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Nephrolithiasis transplant donor

E Favi, N Raison, S Zanetti, G Sampogna, E Montanari, M Ferraresso
Increasing demand drives the expansion of criteria for kidney donation, and nephrolithiasis is now considered a relative contraindication. We report for the first time a case of intra-operative, postperfusion kidney allograft micronephrolithotomy. A 64-year-old man with end-stage renal disease secondary to Alport syndrome underwent primary deceased donor kidney transplantation at our center. Pre-operative ultrasound of the donor identified a 7-mm calculus in the anterior, lower pole calyx. The kidney was extra-peritoneally implanted in the right iliac fossa and reperfused homogenously...
December 2018: Transplantation Proceedings
Vasishta S Tatapudi, David S Goldfarb
PURPOSE OF REVIEW: Traditionally, nephrolithiasis was considered a relative contraindication to kidney donation because of a risk of recurrent stones in donors and adverse stone-related outcomes in recipients. However, the scarcity of organs has driven the transplant community to re-examine and broaden selection criteria for living donors with stones. In this review, we summarize and contrast the guidelines published by various prominent national and international societies on this topic...
December 5, 2018: Current Opinion in Nephrology and Hypertension
Hayet Kaaroud, Amel Harzallah, Mariem Najjar, Nour Houda Chtioui, Mohamed Cherif, Haroun Ayed, W Kerkeni, A Bouzouita, M Chebil, Emna Talbi, Hanene Baccouch, Amal Benzarti, Jaouida Abdelmoula, Fethi Benhamida, Taieb Ben Abdallah
BACKGROUND: Living kidney donation for transplantation has become common practice. The decisions to accept a donor with nephrolithiasis are becoming frequent. AIM: The aim of our study was to report our experience in the living donor kidney with asymptomatic lithiasis. METHODS: Over a period of 4 years from 2009 to 2013 we collected 18 cases. From the clinical, metabolic and radiological data, we have determined the etiology of urolithiasis in our patients and established, after a literature review, a decision tree of kidney donation...
February 2018: La Tunisie Médicale
Giuseppe Ietto, Giovanni Saredi, Gabriele Soldini, Domenico Iovino, Francesco Amico, Elia Zani, Lorenzo Berti, Matteo Tozzi, Giulio Carcano
Urolithiasis is a rare complication after kidney transplant. Over the years, treatment of kidney stones has evolved radically, but a standard approach for transplanted kidneys has not yet been defined. Here, we present a 69-year-old male patient who received successful treatment of nephrolithiasis of the transplanted kidney. The patient, who had received a kidney from a deceased donor, was admitted to our department following a posttransplant Doppler ultrasonography showing severe hydronephrosis of the transplanted kidney associated with acute renal function decay...
September 25, 2018: Experimental and Clinical Transplantation
Musallam Abukhalil, Osama Mehjez, Mohammed Aladdam, Bettina Bottcher, Sobhi Skaik, Mohammed Matter
BACKGROUND: In 2013, al-Shifa Hospital, the largest hospital in the Gaza Strip, introduced an assessment programme for potential kidney donors on the basis of medical and radiological evaluation. The aims of this study and an associated clinical audit were to examine the final outcome of the potential live kidney donors assessment programme, to review the findings and determine the level of accuracy of the radiological evaluations, to assess the completeness and standard of radiological record keeping, and to evaluate adherence to guidelines...
February 21, 2018: Lancet
Joke I Roodnat, Anneke M E de Mik-van Egmond, Wesley J Visser, Stefan P Berger, Wilbert A G van der Meijden, Felix Knauf, Madelon van Agteren, Michiel G H Betjes, Ewout J Hoorn
Background: Enteric hyperoxaluria due to malabsorption may cause chronic oxalate nephropathy and lead to end-stage renal disease. Kidney transplantation is challenging given the risk of recurrent calcium-oxalate deposition and nephrolithiasis. Methods: We established a protocol to reduce plasma oxalic acid levels peritransplantation based on reduced intake and increased removal of oxalate. The outcomes of 10 kidney transplantation patients using this protocol are reported...
December 2017: Transplantation Direct
Chuan-Bao Chen, Liang Zhao, Ming Han, Xiao-Ping Wang, Jian Zhou, Xiao-Peng Yuan, Chang-Xi Wang
OBJECTIVE: To evaluate the outcomes of transplantation of deceased donor stone-bearing kidneys. METHODS: A total of 32 patients who received renal transplantation at our center from July 2011 to June 2016 were included. Eight recipients received kidneys with incidental renal stone(s) (stone group). Twenty-four recipients received kidneys without renal stones (non-stone group). The transplantation outcomes of the 2 groups were compared. RESULTS: There was 1 case of postoperative urinary tract infection in the stone group, and 2 cases in the non-stone group...
