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https://read.qxmd.com/read/30870858/is-the-metronome-paced-tachypnea-test-mpt-ready-for-clinical-use-accuracy-of-the-mpt-in-a-prospective-and-clinical-study
#1
Denise Mannée, Esther Vis, Aranka Hoekstra-Kuik, Jan van der Maten, Alex Jan van 't Hul, Hanneke van Helvoort
BACKGROUND: A simple technique to measure dynamic hyperinflation (DH) in patients with chronic obstructive pulmonary disease (COPD) is the metronome-paced tachypnea test (MPT). Earlier studies show conflicting results about the accuracy of the MPT compared to cardiopulmonary exercise testing (CPET). OBJECTIVES: The focus was to investigate the diagnostic accuracy of MPT to detect DH in a prospective and clinical study. METHODS: COPD patients were included; all underwent spirometry, CPET, and MPT...
March 14, 2019: Respiration; International Review of Thoracic Diseases
https://read.qxmd.com/read/30864670/clinical-characteristics-and-outcome-of-children-hospitalized-with-scrub-typhus-in-an-area-of-endemicity
#2
Tri Wangrangsimakul, Rachel C Greer, Chulapong Chanta, Supalert Nedsuwan, Stuart D Blacksell, Nicholas P J Day, Daniel H Paris
BACKGROUND: Scrub typhus, caused by Orientia tsutsugamushi, is a major cause of acute febrile illness in children in the rural tropics. METHODS: We recruited 60 febrile pediatric patients with a positive scrub typhus rapid diagnostic test result and 40 healthy controls from Chiang Rai Province in northern Thailand. Diagnosis was confirmed by the detection of (1) O. tsutsugamushi-specific DNA in blood or eschar samples with a polymerase chain reaction assay, (2) a fourfold rise in immunoglobulin M (IgM) titer to ≥1:3200 in paired plasma samples with an indirect immunofluorescence assay (IFA), or (3) a single IgM titer of ≥1:3200 in an acute plasma sample with an IFA...
March 13, 2019: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/30863755/clinical-presentation-and-early-predictors-for-poor-outcomes-in-pediatric-myocarditis-a-retrospective-study
#3
Moises Rodriguez-Gonzalez, Maria Isabel Sanchez-Codez, Manuel Lubian-Gutierrez, Ana Castellano-Martinez
BACKGROUND: Myocarditis is an important cause of morbidity and mortality in children, leading to long-term sequelae including chronic congestive heart failure, dilated cardiomyopathy, heart transplantation, and death. The initial diagnosis of myocarditis is usually based on clinical presentation, but this widely ranges from the severe sudden onset of a cardiogenic shock to asymptomatic patients. Early recognition is essential in order to monitor and start supportive treatment prior to the development of severe adverse events...
March 6, 2019: World Journal of Clinical Cases
https://read.qxmd.com/read/30836813/evaluation-of-the-effect-of-antenatal-betamethasone-on-neonatal-respiratory-morbidity-in-early-term-elective-cesarean
#4
Masoomeh Mirzamoradi, Zahra Joshaghani, Fatemeh Hasani Nejhad, Mahya Vafaeenia, Zahra Heidar
BACKGROUND: Compared with vaginal delivery, early-term cesarean section (CS) is associated with an increased risk of neonatal respiratory morbidity. Given the role of steroids in lung maturation in preterm labor, few studies have investigated their effects on early-term delivery. Therefore, this study aimed to investigate the effect of antenatal betamethasone on neonatal respiratory morbidity in early-term elective cesarean (37-38 weeks and 6 d). METHODS: This randomized clinical trial was conducted in Mahdieh Hospital in Tehran in 2017...
March 5, 2019: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/30810692/precordial-pain-leukocytosis-and-bicytopenia-in-a-teenager-with-systemic-juvenile-idiopathic-arthritis-under-immunosuppressive-therapy
#5
Marina de Sousa Vieira, Flávia Regina de Andrade, Letícia Maria Kolachinski Raposo Brandão, Virgínia Tafas da Nóbrega, Vanessa Ramos Guissa, José Roberto Provenza
OBJECTIVE: To highlight the importance of the new classification criteria for the macrophage activation syndrome (MAS) in systemic juvenile idiopathic arthritis in order to reduce morbidity and mortality outcome related to this disease. CASE DESCRIPTION: A 12-year-old female patient with diagnosis of systemic juvenile idiopathic arthritis under immunosuppression therapy for two years developed cough, acute precordial chest pain, tachypnea, tachycardia and hypoxemia for two days...
