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Qian Guo, Hailong Hu, Ying Zhou, Yuheng Yan, Xiangjuan Wei, Xingpei Fan, Daqian Yang, Hongjuan He, Yuri Oh, Kun Chen, Qiong Wu, Chuanpeng Liu, Ning Gu
Glucosamine (GlcN) is a dietary supplement that is widely used to promote joint health. Reports have demonstrated that oral GlcN adversely affects glucose metabolism. Here, we found that oral administration of GlcN induced insulin resistance (IR) and increased plasma glucose levels in mice. Musclin is a muscle-secreted cytokine that participates in the development and aggravation of diabetes. In this study, we found that increased expression of the musclin plays a pathogenic role in GlcN-induced IR in mice...
December 30, 2018: Food and Chemical Toxicology
Avisek Majumder, Mahavir Singh, Akash K George, Rubens Petit Homme, Anwesha Laha, Suresh C Tyagi
Higher levels of nonprotein amino acid homocysteine (Hcy), that is, hyperhomocysteinemia (HHcy) (~5% of general population) has been associated with severe vasculopathies in different organs; however, precise molecular mechanism(s) as to how HHcy plays havoc with body's vascular networks are largely unknown. Interventional modalities have not proven beneficial to counter multifactorial HHcy's effects on the vascular system. An ancient Indian form of exercise called 'yoga' causes transient ischemia as a result of various body postures however the cellular mechanisms are not clear...
January 2019: Journal of Cellular Biochemistry
Caitlin Schafer, Vicky Moore, Nupur Dasgupta, Sabzali Javadov, Jeanne F James, Alexander I Glukhov, Arnold W Strauss, Zaza Khuchua
Aim: Tafazzin knockdown (TazKD) in mice is widely used to create an experimental model of Barth syndrome (BTHS) that exhibits dilated cardiomyopathy and impaired exercise capacity. Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that play essential roles as transcription factors in the regulation of carbohydrate, lipid, and protein metabolism. We hypothesized that the activation of PPAR signaling with PPAR agonist bezafibrate (BF) may ameliorate impaired cardiac and skeletal muscle function in TazKD mice...
2018: Frontiers in Pharmacology
Jaime Gallo-Villegas, Juan Carlos Aristizabal, Mauricio Estrada, Luis H Valbuena, Raul Narvaez-Sanchez, Jorge Osorio, Daniel C Aguirre-Acevedo, Juan C Calderón
BACKGROUND: Evidence of the efficacy of high-intensity, low-volume interval training (HIIT-low volume) in treating insulin resistance (IR) in patients with metabolic disorders is contradictory. In addition, it is unknown whether this effect is mediated through muscle endocrine function, which in turn depends on muscle mass and fiber type composition. Our aims were to assess the efficacy of HIIT-low volume compared to continuous aerobic exercise (CAE) in treating IR in adults with metabolic syndrome (MS) and to establish whether musclin, apelin, muscle mass and muscle composition are mediators of the effect...
February 27, 2018: Trials
Weizhen Li, Hongqiang Zhang, Shuai Qi, Jian Qin, Hong Guan, Jianwei Li, Xiaorong An, Rong Du
Musclin is a bioactive factor that functions in regulating the muscle growth and metabolism. To investigate the transcriptional regulatory mechanism of the gene, the 1.4 kb musclin promoter in sheep was cloned (GenBank accession: JX966391) and the sequence was analyzed to predict the motifs associated with muscle growth. Next the enhanced green fluorescent protein (EGFP) was selected as the reporter gene and various wild-type and motif-mutant vectors were constructed. The transcriptional regulatory activities were compared by observing the fluorescence strength and detecting the EGFP mRNA expression in C2C12 myoblasts transfected with the vectors...
October 5, 2017: DNA and Cell Biology
Wen-Jia Chen, Yue Liu, Yu-Bin Sui, Hong-Tao Yang, Jin-Rui Chang, Chao-Shu Tang, Yong-Fen Qi, Jing Zhang, Xin-Hua Yin
BACKGROUND: Musclin is a novel skeletal muscle-derived secretory factor considered to be a potent regulator of the glucose metabolism and therefore may contribute to the pathogenesis of obesity and insulin resistance (IR). METHODS: To test this hypothesis, we examined the plasma musclin levels in overweight/obese subjects and lean controls. Rats on a high fat diet (HFD) were used as the annimal model of obesity. Radioimmunoassay and western blot were used to determine musclin levels in plasma and skeletal muscle...
