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Pancreatitis and nutrition

Amit S Grover, Alvin J Freeman, Maisam Abu-El-Haija, John F Eisses, Timothy B Gardner, Quin Y Liu, Mark E Lowe, Jaimie D Nathan, Tonya M Palermo, Vikesh K Singh, Andrew T Trout, Aliye Uc, Sohail Z Husain, Veronique D Morinville
The Pancreas Committee of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition aims to promote awareness of pediatric pancreatic diseases, support clinical and basic science research in the field, educate pediatric gastroenterologists, and advocate on behalf of pediatric patients with pancreatic disorders. At the 2017 Annual North American Society for Pediatric Gastroenterology, Hepatology and Nutrition meeting, the Pancreas Committee held a full day symposium on pediatric pancreatic diseases, entitled, "Frontiers in Pediatric Pancreatology...
February 2019: Journal of Pediatric Gastroenterology and Nutrition
Moshe Ashkenazi, N Nathan, I Sarouk, B E Bar Aluma, A Dagan, Y Bezalel, S Keler, D Vilozni, O Efrati
INTRODUCTION: There is a strong association between cystic fibrosis and malnutrition, mainly because of the higher energy needs combined with lower intake. There is also a well-established correlation between good nutritional status and better lung function. To date, however, there are no studies examining nutritional status in childhood and adult lung function. To respond to this need, this innovative study explored the long-term correlations between nutritional status in childhood and lung function in adulthood for the same patient population...
March 18, 2019: Lung
Anne-Laure Védie, Cindy Neuzillet
Palliative and supportive care holds a major place in pancreatic ductal adenocarcinoma (PDAC) management. It aims to prevent and reduce symptoms and hospital admissions, while ensuring optimal health-related quality of life (HRQoL), which has been reported to be correlated with overall survival in PDAC. Best supportive care includes non-specific treatment of pain, anxiety and depression, chemotherapy-related toxicities, as well as thromboembolic disease treatment and prevention in high-risk patients. Moreover, nutrition and physical activity interventions are receiving increasing attention as they are crucial to optimize treatment tolerance and efficacy...
March 13, 2019: La Presse Médicale
Judith Korner, Gary W Cline, Mark Slifstein, Pasquale Barba, Gina R Rayat, Gerardo Febres, Rudolph L Leibel, Antonella Maffei, Paul E Harris
OBJECTIVE: We hypothesized that DA and L-DOPA derived from nutritional tyrosine and the resultant observed postprandial plasma excursions of L-DOPA and DA might affect glucose tolerance via their ability to be taken-up by beta cells and inhibit glucose-stimulated β-cell insulin secretion. METHODS: To investigate a possible circuit between meal-stimulated 3,4-dihydroxy-L-phenylalanine (L-DOPA) and dopamine (DA) production in the GI tract and pancreatic β-cells, we: 1) mapped GI mucosal expression of tyrosine hydroxylase (TH) and aromatic amino acid decarboxylase (AADC); 2) measured L-DOPA and DA content of GI mucosal tissues following meal challenges with different L-tyrosine (TYR) content, 3) determined whether meal TYR content impacts plasma insulin and glucose excursions; and 4) characterized postprandial plasma excursions of L-DOPA and DA in response to meal tyrosine content in rodents and a population of bariatric surgery patients...
February 27, 2019: Molecular Metabolism
Renee King, Jessica L Hill, Bibek Saha, Yuzhen Tong, Brenda J Strutt, Mark A Russell, Noel G Morgan, Sarah J Richardson, David J Hill
Low birth weight is a risk factor for gestational and type 2 diabetes (T2D). Since mammalian target of rapamycin (mTOR) controls pancreatic β-cell mass and hormone release, we hypothesized that nutritional insult in utero might permanently alter mTOR signaling. Mice were fed a low-protein (LP, 8%) or control (C, 20%) diet throughout pregnancy, and offspring examined until 130 days age. Mice receiving LP were born 12% smaller and β-cell mass was significantly reduced throughout life. Islet mTOR levels were lower in LP-exposed mice and localized predominantly to α-rather than β-cells...
March 12, 2019: Nutrients
Ahmed A Shible, Deepa Ramadurai, Daniel Gergen, Paul M Reynolds
BACKGROUND Beriberi due to thiamine (vitamin B1) deficiency has two clinical presentations. Patients with dry beriberi present with neuropathy, and patients with wet beriberi present with heart failure, with or without neuropathy. Dry beriberi can mimic the most common form of Guillain-Barre syndrome (GBS), an acute inflammatory demyelinating polyradiculoneuropathy (AIDP). Severe thiamine deficiency results in Wernicke's encephalopathy. This report of a case of dry beriberi and Wernicke's encephalopathy due to thiamine deficiency includes a review of the literature...