February 25, 2019: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://read.qxmd.com/read/30805902/fatal-awake-malignant-hyperthermia-episodes-in-a-family-with-malignant-hyperthermia-susceptibility-a-case-series
#6
Elena Zvaritch, Robyn Gillies, Natalia Kraeva, Maxime Richer, Heinz Jungbluth, Sheila Riazi
PURPOSE: The present report of two fatal awake malignant hyperthermia (MH) episodes in an MH susceptible (MHS) family is intended to raise awareness among medical personnel and MHS individuals to the possibility of life-threatening non-anesthesia-triggered MH episodes and to provide a strong incentive for development of effective preventive measures. CLINICAL FEATURES: Two young athletic males (28 and 16 yr old), members of the same extended family with a history of anesthesia-related MH episodes and deaths, succumbed ten years apart on two different continents, with symptoms unrelated to anesthesia but strikingly similar to typical anesthetic-induced MH...
February 19, 2019: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://read.qxmd.com/read/30797442/tricuspid-valve-dysplasia-and-a-patent-foramen-ovale-resulting-in-severe-tricuspid-regurgitation-and-right-heart-dilation-in-a-red-angus-calf
#7
A S Dias Moreira, K Grint, R Stepien, G Shaw, S Peek
A two-month-old Red Angus heifer calf presented to the University of Wisconsin Veterinary Care for evaluation of suspected severe bronchopneumonia. Pertinent physical exam findings included tachycardia, tachypnea, dyspnea with a significant abdominal component, and cyanotic mucous membranes. On thoracic auscultation, wheezes were present bilaterally, as well as a grade 2/6 right apical systolic murmur. Thoracic radiographs revealed cardiomegaly, most severely affecting the right side. Echocardiography showed tricuspid valve dysplasia, resulting in severe tricuspid regurgitation and right-heart dilation, as well as a patent foramen ovale...
February 2019: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://read.qxmd.com/read/30787954/lemierre-syndrome-case-report
#8
Rodrigo de Oliveira Veras, Linda Luísa Barasuol, Carolina Pedrassani de Lira, Flávia Caroline Klostermann, Lourenço Sabo Müller, Luiz Eduardo Nercolini, Gustavo Fabiano Nogueira
Lemierre syndrome is characterized by septic thrombophlebitis of the internal jugular vein, after an oropharyngeal infection, with septic embolization to the lungs or other organs. This case report describes a 37-year-old female patient who presented with edema and pain in the right hemiface with onset 3 days previously and progressive fatigue and dyspnea since the previous day. She had had tooth 48 extracted 3 days previously. Physical examination at admission found tachypnea, with 60% saturation (in room air), edema at the angle of the right mandible, diffuse reduction of vesicular murmur, and calves free from clubbing...
October 2018: Jornal Vascular Brasileiro
https://read.qxmd.com/read/30784009/the-value-of-acoustic-respiratory-rate-monitoring-in-a-patient-with-postoperative-hemorrhage-after-thyroidectomy-a-case-report
#9
Masashi Ishikawa, Dai Namizato, Atsuhiro Sakamoto
Acoustic respiratory rate (RRa) monitoring is a non-invasive method of monitoring respiratory rate in spontaneously breathing individuals. The aim of this report is to highlight the clinical utility of this monitoring system in post-thyroidectomy patients by presenting a case of respiratory compromise due to post-thyroidectomy hematoma, in which the alarm of the respiratory rate monitor alerted the nursing staff about the complication. A 61-year-old woman who uneventfully underwent right thyroid lobectomy for adenomatous goiter under general anesthesia with endotracheal intubation was being monitored postoperatively using the RRa monitoring system...
February 19, 2019: Journal of Clinical Monitoring and Computing
https://read.qxmd.com/read/30782143/a-case-report-of-cholinergic-rebound-syndrome-following-abrupt-low-dose-clozapine-discontinuation-in-a-patient-with-type-i-bipolar-affective-disorder
#10
Andrea Galova, Patricia Berney, Jules Desmeules, Ioannis Sergentanis, Marie Besson
BACKGROUND: Rebound cholinergic syndrome is a rare, but well known unwanted phenomenon occurring after abrupt clozapine discontinuation. There have been previous reported cases of cholinergic rebound in the literature; however, these reports described cholinergic rebound following cessation of high doses of clozapine in patients diagnosed with schizophrenia. Here, we report a case of rebound cholinergic syndrome and catatonia in a male patient three days after abrupt discontinuation of 50 mg of clozapine prescribed for type I bipolar affective disorder...
