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H Pylori Cancer

Jibran Sualeh Muhammad, Mohamed Ahmed Eladl, Ghalia Khoder
Gastric cancer is ranked fifth in cancer list and has the third highest mortality rate. Helicobacter pylori is a class I carcinogen and a predominant etiological factor of gastric cancer. H. pylori infection may induce carcinogenesis via epigenetic alterations in the promoter region of various genes. H. pylori is known to induce hypermethylation-silencing of several tumor suppressor genes in H. pylori -infected cancerous and H. pylori -infected non-cancerous gastric mucosae. This article presents a review of the published literature mainly from the last year 15 years...
February 13, 2019: Pathogens
Paweł Krzyżek, Roman Franiczek, Barbara Krzyżanowska, Łukasz Łaczmański, Paweł Migdał, Grażyna Gościniak
Helicobacter pylori (H. pylori) is a bacterium capable of inducing chronic active gastritis, which in some people, develops into gastric cancers. One of the substances that may be useful in the eradication of this microorganism is 3-Bromopyruvate (3-BP), an anticancer compound with antimicrobial properties. The aim of this article was to determine the activity of 3-BP against antibiotic-susceptible and antibiotic-resistant H. pylori strains. The antimicrobial activity was determined using a disk-diffusion method, broth microdilution method, time-killing assay, and checkerboard assay...
February 15, 2019: Cancers
Shuye Lin, Yaping Zhang, Yingqi Hu, Bing Yang, Jiantao Cui, Jiaqiang Huang, Ji Ming Wang, Rui Xing, Youyong Lu
BACKGROUND AND AIMS: Helicobacter pylori invades the mucosal barrier and infects the mucins of gastric epithelial cells. However, whether gastric carcinogenesis caused by H. pylori infection involves the membrane-bound mucins is unclear. This study explored the role of mucin 17 (MUC17) in gastric cancer (GC) associated with H. pylori infection. METHODS: The expression of MUC17 and carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) was examined in human GC cells and tissues with H...
February 18, 2019: Gastric Cancer
Gloria Tavera, Douglas R Morgan, Scott M Williams
Purpose of Review: Chronic infection with Helicobacter pylori infection is necessary but not sufficient to initiate development of intestinal-type gastric adenocarcinoma. It is not clear what additional factors tip the scale from commensal bacteria towards a pathogen that facilitates development of gastric cancer. Genetic variants in both the pathogen and host have been implicated, but neither alone explains a substantial portion of disease risk. Recent Findings: In this review, we consider studies that address the important role of human and bacterial genetics, ancestry and their interactions in determining gastric disease risk...
December 2018: Current Genetic Medicine Reports
Massimo Rugge, Kentaro Sugano, Carmelo Scarpignato, Diana Sacchi, Walker Jove Oblitas, Antonio Giuseppe Naccarato
Gastric cancer (GC) ranks among the most lethal epithelial malignancies, and its striking mortality rate prompts a global prevention strategy. Helicobacter pylori (H. pylori) gastritis is the main GC promoter, and the 2014 Global Kyoto conference recognized H. pylori gastritis as a (treatable) infectious disease. It is therefore plausible that any large-scale intervention for H. pylori eradication would result in cleansing the world of the fifth cause of cancer-related death. Atrophic gastritis is the cancerization field in which GCs (both intestinal and diffuse histotypes) mainly develop...
February 17, 2019: Helicobacter
Indira Tirado-Hurtado, Cristian Carlos, Luciana Lancho, Alejandro Alfaro, Richard Ponce, Luis J Schwarz, Layonel Torres, Michael Ayudant, Joseph A Pinto, Williams Fajardo
Helicobacter pylori (H. pylori) is a cosmopolite bacteria and the main responsible for the high burden of gastric cancer in developing countries, such as Peru. In this review, we describe some historical facts in the H. Pylori discovery, the first researches of this bacterium in Peru, as well as its epidemiology, clinical characteristics, diagnosis, treatments, and outcomes. Our literature and review of real-life data suggest that several efforts should be conducted in our country to deal with antibiotic-resistance and lack of adherence to treatment in order to reduce our incidence of gastric cancer...
February 2019: Critical Reviews in Oncology/hematology
Toshihiko Kakiuchi, Muneaki Matsuo, Hiroyoshi Endo, Aiko Nakayama, Keiko Sato, Ayako Takamori, Kazumi Sasaki, Mitsuhiro Takasaki, Megumi Hara, Yasuhisa Sakata, Masumi Okuda, Shogo Kikuchi, Yuichiro Eguchi, Hirokazu Takahashi, Keizo Anzai, Kazuma Fujimoto
BACKGROUND: To present the strategies and preliminary findings of the first 3 years after implementing a Helicobacter pylori screening and eradication program to prevent gastric cancer in Saga Prefecture. METHODS: A screening and treatment program to eradicate H. pylori from third-grade junior high students was started in Saga Prefecture in 2016, using local governmental grants. Screening was with urinary anti-H. pylori antibody tests, followed by H. pylori stool antigen tests for students who were antibody positive...
