keyword
https://read.qxmd.com/read/38516106/risk-of-acute-kidney-injury-in-critically-ill-patients-with-covid-19-compared-with-seasonal-influenza-a-retrospective-cohort-study
#1
JOURNAL ARTICLE
Pauline Yeung Ng, April Ip, Andrew Kei-Yan Ng, Simon Wai-Ching Sin, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Desmond Yat-Hin Yap
BACKGROUND: The SARS-CoV-2 virus can bind to angiotensin-converting enzyme 2 receptors on host renal cells and may cause acute kidney injury (AKI). The comparative risks of AKI in patients severely ill with COVID-19 and influenza A have not been examined. METHODS: This is a retrospective cohort study including patients with positive PCR results for SARS-CoV-2 or influenza A virus admitted to the intensive care units (ICUs) of 15 public hospitals in Hong Kong between 1st January 2013 and 30th April 2023...
April 2024: EClinicalMedicine
https://read.qxmd.com/read/38487755/should-i-supplement-vitamin-d-in-a-patient-with-sepsis
#2
JOURNAL ARTICLE
Vedran Kovacic
Sepsis is a potentially fatal organ failure produced by the host's immune response to infection. It is critical to identify risk factors associated with a poor prognosis in septic patients in order to develop new therapy options. Vitamin D deficiency (25-hydroxyvitamin cholecalciferol < 20 ng/mL) is common in critical and septic patients. Serum vitamin D concentrations are associated with an increased incidence of mortality in critically ill adult patients. In critically ill patients, vitamin D supplementation (a very high vitamin D 3 or cholecalciferol loading dosage as a single bolus dose ranging from 400,000 to 540,000 IU) is feasible and safe...
March 1, 2024: Journal of Acute Medicine
https://read.qxmd.com/read/38451428/healthcare-resource-utilization-and-goals-of-care-discussions-in-patients-with-cirrhosis-and-acute-kidney-injury
#3
JOURNAL ARTICLE
Romela Petrosyan, Paul Endres, Nneka N Ufere, Shelsea A St Hillien, Scott Krinsky, Sahir Kalim, Sagar U Nigwekar, Tianqi Ouyang, Andrew S Allegretti
BACKGROUND: Patients with cirrhosis and acute kidney injury (AKI) are critically ill and have high health care resource utilization (HCRU). The impact and timing of goals of care discussions on HCRU are not well described. METHODS: 221 patients enrolled in a prospective cohort study of patients admitted with AKI and cirrhosis were reviewed. Documentation and timing of a goals of care discussions were analyzed as predictors of HCRU, defined as a composite outcome of intubation, initiation of renal replacement therapy, and/or admission to the intensive care unit...
March 7, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38444690/improving-outcomes-in-hepatorenal-syndrome-acute-kidney-injury-with-early-diagnoses-and-implementation-of-approved-treatment-regimens
#4
JOURNAL ARTICLE
Nikolaos T Pyrsopoulos, David Bernstein, Marcelo Kugelmas, Emily J Owen, K Rajender Reddy, Nancy Reau, Sammy Saab, Hani M Wadei
Decompensated cirrhosis, defined by the overt manifestations of liver failure and portal hypertension (eg, ascites, hepatic encephalopathy, variceal bleeding), is the inflection point associated with increased morbidity and mortality in chronic liver disease. Acute kidney injury in the setting of cirrhosis (hepatorenal syndrome-acute kidney injury [HRS-AKI]) is a severe and often fatal complication. The goals of treatment of HRS-AKI are to reverse renal failure and prolong survival in these critically ill patients or perhaps to allow the transplant team to complete the pretransplant evaluation and bridge the patient to transplant...
December 2023: Gastroenterology & Hepatology
https://read.qxmd.com/read/38419570/cell-free-dna-predicts-all-cause-mortality-of-sepsis-induced-acute-kidney-injury
#5
JOURNAL ARTICLE
Feixiang Xu, Xiao Tan, Jianli Wang, Su Lu, Hailin Ding, Mingming Xue, Yumei Chen, Sheng Wang, Jie Teng, Yiqin Shi, Zhenju Song
Background Sepsis-induced acute kidney injury (S-AKI) is a common complication in critically ill patients. Therefore, reliable biomarkers for predicting S-AKI outcomes are necessary. Serum cell-free DNA (cfDNA) is a circulating extracellular DNA fragment used as a noninvasive screening tool for many diseases, including sepsis. This study aimed to investigate the prognostic value of cfDNA in S-AKI patients and its relationship with some other parameters. Methods A total of 89 S-AKI patients admitted to the intensive care unit (ICU) from June 2021 to December 2021 were enrolled in this study...
