Psoratic

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Fifty (50) patients with different types of psoriasis and 25 controls were studied. 7 patients with psoriasis had elevated serum uric acid levels without any relation to the extent of skin involvement. AD remaining psoratics ano controls had normal levels of serum uric acid, calcium and phosphorus.

Psoriasis affects 2% of the population in Western countries. Its aetiology and pathogenesis remain unknown but suggestions include abnormalities of blood vessels, neural components, epidermal cell cycle time or maturation of keratinocytes. More recently autoimmune reactions have been implicated involving stratum corneum antibodies(1) and antibodies to nuclei of basal epidermal cells(2). However, there is no convincing evidence that any of these abnormalities are of primary nature. In this article, Helgi Valdimarsson and his colleagues propose that the process leading to psoriatic lesions is triggered by T lymphocytes within the epidermal compartment...

OBJECTIVES: The performance of spondyloarthritis (SpA) classification criteria is not well-established in general early arthritis cohorts. Therefore, the authors tested their performance in the Leiden Early Arthritis Clinic (EAC) cohort and assessed whether these criteria can assist rheumatologists in diagnosing patients. METHODS: The authors identified all SpA and psoriatic arthritis (PsA) patients in the EAC cohort according to the diagnosis of the treating rheumatologist...

PURPOSE: This study evaluated the efficacy of targeted UVB phototherapy treatment of chronic persistent psoratic plaques with localized incoherent UVB phototherapy. METHODS: Sixteen subjects were enrolled. The final group was composed of eight men and seven women, each having one to seven chronic, stable psoriatic plaques. Each plaque was treated with fluences ranging from 3 to 7 MED using a fibre-coupled incoherent phototherapy device twice weekly for a maximum of 13 sessions...

In recent years, interferon-alpha has become widely used for systemic therapy of tumours and infectious diseases. Well-known cutaneous side effects include dry skin, pruritus and hair loss. Since 1986, 17 patients with renal cell carcinoma, malignant melanoma, hepatitis B and C, carcinoid syndrome and hairy cell leukemia have been reported in whom psoriasis with or without psoratic B joint involvement was induced or exacerbated by systemic interferon-alpha therapy. In these patients, the drug was discontinued because of the severity of the psoriatic symptoms induced...

Since both psoriasis and seronegative arthritis occur individually in childhood, they may be expected to occur together occasionally. Clinical features used to identify psoriatic arthritis as a disease sui generi have been assembled in groups of adult patients, establishing the justification for describing a distinct syndrome. A review of the experience in an active children's rheumatology service indicates that the syndrome of psoratic arthritis occurs in the pediatric-aged patient with sufficient frequency to qualify as a diagnostic term appropriate in the classification of childhood-onset arthritis...

Our experiments have shown that cell mediated immunity of psoriatic patients is reduced especially when psoriasis began at an early age and/or when it is "intermittent".