keyword
https://read.qxmd.com/read/38547465/tackling-access-and-payer-barriers-for-growth-hormone-therapy-in-saudi-arabia-a-consensus-statement-for-the-saudi-working-group-for-pediatric-endocrinology
#1
REVIEW
Najya Attia, Khairya Moussa, Abdulaziz Altwaim, Abdulmoein Eid Al-Agha, Ashraf A Amir, Aseel Almuhareb
Prompt diagnosis and early treatment are key goals to optimize the outcomes of children with growth hormone deficiency (GHD) and attain the genetically expected adult height. Nonetheless, several barriers can hinder prompt diagnosis and treatment of GHD, including payer-related issues. In Saudi Arabia, moderate-to-severe short stature was reported in 13.1 and 11.7 % of healthy boys and girls, respectively. Several access and payer barriers can face pediatric endocrinologists during the diagnosis and treatment of GHD in Saudi Arabia...
March 29, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38547425/durable-responses-with-mosunetuzumab-in-relapsed-refractory-indolent-and-aggressive-b-cell-non-hodgkin-lymphomas-extended-follow-up-of-a-phase-i-ii-study
#2
JOURNAL ARTICLE
Lihua E Budde, Sarit Assouline, Laurie H Sehn, Stephen J Schuster, Sung-Soo Yoon, Dok Hyun Yoon, Matthew J Matasar, Francesc Bosch, Won Seog Kim, Loretta J Nastoupil, Ian W Flinn, Mazyar Shadman, Catherine Diefenbach, Chan Yoon Cheah, Connie Y Ma, Huang Huang, Antonia Kwan, Michael C Wei, Shen Yin, Nancy L Bartlett
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. Mosunetuzumab is a CD20xCD3 T-cell-engaging bispecific antibody administered as an off-the-shelf, fixed-duration treatment in an outpatient setting...
March 28, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38547335/impact-of-iodine-supply-in-infancy-and-childhood
#3
JOURNAL ARTICLE
Dominique Turck
PURPOSE OF REVIEW: To assess the most relevant articles on the impact of iodine supply in at-risk populations, namely infants and young children, pregnant and lactating women. RECENT FINDINGS: The 2022 Iodine Global Network Annual Report confirmed the dramatic decrease of severe iodine deficiency over the last 30 years, thanks to universal iodine iodization. However, mild to moderate deficiency is still present in many countries, where recent data showed a decrease of iodine intake and an impairment of iodine status...
March 28, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38547217/factors-related-to-a-sense-of-economic-insecurity-among-older-adults-who-participate-in-social-activities
#4
JOURNAL ARTICLE
Yuriko Inoue, Hisae Nakatani, Ichie Ono, Xuxin Peng
Japan has the highest life expectancy worldwide. Older adults who experience economic insecurity may refrain from seeking medical consultation or using long-term care insurance, and these behaviors may increase the incidence and progression of frailty. This study conducted a cross-sectional survey to identify factors related to a sense of economic insecurity among older adults who participate in social activities, and identified support measures. In total, 1,351 older adults aged ≥65 years who had participated in social activities voluntarily completed an anonymous self-administered questionnaire...
2024: PloS One
https://read.qxmd.com/read/38547040/diagnostic-neuromuscular-ultrasound-to-confirm-clinical-significance-of-a-genetic-variant-for-charcot-marie-tooth-type-4c-a-case-report
#5
JOURNAL ARTICLE
James B Meiling, Vanessa Baute Penry
Neuromuscular ultrasound (NMUS) has emerged as a beneficial, complementary tool to EMG in the diagnosis of neuromuscular diseases as it provides high-resolution anatomic imaging of peripheral nerves and muscles. It has been used previously as an adjunct to EMG to diagnose Charcot-Marie-Tooth disease (CMT). Here, we present a case of a 64-year-old male with bilateral sensorineural hearing loss of 14 years who presented to an outpatient neuromuscular clinic at a tertiary medical center with very slow progressive paresthesias...