February 19, 2019: BMC Psychiatry
https://read.qxmd.com/read/30778892/neonatal-and-pediatric-thoracic-ultrasonography
#11
REVIEW
Gaetano Rea, Marco Sperandeo, Marco Di Serafino, Gianfranco Vallone, Paolo Tomà
Ultrasound examination of the thorax (TUS) can be quite suitable for children because their unique thoracic anatomy provides many acoustic windows into the chest. This review article covers techniques, indications, and applications of TUS in neonates, infants, and children, including common aspects and applications, like pulmonary consolidation and atelectasis, pleural effusion and pneumothorax and main neonatal pathologies such as respiratory distress syndrome (RDS) and transitory tachypnea of the newborn (TTN)...
February 18, 2019: Journal of Ultrasound
https://read.qxmd.com/read/30768454/transient-tachypnea-of-newborns-is-associated-with-maternal-spinal-hypotension-during-elective-cesarean-delivery-a-retrospective-cohort-study
#12
Shubhangi Singh, Mario Isaac Lumbreras-Marquez, Michaela K Farber, Xinling Xu, Prashant Singh, Terri Gorman, Arvind Palanisamy
BACKGROUND: The risk for transient tachypnea of newborns, a common cause of respiratory distress in the neonatal period, is 2- to 6-fold higher during elective cesarean delivery compared to vaginal delivery. Here, we evaluated the association between transient tachypnea of newborns and the degree and duration of predelivery maternal hypotension during spinal anesthesia for elective cesarean delivery. METHODS: Demographic data, details of anesthetic management, blood pressure measurements, and vasopressor requirement preceding delivery were compared between transient tachypnea newborns (n = 30) and healthy neonates (n = 151) with normal respiratory function born via elective cesarean delivery between July 2015 and February 2016...
February 12, 2019: Anesthesia and Analgesia
https://read.qxmd.com/read/30762803/pneumocystis-jirovecii-pneumonia-as-an-initial-manifestation-of-hyper-igm-syndrome-in-an-infant-a-case-report
#13
Danbi Kim, Ju Ae Shin, Seung Beom Han, Nack-Gyun Chung, Dae Chul Jeong
RATIONALE: Pneumocystis jirovecii causes severe pneumonia in immunocompromised hosts. Human immunodeficiency virus infection, malignancy, solid organ or hematopoietic cell transplantation, and primary immune deficiency compose the risk factors for Pneumocystis pneumonia (PCP) in children, and PCP can be an initial clinical manifestation of primary immune deficiency. PATIENT CONCERNS: A 5-month-old infant presented with cyanosis and tachypnea. He had no previous medical or birth history suggesting primary immune deficiency...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30737079/congenital-disorder-of-glycosylation-type-1t-with-a-novel-truncated-homozygous-mutation-in-pgm1-gene-and-literature-review
#14
Wo-Tu Tian, Xing-Hua Luan, Hai-Yan Zhou, Chao Zhang, Xiao-Jun Huang, Xiao-Li Liu, Sheng-Di Chen, Hui-Dong Tang, Li Cao
The congenital disorders of glycosylation are a group of clinically and biochemically heterogeneous diseases characterized by multisystem involvement due to glycosylation defect of protein and lipid. Here we report a 49-year-old man with exercise-induced fatigue and pain of muscle, tachypnea, cleft palate and bifid uvula. Exercise induced elevation of serum creatine kinase (CK), ammonia and lactic acid was recorded. The abnormal levels of myoglobin, CK-MB and LDH as well as S-T elevation in electrocardiogram were observed in repeated hospitalization recordings...
January 6, 2019: Neuromuscular Disorders: NMD
https://read.qxmd.com/read/30723866/methionyl-trna-synthetase-novel-mutation-causes-pulmonary-alveolar-proteinosis
#15
Mohammed Alzaid, Abdullah Alshamrani, Adel S Al Harbi, Ayed Alenzi, Sarar Mohamed
The  methionyl-tRNA  synthetase  (MARS)  mutation is  a  very  rare  cause  of  congenital  pulmonary  alveolar proteinosis.We report a 6-month-old boy born with symmetrical intrauterine growth retardation presented with unexplained persistent tachypnea and hypoxemia associated with severe failure to thrive, anemia, hypoalbuminemia and hepatomegaly. Detailed pulmonary investigations including computed tomography chest scan, bronchoscopy and bronchoalveolar lavage revealed pulmonary alveolar proteinosis...
