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Francesco A Mistretta, Elio Mazzone, Sophie Knipper, Carlotta Palumbo, Zhe Tian, Sebastiano Nazzani, Fred Saad, Emanuele Montanari, Derya Tilki, Alberto Briganti, Shahrokh F Shariat, Ottavio de Cobelli, Pierre I Karakiewicz
BACKGROUND: We analysed contemporary pelvic lymph node dissection (PLND) trend during radical cystectomy (RC) for urothelial carcinoma of urinary bladder (UCUB), as well as PLND association with cancer specific mortality (CSM) and complications after stratification according to octogenarian vs. younger age. MATERIALS AND METHODS: Within the SEER and NIS databases, respectively 10,427 (T2 and T3 stages) and 19,203 (all T-stages) RC patients (2004-2015) for UCUB were identified...
February 13, 2019: Cancer Epidemiology
Cara Haines, Maria Loades, Cara Davis
BACKGROUND: The common sense model (CSM) proposes that illness perceptions guide coping and illness management, which subsequently affects outcomes. Chronic fatigue syndrome (CFS) is associated with severe functional impairment. CFS is distinct from other physical health conditions in that individuals can experience high levels of uncertainty, stigma and disbelief from others. This study aimed to compare illness perceptions in adolescents with CFS with other physical health conditions, using a cross-sectional, between-groups design...
February 15, 2019: Clinical Child Psychology and Psychiatry
Weipu Mao, Xin Huang, Minghao Kong, Jie Fan, Jiang Geng
PURPOSE: For patients with lymph node-positive (LN+) penile cancer, the optimal extent of lymph node dissection (LND) is currently not established. We aimed to reveal the potential association between survival and the number of LND in patients with newly diagnosed LN + penile cancer. METHODS: Patients with LN + penile cancer diagnosed between 2004 and 2015 were identified using the SEER database. The relationships between the number of removed lymph nodes and overall survival (OS), all-cause mortality (ACM), cancer-specific mortality (CSM), and 5-year mortality were tested...
February 13, 2019: International Urology and Nephrology
Elio Mazzone, Sebastiano Nazzani, Sophie Knipper, Zhe Tian, Felix Preisser, Andrea Gallina, Denis Soulières, Derya Tilki, Francesco Montorsi, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Juan Wisnivesky, Pierre I Karakiewicz
BACKGROUND: Locally advanced muscle-invasive bladder cancer (MIBC) patients who are candidates for radical cystectomy (RC) should receive perioperative chemotherapy (CHT). However, the adherence to CHT guidelines is low. Thus, we tested contemporary CHT use rates and associated cancer-specific mortality (CSM) and overall mortality (OM) rates. MATERIALS AND METHODS: Within the SEER database (2004-2015), we identified pT3N0/+ MIBC patients, who underwent RC, with or without perioperative CHT...
February 3, 2019: European Journal of Surgical Oncology
Zi-Hai Wei, Shu-Lin Liang, Di-Ming Wang, Hong-Yun Liu, Metha Wanapat, Jian-Xin Liu
Objective: The objective of current study was to investigate the lactation performance and rumen fermentation characteristics of dairy cows fed a diet with alfalfa hay replaced by corn stover but supplemented with molasses. Methods: Sixteen Holstein cows in mid-lactation were randomly assigned to 1 of 2 dietary treatments: (1) alfalfa based diet (AH), and (2) corn stover based diet supplemented with molasses (CSM). The experiment was conducted according to a 2 × 2 crossover design with 22-d period, each period consisting of 17 d for adaptation and 5 d for data and samples collection...
February 7, 2019: Asian-Australasian Journal of Animal Sciences
Michael J Zelefsky, Debra A Goldman, Victor Reuter, Marisa Kollmeier, Sean McBride, Zhigang Zhang, Melissa Varghese, Xin Pei, Zvi Fuks
PURPOSE: To determine the prognostic importance of a positive post-treatment biopsy after prostate radiotherapy. MATERIALS AND METHODS: 382 patients underwent a post-treatment biopsy after external beam radiotherapy (EBRT) for clinically localized prostate cancer. Post-treatment biopsies were classified as positive (prostatic adenocarcinoma without typical radiation-induced changes), negative (no evidence of carcinoma) or adenocarcinoma with severe treatment effect (STE)...
February 5, 2019: Journal of Urology
Takehiro Iwata, Shoji Kimura, Beat Foerster, Mohammad Abufaraj, Pierre I Karakiewicz, Felix Preisser, Yasutomo Nasu, Shahrokh F Shariat
AIM: To investigate the association of perioperative blood transfusion (PBT) with oncologic outcomes in patients with renal cell carcinoma (RCC), we conducted a systematic review and meta-analysis of the literature to clarify the long-term oncologic effect of PBT in patients undergoing nephrectomy for RCC. MATERIALS AND METHODS: We searched the MEDLINE, Web of Science, Cochrane Library and Scopus on 15th April 2018 to identify studies that compared patients who received PBT undergoing radical or partial nephrectomy for RCC to patients who did not with the aim of evaluating its impact on overall mortality (OM), cancer-specific mortality (CSM) and disease recurrence using multivariable cox regression analysis...
