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JOURNAL ARTICLE
Ruth Johnson, Alexis V Stephens, Rachel Mester, Sergey Knyazev, Lisa A Kohn, Malika K Freund, Leroy Bondhus, Brian L Hill, Tommer Schwarz, Noah Zaitlen, Valerie A Arboleda, Lisa A Bastarache, Bogdan Pasaniuc, Manish J Butte
Human inborn errors of immunity include rare disorders entailing functional and quantitative antibody deficiencies due to impaired B cells called the common variable immunodeficiency (CVID) phenotype. Patients with CVID face delayed diagnoses and treatments for 5 to 15 years after symptom onset because the disorders are rare (prevalence of ~1/25,000), and there is extensive heterogeneity in CVID phenotypes, ranging from infections to autoimmunity to inflammatory conditions, overlapping with other more common disorders...
May 2024: Science Translational Medicine
#2
JOURNAL ARTICLE
Josephine Harrington, Andrew W McCrary, Maggie Nguyen, Winstone Nyandiko, Piers C A Barker, Myra Koech, Nathan M Thielman, Michael J Muehlbauer, Svati H Shah, Gerald S Bloomfield
People with HIV are at increased risk of cardiac dysfunction; however, limited tools are available to identify patients at highest risk for future cardiac disease. We performed proteomic profiling using plasma samples from children and young adults with perinatally acquired HIV without clinical cardiac disease, comparing samples from participants with and without an abnormal myocardial performance index (MPI). We identified four proteins independently associated with subclinical cardiac dysfunction: ST2, CA1, EN-RAGE, and VSIG2...
June 1, 2024: AIDS
#3
JOURNAL ARTICLE
Laurence Meyer, Maarten F Schim van der Loeff
No abstract text is available yet for this article.
June 1, 2024: AIDS
#4
JOURNAL ARTICLE
Ali Vaeli Zadeh, Alexander Justicz, Juan Plate, Michael Cortelli, I-Wen Wang, John Nicholas Melvan
OBJECTIVE: Human immunodeficiency virus infection (HIV+) is associated with a 2-fold increased risk of cardiovascular disease. Increasingly, patients who are HIV + are being evaluated to undergo cardiac surgery. Current risk-adjusted scoring systems, including the Society of Thoracic Surgeons Predicted Risk of Mortality score, fail to stratify HIV + risk. Unfortunately, there exists a paucity of cardiac surgery outcomes data in modern patients who are HIV+. METHODS: We conducted a retrospective review of PearlDiver, an all-payer claims administrative database...
April 2024: JTCVS open
#5
Ali Khreisat, Vickie Xin, Christopher Dado
Granulomatous lymphocytic interstitial lung disease (GL-ILD) is a rare, non-infectious pulmonary manifestation of common variable immunodeficiency (CVID). Diagnosing and managing GLILD remains challenging due to its poorly understood pathogenesis and high mortality. We present a complex case of a young female with CVID associated with lung and spinal cord involvement managed with azathioprine and rituximab.
April 2024: Curēus
#6
JOURNAL ARTICLE
Belayneh Shetie Workneh, Alebachew Ferede Zegeye, Tadesse Tarik Tamir, Enyew Getaneh Mekonen
INTRODUCTION: Risky sexual behavior exposes an individual to the risk of contracting sexually transmitted infections including human immunodeficiency virus (HIV). Even though risky sexual behavior is a devastating problem in low- and middle-income countries, studies on risky sexual behavior and associated factors among reproductive-age women in Eastern African countries are limited. Therefore, this study aimed to assess the magnitude of risky sexual behavior and associated factors among reproductive-age women in Eastern African countries that help to target high-risk groups and set appropriate intervention...
April 30, 2024: BMC Women's Health
#7
MULTICENTER STUDY
Fikre Moga Lencha, Hailemariam Mekonnen Workie, Fikir Tadesse Mequanint, Zenebe Jebero Zaza
BACKGROUND: In environments with limited resources, undernutrition is a serious public health risk. Its dual relationship to human immunodeficiency virus infection (HIV) leads to crises in a child's physical, emotional, social, and economic spheres of life. Nevertheless, little research has been done on the survival rate and risk factors that lead to poor survival outcomes in undernourished children receiving antiretroviral therapy. This study sought to evaluate survival status and its predictors among undernourished children on antiretroviral therapy (ART) in public health facilities, Bahir Dar city, September 1, 2010 - December 31, 2020...
April 30, 2024: BMC Pediatrics
#8
JOURNAL ARTICLE
Yuanjin Song, Lili Sun, Dongning Feng, Qing Sun, Yibing Wang
BACKGROUND: X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disease caused by mutations in the Bruton tyrosine kinase (BTK) gene. Individuals diagnosed with XLA are at an increased risk of developing autoimmune diseases. However, renal involvement are rare in cases of XLA. CASE PRESENTATION: In this report, we discussed a specific case involving a 6-year-old boy with XLA who experienced recurrent upper respiratory tract infections since the age of one...
