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stress response to surgery

Calum D Moulton, Polychronis Pavlidis, Christine Norton, Sam Norton, Carmine Pariante, Bu Hayee, Nick Powell
Depressive symptoms are reported by more than 20% of people with inflammatory bowel disease (IBD), whilst sleep difficulties and fatigue are even more common. Comorbid depressive symptoms predict a poor IBD course, including increased risk of relapse and surgery, which is inconsistently improved by psychological treatments. Rather than being distinct systems, there is compelling evidence for bidirectional communication between gut and brain, driven by neural, metabolic, endocrine and inflammatory mediators...
February 14, 2019: Clinical and Experimental Immunology
Yan Li, Hongquan Dong, Shanbai Tan, Yanning Qian, Wenjie Jin
BACKGROUND: Appropriate postoperative pain management can improve outcomes in patients with esophageal cancer (EC). OBJECTIVE: To compare different combinations of anesthesia and analgesia techniques in patients with EC undergoing open thoracotomy. METHODS: This randomized, controlled, open-label trial enrolled 100 patients with EC (aged 40-65 years; American Society of Anesthesiologists [ASA] grade I/II) receiving elective surgery at Jiangsu Province Hospital (China) between July 2016 and December 2017...
February 2019: Medicine (Baltimore)
Bo-Yu Yang, Guo-Ying Deng, Rui-Zhe Zhao, Chen-Yun Dai, Chen-Yi Jiang, Xing-Jie Wang, Yi-Feng Jing, Xi-Jian Liu, Shu-Jie Xia, Bang-Min Han
Benign prostatic hyperplasia (BPH) patients experience complications after surgery. We studied oxidative stress scavenging by porous Se@SiO2 nanospheres in prostatic urethra wound healing after transurethral resection of the prostate (TURP). Beagle dogs were randomly distributed into two groups after establishing TURP models. Wound recovery and oxidative stress levels were evaluated. Re-epithelialization and the macrophage distribution at the wound site were assessed by histology. The mechanism by which porous Se@SiO2 nanospheres regulated macrophage polarization was investigated by qRT-PCR, western blotting, flow cytometry, immunofluorescence and dual luciferase reporter gene assays...
February 9, 2019: Acta Biomaterialia
Presheet P Patkar, Zheng Hao, Michael B Mumphrey, R Leigh Townsend, Hans-Rudolf Berthoud, Andrew C Shin
OBJECTIVES: Dieting often fails because weight loss triggers strong counter-regulatory biological responses such as increased hunger and hypometabolism that are thought to be critically dependent on the master fuel sensor in the mediobasal hypothalamus (MBH). Because prolonged starvation has been shown to increase AgRP and NPY, the expression level of these two orexigenic genes has been taken as an experimental readout for the presence or absence of hunger. Roux-en-Y gastric bypass (RYGB) surgery leads to a significant weight loss without inducing the associated hunger, indicating possible changes in hypothalamic neuropeptides and/or signaling...
February 4, 2019: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Hirotake Ishida, Shin-Ya Saito, Ayaka Horie, Tomohisa Ishikawa
Reduced blood flow in the skin is observed in patients with neuropathic pain and in animal models. The aim of the present study was to elucidate the relationship between reduced skin blood flow and neuropathic pain in mice with a chronic constriction injury (CCI). Noradrenaline-induced contraction was enhanced in isolated plantar arteries ipsilateral to the CCI surgery compared to the contralateral arteries. Ten μM hydralazine, a peripheral vasodilator, at improved the enhanced contractile response in the ipsilateral arteries...
February 1, 2019: European Journal of Pharmacology
Wei Fan, Li-Xin Guo
Previous studies have compared the effects of different interbody fusion approaches on biomechanical responses of the lumbar spine to static loadings. However, very few have dealt with the whole body vibration (WBV) condition that is typically present in vehicles. This study was designed to determine the biomechanical differences among anterior, posterior and transforaminal lumbar interbody fusion (ALIF, PLIF and TLIF) under vertical WBV. A previously developed and validated finite element (FE) model of the intact L1-sacrum human lumbar spine was modified to simulate ALIF, PLIF and TLIF with bilateral pedicle screw fixation at L4-L5...