February 2019: Saudi Medical Journal
https://read.qxmd.com/read/30722841/differentiating-acute-food-protein-induced-enterocolitis-syndrome-from-its-mimics-a-comparison-of-clinical-features-and-routine-laboratory-biomarkers
#16
Eric Lee, Elizabeth H Barnes, Sam Mehr, Dianne E Campbell
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is frequently misdiagnosed and subject to diagnostic delay. Profuse vomiting, the cardinal feature of acute FPIES, may occur in more common pediatric disorders such as gastroenteritis and sepsis. OBJECTIVES: We sought to determine differentiating features at acute presentation between FPIES, gastroenteritis, and sepsis in young children presenting to an emergency department (ED) with profuse vomiting...
February 2019: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/30715250/safety-and-efficacy-of-c-reactive-protein-guided-antibiotic-use-to-treat-acute-respiratory-infections-in-tanzanian-children-a-planned-subgroup-analysis-of-a-randomized-controlled-non-inferiority-trial-evaluating-a-novel-electronic-clinical-decision-algorithm
#17
Kristina Keitel, Josephine Samaka, John Masimba, Hosiana Temba, Zamzam Said, Frank Kagoro, Tarsis Mlaganile, Willy Sangu, Blaise Genton, Valerie D'Acremont
Background: Antibiotic overuse in pediatric primary care in resource-limited settings is driven by respiratory infections. The safety and efficacy of using C-reactive protein (CRP) to decide on antibiotic prescription among febrile children at risk of pneumonia has not been tested. Methods: Randomized (1:1), controlled, non-inferiority trial in 9 primary care centers in Dar es Salaam, Tanzania (as part of a study evaluating a novel electronic decision algorithm, ePOCT)...
February 2, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://read.qxmd.com/read/30703063/vagal-afferents-contribute-to-sympathoexcitation-driven-metabolic-dysfunctions
#18
L Francisco Lorenzo-Martín, Mauricio Menacho-Márquez, Salvatore Fabbiano, Omar Al-Massadi, Antonio Abad, Sonia Rodríguez-Fdez, María A Sevilla, María J Montero, Carlos Diéguez, Rubén Nogueiras, Xosé R Bustelo
Multiple crosstalk between peripheral organs and the nervous system are required to maintain physiological and metabolic homeostasis. Using Vav3-deficient mice as a model for chronic sympathoexcitation-associated disorders, we report here that afferent fibers of the hepatic branch of the vagus nerve are needed for the development of the peripheral sympathoexcitation, tachycardia, tachypnea, insulin resistance, liver steatosis and adipose tissue thermogenesis present in those mice. This neuronal pathway contributes to proper activity of the rostral ventrolateral medulla, a sympathoregulatory brainstem center hyperactive in Vav3-/- mice...
March 1, 2019: Journal of Endocrinology
https://read.qxmd.com/read/30702345/small-hairpin-rna-and-pharmacological-targeting-of-neutral-sphingomyelinase-prevents-diaphragm-weakness-in-rats-with-heart-failure-and-reduced-ejection-fraction
#19
Philip D Coblentz, Bumsoo Ahn, Linda F Hayward, Jeung-Ki Yoo, Demetra D Christou, Leonardo F Ferreira
Heart failure with reduced ejection fraction (HFREF) increases neutral sphingomyelinase (NSMase) activity, mitochondrial reactive oxygen species emission (ROS), and causes diaphragm weakness. We tested whether a systemic pharmacologic NSMase inhibitor or short-hairpin RNA (shRNA) targeting NSMase isoform 3 (NSMase3) would prevent diaphragm abnormalities induced by HFREF caused by myocardial infarction. In the pharmacological intervention, we used intraperitoneal injection of GW4869 or vehicle. In the genetic intervention, we injected adeno-associated virus serotype 9 (AAV9) containing targeting NSMase3 or a scrambled sequence directly into the diaphragm...
January 31, 2019: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/30697367/effects-of-diabetic-ketoacidosis-in-the-respiratory-system
#20
REVIEW
Alice Gallo de Moraes, Salim Surani
Diabetes affects approximately 30 million persons in the United States. Diabetes ketoacidosis is one of the most serious and acute complications of diabetes. At the time of presentation and during treatment of diabetic ketoacidosis (DKA), several metabolic and electrolyte derangements can ultimately result in respiratory compromise. Most commonly, hypokalemia, hypomagnesemia and hypophosphatemia can eventually lead to respiratory muscles failure. Furthermore, tachypnea, hyperpnea and more severely, Kussmaul breathing pattern can develop...
January 15, 2019: World Journal of Diabetes
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