Jiale Dong, Wei Zhou, Xianli Hu, Jiaxiang Bai, Siming Zhang, Xianzuo Zhang, Lei Yu, Peng Yang, Lingtong Kong, Mingkai Liu, Xifu Shang, Zheng Su, Dechun Geng, Chen Zhu
Implant-associated infections (IAIs) pose a significant threat to orthopedic surgeries. Bacteria colonizing the surface of implants disrupt bone formation-related cells and interfere with the osteoimmune system, resulting in an impaired immune microenvironment and osteogenesis disorders. Inspired by nature, a zeolitic imidazolate framework (ZIF)-sealed smart drug delivery system on Ti substrates (ZSTG) was developed for the "natural-artificial dual-enzyme intervention (NADEI)" strategy to address these challenges...
February 21, 2024: Biomaterials