keyword
https://read.qxmd.com/read/38529522/a-short-treatment-with-resveratrol-after-a-renal-ischaemia-reperfusion-injury-prevents-maladaptive-repair-and-long-term-chronic-kidney-disease-in-rats
#1
JOURNAL ARTICLE
Miguel Ángel Martínez-Rojas, Hiram Balcázar, María Susana Ponce-Nava, Isaac González-Soria, Brenda Marquina-Castillo, Rosalba Pérez-Villalva, Norma A Bobadilla
Acute kidney injury (AKI) often triggers physiological processes aimed at restoring renal function and architecture. However, this response can become maladaptive, leading to nephron loss and fibrosis. Although the therapeutic effects of resveratrol (RSV) are well established, its impact after AKI and for subsequent chronic kidney disease (CKD) remains unclear. This study assessed whether transient administration of RSV following ischaemia-reperfusion injury (IRI) could prevent the progression to CKD. Forty-one male Wistar rats were assigned randomly to sham surgery, bilateral renal ischaemia for 30 min (IR) or IR+RSV...
March 26, 2024: Journal of Physiology
https://read.qxmd.com/read/38517993/multidisciplinary-management-based-on-clinical-nursing-pathway-model-for-the-treatment-of-hypertensive-intracerebral-hemorrhage-a-randomized-controlled-trial
#2
JOURNAL ARTICLE
Lan Zhang, Tingting Shen, Yan Zhou, Xing Xie, Jing Wang, Haixiao Gao
OBJECTIVE: To explore the effectiveness of multidisciplinary management based on a clinical nursing pathway model for the treatment of hypertensive intracerebral hemorrhage (HICH). METHODS: A total of 124 patients with HICH admitted to our hospital between February 2021 and June 2023 were selected as research subjects in this randomized, controlled, unblinded study. They were divided into Control-group and Study-group using a random number table method, with 62 cases in each group...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38509984/cardiac-transcriptomic-changes-induced-by-early-ckd-in-mice-reveal-novel-pathways-involved-in-the-pathogenesis-of-cardiorenal-syndrome-type-4
#3
JOURNAL ARTICLE
Francisco Javier Munguia-Galaviz, Yanet Karina Gutierrez-Mercado, Alejandra Guillermina Miranda-Diaz, Eliseo Portilla de Buen, Mario Eduardo Flores-Soto, Raquel Echavarria
BACKGROUND: Cardiorenal syndrome (CRS) type 4 is prevalent among the chronic kidney disease (CKD) population, with many patients dying from cardiovascular complications. However, limited data regarding cardiac transcriptional changes induced early by CKD is available. METHODS: We used a murine unilateral ureteral obstruction (UUO) model to evaluate renal damage, cardiac remodeling, and transcriptional regulation at 21 days post-surgery through histological analysis, RT-qPCR, RNA-seq, and bioinformatics...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38507134/neuraxial-anesthesia-and-analgesia-during-cardiothoracic-surgery-a-narrative-review
#4
REVIEW
Kevin Chen, Kyle Gashler, Tommy Li, Anvinh Nguyen
PURPOSE OF REVIEW: The purpose of this review is to synthesize and examine the literature on the use of neuraxial anesthesia and analgesia during cardiothoracic surgery. As cardiothoracic procedures often require systemic anticoagulation, neuraxial techniques are quite often underutilized due to the theoretical risk of epidural hematoma. In this review, we seek to examine the literature to review the indications and contraindications and to explore if neuraxial anesthesia and analgesia has a role in cardiothoracic surgery...