April 30, 2024: BMC Pediatrics
#9
REVIEW
Gabriela Assunção Goebel, Cíntia Silva de Assis, Luciana Araújo Oliveira Cunha, Fernanda Gontijo Minafra, Jorge Andrade Pinto
This study aims to perform an extensive review of the literature that evaluates various factors that affect the survival rates of patients with severe combined immunodeficiency (SCID) after hematopoietic stem cell transplantation (HSCT) in developed and developing countries. An extensive search of the literature was made in four different databases (PubMed, Embase, Scopus, and Web of Science). The search was carried out in December 2022 and updated in July 2023, and the terms such as "hematopoietic stem cell transplantation," "bone marrow transplant," "mortality," "opportunistic infections," and "survival" associated with "severe combined immunodeficiency" were sought based on the MeSH terms...
April 30, 2024: Clinical Reviews in Allergy & Immunology
#10
JOURNAL ARTICLE
Muhamad Aidil Zahidin, Noor Haslina Mohd Noor, Muhammad Farid Johan, Abu Dzarr Abdullah, Zefarina Zulkafli, Hisham Atan Edinur
The human mannose-binding lectin (MBL) gene encodes a polymorphic protein that plays a crucial role in the innate immune response. Human MBL deficiency is associated with immunodeficiencies, and its variants have been linked to autoimmune and infectious diseases. Despite this significance, gene studies concerning MBL sequencing are uncommon in Malaysia. Therefore, we aimed to preliminary described the human MBL sequencing dataset based on the Kelantan population. Blood samples were collected from 30 unrelated individuals and underwent DNA extraction, genotyping, and sequencing...
April 30, 2024: Scientific Data
#11
JOURNAL ARTICLE
Daniela Cesana, Maria Pia Cicalese, Andrea Calabria, Pietro Merli, Roberta Caruso, Monica Volpin, Laura Rudilosso, Maddalena Migliavacca, Federica Barzaghi, Claudia Fossati, Francesco Gazzo, Simone Pizzi, Andrea Ciolfi, Alessandro Bruselles, Francesca Tucci, Giulio Spinozzi, Giulia Pais, Fabrizio Benedicenti, Matteo Barcella, Ivan Merelli, Pierangela Gallina, Stefania Giannelli, Francesca Dionisio, Serena Scala, Miriam Casiraghi, Luisa Strocchio, Luciana Vinti, Lucia Pacillo, Eleonora Draghi, Marcella Cesana, Sara Riccardo, Chiara Colantuono, Emmanuelle Six, Marina Cavazzana, Filippo Carlucci, Manfred Schmidt, Caterina Cancrini, Fabio Ciceri, Luca Vago, Davide Cacchiarelli, Bernhard Gentner, Luigi Naldini, Marco Tartaglia, Eugenio Montini, Franco Locatelli, Alessandro Aiuti
Hematopoietic stem cell gene therapy (GT) using a γ-retroviral vector (γ-RV) is an effective treatment for Severe Combined Immunodeficiency due to Adenosine Deaminase deficiency. Here, we describe a case of GT-related T-cell acute lymphoblastic leukemia (T-ALL) that developed 4.7 years after treatment. The patient underwent chemotherapy and haploidentical transplantation and is currently in remission. Blast cells contain a single vector insertion activating the LIM-only protein 2 (LMO2) proto-oncogene, confirmed by physical interaction, and low Adenosine Deaminase (ADA) activity resulting from methylation of viral promoter...
April 30, 2024: Nature Communications
#12
JOURNAL ARTICLE
Keita Oya, Hiroyuki Tsuchie, Hiroyuki Nagasawa, Michio Hongo, Yuji Kasukawa, Daisuke Kudo, Ryo Shoji, Fumihito Kasama, Takashi Kawaragi, Manabu Watanabe, Kenta Tominaga, Naohisa Miyakoshi
BACKGROUND/AIM: Developing animal models of bone metastasis in renal cell carcinoma (RCC) is challenging as immunodeficient mice are required. The aim of this study was to develop a simple immune model of RCC bone metastasis. MATERIALS AND METHODS: RENCA tumor cells were injected into the right femurs of BALB/c mice. Sixty mice were grouped into each twenty-mouse group according to the tumor cell concentration, and the presence or absence and extent of bone metastasis in the total length of the femur were compared using hematoxylin and eosin staining of the excised tissues...
2024: In Vivo
#13
JOURNAL ARTICLE
Johanna Chapin-Bardales, Angel B Algarin, Ricardo Baruch-Dominguez, Laramie R Smith, Mauricio Hernandez-Avila, Travis Sanchez
BACKGROUND: Little is known about awareness and willingness to use or purchase HIV pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) in Mexico. METHODS: MSM in Mexico were recruited via advertisements on online social venues to participate in Encuesta de Sexo Entre Hombres, an online behavioral survey. Awareness of PrEP, willingness to take PrEP if available for free, willingness to purchase PrEP, awareness of post-exposure prophylaxis (PEP), and ever PEP use were assessed in descriptive and multivariate analyses...
