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Thyroid Vitamin D Bone

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https://read.qxmd.com/read/30887870/low-bone-mineral-density-and-renal-malformation-in-mexican-patients-with-turner-syndrome-are-associated-with-single-nucleotide-variants-in-vitamin-d-metabolism-genes
#1
Rehotbevely Barrientos-Rios, Sara Frias, José A Velázquez-Aragón, Camilo E Villaroel, Silvia Sánchez, Bertha Molina, Angélica Martínez, Alessandra Carnevale, Benilde García-de-Teresa, Edmundo Bonilla, Christian David Alvarado-Araiza, Alejandro Valderrama-Hernández, Paul Tadeo Ríos-Gallardo, Raúl Calzada-León, Nelly Altamirano-Bustamante, Leda Torres
Turner syndrome (TS) is a common genetic disorder. TS-phenotype includes short stature, gonadal dysgenesis, cardiac and kidney malformations, low bone mineral density (low-BMD) and thyroiditis. TS-phenotype varies from patient to patient and the cause is not clear, the genomic background may be an important contributor for this variability. Our aim was to identify the association of specific single nucleotide variants in the PTPN22, VDR, KL, and CYP27B1 genes and vitamin D-metabolism, heart malformation, renal malformation, thyroiditis, and low-BMD in 61 Mexican TS-patients...
March 19, 2019: Gynecological Endocrinology
https://read.qxmd.com/read/30847871/relationships-between-thyroid-hormones-insulin-like-growth-factor-1-and-antioxidant-levels-in-hypothalamic-amenorrhea-and-impact-on-bone-metabolism
#2
Antonio Mancini, Edoardo Vergani, Carmine Bruno, Angelina Barini, Andrea Silvestrini, Elisabetta Meucci, Calogero Messana, Daniela Romualdi, Rosanna Apa, Antonio Lanzone
Reduced bone mineral density (BMD) in Functional Hypothalamic Amenorrhea (FHA) is mainly related to hypoestrogenism, but other hormonal derangement (reduced conversion of T4-T3 and GH resistance) can play a role. These hormones are involved in antioxidant systems regulation. We evaluated the impact of hormonal alterations, with special focus on low T3 and IGF-1 levels, on antioxidant systems as a link with osteoporosis in FHA. Forty-three FHA patients, 15-34 years, with BMI range 17.3-23.4 kg/m2 , were divided in 2 groups according to fT3 levels; group A (n=22), low fT3 (<2...
March 7, 2019: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://read.qxmd.com/read/30611239/kyphoscoliosis-with-klippel-trenaunay-syndrome-a-case-report-and-literature-review
#3
Jiliang Zhai, Min-Er Zhong, Jianxiong Shen, Haining Tan, Zheng Li
BACKGROUND: Klippel-Trenaunay syndrome (KTS) is a rare congenital syndrome characterized by the triad of venous varicosities, capillary malformations and limb hypertrophy. However, KTS may rarely occur in combination with kyphoscoliosis. CASE PRESENTATION: We presented an 18-year-old female with KTS and kyphoscoliosis. Hypertrophy of bone and soft tissue affected her left face, trunk and lower limb. Moreover, the patient is associated with subacute thyroiditis, vitamin D deficiency and iron deficiency anemia, high level of D-dimer, swollen tonsil, kyphoscoliosis and Chiari-I-malformation without syringomyelia...
January 5, 2019: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/30579337/identification-of-vitamin-d-and-other-bone-metabolism-parameters-as-risk-factors-for-primary-bone-marrow-oedema-syndrome
#4
Nicola Oehler, Haider Mussawy, Tobias Schmidt, Tim Rolvien, Florian Barvencik
BACKGROUND: The aetiology and pathogenesis of primary bone marrow oedema syndrome (BMES) remain unclear. This retrospective cross-sectional study in a large cohort of patients with BMES was performed to characterise the overall skeletal status and turnover in patients with BMES, with the aim of identifying risk factors for this disease. METHODS: Patients who were diagnosed with BMES on the basis of clinical and radiological (magnetic resonance imaging) findings in our outpatient clinic were identified retrospectively...
