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Bionic kidney

Ying Gan, Ning Hu, Chuanjiang He, Shuqi Zhou, Jiawei Tu, Tao Liang, Yuxiang Pan, Dmitry Kirsanov, Andrey Legin, Hao Wan, Ping Wang
Urolithiasis commonly occurs in kidney and ureteral, and may cause local organ/tissue damage, even kidney failure. The incidence of this disease is increasing worldwide, in which calcium oxalate is the major composition forming the urinary calculus. Therefore, to monitor this disease for the prevention and treatment, measuring the oxalate in the urine is of great significance. Here, a rapid and sensitive colorimetric method was developed based on 3,3',5,5'-tetramethylbenzidine-manganese dioxide (TMB-MnO2 ) nanosheets for oxalate detection...
January 21, 2019: Biosensors & Bioelectronics
Jennifer J Chung, Maria F Arisi, Samir Zaman, Pavan Atluri
No abstract text is available yet for this article.
May 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Steven J Russell, Mallory A Hillard, Courtney Balliro, Kendra L Magyar, Rajendranath Selagamsetty, Manasi Sinha, Kerry Grennan, Debbie Mondesir, Laya Ekhlaspour, Hui Zheng, Edward R Damiano, Firas H El-Khatib
BACKGROUND: The safety and efficacy of continuous, multiday, automated glycaemic management has not been tested in outpatient studies of preadolescent children with type 1 diabetes. We aimed to compare the safety and efficacy of a bihormonal bionic pancreas versus conventional insulin pump therapy in this population of patients in an outpatient setting. METHODS: In this randomised, open-label, crossover study, we enrolled preadolescent children (aged 6-11 years) with type 1 diabetes (diagnosed for ≥1 year) who were on insulin pump therapy, from two diabetes camps in the USA...
March 2016: Lancet Diabetes & Endocrinology
Sudesna Chatterjee, Melanie J Davies
The last 90 years have seen considerable advances in the management of type 1 and type 2 diabetes. Prof MacLean of Guy's Hospital wrote in the Postgraduate Medical Journal in 1926 about the numerous challenges that faced patients and their healthcare professionals in delivering safe and effective diabetes care at that time. The discovery of insulin in 1922 heralded a new age in enabling long-term glycaemic control, which reduced morbidity and mortality. Thirty years later, the first oral agents for diabetes, the biguanides and sulfonylureas, appeared and freed type 2 patients from having to inject insulin following diagnosis...
November 2015: Postgraduate Medical Journal
Silke V Niederhaus
PURPOSE OF REVIEW: The present article aims to review the current state of diabetes, including its treatment options, and highlight current issues in pancreas transplantation. RECENT FINDINGS: Compared with other areas of transplantation, pancreas transplant/transplantation alone in the absence of kidney disease remains a relatively small field. As a consequence, reported new research articles are few in number, and often data regarding pancreas transplant/transplantation alone are mixed in with simultaneous kidney-pancreas and pancreas after kidney transplantation, which are covered separately...
February 2015: Current Opinion in Organ Transplantation
Matthieu Legrand, Benedetta De Berardinis, Hanna K Gaggin, Laura Magrini, Arianna Belcher, Benedetta Zancla, Alexandra Femia, Mandy Simon, Shweta Motiwala, Rasika Sambhare, Salvatore Di Somma, Alexandre Mebazaa, Vishal S Vaidya, James L Januzzi
OBJECTIVE: The objective of the study was to assess urinary biomarkers of renal injury for their individual or collective ability to predict Worsening renal function (WRF) in patients with acutely decompensated heart failure (ADHF). METHODS: In a prospective, blinded international study, 87 emergency department (ED) patients with ADHF were evaluated with biomarkers of cardiac stretch (B type natriuretic peptide [BNP] and its amino terminal equivalent [NT-proBNP], ST2), biomarkers of renal function (creatinine, estimated glomerular filtration rate [eGFR]) and biomarkers of renal injury (plasma neutrophil gelatinase associated lipocalin [pNGAL], urine kidney injury molecule-1 [KIM-1], urine N-acetyl-beta-D-glucosaminidase [NAG], urine Cystatin C, urine fibrinogen)...
2014: PloS One
Steven J Russell, Firas H El-Khatib, Manasi Sinha, Kendra L Magyar, Katherine McKeon, Laura G Goergen, Courtney Balliro, Mallory A Hillard, David M Nathan, Edward R Damiano
BACKGROUND: The safety and effectiveness of automated glycemic management have not been tested in multiday studies under unrestricted outpatient conditions. METHODS: In two random-order, crossover studies with similar but distinct designs, we compared glycemic control with a wearable, bihormonal, automated, "bionic" pancreas (bionic-pancreas period) with glycemic control with an insulin pump (control period) for 5 days in 20 adults and 32 adolescents with type 1 diabetes mellitus...