March 20, 2024: Current Pain and Headache Reports
https://read.qxmd.com/read/38504975/human-tissue-resident-peritoneal-macrophages-reveal-resistance-towards-oxidative-cell-stress-induced-by-non-invasive-physical-plasma
#5
JOURNAL ARTICLE
Laura Schultze-Rhonhof, Julia Marzi, Daniel Alejandro Carvajal Berrio, Myriam Holl, Theresa Braun, Felix Schäfer-Ruoff, Jürgen Andress, Cornelia Bachmann, Markus Templin, Sara Y Brucker, Katja Schenke-Layland, Martin Weiss
In the context of multimodal treatments for abdominal cancer, including procedures such as cytoreductive surgery and intraperitoneal chemotherapy, recurrence rates remain high, and long-term survival benefits are uncertain due to post-operative complications. Notably, treatment-limiting side effects often arise from an uncontrolled activation of the immune system, particularly peritoneally localized macrophages, leading to massive cytokine secretion and phenotype changes. Exploring alternatives, an increasing number of studies investigated the potential of plasma-activated liquids (PAL) for adjuvant peritoneal cancer treatment, aiming to mitigate side effects, preserve healthy tissue, and reduce cytotoxicity towards non-cancer cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38504220/comparison-of-diffusion-ranges-at-different-local-anesthetic-volumes-during-superior-laryngeal-nerve-block
#6
JOURNAL ARTICLE
Yin Bao, Huijun Wang, Lifeng Li, Hongbo Xu, Yun Li, Guyan Wang
OBJECTIVES: Ultrasound-guided superior laryngeal nerve (SLN) block is a practical and painless approach to avoid the hemodynamic stress response during endotracheal intubation and relieve sore throat after laryngeal surgery. The main purpose of this study was to establish an optimal dosage of local anesthetic when performing SLN block to help anesthetists balance analgesia and side effects. METHODS: Twenty fresh larynx specimens were obtained immediately after resection and then injected with 2-, 3-, 4-, or 5- mL of a lidocaine-blue dye mixture at bilateral SLN puncture sites...
March 19, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38501030/pathological-insights-on-polypropylene-mesh-complications-from-laparoscopic-sacrocolpopexy-a-case-series
#7
JOURNAL ARTICLE
Nobuo Okui, Machiko A Okui
Background The use of polypropylene mesh in laparoscopic sacrocolpopexy (LSC) is a common treatment for pelvic organ prolapse (POP). Despite its widespread application, postoperative complications such as mesh pain and infection sometimes necessitate the removal of the mesh. However, it remains unclear in which cases mesh removal is warranted. Our research focused on the pathological changes at the sacral fixation point of the mesh. We sought to evaluate the pathological alterations of the sacral mesh removed through an innovative approach of transvaginal natural orifice transluminal endoscopic surgery (vNOTES)...
March 2024: Curēus
https://read.qxmd.com/read/38500127/lactobacillus-reuteri-mitigates-hepatic-ischemia-reperfusion-injury-by-modulating-gut-microbiota-and-metabolism-through-the-nrf2-ho-1-signaling
#8
JOURNAL ARTICLE
Leiyi Zhang, Xiaoxiang Gong, Juan Tan, Rongsen Zhang, Mingxia Li, Cong Liu, Chenhao Wu, Xiaojing Li
BACKGROUND: This study seeks to investigate the impacts of Lactobacillus reuteri (L. reuteri) on hepatic ischemia-reperfusion (I/R) injury and uncover the mechanisms involved. METHODS: Mice in the I/R groups were orally administered low and high doses of L.reuteri (L.reuteri-low and L. reuteri-hi; 1 × 1010 CFU/d and 1 × 1011 CFU/d), for 4 weeks prior to surgery. Following this, mice in the model group were treated with an Nrf2 inhibitor (ML-385), palmitoylcarnitine, or a combination of both...
March 18, 2024: Biology Direct
https://read.qxmd.com/read/38498212/robotic-assisted-surgery-for-left-sided-colon-and-rectal-resections-is-associated-with-reduction-in-the-postoperative-surgical-stress-response-and-improved-short-term-outcomes-a-cohort-study
#9
JOURNAL ARTICLE
Abigail R Ingham, Chia Yew Kong, Tin-Ning Wong, Stephen T McSorley, Donald C McMillan, Gary A Nicholson, Ahmed Alani, David Mansouri, David Chong, Graham J MacKay, Campbell S D Roxburgh
INTRODUCTION: There is growing evidence that the use of robotic-assisted surgery (RAS) in colorectal cancer resections is associated with improved short-term outcomes when compared to laparoscopic surgery (LS) or open surgery (OS), possibly through a reduced systemic inflammatory response (SIR). Serum C-reactive protein (CRP) is a sensitive SIR biomarker and its utility in the early identification of post-operative complications has been validated in a variety of surgical procedures. There remains a paucity of studies characterising post-operative SIR in RAS...