December 22, 2018: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/30509511/air-pollution-environmental-chemicals-and-smoking-may-trigger-vitamin-d-deficiency-evidence-and-potential-mechanisms
#5
REVIEW
Sayed Esmaeil Mousavi, Heresh Amini, Pouria Heydarpour, Fatemeh Amini Chermahini, Lode Godderis
Beyond vitamin D (VD) effect on bone homeostasis, numerous physiological functions in human health have been described for this versatile prohormone. In 2016, 95% of the world's population lived in areas where annual mean ambient particulate matter (<2.5 μm) levels exceeded the World Health Organization guideline value (Shaddick et al., 2018). On the other hand, industries disperse thousands of chemicals continually into the environment. Further, considerable fraction of populations are exposed to tobacco smoke...
November 30, 2018: Environment International
https://read.qxmd.com/read/30349302/effects-of-thyrotropin-suppression-on-lumbar-bone-mineral-density-in-postmenopausal-women-with-differentiated-thyroid-carcinoma
#6
Pei Zhang, Hui Xi, Ruihong Yan
Purpose: The aim of this study was to evaluate the effect of postoperative thyroid-stimulating hormone suppression (TSHS) on bone mineral density (BMD) in Chinese postmenopausal women with differentiated thyroid carcinoma (DTC). Patients and methods: A total of 225 postmenopausal women with DTC who had received TSHS were included in the study. Postmenopausal women with postoperative DTC undergoing thyroid residual ablation or metastasis treatment between 2009 and 2015 were enrolled and followed up for 2 years...
2018: OncoTargets and Therapy
https://read.qxmd.com/read/30317121/jaw-tumor-in-recurrent-primary-hyperparathyroidism-a-case-report
#7
Farzaneh Amini Nezhad, Moloud Payab, Sara Nayebandi, Shirin Hasani-Ranjbar
BACKGROUND: Brown tumor may present as uni/multilocular osteolytic lesions with bone expansion, bone pain or pathologic fracture in primary, secondary and tertiary hyperparathyroidism. However, recently, such presentation is rare due to early detection using blood screening techniques before symptomatic bone lesions appear. CASE REPORT: A 65-year-old woman was admitted to our hospital with generalized bone pain and a progressive painless mass in her jaw appeared since 6 months ago...
2018: International Journal of Surgery Case Reports
https://read.qxmd.com/read/30300686/genetic-hypercalcemia
#8
Catherine Cormier
A genetic disorder should be suspected in patients with hypercalcemia, notably those who are young; have family members with hypercalcemia; or have had a tumor of the endocrine pancreas, thyroid, pituitary, adrenal gland, or jaw bone. All forms of hypercalcemia should be interpreted according to the serum level of parathyroid hormone (PTH). Genetic forms are thus classified as related or unrelated to a parathyroid gland disorder. When the PTH level is elevated or is not depressed despite the hypercalcemia, findings that suggest family history of hypercalcemia due to a genetic cause include syndromic manifestations in the patient or family members, parathyroid cancer (either suspected before surgery or confirmed during parathyroidectomy), multiple or recurrent parathyroid tumors, a family history of primary hyperparathyroidism, and the onset of primary hyperthyroidism before 50 years of age...
October 6, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://read.qxmd.com/read/30240466/low-yield-for-routine-laboratory-checks-in-follow-up-of-coeliac-disease
#9
Jordy P W Burger, Jouke J H van der Laan, Tom A Jansen, Joost P H Drenth, Elisabeth A Roovers, Margreet M S Wessels, Peter J Wahab
AIM: To evaluate the yield of routine laboratory tests and Dual Energy X-ray Absorptiometry (DEXA) scans in coeliac disease. METHODS: A retrospective analysis of medical files of all followed-up patients with coeliac disease attending Rijnstate Hospital in 2016 was conducted with respect to blood tests of hemoglobin, vitamin B12, folate acid, iron status, calcium, vitamin D, glucose, thyroid function, DEXA-scans and related symptoms or signs of abnormalities. All patients had positive coeliac serology and/or biopsy-proven coeliac disease and attended regular visits after diagnosis...
September 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
https://read.qxmd.com/read/29606182/review-dairy-foods-red-meat-and-processed-meat-in-the-diet-implications-for-health-at-key-life-stages
#10
D I Givens
Social and health care provision have led to substantial increases in life expectancy. In the UK this has become higher than 80 years with an even greater proportional increase in those aged 85 years and over. The different life stages give rise to important nutritional challenges and recent reductions in milk consumption have led to sub-optimal intakes of calcium by teenage females in particular when bone growth is at its maximum and of iodine during pregnancy needed to ensure that supply/production of thyroid hormones to the foetus is adequate...