April 30, 2024: International Journal of STD & AIDS
#14
REVIEW
Sharana Mahomed
SUMMARYThe human immunodeficiency virus (HIV) epidemic remains a formidable global health concern, with 39 million people living with the virus and 1.3 million new infections reported in 2022. Despite anti-retroviral therapy's effectiveness in pre-exposure prophylaxis, its global adoption is limited. Broadly neutralizing antibodies (bNAbs) offer an alternative strategy for HIV prevention through passive immunization. Historically, passive immunization has been efficacious in the treatment of various diseases ranging from oncology to infectious diseases...
April 30, 2024: Clinical Microbiology Reviews
#15
JOURNAL ARTICLE
Bai-Yi Liu, Dan Zhang, Zhu Fan, Jing-Jing Jin, Cai-Hong Li, Rui-Nan Guo, Xue-Juan Li, Yan Huang
OBJECTIVE: To study the etiological characteristics of community-acquired pneumonia (CAP) combined with type 2 diabetes (T2D), providing a reference for early clinical diagnosis and treatment of the disease. METHODS: We selected a total of 93 patients with CAP and analyzed their metagenomics nextgeneration sequencing (mNGS) data. The case group comprised 46 patients with combined CAP/T2D, and the control group comprised 47 patients without diabetes. We analyzed the pathogenic findings of the two groups...
November 22, 2023: Endocrine, Metabolic & Immune Disorders Drug Targets
#16
JOURNAL ARTICLE
Stephanie Farah, Leah Nasr, Jocelyne Eid Fares
BACKGROUND: A far more common disease than Cushing's syndrome is subclinical hypercortisolism or mild autonomous cortisol secretion (MACS), with an overall prevalence of 0.2-2%. OBJECTIVE: This review aims to shed light on the prevalence, screening and diagnostic criteria, comorbidities, and management of Mild Autonomous Cortisol Secretion (MACS). METHODS: Studies eligible targeted MACS regarding prevalence, screening, comorbidities, management, and clinical outcome...
February 16, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
#17
JOURNAL ARTICLE
Fabrícia Heloisa Cavicchioli Sugiyama, Lisa Loksø Dietz, Ole Schmeltz Søgaard
PURPOSE OF REVIEW: Advancements in antiretroviral therapy (ART) have positively impacted the life expectancy and possibility of living a normal life for people with HIV-1. However, lifelong daily medication is necessary to prevent disease progression. To this end, immunotherapeutic strategies are being tested with the aim of developing a functional cure in which the immune system effectively controls HIV-1 in the absence of ART. RECENT FINDINGS: The most promising advances in achieving sustained HIV-1 remission or cure include broadly neutralizing antibodies (bNAbs) that are administered alone or in combination with other agents...
April 12, 2024: Current Opinion in HIV and AIDS
#18
JOURNAL ARTICLE
Rebecca J Fisk-Hoffman, Sashaun S Ranger, Abigail Gracy, Hannah Gracy, Preeti Manavalan, Maya Widmeyer, Robert F Leeman, Robert L Cook, Shantrel Canidate
Long-acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) for antiretroviral therapy (ART) could benefit many people with HIV (PWH). However, its impact will largely be determined by providers' willingness to prescribe it and PWH's willingness to take it. This study explores the perceived barriers and facilitators of LAI CAB/RPV implementation among PWH and HIV care providers in Florida, a high prevalence setting. Semi-structured qualitative interviews were conducted in English with 16 PWH (50% non-Hispanic White, 50% cis men, and 94% on oral ART) and 11 providers (27% non-Hispanic Black, 27% Hispanic, 73% cis women, and 64% prescribed LAI CAB/RPV) throughout the state...
April 30, 2024: AIDS Patient Care and STDs
#19
JOURNAL ARTICLE
Deepak Kumar, Govind Singh, Tarun, Meenakshi Dhanawat, Sumeet Gupta, Mohamed A Morsy, Anroop B Nair, Asmaa I Matouk
BACKGROUND: Alzheimer's disease is a neurological dysfunction of the brain caused by neurodegeneration and oxidative stress. Some viruses, such as herpes viruses, HSV-1, and HSV-2, are causative agents of Alzheimer's disease and result in β-amyloid peptide and tau protein accumulation in the brain. Some antiviral drugs, such as valacyclovir, acyclovir, and foscarnet, reduce amyloid-beta and P-tau. Pavetta indica leaves are also reported for their antiviral properties. The current study aimed to find out the significance of using Pavetta indica methanolic extract and acyclovir against Alzheimer's disease induced by streptozotocin...
April 27, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
#20
JOURNAL ARTICLE
Santiago I Rossi, Silvia Baleani, Ximena Prado, Carolina Pascual, Cecilia Tennina, Pablo Malagrino, Ana Vieites, Alejandro Parra, Mario Cazalla, Jair Tenorio Castano, Pablo Lapunzina
Very early onset inflammatory bowel disease (VEOIBD) is a rare entity in pediatrics. Its association with primary immunodeficiencies of monogenic origin is known. We present the case of a patient diagnosed with VEOIBD who underwent massive paralleled exome sequencing. The result of the study showed a pathogenic variant in the RET proto-oncogene, associated with multiple endocrine neoplasia type 2A disease. There are no previous reports of association of RET proto-oncogene variants with VEOIBD. The presence of these two clinical entities cannot be attributed to a single genetic cause...
2024: Medicina
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