February 5, 2019: Urologic Oncology
Deborah Rohner, Michael P Kowaleski, Günter Schwarz, Franck Forterre
OBJECTIVES:  The purpose of this study was to assess the short-term outcome of a new intervertebral anchored fusion device (C-LOX) for the treatment of disc associated cervical spondylomyelopathy (DA-CSM) in dogs, based on clinical and radiographical follow-up data. MATERIALS AND METHODS:  To be included in the study, dogs had to be clinically affected by DA-CSM treated with surgical distraction/stabilization using the anchored intervertebral spacer (C-LOX)...
February 8, 2019: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Maxwell Mewa-Ngongang, Heinrich W du Plessis, Seteno K O Ntwampe, Boredi S Chidi, Ucrecia F Hutchinson, Lukhanyo Mekuto, Neil P Jolly
Microbial spoilage causes food losses in the food industry and as such, the use of synthetic chemical preservatives is still required. The current study proposes the use of agro-waste, i.e., grape pomace extracts (GPE), as production medium for biopreservation compounds. Production kinetics, subsequent to optimization using response surface methodology (RSM) for biopreservation compounds production was studied for three yeasts using GPE broth as a fermentation medium. The results showed that the highest volumetric zone of inhibition (VZI) was 1...
February 2, 2019: Foods (Basel, Switzerland)
Naohiko Kawaguchi, Kaoru Okishige, Yasuteru Yamauchi, Manabu Kurabayashi, Tomofumi Nakamura, Takehiko Keida, Tetsuo Sasano, Kenzo Hirao, Miguel Valderrábano
BACKGROUND: The left atrial myocardium (LAM) and coronary sinus (CS) musculature (CSM) generate atrial electrograms recorded inside the CS (AECSs). The vein of Marshall (VOM) courses the mitral isthmus (MI) and VOM ethanol infusion (EI-VOM) is useful to ablate it. Its detailed effect on the MI, which contains LAM, CSM and those connections, is unknown. OBJECTIVE: To investigate the impact of EI-VOM on the MI by assessing the AECS. METHODS: Eighty-four consecutive patients with atrial fibrillation undergoing MI ablation with successful EI-VOM were included...
January 30, 2019: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Haley Kranstuber Horstman, Amanda Holman, M Chad McBride
With approximately 20 % of pregnancies ending in loss, miscarriage is a relatively common and stressful occurrence. Because romantic partners' coping efforts are intimately connected, the way one partner copes with the other's miscarriage has important implications for individual and relational well-being. Grounded in the communicated sense-making (CSM) model, the current study investigated how cis-gender men in heterosexual marriages (n = 45) communicatively constructed the meaning of their wife's miscarriage through metaphors...
February 1, 2019: Health Communication
Marco Moschini, Stefania Zamboni, Agostino Mattei, Philipp Baumeister, Carlo Di Bona, Julian Cornelius, Shahrokh F Shariat, Massimo Freschi, Emanuele Zaffuto, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Andrea Gallina
INTRODUCTION: According to TNM staging, pathological T4ab are comprehensive of the invasion of prostate, seminal vesicles, uterus or vagina and pelvic or abdominal wall. However, few data are available on the perioperative and oncological outcomes of specific organ invasion. MATERIALS AND METHODS: A total of 917 consecutive bladder cancer (BCa) patients treated with radical cystectomy (RC) at a single institution between 1990 and 2015 were studies. Cox regression analyses were used to stratify pT4ab according to the site of invasion and survival...
January 29, 2019: Urologia Internationalis
Jakob T Rostøl, Luciano A Marraffini
Type III-A CRISPR-Cas systems employ the Cas10-Csm complex to destroy bacteriophages and plasmids, using a guide RNA to locate complementary RNA molecules from the invader and trigger an immune response that eliminates the infecting DNA. In addition, these systems possess the non-specific RNase Csm6, which provides further protection for the host. While the role of Csm6 in immunity during phage infection has been determined, how this RNase is used against plasmids is unclear. Here, we show that Staphylococcus epidermidis Csm6 is required for immunity when transcription across the plasmid target is infrequent, leading to impaired target recognition and inefficient DNA degradation by the Cas10-Csm complex...