February 15, 2019: Journal of Gastroenterology
Mototsugu Kato
No abstract text is available yet for this article.
February 15, 2019: Journal of Gastroenterology
Takashi Yoshida, Tatsuya Yamaguchi, Shinya Maekawa, Shinichi Takano, Toru Kuno, Keisuke Tanaka, Fumihiko Iwamoto, Yuya Tsukui, Shoji Kobayashi, Yukiko Asakawa, Hiroko Shindo, Mitsuharu Fukasawa, Yasuhiro Nakayama, Taisuke Inoue, Tomoyoshi Uetake, Masahiko Ohtaka, Tadashi Sato, Kunio Mochizuki, Nobuyuki Enomoto
BACKGROUND AND AIMS: The recent advancement of next-generation sequencing (NGS) has enabled the identification of cancer-related somatic aberrations in advanced gastric cancer. However, these remain unclear in early gastric cancers, especially in intramucosal gastric cancers. PATIENTS AND METHODS: Thirty-one well-differentiated (tub1) intramucosal gastric cancers obtained by endoscopic submucosal dissection (ESD) from 29 patients were analyzed. After precise collection of tumors and non-tumors from formalin-fixed paraffin-embedded tissues using laser-captured microdissection (LCM), target sequencing analysis of 50 cancer-related genes was performed using an Ion-Proton sequencer...
February 11, 2019: Gastric Cancer
Kichul Yoon, Nayoung Kim, Youngmi Park, Bo Kyung Kim, Ji Hyun Park, Cheol Min Shin, Dong Ho Lee, Young-Joon Surh
The role of macrophage migration inhibitory factor (MIF) and autophagy in gastric cancer is not clear. We determined H. pylori infection status of the subjects and investigated the expression of MIF and autophagy markers (Atg5, LC3A and LC3B) in human gastric tissue at baseline. Then H. pylori eradication was done for H. pylori positive patients and MIF and Atg5 levels were investigated on each follow-up for both H. pylori-eradicated and H. pylori negative patients. Baseline tissue mRNA expression of MIF, Atg5, LC3A and LC3B was measured by real-time PCR in 453 patients (control 165, gastric dysplasia 82, and gastric cancer 206)...
2019: PloS One
Y F Dong, T Guo, H Yang, J M Qian, J N Li
Objective: To investigate the correlations between gastric Helicobacter pylori (Hp) infection and colorectal polyps or cancer. Methods: Among patients who finished colonoscopy exams in Peking Union Medical College Hospital (PUMCH) between May 2012 and May 2017, 3 483 patients were diagnosed with colorectal polyps, 135 patients with newly diagnosed colorectal cancer. A total of 1 925 healthy subjects were enrolled as normal controls. Gastric rapid urease tests (RUT) were done in all patients. General clinical data, RUT results, sizes and numbers of polyps, cancer location were analyzed...
February 1, 2019: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Loryn Holokai, Jayati Chakrabarti, Taylor Broda, Julie Chang, Jennifer A Hawkins, Nambirajan Sundaram, Lydia E Wroblewski, Richard M Peek, Jiang Wang, Michael Helmrath, James M Wells, Yana Zavros
Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response to infection that is fundamental to the initiation of H. pylori-induced gastritis. H. pylori also induces programmed death ligand 1 (PD-L1) expression on gastric epithelial cells, yet the mechanism is unknown. We hypothesize that H. pylori-induced PD-L1 expression within the gastric epithelium is mediated by the Shh signaling pathway during infection...
January 31, 2019: PLoS Pathogens
Khitam Muhsen, Ronit Sinnreich, Dafna Merom, Gany Beer-Davidson, Hisham Nassar, Dani Cohen, Jeremy D Kark
OBJECTIVE: Understanding the correlates of premalignant gastric lesions is essential for gastric cancer prevention. We examined the prevalence and correlates of serological evidence of atrophic gastritis, a premalignant gastric condition, using serum pepsinogens (PGs) in two populations with differing trends in gastric cancer incidence. METHODS: In a cross-sectional study, using ELISA we measured serum PGI and PGII concentrations (Biohit, Finland), Helicobacter pylori serum IgG and cytotoxin-associated gene A (CagA) antigen IgG antibodies in archived sera of 692 Jews and 952 Arabs aged 25-78 years, randomly selected from Israel's population registry in age-sex and population strata...