February 4, 2019: Computer Methods in Biomechanics and Biomedical Engineering
Fatemeh Fazlollahpour-Rokni, Seyed Afshin Shorofi, Nouraddin Mousavinasab, Rahman Ghafari, Ravanbakhsh Esmaeili
BACKGROUND AND PURPOSE: Anxiety is one of the most common responses of patients awaiting coronary artery bypass graft (CABG) surgery to stressful conditions before surgery. This study is intended to examine the effect of inhalation aromatherapy with rose essential oil on the anxiety of patients undergoing CABG surgery. MATERIALS AND METHODS: This was a single-blind randomized clinical trial of 66 patients undergoing CABG surgery. The experimental group inhaled three drops of 4% rose essential oil for 10 minutes one night and one hour before surgery...
February 2019: Complementary Therapies in Clinical Practice
Amy Robinson-Junker, Bruce O'Hara, Abigail Durkes, Brianna Gaskill
Many aspects of the laboratory environment are not tailored to the needs of rodents, which may cause stress. Unpredictable stressors can cause ulcers, prolonged pituitary-adrenal activation, and anhedonia. Similarly, pain has been demonstrated to slow wound healing, and mice experiencing pain exhibit altered behavior. However it is unknown how husbandry, which occurs when the mice are inactive, and lack of analgesia, specifically in a punch biopsy procedure, effects animal physiology, behavior, and welfare, particularly as it relates to sleep fragmentation...
2019: PloS One
Alina Constantin, Mădălina Dumitrescu, Miruna Nemecz, Ariana Picu, Bogdan Smeu, Cristian Guja, Nicoleta Alexandru, Adriana Georgescu, Gabriela Tanko
BACKGROUND: Pancreatic beta cells are highly sensitive to oxidative and endoplasmic reticulum (ER) stress, commonly occurring in type 2 diabetes (T2D) and obesity. OBJECTIVE: We aimed at investigating cellular responses of human beta cells exposed to sera from obese T2D patients treated differently, namely by conventional therapy or laparoscopic sleeve gastrectomy (LSG). METHODS: Serum samples from obese T2D men randomized to conventional treatment or LSG were taken at baseline and 6 months later...
January 30, 2019: Obesity Surgery
Zhiling Li, Mingshi Yang, Yue Peng, Min Gao, Bingchang Yang
BACKGROUND: Sepsis is a life-threatening organ dysfunction disease caused by a dysregulated host response to infection. Rutaecarpine is an important alkaloid component of Evodia rutaecarpa. There has been no study on the therapeutic effects of rutaecarpine in sepsis. METHODS: Mice were randomly assigned into four groups: sham, sepsis, sepsis plus vehicle and sepsis plus rutaecarpine groups. Mice in sepsis were administered CLP surgery. Rutaecarpine or vehicle was injected intraperitoneally 1 h after CLP...
January 25, 2019: Life Sciences
Kazuki Sugimoto, Takayuki Nakamura, Takuya Tokunaga, Yusuke Uehara, Tatsuya Okada, Takuya Taniwaki, Toru Fujimoto, Yuichi Oike, Eiichi Nakamura
Study Design: Experimental human study. Purpose: To determine whether angiopoietin-like protein 2 (ANGPTL2) is highly expressed in the hyperplastic facet joint (FJ) synovium and whether it activates interleukin-6 (IL-6) secretion in FJ synoviocytes. Overview of Literature: Mechanical stress-induced synovitis is partially, but significantly, responsible for degenerative and subsequently osteoarthritic changes in the FJ tissues in patients with lumbar spinal stenosis (LSS)...
January 29, 2019: Asian Spine Journal
Caiju Zhang, Mintao Zhou, Man Li
OBJECTIVE: To investigate the change trend and correlation between the perioperative pain degree and neuroendocrine hormone levels in the perioperative period on patients with thyroid surgery by electroacupuncture combined with cervical plexus block. METHODS: Forty patients with elective thyroidectomy were enrolled and divided into a control group and an observation group according to the random number table method, 20 cases in each group. In the control group, cervical plexus block was performed...
December 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Dharma Jivan Samantaray, Meena Trehan, Vivek Chowdhry, Satish Reedy
Context: Regional anesthesia may attenuate adverse physiological stress responses associated with cardiothoracic surgery. In this study, hemodynamic stress response at the different time of surgical stimuli was compared between patients receiving general anesthesia (GA) along with caudal epidural analgesia with GA with intravenous analgesia in pediatric population undergoing open-heart surgery. Aims: This study aims to compare the hemodynamic response at the different time of surgical stimuli and postoperative pain score, in pediatric patients undergoing open-heart procedures...