September 2017: Urology
Thomas B McGregor, Christie Rampersad, Premal Patel
INTRODUCTION: Renal transplantation remains the gold standard treatment for end-stage renal disease, with living donor kidneys providing the best outcomes in terms of allograft survival. As the number of patients on the waitlist continues to grow, solutions to expand the donor pool are ongoing. A paradigm shift in the eligibility of donors with renal anomalies has been looked at as a potential source to expand the living donor pool. We sought to determine how many patients presented with anatomic renal anomalies at our transplant centre and describe the ex-vivo surgical techniques used to render these kidneys suitable for transplantation...
September 2016: Canadian Urological Association Journal
Ahmed I Kamal, Ahmed M Harraz, Ahmed A Shokeir
BACKGROUND: Increasing the living-donor pool by accepting donors with an isolated medical abnormality (IMA) can significantly decrease the huge gap between limited supply and rising demand for organs. There is a wide range of variation among different centres in dealing with these categories of donors. We reviewed studies discussing living kidney donors with IMA, including greater age, obesity, hypertension, microscopic haematuria and nephrolithiasis, to highlight the effect of these abnormalities on both donor and recipient sides from medical and surgical perspectives...
December 2011: Arab Journal of Urology
Tobias August Siemens, Itamara Pereira Danucalov, Alexandre Tortoza Bignelli, Sílvia Regina Hokazono, Luiz Sérgio Santos, Fernando Meyer, Ziliane Caetano Lopes Martins, Miguel Carlos Riella
INTRODUCTION: The difference between available kidneys and the number of patients on waiting list for kidney transplantation continues to grow. For this reason the trend is to use donors with expanded criteria, such as a pelvic kidney, as we describe below. CASE REPORT: Male patient 25 years-old with end-stage kidney disease, receives as a graft a pelvic kidney from his father, 49 years-old, known to have controlled systemic arterial hypertension and nephrolithiasis by history without new episodes in the last 10 years...
July 2015: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Guo-Yong Chen, Si-Dong Wei, Zhong-Wu Zou, Gao-Feng Tang, Jian-Jun Sun, Shao-Tang Zhou
Primary hyperoxaluria type I (PH1), the most severe form of primary hyperoxalurias, is a liver disease of the metabolic defect in glyoxylate detoxification that can be corrected by liver transplantation. A 21-year-old man presented to our center after 4 months of regular hemodialysis for kidney failure caused by nephrolithiasis. A diagnosis of PH1 was confirmed by mutations of the AGXT gene. Left lateral sectionectomy of the native liver was performed; and auxiliary partial orthotopic liver transplantation (APOLT) and kidney transplantation were carried out synchronously using a living donor...
August 2015: Medicine (Baltimore)
He-jia Yuan, Dian-dong Yang, Yuan-shan Cui, Chang-ping Men, Zhen-li Gao, L Shi, Ji-tao Wu
PURPOSE: Urolithiasis is a rare complication of renal transplantation, and there is limited evidence to guide treatment. Management of stones in the transplanted kidney can be challenging. We present our experience in treating upper urinary tract (UUT) allograft lithiasis using minimally invasive procedures, with the aim of demonstrating their efficacy and safety in renal transplant recipients. METHODS: The records of 1615 patients undergoing kidney transplantation and follow-up in our center between August 2000 and July 2014 were reviewed...
December 2015: World Journal of Urology
Paweł Cichocki, Marian Surma, Wojciech Woźnicki, Małgorzata Bieńkiewicz, Anna Płachcińska, Jacek Kuśmierek
BACKGROUND: The clinical significance of MTT and PTT, determined by deconvolution of renographic curves, is arguable. Their usefulness in diagnosis of obstructive uro- and nephropathy, renovascular hypertension and monitoring of transplanted kidneys is pointed out, but susceptibility of deconvolution methods to errors resulting from "statistical noise" is also stressed. So far there are no reports on normative MTT values for 99mTc-EC, although such values were already determined for ¹³¹I-OIH, 99mTc-DTPA and 99mTc-MAG3...