March 18, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38492809/improving-geriatric-outcomes-through-nutritional-and-immunonutritional-strategies-focus-on-surgical-setting-by-a-comprehensive-evidence-review
#10
REVIEW
Virginia Boccardi, Luigi Marano
The aging population worldwide has led to an increased request for surgical interventions in older, geriatric, and frail patients. However, all the physiological changes associated with aging are associated with many challenges in the perioperative period, that strongly impacting surgical outcomes. Nutritional status plays a pivotal role in determining the resilience of older adults to surgical stress and their ability to recover postoperatively. It is well known that malnutrition, a prevalent concern in geriatrics, is linked to increased adverse outcomes, including morbidity and mortality...
March 14, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38492724/work-environment-differences-between-outpatient-and-inpatient-surgery-a-pilot-study-on-the-vascular-surgeons-perceptions
#11
JOURNAL ARTICLE
Laurence Destrieux, Youssra Yemmas, Sydney Williams, Nolwenn Le Meur
BACKGROUND: In France, outpatient endovascular surgical procedures have been slowly implemented in hospitals since 2015. Their development has been heterogeneous across France and is not yet the standard of care despite their benefits concerning patients' outcomes and healthcare professionals' satisfaction. However, since the COVID-19 pandemic, the demand for patient beds has been increasing, while human resources have been decreasing. This encouraged the surgery service reorganization and accelerated the shift from inpatient to outpatient surgery...
March 14, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38488623/the-aetiology-of-fracture-and-nonunion-in-the-hook-of-the-hamate
#12
EDITORIAL
Fiona C Campbell, Stuart W Jones, Doug A Campbell
Fractures of the hook of the hamate are traditionally thought to be caused by direct trauma. A review of the anatomy and function of the hamate hook suggests that fracture is more likely as a result of a fatigue response that develops in the hook from repetitive load applied by the adjacent deep flexor tendons. Additional vascular compromise, from direct pressure of the tendons on critical local vessels, reduces blood flow leading to both mechanical and vascular effects that create pathological osseous change and weakening...
March 15, 2024: Journal of Hand Surgery, European Volume
https://read.qxmd.com/read/38481729/trial-watch-dexmedetomidine-in-cancer-therapy
#13
REVIEW
Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer, Lucillia Bezu
Dexmedetomidine (DEX) is a highly selective α2-adrenoceptor agonist that is widely used in intensive and anesthetic care for its sedative and anxiolytic properties. DEX has the capacity to alleviate inflammatory pain while limiting immunosuppressive glucocorticoid stress during major surgery, thus harboring therapeutic benefits for oncological procedures. Recently, the molecular mechanisms of DEX-mediated anticancer effects have been partially deciphered. Together with additional preclinical data, these mechanistic insights support the hypothesis that DEX-induced therapeutic benefits are mediated via the stimulation of adaptive anti-tumor immune responses...
2024: Oncoimmunology
https://read.qxmd.com/read/38475745/clinical-study-of-electroacupuncture-on-the-recovery-of-gastrointestinal-dysfunction-after-laparoscopic-surgery-for-gastrointestinal-cancer-study-protocol-for-a-randomized-controlled-trial
#14
JOURNAL ARTICLE
Shuet Ling Chung, Wen Li, Qiuyue Wang, Xiaofeng Qiu, Yuncheng Tang, Sheng Hu, Huangan Wu, Zhu Jin
BACKGROUND: Gastrointestinal dysfunction is one of the common complaints for patient post-surgery. Acupuncture has been employed to improve gastrointestinal function and sleeping quality and has confirmed clinical efficacy for emotional problems. This study aims to evaluate the clinical effect of electroacupuncture for postoperative rapid recovery. METHODS: This study design is a two-arm, parallel, double-blinded randomized controlled trial. 104 subjects, aged from 40 to 89 years old, diagnosed with gastrointestinal cancer undergoing laparoscopic surgery, will be divided into Interventional Group and Control Group...
March 12, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38467056/application-of-hip-capsule-peripheral-nerve-block-in-early-analgesia-in-elderly-patients-with-hip-fracture
#15
JOURNAL ARTICLE
Jiangbo Zheng, Zhaoming Feng, Junfeng Zhu, Yuqing Kang
OBJECTIVE: The objective of the study is to investigate the effect of pericapsular nerve group (PENG) block in early analgesia in elderly patients with hip fracture. METHODS: A total of 44 elderly patients with hip fracture admitted to our hospital from August 2021 to December 2022 were selected and divided into 2 groups according to different analgesia programs. RESULTS: At T1~T4, the resting and active visual analog scale (VAS) scores in group P were lower than group F (p < 0...