March 26, 2024: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/38547024/tuberculosis-united-states-2023
#6
JOURNAL ARTICLE
Paula M Williams, Robert H Pratt, William L Walker, Sandy F Price, Rebekah J Stewart, Pei-Jean I Feng
After 27 years of declining U.S. tuberculosis (TB) case counts, the number of TB cases declined considerably in 2020, coinciding with the COVID-19 pandemic. For this analysis, TB case counts were obtained from the National TB Surveillance System. U.S. Census Bureau population estimates were used to calculate rates overall, by jurisdiction, birth origin, race and ethnicity, and age group. Since 2020, TB case counts and rates have increased each year. During 2023, a total of 9,615 TB cases were provisionally reported by the 50 U...
March 28, 2024: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/38547003/plain-language-summary-of-the-transform-study-primary-analysis-results-liso-cell-as-a-second-treatment-regimen-for-large-b-cell-lymphoma-following-failure-of-the-first-treatment-regimen
#7
REVIEW
Jeremy S Abramson, Scott R Solomon, Jon Arnason, Patrick B Johnston, Bertram Glass, Veronika Bachanova, Sami Ibrahimi, Stephan Mielke, Pim Mutsaers, Francisco Hernandez-Ilizaliturri, Koji Izutsu, Franck Morschhauser, Matthew Lunning, Alessandro Crotta, Sandrine Montheard, Alessandro Previtali, Ken Ogasawara, Manali Kamdar
WHAT IS THIS SUMMARY ABOUT?: People diagnosed with a disease called large B-cell lymphoma (LBCL) may experience return, or early relapse, of their disease within the first year after receiving and responding to their first (first-line) treatment regimen. Others may have primary refractory disease, meaning that the disease either did not respond to first-line treatment at all or only responded for a very brief period. Second (second-line) treatment includes immunotherapy followed by high-dose chemotherapy and ASCT, which has the potential to cure LBCL...
March 28, 2024: Future Oncology
https://read.qxmd.com/read/38547000/mixed-supervision-of-histopathology-improves-prostate-cancer-classification-from-mri
#8
JOURNAL ARTICLE
Abhejit Rajagopal, Antonio C Westphalen, Nathan Velarde, Jeffry P Simko, Hao Nguyen, Thomas A Hope, Peder E Z Larson, Kirti Magudia
Non-invasive prostate cancer classification from MRI has the potential to revolutionize patient care by providing early detection of clinically significant disease, but has thus far shown limited positive predictive value. To address this, we present a image-based deep learning method to predict clinically significant prostate cancer from screening MRI in patients that subsequently underwent biopsy with results ranging from benign pathology to the highest grade tumors. Specifically, we demonstrate that mixed supervision via diverse histopathological ground truth improves classification performance despite the cost of reduced concordance with image-based segmentation...
March 28, 2024: IEEE Transactions on Medical Imaging
https://read.qxmd.com/read/38546985/reporting-health-consequences-of-war-in-medical-journals-first-do-no-harm
#9
JOURNAL ARTICLE
Philip Greenland, Oren Lakser, Lisa Lipschutz
No abstract text is available yet for this article.
March 28, 2024: JAMA
https://read.qxmd.com/read/38546979/reporting-on-health-and-war-in-medical-journals
#10
JOURNAL ARTICLE
Gregory Curfman, Kirsten Bibbins-Domingo
No abstract text is available yet for this article.
March 28, 2024: JAMA
https://read.qxmd.com/read/38546936/implications-of-vascular-depression-for-successful-cognitive-aging-in-hiv-disease
#11
JOURNAL ARTICLE
Andrea I Mustafa, Ilex Beltran-Najera, Darrian Evans, Alexandria Bartlett, Vonetta M Dotson, Steven Paul Woods
Although older adults with HIV are at high risk for mild neurocognitive disorders, a subset experience successful cognitive aging (SCA). HIV is associated with an increased risk of vascular depression (VasDep), which can affect cognitive and daily functioning. The current study examined whether VasDep impedes SCA among older adults with HIV. 136 persons with HIV aged 50 years and older were classified as either SCA+ (n = 37) or SCA- (n = 99) based on a battery of demographically adjusted neurocognitive tests and self-reported cognitive symptoms...