March 13, 2019: American Journal of Case Reports
David J Carabetta, Amy M Koenigshof, Matthew W Beal
OBJECTIVE: To describe the clinical use of a novel, minimally invasive technique for fluoroscopic wire-guided esophagojejunal tube (FEJT) placement in dogs and cats. DESIGN: Retrospective study (February 2010-September 2013). SETTING: University veterinary teaching hospital. ANIMALS: Eighteen dogs and 2 cats with intolerance of, or contraindications to, gastric feeding that underwent attempted FEJT placement. INTERVENTIONS: All patients underwent attempted FEJT placement using a novel fluoroscopic wire-guided technique...
March 12, 2019: Journal of Veterinary Emergency and Critical Care
Bimbadhar Valluru, Bin Yang, Kalyan Sharma, Ahmed Abdullahi Adam, Du Wei, Zhou Zhou, Mahamed Osman Ali
RATIONALE: Left gastric artery aneurysms are very rare which progresses into hemorrhagic shock and diagnosis is very challenging particularly in patients with acute pancreatitis and cholecystitis whose vitals become unstable suddenly. PATIENT CONCERNS: A 72-year-old female has presented with severe progressing abdominal pain was treated with total parenteral nutrition for acute pancreatitis based on preliminary work up, but suddenly became unstable with dropping vitals over the ensuing 48 hours...
March 2019: Medicine (Baltimore)
Renata Germano Borges de Oliveira Nascimento Freitas, Gabriel Hessel, Silvia Maria Franciscato Cozzolino, Ana Carolina Junqueira Vasques, Kaluce Gonçalves de Sousa Almondes, José Alexandre Coelho Pimentel, Roberto José Negrão Nogueira
OBJECTIVE: The aim of this study was to verify if the selenium status of patients residing in locations with selenium-poor soil who receive parenteral nutrition (PN) without selenium supplementation is associated with the inflammatory process. METHODS: This was a prospective cohort study with hospitalized patients who started PN. The analyzed biochemical tests were plasma selenium, glutathione peroxidase (GPx), C-reactive protein, prealbumin, albumin, creatinine, lymphocytes, total cholesterol, high-density lipoprotein, and triglycerides...
October 26, 2018: Nutrition
Alfred Adiamah, Pavel Skořepa, Arved Weimann, Dileep N Lobo
MINI: This meta-analysis of 16 randomized controlled trials reporting on 1387 patients has shown that preoperative immune-enhancing nutrition significantly reduces infectious complications, but not noninfectious complications, in patients undergoing surgery for gastrointestinal cancer.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons...
February 26, 2019: Annals of Surgery
A I Kozlov
By the end of the 2010-s the prevalence of obesity among the indigenous people of the North approached to the all-Russia one and the speed of the spread of other metabolic disorders exceeded the average all-country levels. Aim of this review is to analyze data on the increase in consumption and variety of sugars coupled with a genetic specificity of regulation of saccharidase activity and their possible impact on the matters. Results. It have been shown that the traditional protein-lipid-based northern type diet has substantially changed and now contains a high proportion of carbohydrates...
2019: Voprosy Pitaniia
Junxiang Li, Jing Chen, Wenfu Tang
Acute pancreatitis (AP) is one of the most common acute abdominal diseases. The digestive disease committee, Chinese Association of Integrative Medicine, released Integrated traditional Chinese and Western medicine for diagnosis and treatment of acute pancreatitis in 2010.1 Since then, further studies and great progress have been made by domestic and foreign counterparts from the perspective of both Chinese and Western medicine in AP, including the classification, fluid resuscitation, organ function maintenance, surgery intervention, enteral nutrition (EN), and syndrome differentiation and treatment...
February 2019: Journal of Evidence-based Medicine
Wolfgang Huber, Hana Algül
Acute pancreatitis (AP) has an annual incidence of 30-45 per 100,000 inhabitants. In Germany approximately one third of the cases are of biliary or alcoholic origin. The diagnosis is based on the typical epigastric pain with radiation and a threefold increase of lipase or amylase in serum. Imaging procedures only rarely need to be included for the primary diagnostics. An early risk assessment is important to be able to allocate patients with severe AP to surveillance in an intensive care unit (ICU). Elevation of blood urea nitrogen, hematocrit and blood glucose are early predictors of poor outcome...
February 25, 2019: Der Internist
Nicole Fakhoury-Sayegh, Viviane Trak-Smayra, Raymond Sayegh, Faten Haidar, Omar Obeid, Sabine Asmar, Aline Khazzaka
A fructose-enriched diet has been shown to be associated with an increase in fatty infiltration of liver, kidney, and pancreas. Our objective was to determine the concentration threshold at which a fructose-enriched diet induces damage in these organs. We hypothesized that a 20% fructose-enriched diet will induce steatosis or histopathological changes in the kidneys or pancreas. In this study, 40 Wistar male rats were randomly divided into 4 groups of 10, and each group was assigned a diet of equal quantity (15 g/rat) but of varying fructose amount...