December 2024: Renal Failure
https://read.qxmd.com/read/38416516/prediction-of-successful-weaning-from-renal-replacement-therapy-in-critically-ill-patients-based-on-machine-learning
#6
JOURNAL ARTICLE
Qiqiang Liang, Xin Xu, Shuo Ding, Jin Wu, Man Huang
BACKGROUND: Predicting the successful weaning of acute kidney injury (AKI) patients from renal replacement therapy (RRT) has emerged as a research focus, and we successfully built predictive models for RRT withdrawal in patients with severe AKI by machine learning. METHODS: This retrospective single-center study utilized data from our general intensive care unit (ICU) Database, focusing on patients diagnosed with severe AKI who underwent RRT. We evaluated RRT weaning success based on patients being free of RRT in the subsequent week and their overall survival...
December 2024: Renal Failure
https://read.qxmd.com/read/38396124/-artificial-intelligence-and-acute-kidney-injury
#7
REVIEW
Fabian Perschinka, Andreas Peer, Michael Joannidis
Digitalization is increasingly finding its way into intensive care units and with it artificial intelligence (AI) for critically ill patients. One promising area for the use of AI is in the field of acute kidney injury (AKI). The use of AI is primarily focused on the prediction of AKI, but further approaches are also being used to classify existing AKI into different phenotypes. Different AI models are used for prediction. The area under the receiver operating characteristic curve values (AUROC) achieved with these models vary and are influenced by several factors, such as the prediction time and the definition of AKI...
February 23, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://read.qxmd.com/read/38390828/association-between-the-levels-of-urinary-cell-cycle-biomarkers-and-non-recovery-of-renal-function-among-critically-ill-geriatric-patients-with-acute-kidney-injury
#8
JOURNAL ARTICLE
Li Cheng, Hui-Miao Jia, Xi Zheng, Yi-Jia Jiang, Xin Xin, Wen-Xiong Li
The lack of early renal function recovery among geriatric patients with acute kidney injury (AKI) in the intensive care unit (ICU) is a commonly observed and acknowledged poor prognostic factor, especially for older adults. However, no reliable prognostic biomarker is available for identifying individuals at risk of renal non-recovery or mortality in older adults. In this prospective observational cohort study, we enrolled critically ill older adults (aged ≥ 60 years) with AKI from the ICU and followed their disease progression...
February 23, 2024: Renal Failure
https://read.qxmd.com/read/38387296/the-occurrence-of-pressure-injuries-and-related-risk-factors-in-patients-undergoing-extracorporeal-membrane-oxygenation-for-respiratory-failure-a-retrospective-single-centre-study
#9
JOURNAL ARTICLE
Alberto Lucchini, Marta Villa, Clara Maino, Francesca Alongi, Valentina Fiorica, Barbara Lipani, Giuseppe Ponzetta, Veronica Vigo, Emanuele Rezoagli, Marco Giani
INTRODUCTION: Limited data is available regarding the incidence of pressure injuries in patients who have undergone Extracorporeal Membrane Oxygenation (ECMO), a life-saving technique that provides respiratory support for hypoxemia that does not respond to conventional treatment. AIM: To assess the incidence of pressure injuries and identify the risk factors in Acute Respiratory Distress Syndrome patients receiving ECMO. METHODS: A retrospective observational study utilizing prospectively collected data was performed in an Italian intensive care unit, between 1 January 2012 and 30 April 2022 enrolling all consecutive patients with Acute Respiratory Distress Syndrome who underwent ECMO...
February 20, 2024: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://read.qxmd.com/read/38374034/evaluation-of-characteristics-and-prognosis-of-covid-19-patients-requiring-invasive-mechanical-ventilation-during-dominance-of-nonvariant-alpha-delta-and-omicron-variants-in-tertiary-hospitals-of-japan
#10
JOURNAL ARTICLE
Kazuhito Sakuramoto, Daiki Wada, Shuhei Maruyama, Takashi Muroya, Fukuki Saito, Yasushi Nakamori, Yasuyuki Kuwagata
BACKGROUND: In November 2021, the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected in South Africa and subsequently rapidly spread around the world. Despite the reduced severity of the omicron variants, many patients become severely ill after infection and undergo invasive mechanical ventilation, but there are few reports on their background and prognosis throughout all variant periods. This study aimed to evaluate risk factors affecting patients requiring invasive mechanical ventilation with each variant of COVID-19 pandemic in Japan from nonvariants to omicron variants...