July 24, 2014: New England Journal of Medicine
Brian L Cook, Karin E Ernberg, Hyeyoun Chung, Shuguang Zhang
In order to begin to study the structural and functional mechanisms of olfactory receptors, methods for milligram-scale purification are required. Here we demonstrate the production and expression of a synthetically engineered human olfactory receptor hOR17-4 gene in a stable tetracycline-inducible mammalian cell line (HEK293S). The olfactory receptor gene was fabricated from scratch using PCR-based gene-assembly, which facilitated codon optimization and attachment of a 9-residue bovine rhodopsin affinity tag for detection and purification...
2008: PloS One
V Bonomini
Bionic Kidney is a project still in progress which aims at replacing all renal functions, which has been carried out in an ideal attempt to improve the overall results of Renal Replacement Therapy. It contains all the requisites for a complete rehabilitation from Uremia. As a futuristic mini-device implanted in the body, it should be a reliable support to Transplantation performance, considering the scarcity of kidney donors.
May 2003: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
L P Wollmuth, T Kuner, B Sakmann
1. N-methyl-D-aspartate (NMDA) receptor channels are blocked by intracellular Mg2+ in a voltage-dependent manner. Amino acid residues positioned at or near the narrow constriction that interact with intracellular Mg2+ were identified in recombinant NR1-NR2A channels expressed in Xenopus oocytes or human embryonic kidney (HEK) 293 cells. 2. In the absence of extracellular Ca2+, the block of wild-type channel by intracellular Mg2+ measured using macroscopic currents showed a voltage dependence (delta) of around 0...
January 1, 1998: Journal of Physiology
L P Wollmuth, T Kuner, B Sakmann
1. The voltage-dependent block of N-methyl-D-aspartate (NMDA) receptor channels by extracellular Mg2+ is a critical determinant of its contribution to CNS synaptic physiology. The function of the narrow constriction of the channel in determining the block was investigated by analysing the effects of a set different amino acid substitutions at exposed residues positioned at or near this region. NMDA receptor channels, composed of wild-type and mutant NR1- and NR2A-subunits, were expressed in Xenopus oocytes or human embryonic kidney (HEK) 293 cells...
January 1, 1998: Journal of Physiology
V Bonomini, S Stefoni, R Giardino, G Pallotti
No abstract text is available yet for this article.
January 1996: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
V Bonomini, S Stefoni, M P Scolari, G Feliciangeli, L Colì, A Buscaroli
No abstract text is available yet for this article.
April 1993: Artificial Organs
V Bonomini, G Feliciangeli, L Coli, A Nanni Costa, M P Scolari, S Stefoni
No abstract text is available yet for this article.
1993: Contributions to Nephrology
E A Friedman
No abstract text is available yet for this article.
December 1980: Transplantation Proceedings
L L Bailey
No abstract text is available yet for this article.
April 1987: ASAIO Transactions
B R McAuslan, G Johnson, G W Delamore, M A Gibson, J G Steele
Ferrous based, corrosion resistant amorphous alloys supported the adhesion and growth of cultured chick neuronal cells, human marrow stromal cells (presumptive osteoblasts), bovine aortal endothelial cells, and hamster kidney fibroblasts. Alloys of compositions Fe60Ni10Cr10P13C7, Fe70Cr10P13C7, and Fe70Cr10P13B7 were found to be suitable. In contrast the crystalline form of these alloys was markedly less effective. Outgrowth of neurites from neuronal cells was promoted by precoating the metal surface with either laminin or neurite promotion factor...
October 1988: Journal of Biomedical Materials Research
P M Galletti
When a lizard loses its tail, a new caudal appendage soon grows to replace the one that is missing. But when a human loses a kidney, severs a peripheral nerve or worse, the spinal cord, that organ is lost forever. Such at least is conventional thinking. But imagine that the victim of an industrial accident with a paralyzed hand could achieve new levels of function by inducing axonal regrowth through a synthetic nerve guidance channel; or that a Parkinsonian patient's symptoms could be relieved by implanting in his brain neural tissue encased in a selectively permeable polymer envelope; or that the inexorable progression of the vascular complications of juvenile diabetes could be stopped, even reversed, by a membrane-protected xenograft of insulin-producing tissue...
1991: Verhandelingen—Koninklijke Academie Voor Geneeskunde Van België
V Bonomini, G Feliciangeli, A Nanni-Costa, M P Scolari, S Stefoni
No abstract text is available yet for this article.
February 1992: Artificial Organs
E S Bücherl
The state of the art in the development of artificial heart research based on more than 100 own animal experiments and information from the other groups working in the same field is laid out. Consideration is given to a variety of special problems. The use of biomaterials (blood compatibility and mechanical strength and durability), the flow pattern in the pumps (clot formation), and special hemodynamical effects are discussed as well as different driving systems and percutane energy transmission (avoidance of infection)...
July 20, 1976: Medical Progress Through Technology
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