January 29, 2019: BMJ Open
Diana F Rojas-Rengifo, Cindy P Ulloa-Guerrero, Markus Joppich, Rainer Haas, Maria Del Pilar Delgado, Carlos Jaramillo, Luisa F Jiménez-Soto
Because of its association with severe gastric pathologies, including gastric cancer, Helicobacter pylori has been subject of research for more than 30 years. Its capacity to adapt and survive in the human stomach can be attributed to its genetic flexibility. Its natural competence and its capacity to turn genes on and off allows H. pylori to adapt rapidly to the changing conditions of its host. Because of its genetic variability, it is difficult to establish the uniqueness of each strain obtained from a human host...
January 29, 2019: Scientific Reports
Giovanni Suarez, Judith Romero-Gallo, Maria Blanca Piazuelo, Johanna C Sierra, Alberto G Delgado, M Kay Washington, Shailja C Shah, Keith T Wilson, Richard M Peek
Helicobacter pylori is the strongest known risk for gastric cancer. The H. pylori cag type IV secretion system is an oncogenic locus which translocates peptidoglycan into host cells where it is recognized by NOD1, an innate immune receptor. Beyond this, the role of NOD1 in H. pylori-induced cancer remains undefined. To address this knowledge gap, we infected two genetic models of Nod1 deficiency with the H. pylori cag+ strain PMSS1: C57BL/6 mice which rarely develop cancer, and INS-GAS FVB/N mice which commonly develop cancer...
January 29, 2019: Cancer Research
Shaoqing Lai
Gastric cancer is a malignant tumor originating from the gastric mucosa epithelium. Intestinal type gastric cancer is frequently taken on elderly men, and there are many high incidence areas around the world. Intestinal type gastric cancer often is accompanied by gastric mucosal atrophy, intestinal metaplasia. The clinical manifestation involves hypergastrinemia, low stomach acid, PG I/II progressive decreasing, anemia, and protein energy malnutrition. The neck cells of gastric glands act as tissue stem cells to regenerate the gastric glands...
February 2019: Medical Hypotheses
Nora J Foegeding, Krishnan Raghunathan, Anne M Campbell, Sun Wook Kim, Ken S Lau, Anne K Kenworthy, Timothy L Cover, Melanie D Ohi
Helicobacter pylori VacA is a secreted pore-forming toxin that induces cell vacuolation in vitro and contributes to the pathogenesis of gastric cancer and peptic ulcer disease. We observed that purified VacA has relatively little effect on the viability of AGS gastric epithelial cells, but the presence of exogenous weak bases such as ammonium chloride (NH4 Cl) enhances the susceptibility of these cells to VacA-induced vacuolation and cell death. Therefore, we tested the hypothesis that NH4 Cl augments VacA toxicity by altering the intracellular trafficking of VacA or inhibiting intracellular VacA degradation...
January 28, 2019: Infection and Immunity
Meng-Chen Wu, Hsin-Hung Cheng, Ta-Sen Yeh, Yi-Chen Li, Tsan-Jan Chen, Wei Yang Sit, Chih-Pin Chuu, Hsing-Jien Kung, Shu Chien, Wen-Ching Wang
KDM4/JMJD2 Jumonji C-containing histone lysine demethylases (KDM4A-D) constitute an important class of epigenetic modulators in the transcriptional activation of cellular processes and genome stability. Interleukin-8 (IL-8) is overexpressed in gastric cancer, but the mechanisms and particularly the role of the epigenetic regulation of IL-8, are unclear. Here, we report that KDM4B, but not KDM4A/4C, upregulated IL-8 production in the absence or presence of Helicobacter pylori. Moreover, KDM4B physically interacts with c-Jun on IL-8, MMP1, and ITGAV promoters via its demethylation activity...
January 25, 2019: Cell Death & Disease
Kean Ghee Lim, Kandasami Palayan
Incidence rates of gastric cancer in Malaysia has declined by 48% among males and 31% among females in the latest reporting period of 13 years. Malays used to have age-standardized-rates only a fifth of those in Chinese and Indians, but the incidence among them is slightly rising even as the rates drop in the other races. Besides ethnicity, a low level of education, high intake of salted fish and vegetables, H pylori infection and smoking are risk factors. Consumption of fresh fruit and vegetable is protective...
January 25, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Qi Chen, Xiao Liang, Xiaohua Long, Lou Yu, Wenzhong Liu, Hong Lu
BACKGROUND: The high prevalence of Helicobacter pylori (H pylori) infection in China results in a substantial public health burden. Medical experts have not agreed on the best solution of population intervention for this problem. We presented a health economic evaluation of a population-based H pylori screen-and-treat strategy for preventing gastric cancer, peptic ulcer disease (PUD), and nonulcer dyspepsia (NUD). MATERIALS AND METHODS: Decision trees and Markov models were developed to evaluate the cost-effectiveness of H pylori screening followed by eradication treatment in asymptomatic Chinese...
January 22, 2019: Helicobacter
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