2017: Nutrition & Metabolism
Naoki Nishizawa, Goshi Nakamura, Yoko Noguchi, Hideyuki Nakagawa, Ayako Shimizu, Masaharu Nakayama, Shiro Takekawa, Taiji Asami
The natriuretic peptide (NP) system is a critical endocrine, autocrine, and paracrine system and has been investigated for potential use against cardiovascular and metabolic diseases. The clearance of NPs is regulated by the proteolysis of neutral endopeptidase (NEP) and by endocytosis via natriuretic peptide receptor-3 (NPR3). A linear NPR3-selective peptide, [Cha8 ]-ANP(7-16)-NH2 (1), showed potent binding affinity for NPR3 but poor predicted chemical stability due to its free thiol group. A 12-mer peptide (9) without a thiol group was designed by the hybridization of two NPR3-binding peptides: a linear ANP fragment peptide analog and musclin, a murine member of the bHLH family of transcription factors, possessed high binding affinity and strict selectivity for NPR3...
August 1, 2017: Bioorganic & Medicinal Chemistry Letters
Wen-Jia Chen, Yue Liu, Yu-Bin Sui, Bo Zhang, Xiao-Hui Zhang, Xin-Hua Yin
BACKGROUND: Musclin is a newly identified skeletal muscle-derived secretory factor, which has been recently characterized as a stimulator that induces insulin resistance in mice. However, the pathophysiological role of musclin in humans remains poorly understood. The aim of this study was to explore the potential correlations between musclin plasma levels and various metabolic parameters in patients with type 2 diabetes mellitus. MATERIALS AND METHODS: In this hospital-based study, plasma samples were collected from the enrolled individuals, including 38 newly diagnosed, treatment-naive type 2 diabetes mellitus patients and 41 age- and gender-matched control subjects...
March 2017: Diabetes & Vascular Disease Research
Alex A Pollen, Arnold R Kriegstein
Sensory experience evokes long-lasting changes in neural circuits through activity-dependent gene expression. Ataman et al. (2016) report in Nature that primates evolved novel transcriptional responses to neuronal activity, including induction of musclin/osteocrin (OSTN), which may regulate specialized aspects of primate neural circuits.
November 23, 2016: Neuron
Nevena Jeremic, Pankaj Chaturvedi, Suresh C Tyagi
What is more interesting about brown adipose tissue (BAT) is its ability to provide thermogenesis, protection against obesity by clearing triglycerides, releasing batokines, and mitigating insulin resistance. White adipose tissue (WAT) on the other hand stores excess energy and secretes some endocrine factors like leptin for regulating satiety. For the last decade there has been an increasing interest in the browning of fat keeping in view its beneficial effects on metabolic disorders and protection in the form of perivascular fat...
January 2017: Journal of Cellular Physiology
J Yu, J Zheng, X F Liu, Z L Feng, X P Zhang, L L Cao, Z P Zhou
This study aimed to evaluate the effects of exercise training on triglyceride deposition and the expression of musclin and glucose transporter 4 (GLUT4) in a rat model of insulin resistance. Thirty male Sprague-Dawley rats (8 weeks old, weight 160±10 g) were fed a high-fat diet (40% calories from fat) and randomly divided into high-fat control group and swimming intervention group. Rats fed with standard food served as normal control. We found that 8-week swimming intervention significantly decreased body weight (from 516...
2016: Brazilian Journal of Medical and Biological Research
Ana Sierra, Ekaterina Subbotina, Zhiyong Zhu, Zhan Gao, Siva Rama Krishna Koganti, William A Coetzee, David J Goldhamer, Denice M Hodgson-Zingman, Leonid V Zingman
Sarcolemmal ATP-sensitive potassium (KATP) channels control skeletal muscle energy use through their ability to adjust membrane excitability and related cell functions in accordance with cellular metabolic status. Mice with disrupted skeletal muscle KATP channels exhibit reduced adipocyte size and increased fatty acid release into the circulation. As yet, the molecular mechanisms underlying this link between skeletal muscle KATP channel function and adipose mobilization have not been established. Here, we demonstrate that skeletal muscle-specific disruption of KATP channel function in transgenic (TG) mice promotes production and secretion of musclin...
February 26, 2016: Biochemical and Biophysical Research Communications
Ekaterina Subbotina, Ana Sierra, Zhiyong Zhu, Zhan Gao, Siva Rama Krishna Koganti, Santiago Reyes, Elizabeth Stepniak, Susan A Walsh, Michael R Acevedo, Carmen M Perez-Terzic, Denice M Hodgson-Zingman, Leonid V Zingman
Exercise remains the most effective way to promote physical and metabolic wellbeing, but molecular mechanisms underlying exercise tolerance and its plasticity are only partially understood. In this study we identify musclin-a peptide with high homology to natriuretic peptides (NP)-as an exercise-responsive myokine that acts to enhance exercise capacity in mice. We use human primary myoblast culture and in vivo murine models to establish that the activity-related production of musclin is driven by Ca(2+)-dependent activation of Akt1 and the release of musclin-encoding gene (Ostn) transcription from forkhead box O1 transcription factor inhibition...
