keyword
https://read.qxmd.com/read/38504987/causal-associations-between-circulating-cytokines-and-risk-of-sepsis-and-related-outcomes-a-two-sample-mendelian-randomization-study
#21
JOURNAL ARTICLE
Feng Zhi, Jia-Wei Ma, Dan-Dan Ji, Jie Bao, Qian-Qian Li
INTRODUCTION: Sepsis represents a critical medical condition that arises due to an imbalanced host reaction to infection. Central to its pathophysiology are cytokines. However, observational investigations that explore the interrelationships between circulating cytokines and susceptibility to sepsis frequently encounter challenges pertaining to confounding variables and reverse causality. METHODS: To elucidate the potential causal impact of cytokines on the risk of sepsis, we conducted two-sample Mendelian randomization (MR) analyses...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38504695/predictive-and-prognostic-potentials-of-lymphocyte-c-reactive-protein-ratio-upon-hospitalization-in-adult-patients-with-acute-pancreatitis
#22
JOURNAL ARTICLE
Xiao-Yu Xu, Yang Gao, Chuang-Shi Yue, Yu-Jia Tang, Zhao-Jin Zhang, Feng-Jie Xie, Hong Zhang, Yu-Cheng Zhu, Yan Zhang, Qi-Qi Lai, Xin-Tong Wang, Jia-Xi Xu, Jia-Ning Zhang, Bo-Wen Liu, Jian-Nan Zhang, Kai Kang
PURPOSE: In this study, our objective was to investigate the potential utility of lymphocyte-C-reactive protein ratio (LCR) as a predictor of disease progression and a screening tool for intensive care unit (ICU) admission in adult patients with acute pancreatitis (AP). METHODS: We included a total of 217 adult patients with AP who were admitted to the First Affiliated Hospital of Harbin Medical University between July 2019 and June 2022. These patients were categorized into three groups: mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP), based on the presence and duration of organ dysfunction...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38502804/biomarkers-improve-diagnostics-of-sepsis-in-adult-patients-with-suspected-organ-dysfunction-based-on-the-quick-sepsis-related-organ-failure-assessment-qsofa-score-in-the-emergency-department
#23
JOURNAL ARTICLE
Myrto Bolanaki, Johannes Winning, Anna Slagman, Thomas Lehmann, Michael Kiehntopf, Angelika Stacke, Caroline Neumann, Konrad Reinhart, Martin Möckel, Michael Bauer
OBJECTIVES: Consensus regarding biomarkers for detection of infection-related organ dysfunction in the emergency department is lacking. We aimed to identify and validate biomarkers that could improve risk prediction for overt or incipient organ dysfunction when added to quick Sepsis-related Organ Failure Assessment (qSOFA) as a screening tool. DESIGN: In a large prospective multicenter cohort of adult patients presenting to the emergency department with a qSOFA score greater than or equal to 1, admission plasma levels of C-reactive protein, procalcitonin, adrenomedullin (either bioavailable adrenomedullin or midregional fragment of proadrenomedullin), proenkephalin, and dipeptidyl peptidase 3 were assessed...
February 7, 2024: Critical Care Medicine
https://read.qxmd.com/read/38500153/the-effect-of-channa-striata-moringa-oleifera-and-curcuma-xanthorrhiza-extract-on-accelerating-recovery-in-a-ventilated-patient-with-hemorrhagic-shock-grade-3-due-to-prolonged-retained-placenta-a-case-report
#24
JOURNAL ARTICLE
Theresia Monica Rahardjo, Aloysius Suryawan, Nadya Rosa Amelia Rumouw, Hizkia Santoso, Amadea Jovita Miko Faustin
BACKGROUND: Most of critically ventilated patients with severe hemorrhagic shock experience metabolic acidosis, hypoalbuminemia, electrolyte imbalance, and increased production of free radical. Channa striata has a high content of albumin, an essential binding protein that contributes to homeostasis, and when combined with Moringa oleifera and Curcuma xanthorrhiza, they act as powerful antioxidants. Administration of C. striata, M. oleifera, and C. xanthorrhiza extract orally may benefit patient with hemodynamic issues, including significant blood loss...