February 20, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38369749/machine-learning-based-prediction-of-in-hospital-mortality-for-critically-ill-patients-with-sepsis-associated-acute-kidney-injury
#11
JOURNAL ARTICLE
Tianyun Gao, Zhiqiang Nong, Yuzhen Luo, Manqiu Mo, Zhaoyan Chen, Zhenhua Yang, Ling Pan
OBJECTIVES: This study aims to develop and validate a prediction model in-hospital mortality in critically ill patients with sepsis-associated acute kidney injury (SA-AKI) based on machine learning algorithms. METHODS: Patients who met the criteria for inclusion were identified in the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and divided according to the validation ( n  = 2440) and development ( n  = 9756, 80%) queues...
December 2024: Renal Failure
https://read.qxmd.com/read/38357763/machine-learning-algorithm-for-predict-the-in-hospital-mortality-in-critically-ill-patients-with-congestive-heart-failure-combined-with-chronic-kidney-disease
#12
JOURNAL ARTICLE
Xunliang Li, Zhijuan Wang, Wenman Zhao, Rui Shi, Yuyu Zhu, Haifeng Pan, Deguang Wang
BACKGROUND: The objective of this study was to develop and validate a machine learning (ML) model for predict in-hospital mortality among critically ill patients with congestive heart failure (CHF) combined with chronic kidney disease (CKD). METHODS: After employing least absolute shrinkage and selection operator regression for feature selection, six distinct methodologies were employed in the construction of the model. The selection of the optimal model was based on the area under the curve (AUC)...
December 2024: Renal Failure
https://read.qxmd.com/read/38357758/association-between-estimated-pulse-wave-velocity-and-in-hospital-mortality-of-patients-with-acute-kidney-injury-a-retrospective-cohort-analysis-of-the-mimic-iv-database
#13
JOURNAL ARTICLE
Xinhai Cui, Yuanlong Hu, Dongxiao Li, Mengkai Lu, Zhiyuan Zhang, Dongfang Kan, Chao Li
BACKGROUND: Estimated pulse wave velocity (ePWV) has been found to be an independent predictor of cardiovascular mortality and kidney injury, which can be estimated noninvasively. This study aimed to investigate the association between ePWV and in-hospital mortality in critically ill patients with acute kidney injury (AKI). METHODS: This study included 5960 patients with AKI from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The low and high ePWV groups were compared using a Kaplan-Meier survival curve to evaluate the differences in survival status...
December 2024: Renal Failure
https://read.qxmd.com/read/38357011/cystic-duct-disimpaction-for-acute-cholecystitis-in-the-high-risk-cholecystectomy-patient-case-report
#14
Humzah Iqbal, Aalam Sohal, Kanana Aburayyan, Bandhul Hans, Juliana Yang
Acute cholecystitis is a common cause of Emergency Department presentation and hospital admission. It is usually treated with early surgical removal of the gallbladder; however, some patients may not be fit to undergo the procedure due to critical illness or comorbidities. In these patients, options are limited. Endoscopic retrograde cholangiopancreatography interventions in this population are not well-studied. We present a case of a high-risk 59 year old female patient with a history of end-stage renal disease, heart failure, hypertension, pulmonary hypertension, and type 2 diabetes who presented with acute cholecystitis...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38333019/patients-with-hemophagocytic-lymphohistiocytosis-who-need-intensive-care-can-be-successfully-rescued-by-timely-using-etoposide-based-hlh-regimens
#15
JOURNAL ARTICLE
Kebing Lv, Xiaoye Cheng, Yulan Zhou, Min Yu, Shixuan Wang, Huimin Shen, Fei Li
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) patients who need intensive care usually have multiple organ failure and poor prognosis. However, the clinical characteristics, therapeutic efficacy and outcome in these critically ill HLH patients have remained unclear. METHODS: We performed a retrospective study of 50 critically ill HLH patients from September 2013 to October 2022. Patients' information was collected, and the overall survival rate was estimated...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38330092/when-a-critically-ill-child-is-oceans-away-from-a-picu-a-military-pediatric-ccat-mission
#16
JOURNAL ARTICLE
Kevin M Brinkman, Luke Zabrocki, Noelle Cadotte, Renée I Matos
A 4-year-old former 26-week premature male presented to the U.S. Naval Hospital Guam emergency department in respiratory failure secondary to human metapneumovirus requiring urgent intubation. His condition was complicated by a bradycardic arrest requiring 15 minutes of resuscitation before the return of circulation. He was admitted to the adult intensive care unit and was managed via pediatric telecritical care from San Diego. He developed acute respiratory distress syndrome, acute renal failure, hypotension requiring multiple pressors, and fluid overload necessitating bilateral chest tubes and two peritoneal drains...