February 2019: Nutrition Research
Kristen M Roberts, Paige Golian, Marcia Nahikian-Nelms, Alice Hinton, Peter Madril, Kathleen Basch, Darwin Conwell, Phil A Hart
BACKGROUND: Chronic pancreatitis (CP) is a progressive, irreversible disease characterized by maldigestion and frequently accompanied by epigastric pain, exocrine insufficiency, and/or endocrine insufficiency. There is limited information about the dietary patterns in CP from which to guide medical nutrition therapy recommendations. METHODS: Study design was a cross-sectional, case-control study comparing subjects with CP (n = 52) to healthy controls (n = 48)...
February 23, 2019: Digestive Diseases and Sciences
Namrata Singh, Vineet Ahuja, Vikas Sachdev, Ashish D Upadhyay, Ravinder Goswami, Lakshmy Ramakrishnan, Supriya Dwivedi, Anoop Saraya
BACKGROUND: Antioxidants (AO) supplementation in chronic pancreatitis (CP) has been evaluated for pain. But it is not clear whether AO in CP have an effect on pancreatic functions and other clinical outcomes. We evaluated effect of AO on endocrine function in CP. MATERIALS AND METHODS: Double-blind placebo (PL)-controlled randomized pilot study on 107 patients with CP assigned to receive daily combined AO or PL for 6 months. Primary outcome was: improvement in endocrine function (Homeostasis Model Assessment-Insulin Resistance)...
February 15, 2019: Journal of Clinical Gastroenterology
Alfred Adiamah, Reesha Ranat, Dhanwant Gomez
BACKGROUND: The need for nutritional support following pancreaticoduodenectomy is well recognised due to the high prevalence of malnutrition, but the optimal delivery route is still debated. This meta-analysis evaluated postoperative outcomes in patients receiving enteral or parenteral nutrition. METHODS: EMBASE, MEDLINE and Cochrane databases were searched to identify randomised controlled trials comparing enteral and parenteral nutrition in patients undergoing pancreaticoduodenectomy...
February 14, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Manabu Kawai, Seiko Hirono, Ken-Ichi Okada, Motoki Miyazawa, Atsushi Shimizu, Yuji Kitahata, Ryohei Kobayashi, Masaki Ueno, Shinya Hayami, Kensuke Tanioka, Hiroki Yamaue
BACKGROUND: The impact of systemic immune inflammatory markers to predict survival in patients receiving neoadjuvant therapy for borderline resectable pancreatic cancer has not been sufficiently investigated. This study aims to evaluate whether systemic immune inflammatory markers after neoadjuvant therapy followed by pancreatectomy become preoperative prognostic factors to predict survival in patients with borderline resectable pancreatic cancer. METHODS: We retrospectively reviewed 67 borderline resectable pancreatic cancer patients receiving neoadjuvant therapy and 58 borderline resectable pancreatic cancer patients undergoing upfront surgery between 2010 and 2016...
February 11, 2019: Surgery
C Roberto Simons-Linares, Sunguk Jang, Madhusudan Sanaka, Amit Bhatt, Rocio Lopez, John Vargo, Tyler Stevens, Prabhleen Chahal
The triad of acute pancreatitis (AP) coexisting with diabetes ketoacidosis (DKA) and hypertriglyceridemia (HTG) has been reported, but no impact on mortality has been found to date. We aim to assess if patients with this triad are at a higher inpatient mortality compared to patients with acute pancreatitis only.Retrospective cohort. The National Inpatient Sample (NIS) database from 2003 to 2013 was queried for patients with a discharge diagnosis of AP and presence of DKA and HTG was ascertained based on International Classification of Diseases, 9th revision (ICD9) codes...
February 2019: Medicine (Baltimore)
Andrew W Norris, Katie Larson Ode, Lina Merjaneh, Srinath Sanda, Yaling Yi, Xingshen Sun, John F Engelhardt, Rebecca L Hull
In cystic fibrosis (CF), ductal plugging and acinar loss result in rapid decline of exocrine pancreatic function. This destructive process results in remodeled islets, with only a modest reduction in insulin producing β cells. However, β-cell function is profoundly impaired, with decreased insulin release and abnormal glucose tolerance being present even in infants with CF. Ultimately, roughly half of CF subjects develop diabetes (termed CF-related diabetes, CFRD). Importantly, CFRD increases CF morbidity and mortality via worsening catabolism and pulmonary disease...
February 1, 2019: Journal of Endocrinology
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