March 19, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38500106/lung-tissue-expression-of-epithelial-injury-markers-is-associated-with-acute-lung-injury-severity-but-does-not-discriminate-sepsis-from-ards
#25
JOURNAL ARTICLE
Natália de Souza Xavier Costa, Giovana da Costa Sigrist, Alexandre Santos Schalch, Luciano Belotti, Marisa Dolhnikoff, Luiz Fernando Ferraz da Silva
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in critically ill patients, and diffuse alveolar damage (DAD) is considered its histological hallmark. Sepsis is one of the most common aetiology of ARDS with the highest case-fatality rate. Identifying ARDS patients and differentiate them from other causes of acute respiratory failure remains a challenge. To address this, many studies have focused on identifying biomarkers that can help assess lung epithelial injury...
March 18, 2024: Respiratory Research
https://read.qxmd.com/read/38494365/lipopolysaccharide-delivery-systems-in-innate-immunity
#26
REVIEW
Jiao Liu, Rui Kang, Daolin Tang
Lipopolysaccharide (LPS), a key component of the outer membrane in Gram-negative bacteria (GNB), is widely recognized for its crucial role in mammalian innate immunity and its link to mortality in intensive care units. While its recognition via the Toll-like receptor (TLR)-4 receptor on cell membranes is well established, the activation of the cytosolic receptor caspase-11 by LPS is now known to lead to inflammasome activation and subsequent induction of pyroptosis. Nevertheless, a fundamental question persists regarding the mechanism by which LPS enters host cells...
March 16, 2024: Trends in Immunology
https://read.qxmd.com/read/38492030/clinical-course-and-peculiarities-of-parechovirus-and-enterovirus-central-nervous-system-infections-in-newborns-a-single-center-experience
#27
JOURNAL ARTICLE
Giacomo Brisca, Tommaso Bellini, Mattia Pasquinucci, Marcello Mariani, Marta Romanengo, Isabella Buffoni, Domenico Tortora, Alessandro Parodi, Elena Fueri, Alessio Mesini, Jessica Tibaldi, Emanuela Piccotti, Luca Antonio Ramenghi, Andrea Moscatelli
Parechovirus (HpEV) and Enterovirus (EV) infections in children mostly have a mild course but are particularly fearsome in newborns in whom they may cause aseptic meningitis, encephalitis, and myocarditis. Our study aimed to describe the clinical presentations and peculiarities of CNS infection by HpEV and EV in neonates. This is a single-center retrospective study at Istituto Gaslini, Genoa, Italy. Infants aged ≤ 30 days with a CSF RTq-PCR positive for EV or HpEV from January 1, 2022, to December 1, 2023, were enrolled...
March 16, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38490312/clinical-usefulness-of-a-host-signature-based-on-trail-ip10-and-crp-memed-bv-as-infection-biomarkers-in-intensive-care-units-patients-a-retrospective-observational-study
#28
JOURNAL ARTICLE
Karol P Steckiewicz, Magdalena A Wujtewicz, Michał Okrągły, Aleksander Aszkiełowicz, Malgorzata Dąbrowska, Radosław Owczuk
INTRODUCTION: Infection complications are common in intensive care unit patients, and early detection remains a diagnostic challenge. Procalcitonin (PCT) and C-reactive protein (CRP) are commonly used biomarkers. A novel diagnostic approach focuses on the host immune response. One of the novel approaches, the MMBV index, is based on measuring in a blood sample three parameters: (i) tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), (ii) interferon-γ-induced protein-10 (IP10), and (iii) CRP...
March 13, 2024: Clinical Biochemistry
https://read.qxmd.com/read/38489347/identifying-prognostic-factors-for-survival-in-intensive-care-unit-patients-with-sirs-or-sepsis-by-machine-learning-analysis-on-electronic-health-records
#29
JOURNAL ARTICLE
Maximiliano Mollura, Davide Chicco, Alessia Paglialonga, Riccardo Barbieri
BACKGROUND: Systemic inflammatory response syndrome (SIRS) and sepsis are the most common causes of in-hospital death. However, the characteristics associated with the improvement in the patient conditions during the ICU stay were not fully elucidated for each population as well as the possible differences between the two. GOAL: The aim of this study is to highlight the differences between the prognostic clinical features for the survival of patients diagnosed with SIRS and those of patients diagnosed with sepsis by using a multi-variable predictive modeling approach with a reduced set of easily available measurements collected at the admission to the intensive care unit (ICU)...