March 28, 2024: Journal of Neurovirology
https://read.qxmd.com/read/38546873/decision-regret-of-cancer-patients-after-radiotherapy-results-from-a-cross-sectional-observational-study-at-a-large-tertiary-cancer-center-in-germany
#12
JOURNAL ARTICLE
Alexander Rühle, Leonie Wieland, Andreas Hinz, Anja Mehnert-Theuerkauf, Nils H Nicolay, Clemens Seidel
PURPOSE: The decision-making process regarding cancer treatment is emotionally challenging for patients and families, harboring the risk of decision regret. We aimed to explore prevalence and determinants of decision regret following radiotherapy. METHODS: This cross-sectional observational study was conducted at a tertiary cancer center to assess decision regret following radiotherapy. The study employed the German version of the Ottawa Decision Regret Scale (DRS) which was validated in the study population...
March 28, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38546867/prosecuting-cases-of-abusive-head-trauma-in-switzerland-a-descriptive-study-of-the-impact-of-medical-documentation-and-delay-of-reporting-on-judicial-outcome
#13
JOURNAL ARTICLE
Sarah Held, Jean-Jacques Cheseaux, Jean-François Tolsa, Sarah Depallens
Abusive head trauma (AHT) is a criminal offence that is prosecuted ex officio, following report to the police from physicians or child protection services. The aim of this study was to assess whether the judicial outcome (dismissal vs indictment) was influenced by the quality of the medical documentation and/or the time span between AHT diagnosis and reporting child abuse to the police. The cohort was divided in two groups: 13/23 dismissals (57%) and 10/23 indictments (43%). The diagnostic probability of the AHT cases was certain for both groups...
March 28, 2024: International Journal of Legal Medicine
https://read.qxmd.com/read/38546861/long-term-survival-and-clinical-outcomes-of-delayed-chest-closure-following-lung-transplantation
#14
JOURNAL ARTICLE
Takashi Hirama, Miki Akiba, Masahiro Ui, Saori Shibata, Fumiko Tomiyama, Tatsuaki Watanabe, Yui Watanabe, Hirotsugu Notsuda, Takaya Suzuki, Hisashi Oishi, Hiromichi Niikawa, Masafumi Noda, Yoshinori Okada
PURPOSES: Delayed chest closure (DCC) is a widely accepted procedure in the context of lung transplantation (LTx); yet there are few reports detailing its long-term survival and clinical outcomes. METHODS: We reviewed the medical records of recipients who underwent deceased-donor lung transplantation (LTx) at Tohoku University Hospital. Long-term survival, including overall survival, freedom from chronic lung allograft dysfunction (CLAD), and CLAD-free survival and the clinical outcomes of graft function and physical performance and constitution were reviewed in recipients with DCC...
March 28, 2024: Surgery Today
https://read.qxmd.com/read/38546788/publication-bias-in-upper-gastrointestinal-oncology-clinical-trials
#15
JOURNAL ARTICLE
Trenton Lippert, Erin Schmucker, Anchal Shukla, Ruha Reddy, Pooja Neerumalla, Gabriella Blanco, Vic Velanovich
PURPOSE: Evidence-based medicine requires evaluation of the medical literature to guide clinical reasoning and treatment recommendations. The presence of publication bias towards exclusion of non-statistically significant clinical trials may be leading to an incomplete evaluation of the literature and cause potentially incomplete guidance for patients. We aimed to compare publication rates and impact of publications of positive and negative outcome clinical trials. METHODS: We queried the US National Library of Medicine Clinical Trials database identifying clinical trials with reported results on the topics of pancreatic, liver, and gastric cancer...