January 28, 2019: Nature Microbiology
Kwang-Hyun Park, Yan An, Eui-Jeon Woo
The CRISPR-Cas system is the prokaryotic immune response that destroys invading foreign nucleic acids. Based on the architecture and distinct mechanism of targeting, the CRISPR-Cas system is classified into six types (I-VI). The Csm complex belongs to the type III system and consists of five subunits (Cas10 and Csm2-5) and a crRNA. The Csm complex targets RNA and RNA-dependent single-strand DNA. Here, we present a protocol for in vitro reconstitution of a Csm complex from a hyperthermophilic archaeon Thermococcus onnurineus NA1 (ToCsm complex)...
2019: Methods in Enzymology
Mohamed Mohamed Farid Roaiah, Ann Ali Abdel Kader, Ahmed Mohamed Hassanin, Mai Maged, Murshed Ahmed Murshed
INTRODUCTION: Diagnostic tests for vascular erectile dysfunction (ED) depend on cavernous smooth muscles (CSM) relaxation following an intracorporal injection (ICI). Enhanced sympathetic tone, which is not uncommon during performance of these tests, can bias its results. Also, CSM diseases can cause veno-occlusive diseases (VOD) ED. Corpus cavernosum electromyography (CC-EMG) potentials' amplitudes represent the integrated sympathetic activity of healthy CSM. Stem-cells and gene-therapy are potential therapeutic options for impaired CSM...
January 2019: Revista Internacional de Andrología
Min Li, Ming Xie, Liang Zhou, Shuyi Wang
BACKGROUND: The extent of surgical safety margin remained unclear in hypopharyngeal carcinoma surgery. AIM: The purpose of this study was to evaluate the influence of surgical margin status on the outcomes of patients with advanced hypopharyngeal carcinoma. MATERIAL AND METHODS: A retrospective analysis of clinical data was performed in 205 patients with stage III/IV hypopharyngeal carcinoma treated by primary surgery between January 2005 and December 2014...
January 28, 2019: Acta Oto-laryngologica
Plinio Pelegrini Morita, Melanie S Yeung, Madonna Ferrone, Ann K Taite, Carole Madeley, Andrea Stevens Lavigne, Teresa To, M Diane Lougheed, Samir Gupta, Andrew G Day, Joseph A Cafazzo, Christopher Licskai
BACKGROUND: Uncontrolled asthma poses substantial negative personal and health system impacts. Web-based technologies, including smartphones, are novel means to enable evidence-based care and improve patient outcomes. OBJECTIVE: The aim of this study was to design, develop, and assess the utilization of an asthma collaborative self-management (CSM) platform (breathe) using content based on international evidence-based clinical guidelines. METHODS: We designed and developed breathe as a Web-based mobile health (mHealth) platform accessible on smartphones, tablets, or desktop with user-centered design methods and International Organization for Standardization-certified quality development processes...
January 28, 2019: JMIR MHealth and UHealth
Naveen Pandita, Sanjeev Gupta, Prince Raina, Abhishek Srivastava, Aamir Yaqoob Hakak, Omeshwar Singh, Mohd Azhar-Ud-Din Darokhan, Mohd Farooq Butt
Study Design: Prospective clinical study. Purpose: The present study aimed to examine the neurological recovery pattern in cervical spondylotic myelopathy (CSM) after anterior cervical decompression and compare it with the existing reports in the literature. Overview of Literature: Neurological recovery and regression of myelopathy symptoms is an important factor that determines the outcomes of surgical decompression. The present findings contribute to the literature on the pattern of neurological recovery and patient prognosis with respect to the resolution of myelopathy symptoms after surgery...
January 29, 2019: Asian Spine Journal
Euddeum Shim, Joon Woo Lee, Eugene Lee, Yusuhn Kang, Heung Sik Kang, Woo Young Kang, Tae Seong Im
BACKGROUND: Although both 1.5-Tesla (T) and 3-T magnetic resonance imaging (MRI) are widely used for the diagnosis of cervical spondylotic myelopathy (CSM), there have been no comparative studies. PURPOSE: This study compared the performance of both imaging modalities for diagnosing CSM among radiologists with varying experience levels. MATERIAL AND METHODS: Four independent readers with different levels of experience reviewed 1.5-T and 3-T MR images of 79 patients with cervical spondylopathies...
January 23, 2019: Acta Radiologica
Jiajie Kang, Mingzheng Wang, Wen Yue, Zhiqiang Fu, Lina Zhu, Dingshun She, Chengbiao Wang
This study experimentally investigated the effect of surface textures on the tribological mechanism of nitrided titanium alloy (Ti⁻6Al⁻4V). The titanium alloy samples were nitrided at various temperatures ranging from 750 to 950 °C for 10 h in a plasma nitriding furnace. Then, surface textures were fabricated on the polished titanium alloy and plasma nitrided samples by laser process system. The surface roughness, microhardness, and constitution of samples treated by single nitriding and samples treated by composite technology were characterized...
January 18, 2019: Materials
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