March 2024: PLOS Digit Health
https://read.qxmd.com/read/38483225/in-the-critically-ill-obese-should-we-tip-the-scale-with-more-protein
#30
JOURNAL ARTICLE
Beth E Taylor, Stephen A McClave
No abstract text is available yet for this article.
April 1, 2024: Critical Care Medicine
https://read.qxmd.com/read/38476861/prognostic-biomarkers-and-aki-potential-to-enhance-the-identification-of-post-operative-patients-at-risk-of-loss-of-renal-function
#31
REVIEW
Rishabh Singh, James C Watchorn, Alexander Zarbock, Lui G Forni
Acute kidney injury (AKI) is a common complication after surgery and the more complex the surgery, the greater the risk. During surgery, patients are exposed to a combination of factors all of which are associated with the development of AKI. These include hypotension and hypovolaemia, sepsis, systemic inflammation, the use of nephrotoxic agents, tissue injury, the infusion of blood or blood products, ischaemia, oxidative stress and reperfusion injury. Given the risks of AKI, it would seem logical to conclude that early identification of patients at risk of AKI would translate into benefit...
2024: Research and Reports in Urology
https://read.qxmd.com/read/38475703/analysis-of-viral-pneumonia-and-risk-factors-associated-with-severity-of-influenza-virus-infection-in-hospitalized-patients-from-2012-to-2016
#32
JOURNAL ARTICLE
M I Fullana Barceló, F Artigues Serra, A R Millan Pons, J Asensio Rodriguez, A Ferre Beltran, M Del Carmen Lopez Bilbao, J Reina Prieto, M Riera Jaume
BACKGROUND: Influenza viruses cause pneumonia in approximately one-third of cases, and pneumonia is an important cause of death. The aim was to identify risk factors associated with severity and those that could predict the development of pneumonia. METHODS: This retrospective, observational study included all adult patients with confirmed influenza virus infection admitted to Son Espases University Hospital during four influenza seasons in Spain (October to May) from to 2012-2016...
March 12, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38471985/application-of-a-multiplex-molecular-pneumonia-panel-and-real-world-impact-on-antimicrobial-stewardship-among-patients-with-hospital-acquired-and-ventilator-associated-pneumonia-in-intensive-care-units
#33
JOURNAL ARTICLE
Chieh-Lung Chen, How-Yang Tseng, Wei-Cheng Chen, Shinn-Jye Liang, Chih-Yen Tu, Yu-Chao Lin, Po-Ren Hsueh
BACKGROUND: The optimal timing for applying the BioFire FilmArray Pneumonia Panel (FAPP) in intensive care unit (ICU) patients with hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP) remains undefined, and there are limited data on its impact on antimicrobial stewardship. METHODS: This retrospective study was conducted at a referral hospital in Taiwan from November 2019 to October 2022. Adult ICU patients with HAP/VAP who underwent FAPP testing were enrolled...
March 6, 2024: Journal of Microbiology Immunology and Infection
https://read.qxmd.com/read/38471804/relevance-and-antimicrobial-resistance-profile-of-klebsiella-pneumoniae-in-neonatal-sepsis
#34
JOURNAL ARTICLE
Hui Ma, JingWen Xu, YanHong Zhang, RenYan Zhang, Jie Wu
BACKGROUND: Newborns are particularly susceptible to infection in hospitals, with neonatal sepsis being the most common infection symptom and the third leading cause of neonatal death. Klebsiella pneumoniae is a gram-negative bacterium of Enterobacteriaceae, which is a common pathogen of neonatal septicemia. In this study, we will analyze and evaluate the current status, clinical characteristics, and drug resistance of Klebsiella pneumoniae sepsis infection in Neonatal Intensive Care Unit (NICU), with the aim of providing effective basis for timely and accurate clinical diagnosis and treatment in clinical practice...