January 2019: Annals of Cardiac Anaesthesia
Song Jianrong, Zhao Yanjun, Yu Chen, Xu Jianwen
Ischemic stroke is the second most common cause of death, a major cause of acquired disability in adults. However, the pathogenesis that contributes to ischemic stroke has not been fully understood. Dual-specificity phosphatase 14 (DUSP14, also known as MKP6) is a MAP kinase phosphatase, playing important role in regulating various cellular processes, including oxidative stress and inflammation. However, its effects on cerebral ischemia/reperfusion (IR) are unclear. In the study, we found that DUSP14 expression was decreased responding to IR surgery...
January 8, 2019: Biochemical and Biophysical Research Communications
Chloe J Taub, Marc E Lippman, Barry I Hudson, Bonnie B Blomberg, Alain Diaz, Hannah M Fisher, Erica R Nahin, Suzanne C Lechner, Taekyoung Kwak, Gyong Ha Hwang, Michael H Antoni
BACKGROUND: Women with breast cancer (BCa) experience heightened distress, which is related to greater inflammation and poorer outcomes. The s100 protein family facilitates the inflammatory response by regulating myeloid cell function through the binding of Toll-like receptor 4 and the receptor for advanced glycation end products (RAGE). The heterodimer s100A8/A9 RAGE ligand is associated with hastened tumor development and metastasis. Previously, a 10-week stress-management intervention using cognitive behavioral therapy (CBT) and relaxation training (RT) was associated with less leukocyte inflammatory gene expression in patients with BCa; however, its impact on s100A8/A9 was not examined...
January 11, 2019: Cancer
Yang Qin, Jinping Ni, Li Kang, Zhidong Zhong, Liren Wang, Shuzhou Yin
OBJECTIVE: To investigate the effects of sustained inhalation of sevoflurane on cognitive function and the expression of oxidative stress response proteins such as NADPH oxidase subunits NOX2 and NOX4 in elderly patients undergoing radical surgery for lung cancer. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, China, from February 2016 to October 2017...
January 2019: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Katarzyna Powezka, Tricia Adjei, Wilhelm von Rosenberg, Pasha Normahani, Valentin Goverdovsky, Nigel J Standfield, Danilo P Mandic, Usman Jaffer
OBJECTIVE: Local anesthetic endovenous procedures were shown to reduce recovery time, to decrease postoperative pain, and to more quickly return the patient to baseline activities. However, a substantial number of patients experience pain during these procedures. The autonomic nervous system modulates pain perception, and its influence on stress response can be noninvasively quantified using heart rate variability (HRV) indices. The aim of our study was to evaluate whether preoperative baseline HRV can predict intraoperative pain during local anesthetic varicose vein surgery...
January 3, 2019: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Z Y Zhu, J X Xue, L X Yu, W H Bian, Y F Zhang, K C Sohn, I H Shin, C Yao
Background: Reducing inflammatory factors in wound exudate is a promising treatment approach for healing wounds in postsurgical breast cancer patients. Traditional Chinese Medicine (tcm) treatments have been shown to be beneficial and safe for optimal regulation of oxidative stress during the postoperative period. In the present clinical trial, we evaluated the effectiveness of a promising Chinese herbal formula, San Huang decoction [shd (Radix astragali, Radix et rhizoma rhei, and Rhizoma curcuma longa, 3:1:1; supplemental Table 1)], on wound inflammatory response after mastectomy...
December 2018: Current Oncology
Roseanna Valant, Bogdan Grigorescu, Sara Benerofe, George Lazarou
OBJECTIVES: Given the complex anatomy and pathophysiology of urogynecologic disorders, obstetrics and gynecology residents can have difficulty learning the subject's principles. There are no standardized resources for educators in this subspecialty. We hypothesized that our case-based educational intervention was associated with enhanced knowledge and greater resident satisfaction versus traditional urogynecology lectures. METHODS: This is a prospective study involving 19 obstetrics and gynecology residents at a single institution...
December 28, 2018: Female Pelvic Medicine & Reconstructive Surgery
Abhay B Ramachandra, Jay D Humphrey
The biomechanical properties of the major pulmonary arteries play critical roles in normal physiology as well as in diverse pathophysiologies and clinical interventions. Importantly, advances in medical imaging enable simulations of pulmonary hemodynamics, but such models cannot reach their full potential until they are informed with region-specific material properties. In this paper, we present passive and active biaxial biomechanical data for the right and left main pulmonary arteries from wild-type mice...
December 12, 2018: Journal of Biomechanics
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