August 2018: Animal: An International Journal of Animal Bioscience
https://read.qxmd.com/read/29589297/clinical-impact-of-p27-kip1-and-casr-expression-on-primary-hyperparathyroidism
#11
Gozde Sengul Aycicek, Berna Imge Aydogan, Mustafa Sahin, Cevriye Cansız Ersoz, Serpil Dizbay Sak, Nilgun Baskal
We aimed to investigate the expressions of p27 kinase inhibitory protein 1 (p27Kip1 ) and calcium sensing receptor (CaSR) in adenomas and normal parathyroid tissue and to evaluate the relationship of these molecules with clinical and biochemical parameters in primary hyperparathyroidism (PHPT). Fifty-one patients with histopathologically confirmed parathyroid adenomas and 20 patients with normal parathyroid glands (which were removed incidentally during thyroid resection) were included. Immunohistochemical stainings of CaSR and p27Kip1 were performed in surgical specimens...
September 2018: Endocrine Pathology
https://read.qxmd.com/read/29567842/prevalence-of-potentially-inappropriate-prescribing-in-a-subpopulation-of-older-european-clinical-trial-participants-a-cross-sectional-study
#12
MULTICENTER STUDY
David O Riordan, Carole Elodie Aubert, Kieran A Walsh, Anette Van Dorland, Nicolas Rodondi, Robert S Du Puy, Rosalinde K E Poortvliet, Jacobijn Gussekloo, Carol Sinnott, Stephen Byrne, Rose Galvin, J Wouter Jukema, Simon P Mooijaart, Christine Baumgartner, Vera McCarthy, Elaine K Walsh, Tinh-Hai Collet, Olaf M Dekkers, Manuel R Blum, Patricia M Kearney
OBJECTIVES: To estimate and compare the prevalence and type of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) among community-dwelling older adults (≥65 years) enrolled to a clinical trial in three European countries. DESIGN: A secondary analysis of the Thyroid Hormone Replacement for Subclinical Hypothyroidism Trial dataset. PARTICIPANTS: A subset of 48/80 PIP and 22/34 PPOs indicators from the Screening Tool of Older Persons Prescriptions/Screening Tool to Alert doctors to Right Treatment (STOPP/START) V2 criteria were applied to prescribed medication data for 532/737 trial participants in Ireland, Switzerland and the Netherlands...
March 22, 2018: BMJ Open
https://read.qxmd.com/read/29452318/bone-metabolic-markers-in-the-clinical-assessment-of-patients-with-superior-semicircular-canal-dehiscence
#13
Thien Nguyen, Carlito Lagman, John P Sheppard, Courtney Duong, Vera Ong, Jessica Poon, Yasmine Alkhalid, Daniel Azzam, Prasanth Romiyo, Giyarpuram N Prashant, Quinton Gopen, Isaac Yang
BACKGROUND: Superior semicircular canal dehiscence (SSCD) is a bony defect in the osseous shell of the petrous temporal bone. The pathophysiological association between osteoporosis and SSCD remains poorly understood. We investigated the relationship between bone metabolic markers and symptoms in patients with SSCD. METHODS: We collected patient demographics and clinical parameters for adult patients diagnosed with SSCD on high-resolution computed tomography scans...
June 2018: World Neurosurgery
https://read.qxmd.com/read/29368538/the-bone-remodelling-cycle
#14
J S Kenkre, Jhd Bassett
The bone remodelling cycle replaces old and damaged bone and is a highly regulated, lifelong process essential for preserving bone integrity and maintaining mineral homeostasis. During the bone remodelling cycle, osteoclastic resorption is tightly coupled to osteoblastic bone formation. The remodelling cycle occurs within the basic multicellular unit and comprises five co-ordinated steps; activation, resorption, reversal, formation and termination. These steps occur simultaneously but asynchronously at multiple different locations within the skeleton...
May 2018: Annals of Clinical Biochemistry
https://read.qxmd.com/read/29324909/effect-of-hypoparathyroid-on-bone-mineral-density-of-lumber-spine-in-postmenopausal-women-with-differentiated-thyroid-cancinoma
#15
Yongli Bai, Yanlei Huo, Fei Yu, Danyang Wang, Chao Ma
OBJECTIVE: To investigate the effect of hypoparathyroid on bone mineral density in postmenopausal women with differentiated thyroid carcinoma (DTC). SUBJECT AND METHODS: Postmenopausal women with postoperative DTC, and undergoing thyroid residual ablation or for metastases treatment were collected and followed for two years. They were divided into hypoparathyroid group (PTH<15pg/mL) and a normal cognitive group (PTH>15pg/mL). Bone mineral density (BMD) at the lumbar spine was analyzed using dual-energy X-ray absorptiometry (DXA) at baseline, 6, 12 and 24 months...