March 28, 2024: Journal of Gastrointestinal Cancer
https://read.qxmd.com/read/38546773/exploring-how-a-patient-encounter-tracking-and-learning-tool-is-used-within-general-practice-training-a-qualitative-study
#16
JOURNAL ARTICLE
Michael Bentley, Jennifer Taylor, Alison Fielding, Andrew Davey, Dominica Moad, Mieke van Driel, Parker Magin, Linda Klein
Introduction In Australian general practitioner (GP) training, feedback and reflection on in-practice experience is central to developing GP registrars' (trainees') clinical competencies. Patient encounter tracking and learning tools (PETALs) that encompass an audit of consecutive patient consultations, feedback, and reflection are used to determine registrars' in-practice exposure and have been suggested as a tool for learning within a programmatic assessment framework. However, there is limited qualitative literature on the utility of PETALs in GP training...
March 2024: Journal of Primary Health Care
https://read.qxmd.com/read/38546771/the-impact-of-nurse-prescribing-on-health-care-delivery-for-patients-with-diabetes-a-rapid-review
#17
JOURNAL ARTICLE
Kylie Short, Cathy Andrew, Wenting Yang, Isabel Jamieson
Introduction The global prevalence of diabetes is a pressing public health concern. Over 400 million individuals live with the effects of the disease, predominantly in low- and middle-income countries. In Aotearoa New Zealand (NZ), over 300 000 people have diabetes, resulting in a population rate of 43.1 per 1000. Enabling nurses to prescribe diabetes medications enhances accessibility and improves health outcomes for large sections of the population. Aim This rapid review was undertaken to investigate the influence of nurse prescribing on health care delivery for individuals with diabetes in NZ, Australia, the United Kingdom, and Canada, countries sharing comparable health care systems and multicultural backgrounds...
March 2024: Journal of Primary Health Care
https://read.qxmd.com/read/38546767/perceptions-of-the-effectiveness-of-using-patient-encounter-data-as-an-education-and-reflection-tool-in-general-practice-training
#18
JOURNAL ARTICLE
Linda Klein, Michael Bentley, Dominica Moad, Alison Fielding, Amanda Tapley, Mieke van Driel, Andrew Davey, Ben Mundy, Kristen FitzGerald, Jennifer Taylor, Racheal Norris, Elizabeth Holliday, Parker Magin
Introduction Patient encounter tools provide feedback and potentially reflection on general practitioner (GP) registrars' in-practice learning and may contribute to the formative assessment of clinical competencies. However, little is known about the perceived utility of such tools. Aim To investigate the perceived utility of a patient encounter tool by GP registrars, their supervisors, and medical educators (MEs). Methods General practice registrars, supervisors and MEs from two Australian regional training organisations completed a cross-sectional questionnaire...
March 2024: Journal of Primary Health Care
https://read.qxmd.com/read/38546728/a-mobile-app-concerto-to-empower-hospitalized-patients-in-a-swiss-university-hospital-development-design-and-implementation-report
#19
JOURNAL ARTICLE
Damien Dietrich, Helena Bornet Dit Vorgeat, Caroline Perrin Franck, Quentin Ligier
BACKGROUND: Patient empowerment can be associated with better health outcomes, especially in the management of chronic diseases. Digital health has the potential to promote patient empowerment. OBJECTIVE: Concerto is a mobile app designed to promote patient empowerment in an in-patient setting. This implementation report focuses on the lessons learned during its implementation. METHODS: The app was conceptualized and prototyped during a hackathon...
March 28, 2024: JMIR Medical Informatics
https://read.qxmd.com/read/38546452/exploring-the-diversity-of-vaginal-microbiota-between-healthy-women-and-cervical-cancer-patients-in-india
#20
JOURNAL ARTICLE
Ashwini Kamble, Shilpa Naik, Manju Talathi, Deepali Jadhav, Meena Sakharkar, Jian Yang, Om Prakash, Ruchika Kaul-Ghanekar
Introduction. Cervicovaginal diversity has been reported as a predictive biomarker for cervical cancer risk. We recently reported the bio-therapeutic potential of vaginal probiotics from healthy Indian women against vaginal pathogens, isolated from the invasive cervical cancer (ICC) patients. Gap Statement. The cervicovaginal microflora from cervical cancer patients has not yet been reported from Indian population. Aim. The present study aimed at comparing the cervicovaginal microbiome between healthy controls (HC) and ICC patients from the Indian population...
March 2024: Journal of Medical Microbiology
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