February 5, 2024: Military Medicine
https://read.qxmd.com/read/38314424/carnitine-deficiency-in-intensive-care-unit-patients-undergoing-continuous-renal-replacement-therapy-a-single-center-retrospective-study
#17
JOURNAL ARTICLE
Marina Oi, Takaaki Maruhashi, Yasushi Asari
INTRODUCTION: Carnitine deficiency is common in patients undergoing intermittent hemodialysis and may also occur during continuous renal replacement therapy (CRRT). We evaluated intensive care unit (ICU) patients undergoing CRRT for carnitine deficiency and its associated risk factors. METHODS: This was a single-center, retrospective, observational study performed between June 2019 and March 2020. The primary outcome was the incidence of carnitine deficiency in ICU patients undergoing CRRT...
January 15, 2024: JMA journal
https://read.qxmd.com/read/38289005/clinical-value-of-soluble-urokinase-type-plasminogen-activator-receptor-in-predicting-sepsis-associated-acute-kidney-injury
#18
JOURNAL ARTICLE
Wenwen Zhang, Yue Gu, Jing Zhou, Juntao Wang, Xiaoru Zhao, Xiaoyu Deng, Han Li, Lei Yan, Xiaojing Jiao, Fengmin Shao
BACKGROUND: Sepsis-associated acute kidney injury (S-AKI) is a critical illness and is often associated with high morbidity and mortality rates. The soluble urokinase-type plasminogen activator receptor (suPAR) is an important immune mediator and is involved in kidney injury. However, its diagnostic value in S-AKI patients remains unclear. Therefore, we assessed the early predictive value of suPAR for S-AKI patients. METHODS: We prospectively enrolled adult patients, immediately after fulfilling the sepsis-3 criteria...
December 2024: Renal Failure
https://read.qxmd.com/read/38285892/acute-appendicitis-treatment-strategies-and-mortality-based-on-critical-illness-on-admission-an-observational-study
#19
JOURNAL ARTICLE
Samantha King, Jennifer Proper, Lianne K Siegel, Nicholas E Ingraham, Christopher J Tignanelli, Jeffrey G Chipman, Jason Ho
Background: Trials have shown non-inferiority of non-operative management (NOM) for appendicitis, although critically ill patients have been often excluded. The purpose of this study is to evaluate surgical versus NOM outcomes in critically ill patients with appendicitis by measuring mortality and hospital length of stay (LOS). Patients and Methods: The Healthcare Cost and Utilization Project's (HCUP) Database was utilized to analyze data from 10 states between 2008 and 2015. All patients with acute appendicitis by International Classification of Diseases, Ninth Revision (ICD-9) codes over the age of 18 were included...
February 2024: Surgical Infections
https://read.qxmd.com/read/38264967/predictive-model-of-acute-kidney-injury-in-critically-ill-patients-with-acute-pancreatitis-a-machine-learning-approach-using-the-mimic-iv-database
#20
JOURNAL ARTICLE
Shengwei Lin, Wenbin Lu, Ting Wang, Ying Wang, Xueqian Leng, Lidan Chi, Peipei Jin, Jinjun Bian
BACKGROUND: Acute kidney injury (AKI) is a common and serious complication in severe acute pancreatitis (AP), associated with high mortality rate. Early detection of AKI is crucial for prompt intervention and better outcomes. This study aims to develop and validate predictive models using machine learning (ML) to identify the onset of AKI in patients with AP. METHODS: Patients with AP were extracted from the MIMIC-IV database. We performed feature selection using the random forest method...
December 2024: Renal Failure
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