December 29, 2015: Proceedings of the National Academy of Sciences of the United States of America
Ning Gu, Qian Guo, Ke Mao, Hailong Hu, Sanli Jin, Ying Zhou, Hongjuan He, Yuri Oh, Chuanpeng Liu, Qiong Wu
Musclin is a type of muscle-secreted cytokine and its increased gene expression induces insulin resistance in type 2 diabetes. However, the mechanism underlying increased musclin gene expression is currently unclear. Excessive saturated fatty acids (SFA) can activate the secretion of several muscle-secreted cytokines as well as endoplasmic reticulum (ER) stress pathway, thereby contributing to the development of type 2 diabetes. The purpose of this study was to investigate the mechanisms responsible for the effect of palmitate, the most abundant SFA in the plasma, on the gene expression of musclin in C2C12 myotubes...
November 20, 2015: Biochemical and Biophysical Research Communications
Jia-Wei Lin, Cheng-Chia Tsai, Li-Jen Chen, Ho-Shan Niu, Chen Kuei Chang, Chiang-Shan Niu
Musclin is a novel skeletal muscle-derived factor found in the signal sequence trap of mouse skeletal muscle cDNAs. Recently, it has been demonstrated that musclin is involved in the pathogenesis of spontaneously hypertensive rats (SHRs). However, it is known as a genetic hypertension model. In the present study, we aim to investigate the role of musclin in another animal model of hypertension and characterize the direct effect of musclin on vascular contraction. The results show that expression of musclin was increased in arterial tissues isolated from DOCA-salt induced hypertensive rats or the normal rats received repeated vasoconstriction with phenylephrine...
2014: BioMed Research International
Ying-Xiao Li, Kai-Chun Cheng, Akihiro Asakawa, Ikuo Kato, Yuki Sato, Haruka Amitani, Namiko Kawamura, Juei-Tang Cheng, Akio Inui
Musclin is a novel skeletal muscle-derived secretory factor found in the signal sequence trap of mouse skeletal muscle cDNAs. Musclin possesses a region homologous to the natriuretic peptide family. Thus, musclin is found to bind with the natriuretic peptide clearance receptors. However, the role of musclin in vascular regulation remains unclear. In this study, we aim to investigate the direct effect of musclin on vascular tone and to analyze its role in hypertension using the spontaneously hypertensive rats (SHR)...
2013: PloS One
Wen-Jia Chen, Yu-Bin Sui, Xin-Hua Yin
No abstract text is available yet for this article.
February 2012: Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
Nicole H Rogers, James W Perfield, Katherine J Strissel, Martin S Obin, Andrew S Greenberg
Menopause, the age-related loss of ovarian hormone production, promotes increased adiposity and associated metabolic pathology, but molecular mechanisms remain unclear. We previously reported that estrogen increases skeletal muscle PPARdelta expression in vivo, and transgenic mice overexpressing muscle-specific PPARdelta are reportedly protected from diet-induced obesity. We thus hypothesized that obesity observed in ovariectomized mice, a model of menopause, may result in part from abrogated expression of muscle PPARdelta and/or downstream mediators such as FoxO1...
January 29, 2010: Biochemical and Biophysical Research Communications
Shunbun Kita, Hitoshi Nishizawa, Yosuke Okuno, Masaki Tanaka, Atsutaka Yasui, Morihiro Matsuda, Yukio Yamada, Iichiro Shimomura
Musclin is a novel skeletal muscle-derived secretory factor that was isolated by our group. Musclin contains a region homologous to natriuretic peptides (NPs). This study investigated the interaction between musclin and NP receptors (NPRs). Musclin specifically bound to NPR3, but not to NPR1 or NPR2. Musclin and atrial natriuretic peptide (ANP) competed for binding to NPR3. We conducted binding assays using various synthetic musclin peptides and mutant musclin proteins. The first NP-homologous region in musclin ((88)LDRL(91)) and the second homologous region ((117)MDRI(120)) were responsible cooperatively for high-affinity binding to NPR3...
May 2009: Journal of Endocrinology
Weijie Wang, Hongji Li, Liqiang Han, Yueying Wang, Jing Wang, Weihua Li, Maowang Lin, Yulei Tai, Zhiqiang Zhang, Meng Zang, Yanling Wang, Guoyu Yang
We found seven tag sequence with high homology in dbEST by using human musclin gene, and got its cDNA sequence, which consists of 651bp and the open reading frame was 54-452 bp detected by RT-PCR, encoding 132 amino acid residue protein. The new gene has high homology with that of human, mouse and rat, the rate is 87.2%, 77.6% and 77.9%, respectively; the gene fragment was cloned into expression vector pGEX-4T-1, and the recombinant was transformed into E. coli BL21. Induced by IPTG, the fusion protein GST-musclin, a 38...
July 2008: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
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