2015: Nuclear Medicine Review. Central & Eastern Europe
María E Arteaga, Walter Hunziker, Audrey S M Teo, Axel M Hillmer, Osvaldo M Mutchinick
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis is a rare autosomal recessive renal disease caused by mutations in genes for the tight junction transmembrane proteins Claudin-16 (CLDN16) and Claudin-19 (CLDN19). We present the first case report of a Mexican family with three affected sisters carrying a p.Gly20Asp mutation in CLDN19 whose heterozygous mother showed evident hypercalciuria and normal low magnesemia without any other clinical, laboratory, and radiological symptoms of renal disease making of her an unsuitable donor...
February 2015: Renal Failure
Emad Rizkala, Sarah Coleman, Christine Tran, Wahib Isac, Stuart M Flechner, David Goldfarb, Manoj Monga
BACKGROUND AND PURPOSE: Historically, patients wishing to donate their kidney to living related recipients were deemed ineligible if preoperative imaging demonstrated nephrolithiasis. We assess the outcomes of donors with nephrolithiasis and the outcomes of their recipients. METHODS: Donors undergoing nephrectomy between 2001 and 2011 who had nephrolithiasis on preoperative computed tomography (CT) imaging or a history of stone passage were identified. A retrospective chart review documented donor and recipient demographics, donor 24-hour urine collections, stone size and location, stone events after transplant, and graft function...
December 2013: Journal of Endourology
Emad Rizkala, Sarah Coleman, Christine Tran, Wahib Isac, Stuart M Flechner, David Goldfarb, Manoj Monga
Introduction: Historically patients wishing to donate their kidney to living related recipients were deemed ineligible if pre-operative imaging demonstrated nephrolithiasis. We assess the outcomes of donors with nephrolithiasis and the outcomes of their recipients. Methods: Donors undergoing nephrectomy between 2001-2011 who had nephrolithiasis on preoperative CT imaging or a history of stone passage were identified. A retrospective chart review documented donor and recipient demographics, donor 24-hour urine collections, stone size and location, stone events following transplant and graft function...
September 2, 2013: Journal of Endourology
M Ferreira Cassini, A J Cologna, M Ferreira Andrade, G J Lima, U Medeiros Albuquerque, A C Pereira Martins, S Tucci Junior
BACKGROUND: Renal transplantation remains the optimal treatment of patients with end-stage renal disease. Urinary lithiasis represents an unusual urologic complication in renal transplantation, with an incidence of <1%. Today, recipients of kidneys from deceased donors are more likely to receive grafts with undiagnosed lithiasis, which does not occur in patients from living donors, owing to screening with computerized tomography. OBJECTIVE: The aim of this study was to evaluate the incidence, diagnosis, and therapeutic management of renal lithiasis in transplanted kidneys at a single institution...
October 2012: Transplantation Proceedings
Tomohide Hori, Toshimi Kaido, Nobuyuki Tamaki, Yasuko Toshimitsu, Kohei Ogawa, Shinji Uemoto
A 32-year-old male was suspected to have primary hyperoxaluria type 1 (PH1) and eventually underwent liver transplantation (LT). He was diagnosed with nephrolithiasis at 9 years of age. Right heminephrectomy was performed for a staghorn calculus. He underwent urethrotomy for urinary retention at 12 years of age. Percutaneous nephrolithotomy was performed for nephrolithiasis when he was 16 years of age. He underwent frequent extracorporeal shock wave lithotripsy for recurrent nephrolithiasis from 18 to 24 years of age...
October 2013: Surgery Today
David D Lee, Christie W Gooden, Satish N Nadig, Christopher J Sonnenday, Chad Abbott, John C Magee, Michael J Englesbe, Jeff D Punch, Milagros Samaniego, Robert M Merion, Randall S Sung
Since renal transplantation is the definitive therapy for most patients with end stage renal disease, we have the challenge of meeting the needs of this rapidly growing population. Currently greater than 1000 patients are waiting for kidney transplantation at the University of Michigan. To meet this demand we have aggressively expanded the donor pool from both deceased and living donors. The focus of this update has been the evolving living donor program at the University of Michigan. In light of the rising rates of obesity in America, we have developed a specialized evaluation to assess potential obese donors...
2011: Clinical Transplants
Amarpali Brar, Rahul M Jindal, Kevin C Abbott, Frank P Hurst, Moro O Salifu
INTRODUCTION: The current pattern of evaluation for living kidney donors was investigated. METHODS: We designed a 37-question electronic survey to collect information about living kidney donor evaluation. Of the 181 United Network for Organ Sharing (UNOS)-approved centers, 72 responded. Survey responses were coded and downloaded into SPSS. Data was expressed as means and standard deviations or the percentage of centers with specific responses. RESULTS: 66% of the centers used a cut-off of <80 ml/min for exclusion of living kidney donors...
2012: American Journal of Nephrology
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