2000 and 2015...
February 4, 2019: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://read.qxmd.com/read/30718622/baduanjin-exercise-intervention-for-community-adults-at-risk-of-ischamic-stroke-a-randomized-controlled-trial
#17
Guohua Zheng, Bai Chen, Qianying Fang, Qiu Lin, Jing Tao, Lidian Chen
The aim of current study was to assess the effects of Baduanjin exercise on cerebrovascular function, cardiac structure and cardiac function, static pulmonary function, traditional risk factors of CVD and the related psychological outcomes in older community adults at risk for ischaemic stroke. A randomized controlled trial was conducted in three community between November 2013 and October 2015. Older community-dwelling adults (N = 170) were randomly allocated into either a Baduanjin training (5 × 60 min/weekly) or control group who kept their unaltered lifestyle during a 12-week intervention period...
February 4, 2019: Scientific Reports
https://read.qxmd.com/read/30705937/gender-differences-and-management-of-stroke-risk-of-nonvalvular-atrial-fibrillation-in-an-upper-middle-income-country-insights-from-the-carmen-af-registry
#18
J Antonio González-Hermosillo, Manuel A Baños-González, Milton E Guevara-Valdivia, Jorge A Vázquez-Acosta, Manuel Odín de Los Ríos Ibarra, Kulio A Aguilar-Linares, Carlos Cantú-Brito, José L Leiva-Pons, Gerardo Pozas-Garza, Eddie A Favela-Pérez, Manlio F Márquez
Background: Atrial Fibrillation (AF) is associated with an increased risk of stroke and systemic embolism. Several studies have suggested that female AF patients could have a greater risk for stroke. There is scarce information about clinical characteristics and use of antithrombotic therapies in Latin American patients with nonvalvular AF. Objective: To describe the gender differences in clinical characteristics, thromboembolic risk, and antithrombotic therapy of patients with nonvalvular AF recruited in Mexico, an upper middle-income country, into the prospective national CARMEN-AF Registry...
March 2019: IJC Heart & Vasculature
https://read.qxmd.com/read/30704197/-experts-consensus-on-the-management-of-delirium-in-critically-ill-patients
#19
B Tang, X T Wang, W J Chen, S H Zhu, Y G Chao, B Zhu, W He, B Wang, F F Cao, Y J Liu, X J Fan, H Yang, Q H Xu, H Zhang, R C Gong, W Z Chai, H M Zhang, G Z Shi, L H Li, Q B Huang, L N Zhang, M G Yin, X L Shang, X M Wang, F Tian, L X Liu, R Zhu, J Wu, Y Q Wu, C L Li, Y Zong, J T Hu, J Liu, Q Zhai, L J Deng, Y Y Deng, D W Liu
To establish the experts consensus on the management of delirium in critically ill patients. A special committee was set up by 15 experts from the Chinese Critical Hypothermia-Sedation Therapy Study Group. Each statement was assessed based on the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) principle. Then the Delphi method was adopted by 36 experts to reassess all the statements. (1) Delirium is not only a mental change, but also a clinical syndrome with multiple pathophysiological changes...
February 1, 2019: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://read.qxmd.com/read/30689176/mandibular-advancement-devices-in-patients-with-symptoms-of-obstructive-sleep-apnea-a-review
#20
M Wojda, P Jurkowski, A Lewandowska, E Mierzwińska-Nastalska, J Kostrzewa-Janicka
Obstructive sleep apnea (OSA) is a sleep disorder resulting from the repetitive narrowing and collapse of the upper respiratory tract. The results of previous epidemiological studies confirm a significant impact of OSA on the health situation around the world. Untreated OSA is associated with many adverse health effects, such as hypertension, coronary artery disease, stroke, atrial fibrillation, congestive heart failure, and daytime sleepiness. Excessive mortality of OSA patients, especially in men under 50 years of age, associated with advanced disease, obesity, cardiovascular complications, and a greater risk of road accidents, requires an urgent extension of the diagnostic-therapeutic database dealing with this problem...
January 29, 2019: Advances in Experimental Medicine and Biology
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