March 11, 2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38463759/propionyl-l-carnitine-mitigates-ischemia-reperfusion-injury-in-rat-epigastric-island-flaps
#16
JOURNAL ARTICLE
Atilla Adnan Eyuboglu, Ovunc Akdemir, Oytun Erbas, Mustafa Tonguc Isken, Feng Zhang, William C Lineaweaver
BACKGROUND: Ischemia-reperfusion injury presents a substantial concern in various medical scenarios, notably in reconstructive surgery involving tissue flaps. Despite reports on the protective benefits of Propionyl-l-carnitine against ischemia-reperfusion injury, a thorough assessment of its efficacy in epigastric island flap models is currently lacking. METHODS: Sixteen male Sprague-Dawley rats underwent epigastric island flap surgery and were divided into two groups: a Propionyl-l-carnitine group that received intraperitoneal Propionyl-l-carnitine prior to ischemia induction and a sham group that received saline treatment...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38460367/effect-of-high-dose-vitamin-c-on-renal-ischemia-reperfusion-injury
#17
JOURNAL ARTICLE
Seo Hee Ko, Ji Hae Jun, Ju Eun Oh, Eunah Shin, Young-Lan Kwak, Jae-Kwang Shim
Acute kidney injury frequently occurs after cardiac surgery, and is primarily attributed to renal ischemia-reperfusion (I/R) injury and inflammation from surgery and cardiopulmonary bypass. Vitamin C, an antioxidant that is often depleted in critically ill patients, could potentially mitigate I/R-induced oxidative stress at high doses. We investigated the effectiveness of high-dose vitamin C in preventing I/R-induced renal injury. The ideal time and optimal dosage for administration were determined in a two-phase experiment on Sprague-Dawley rats...
March 8, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38457039/blockade-of-sympathetic-ganglia-improves-vascular-dysfunction-in-septic-shock
#18
JOURNAL ARTICLE
Ana Maria Favero, Thiele Osvaldt Rosales, Karin Scheschowitsch, Muryel Carvalho Gonçalves, Patricia Oliveira Benedet, Regina Sordi, Geisson Marcos Nardi, Jamil Assreuy
Sepsis/septic shock activates the sympathetic nervous system (SNS) to deal with the infection stress. However, an imbalanced or maladaptive response due to excessive or uncontrolled activation characterizes autonomic dysfunction. Our hypothesis was that reducing this excessive activation of the autonomic nervous system would impact positively in sepsis. Using ganglionic blockers as a pharmacological approach, the main aim of the present report was to assess the role of ganglionic transmission in the vascular dysfunction associated with sepsis...
March 8, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38454447/pathophysiology-of-acute-lung-injury-in-patients-with-acute-brain-injury-the-triple-hit-hypothesis
#19
REVIEW
Mairi Ziaka, Aristomenis Exadaktylos
It has been convincingly demonstrated in recent years that isolated acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and systems. Of all potential target organs and systems, the lung appears to be the most vulnerable to damage after ABI. The pathophysiology of the bidirectional brain-lung interactions is multifactorial and involves inflammatory cascades, immune suppression, and dysfunction of the autonomic system. Indeed, the systemic effects of inflammatory mediators in patients with ABI create a systemic inflammatory environment ("first hit") that makes extracranial organs vulnerable to secondary procedures that enhance inflammation, such as mechanical ventilation (MV), surgery, and infections ("second hit")...
March 7, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38452285/the-role-of-psychiatry-for-transgender-and-gender-diverse-adults
#20
JOURNAL ARTICLE
Maggie Beazer, Micah Breiger, Alex S Keuroghlian
Since the inclusion of gender identity disorder in the third edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III), psychiatry and the broader medical field have made substantial alterations in their recognition of and respect for transgender and gender diverse (TGD) identities. As this recognition continues to expand, psychiatrists should be aware of both historical harm and current best care practices, especially in light of psychiatric morbidity in TGD populations relative to the general population...
March 2024: Harvard Review of Psychiatry
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