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circulating microRNA

Zofia M Szemraj-Rogucka, Janusz Szemraj, Konrad Masiarek, Agata Majos
Introduction: Despite the fact that cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) is a proven method for detecting myocardial fibrosis, there is a need for new and reliable serological biomarkers. Circulating miRNAs could be a practical and attractive alternative. The purpose of the study was to assess the miRNAs well established in myocardial fibrosis - miR-21, miR-29a, miR-30d and miR-133a - in the plasma of patients with left ventricular non-compaction (LVNC) that have areas of LGE assessed by CMR...
March 2019: Archives of Medical Science: AMS
Naofumi Asano, Juntaro Matsuzaki, Makiko Ichikawa, Junpei Kawauchi, Satoko Takizawa, Yoshiaki Aoki, Hiromi Sakamoto, Akihiko Yoshida, Eisuke Kobayashi, Yoshikazu Tanzawa, Robert Nakayama, Hideo Morioka, Morio Matsumoto, Masaya Nakamura, Tadashi Kondo, Ken Kato, Naoto Tsuchiya, Akira Kawai, Takahiro Ochiya
Due to their rarity and diversity, sarcomas are difficult to diagnose. Consequently, there is an urgent demand for a novel diagnostic test for these cancers. In this study, we investigated serum miRNA profiles from 1002 patients with bone and soft tissue tumors representing more than 43 histological subtypes, including sarcomas, intermediate tumors, and benign tumors, to determine whether serum miRNA profiles could be used to specifically detect sarcomas. Circulating serum miRNA profiles in sarcoma patients were clearly distinct from those in patients with other types of tumors...
March 21, 2019: Nature Communications
Ravi V Shah, Saumya Das, Gregory D Lewis
No abstract text is available yet for this article.
March 26, 2019: Journal of the American College of Cardiology
Lee Lee Wong, Ruiyang Zou, Lihan Zhou, Jia Yuen Lim, Dominic C Y Phua, Chengcheng Liu, Jenny P C Chong, Jessica Y X Ng, Oi Wah Liew, Siew Pang Chan, Yei-Tsung Chen, Michelle M Y Chan, Poh Shuan D Yeo, Tze Pin Ng, Lieng H Ling, David Sim, Kui Toh G Leong, Hean Y Ong, Fazlur Jaufeerally, Raymond Wong, Ping Chai, Adrian F Low, Mayanna Lund, Gerry Devlin, Richard Troughton, Vicky A Cameron, Robert N Doughty, Carolyn S P Lam, Heng Phon Too, Arthur Mark Richards
BACKGROUND: Clinicians need improved tools to better identify nonacute heart failure with preserved ejection fraction (HFpEF). OBJECTIVES: The purpose of this study was to derive and validate circulating microRNA signatures for nonacute heart failure (HF). METHODS: Discovery and validation cohorts (N = 1,710), comprised 903 HF and 807 non-HF patients from Singapore and New Zealand (NZ). MicroRNA biomarker panel discovery in a Singapore cohort (n = 546) was independently validated in a second Singapore cohort (Validation 1; n = 448) and a NZ cohort (Validation 2; n = 716)...
March 26, 2019: Journal of the American College of Cardiology
Xinshuai Wang, Dejiu Kong, Chaokun Wang, Xuezhen Ding, Li Zhang, Mengqi Zhao, Jing Chen, Xiangyun Xu, Xiaochen Hu, Junqiang Yang, Shegan Gao
OBJECT: Ovarian cancer is the primary cause of cancer-associated deaths among gynaecological malignancies. Increasing evidence suggests that microRNAs may be potential biomarkers for the diagnosis and prognosis of cancer. In this study, we conducted a systematic review and meta-analysis to summarize the global research and to evaluate the overall diagnostic accuracy of miRNAs in detecting ovarian cancer. METHODS: A systematic literature search was conducted for relevant studies through July 20, 2017, in English databases (CENTRAL, MEDLINE, and EMBASE), the Grey reference database and Chinese databases...
March 21, 2019: Journal of Ovarian Research
Farha Ramzan, Cameron J Mitchell, Amber M Milan, William Schierding, Nina Zeng, Pankaja Sharma, Sarah M Mitchell, Randall F D'Souza, Scott O Knowles, Nicole C Roy, Anders Sjödin, Karl-Heinz Wagner, David Cameron-Smith
SCOPE: MicroRNA are critical to the coordinated post-transcriptional regulation of gene expression, yet few studies have addressed the influence of habitual diet on microRNA expression. High protein diets impact cardiometabolic health and body composition in the elderly suggesting the possibility of a complex systems response. Therefore, high-throughput small RNA sequencing technology was applied in response to doubling the protein recommended dietary allowance (RDA) over 10 weeks in older men to examine alterations in circulating miRNAome...