September 2017: Hellenic Journal of Nuclear Medicine
https://read.qxmd.com/read/29249510/bone-health-and-endocrine-comorbidities-in-pediatric-epilepsy
#16
REVIEW
Nancy A McNamara, Erin Marie Fedak Romanowski, David P Olson, Renee A Shellhaas
Antiseizure medications and dietary therapies have associated effects on the endocrine system. We provided an overview of the relationship between epilepsy treatment and bone health in children with epilepsy. Additionally, we discussed the effects of epilepsy treatment on other endocrine systems including thyroid function, growth, reproduction, and weight. The effect of epilepsy on bone health is multifactorial; there are direct and indirect effects of medication and dietary treatments as well as a decrease in physical activity, decreased sunlight exposure, decreased vitamin D levels, and additional comorbidities...
November 2017: Seminars in Pediatric Neurology
https://read.qxmd.com/read/29236646/evaluation-of-bone-mineral-density-bmd-and-indicators-of-bone-turnover-in-patients-with-hemophilia
#17
Mehmet Dagli, Ali Kutlucan, Sedat Abusoglu, Abdulkadir Basturk, Mehmet Sozen, Leyla Kutlucan, Ali Unlu, Farise Yilmaz
A decrease in bone mass is observed in hemophilic patients. The aim of this study was to evaluate bone mineral density (BMD), parathyroid hormone (PTH), 25-hydroxy vitamin D (vitamin D), and a bone formation and resorption marker, procollagen type I N-terminal propeptide (PINP) and urinary N-terminal telopeptide (uNTX) respectively, in hemophilic patients and healthy controls. Laboratory parameters related to the pathogenesis of bone loss such as neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were also evaluated...
May 20, 2018: Bosnian Journal of Basic Medical Sciences
https://read.qxmd.com/read/29146231/is-hungry-bone-syndrome-a-cause-of-postoperative-hypocalcemia-after-total-thyroidectomy-in-thyrotoxicosis-a-prospective-study-with-bone-mineral-density-correlation
#18
Poongkodi Karunakaran, Chandrasekaran Maharajan, Srinivasan Ramalingam, Suresh Venkatesh Rachmadugu
BACKGROUND: Hungry bone syndrome is a well-established cause of postoperative hypocalcemia in thyrotoxicosis. To date, the incidence of hungry bone syndrome after total thyroidectomy is unclear. This prospective study examined the incidence of postthyroidectomy hungry bone syndrome and its correlation with preoperative bone mineral density. METHODS: Forty thyrotoxic subjects (Group A; age: mean ± SD; 36.5 ± 9.8 years) and 40 euthyroid controls with benign thyroid nodules (Group B) undergoing total thyroidectomy were evaluated for preoperative bone mineral density and serum calcium, magnesium, phosphorus, parathyroid hormone, alkaline phosphatase, and 25-Hydroxy Vitamin D serially...
February 2018: Surgery
https://read.qxmd.com/read/29063198/dental-fluorosis-nutritional-status-kidney-damage-and-thyroid-function-along-with-bone-metabolic-indicators-in-school-going-children-living-in-fluoride-affected-hilly-areas-of-doda-district-jammu-and-kashmir-india
#19
Arjun L Khandare, Shankar Rao Gourineni, Vakdevi Validandi
A case-control study was undertaken among the school children aged 8-15 years to know the presence and severity of dental fluorosis, nutrition and kidney status, and thyroid function along with bone metabolic indicators in Doda district situated at high altitude where drinking water was contaminated and heat stress. This study included 824 participants with an age of 8-15 years. The results of the study reviled that dental fluorosis was significantly higher in affected than control area children. Urinary fluoride was significantly higher (p < 0...
October 23, 2017: Environmental Monitoring and Assessment
https://read.qxmd.com/read/28895880/the-role-of-vitamin-d-in-thyroid-diseases
#20
REVIEW
Dohee Kim
The main role of vitamin D is regulating bone metabolism and calcium and phosphorus homeostasis. Over the past few decades, the importance of vitamin D in non-skeletal actions has been studied, including the role of vitamin D in autoimmune diseases, metabolic syndromes, cardiovascular disease, cancers, and all-cause mortality. Recent evidence has demonstrated an association between low vitamin D status and autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease, and impaired vitamin D signaling has been reported in thyroid cancers...
September 12, 2017: International Journal of Molecular Sciences
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