March 20, 2019: Molecular Nutrition & Food Research
Nidhi Gupta, Raman Kumar, Tulika Seth, Bhavuk Garg, Hem Chandra Sati, Alpana Sharma
PURPOSE: Multiple myeloma (MM) is a hematological malignancy marked by uncontrolled proliferation and accumulation of plasma cells in bone marrow. Despite presence of numerous diagnostic markers for MM, their invasive and non-specific nature demands identification of some effective biomarker. Small non-coding RNAs, i.e., microRNAs being secreted out in circulation could depict the change in homeostasis. Earlier, we reported diagnostic potential of a proteoglycan, Versican (VCAN) in MM, hence, VCAN linked cell-free microRNAs have been explored to study their diagnostic involvement in MM...
March 19, 2019: Journal of Cancer Research and Clinical Oncology
Hikaru Nakashima, Ryoji Yoshida, Akiyuki Hirosue, Kenta Kawahara, Junki Sakata, Hidetaka Arita, Tatsuro Yamamoto, Ryo Toya, Ryuji Murakami, Akimitsu Hiraki, Masanori Shinohara, Takaaki Ito, Yoshikazu Kuwahara, Hideki Nakayama
MicroRNAs are a class of small, endogenous, noncoding 18- to 24-nucleotide-long RNAs that can regulate multiple processes related to cancer progression. However, their clinical value in patients with oral squamous cell carcinoma has not yet been fully explored. Therefore, the aim of this study was to investigate the clinical significance of circulating microRNAs in oral squamous cell carcinoma patients. The expression levels of circulating miR-1246 and miR-1290 in healthy volunteers and oral squamous cell carcinoma patients were examined by quantitative real-time polymerase chain reaction...
March 2019: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Bruna Jardim Quintanilha, Ludmila Rodrigues Pinto Ferreira, Frederico Moraes Ferreira, Edécio Cunha Neto, Geni Rodrigues Sampaio, Marcelo Macedo Rogero
High-fat diet increase two to three times the plasma lipopolysaccharide (LPS) levels and induce subclinical inflammation. Diet can modify gene expression due to epigenetic processes related to MicroRNAs (miRNAs). MicroRNAs (miRNAs) play important role in the post-transcriptional mechanisms involved in regulation of expression of genes related to the inflammatory response. Also, diet can indirectly induce post-transcriptional regulation of gene expression by miRNAs, which may affect the risk for the development of chronic diseases...
March 7, 2019: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Lamya Garabet, Waleed Ghanima, Anbjørg Rangberg, Raul Teruel-Montoya, Constantino Martinez, Maria Luisa Lozano, Camilla F Nystrand, James B Bussel, Per Morten Sandset, Christine M Jonassen
MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of gene expression. Dysregulated expression of several miRNAs has been found in primary immune thrombocytopenia (ITP) suggesting that miRNAs are likely involved in the pathogenesis of ITP. We aimed to explore the differential expression of miRNAs in patients with ITP before and after starting treatment with thrombopoietin-receptor agonists (TPO-RAs) to clarify their roles in the pathophysiology of ITP, and as potential diagnostic and prognostic markers of this disorder...
March 18, 2019: Platelets
Barbara Pardini, George A Calin
Hormones are messengers circulating in the body that interact with specific receptors on the cell membrane or inside the cells and regulate, at a distal site, the activities of specific target organs. The definition of hormone has evolved in the last years. Hormones are considered in the context of cell⁻cell communication and mechanisms of cellular signaling. The best-known mechanisms of this kind are chemical receptor-mediated events, the cell⁻cell direct interactions through synapses, and, more recently, the extracellular vesicle (EV) transfer between cells...
March 17, 2019: Cancers
Xin-Wei He, Yan-Hui Shi, Rong Zhao, Yi-Sheng Liu, Ge-Fei Li, Yue Hu, Wei Chen, Guo-Hong Cui, Jing-Jing Su, Jian-Ren Liu
INTRODUCTION: Multiple microRNAs (miRNAs) participate in the response to hypoxic/ischemic and ischemia-reperfusion events. However, the expression of these miRNAs in circulation from patients with acute ischemic stroke (AIS) receiving recanalization treatment has not been examined, and whether they are associated with the severity and outcome of stroke is still unknown. MATERIALS AND METHODS: In this prospective cohort study, plasma levels of miR-125b-5p, miR-15a-3p, miR-15a-5p, and miR-206 were measured at 24hours after thrombolysis with or without endovascular treatment in 94 patients with AIS, as determined by qRT-PCR...
March 14, 2019: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Nuwan Dharmawardana, Eng Hooi Ooi, Charmaine Woods, Damian Hussey
Circulating microRNAs have been described as head and neck cancer biomarkers in multiple anatomical subsites including the oral cavity, nasopharynx, larynx, salivary glands and the skin. While there is an expanding volume of published literature showing the significance of individual or panels of microRNAs, the clinical validation of candidate biomarkers is lacking. The various methods used to collect, store, process and interpret these microRNAs are likely introducing bias and contributing to the inconsistent results...
March 14, 2019: Clinical & Experimental Metastasis
Jiahao Lin, Lie Ma, Di Zhang, Jiafeng Gao, Yipeng Jin, Zhihai Han, Degui Lin
In recent years, with the increase in cancer mortality caused by metastasis, and with the development of individualized and precise medical treatment, early diagnosis with precision becomes the key to decrease the death rate. Since detecting tumour biomarkers in body fluids is the most non-invasive way to identify the status of tumour development, it has been widely investigated for the usage in clinic. These biomarkers include different expression or mutation in microRNAs (miRNAs), circulating tumour DNAs (ctDNAs), proteins, exosomes and circulating tumour cells (CTCs)...
March 14, 2019: Cell Proliferation
Ophélie Fourdinier, Eva Schepers, Valérie Metzinger-Le Meuth, Griet Glorieux, Sophie Liabeuf, Francis Verbeke, Raymond Vanholder, Benjamin Brigant, Anneleen Pletinck, Momar Diouf, Stéphane Burtey, Gabriel Choukroun, Ziad A Massy, Laurent Metzinger
Several microRNAs (miRNAs) have been linked to chronic kidney disease (CKD) mortality, cardiovascular (CV) complications and kidney disease progression. However, their association with clinical outcomes remains poorly evaluated. We used real-time qPCR to measure serum levels of miR-126 and miR-223 in a large cohort of 601 CKD patients (CKD stage G1 to G5 patients or on renal replacement therapy - CKD G5D) from Ghent University Hospital and 31 healthy controls. All-cause mortality and cardiovascular and renal events were registered as endpoints over a 6 year follow-up period...
March 14, 2019: Scientific Reports
Anna Gajos-Michniewicz, Malgorzata Czyz
Tumour metastasis is a multistep process. Melanoma is a highly aggressive cancer and metastasis accounts for the majority of patient deaths. microRNAs (miRNAs) are non-coding RNAs that affect the expression of their target genes. When aberrantly expressed they contribute to the development of melanoma. While miRNAs can act locally in the cell where they are synthesized, they can also influence the phenotype of neighboring melanoma cells or execute their function in the direct tumour microenvironment by modulating ECM (extracellular matrix) and the activity of fibroblasts, endothelial cells, and immune cells...
March 7, 2019: Cancers
Bo Lönnerdal
Human milk contains a wide variety of bioactive components, including long-chain fatty acids, complex oligosaccharides, and bioactive proteins. More recently, it was discovered that breast milk also contains exosomes, i.e., microvesicles containing microRNAs (miRNAs) with sizes of ∼22 nucleotides. Several of these miRNAs have been shown to originate from the mammary gland, and many of them are involved in cellular development and immune function. Exosome-mediated transfer of miRNAs is a novel mechanism of genetic exchange between cells...
2019: Nestlé Nutrition Institute Workshop Series
Fernando Santamaria-Martos, Ivan Benítez, Andrea Zapater, Cristina Girón, Lucía Pinilla, Jose Manuel Fernandez-Real, Ferran Barbé, Francisco Jose Ortega, Manuel Sánchez-de-la-Torre
microRNAs (miRNAs) are non-coding RNAs highly relevant as biomarkers for disease. A seminal study that explored the role of miRNAs in obstructive sleep apnea syndrome (OSA) demonstrated their usefulness in clinical management. Nevertheless, the miRNAs that may act as endogenous controls (ECs) have not yet been established. The identification of ECs would contribute to the standardization of these biomarkers in OSA. The objective of the study is to identify miRNAs that can be used as ECs in OSA. We evaluated 100 patients divided into two different cohorts: a learning cohort of 10 non-OSA and 30 OSA patients, and a validation cohort (20 non-OSA and 40 OSA patients)...
2019: PloS One
Peter Androvic, Nataliya Romanyuk, Lucia Urdzikova-Machova, Eva Rohlova, Mikael Kubista, Lukas Valihrach
Circulating cell-free microRNAs are promising candidates for minimally invasive clinical biomarkers for the diagnosis, prognosis and monitoring of many human diseases. Despite substantial efforts invested in the field, the research so far has failed to deliver expected results. One of the contributing factors is general lack of agreement between various studies, partly due to the considerable technical challenges accompanying the workflow. Pre-analytical variables including sample collection, RNA isolation, and quantification are sources of bias that may hamper biological interpretation of the results...
March 12, 2019: Scientific Reports
Parisa ZiaSarabi, Saba Sorayayi, AmirReza Hesari, Faezeh Ghasemi
Gastric cancer is one of the most common malignancies in the world and is considered as the most lethal gastrointestinal cancer. microRNAs (miRNAs) can be very important in detecting a disease at an early stage. The aim of this study was to investigate the microRNA-17 (miR-17), miR-25, and miR-133b in the serum of gastric cancer subjects. Serum samples were obtained from 120 gastric cancers and 102 healthy subjects. We evaluated expression levels of miR-17, miR-25 and miR-133b by quantitative real-time polymerase chain reaction...
March 12, 2019: Journal of Cellular Biochemistry
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