December 2024: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/38471247/serial-monitoring-of-pancreatic-stone-protein-for-the-detection-of-sepsis-in-intensive-care-unit-patients-with-complicated-abdominal-surgery-a-prospective-longitudinal-cohort-study
#35
JOURNAL ARTICLE
Paraskevas Filippidis, Leana Hovius, Frederic Tissot, Christina Orasch, Ursula Flückiger, Martin Siegemund, Jean-Luc Pagani, Philippe Eggimann, Oscar Marchetti, Frederic Lamoth
PURPOSE: The objective of this study was to assess the performance of pancreatic stone protein (PSP) monitoring for the detection of sepsis, prediction of outcome and distinction between bacterial and fungal infections in intensive care unit (ICU) patients with complicated abdominal surgery. MATERIALS AND METHODS: In this prospective multicenter cohort study, patients with complicated abdominal surgery had serial PSP measurements during their ICU stay. Infectious episodes were classified as bacterial, fungal or mixed...
March 11, 2024: Journal of Critical Care
https://read.qxmd.com/read/38465756/c-reactive-protein-in-the-early-diagnosis-of-pneumonia-complicating-severe-blunt-chest-trauma
#36
JOURNAL ARTICLE
Becem Trabelsi, Sahar Ghorbel, Rania Ben Rabeh, Mahdi Bouassida, Mechaal Ben Ali
INTRODUCTION: The early diagnosis of pneumonia following severe blunt chest trauma (SBCT) allows the early prescription of antibiotics and initiation of adequate supportive care. AIM: To assess the usefulness of C-reactive protein (CRP) in the early diagnosis of pneumonia complicating SBCT. METHODS: We conducted a prospective study of patients admitted to trauma intensive care unit for SBCT between January 2020 and February 2023. Patients were divided into two groups according to whether or not they developed pneumonia...
October 5, 2023: La Tunisie Médicale
https://read.qxmd.com/read/38463489/urinary-liver-type-fatty-acid-binding-protein-levels-may-be-associated-with-the-occurrence-of-acute-kidney-injury-induced-by-trauma
#37
JOURNAL ARTICLE
Ryu Yasuda, Keiko Suzuki, Hideshi Okada, Takuma Ishihara, Toru Minamiyama, Ryo Kamidani, Yuichiro Kitagawa, Tetsuya Fukuta, Kodai Suzuki, Takahito Miyake, Shozo Yoshida, Nobuyuki Tetsuka, Shinji Ogura
INTRODUCTION: Acute kidney injury (AKI), with a fatality rate of 8.6%, is one of the most common types of multiorgan failure in the intensive care unit (ICU). Thus, AKI should be diagnosed early, and early interventions should be implemented. Urinary liver-type fatty acid-binding protein (L-FABP) could aid in the diagnosis of AKI. METHODS: In this prospective, single-center, observational study, we included 100 patients with trauma. Urinary L-FABP levels were measured using a semi-quantitative rapid assay kit 6 and 12 h after injury...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38463105/safety-and-efficacy-of-extended-thrombophilia-screening-directed-venous-thromboembolic-events-vte-prophylaxis-in-live-liver-donors-do-we-really-need-extended-thrombophilia-screening-routinely
#38
JOURNAL ARTICLE
Abdul Wahab Dogar, Azhar Hussain, Kaleem Ullah, Shams-Ud-Din, Abdul Ghaffar, Khabab Abbasher Hussien Mohamed Ahmed, Muhammad Junaid Tahir
BACKGROUND AND AIMS: The study aimed to determine the prevalence of hereditary thrombophilia, and stratify its severity among live liver donors in Pakistan. Also, the authors evaluated the safety and efficacy of thrombophilia profile testing directed venous thromboembolic events (VTE) prophylaxis while balancing bleeding risk and the need for routine thrombophilia testing before live liver donation among living donor candidates. MATERIALS AND METHODS: Protein S (PS), protein C (PC), anti-thrombin (AT) III, and anti-phospholipid antibody panel (APLA) levels were measured in 567 potential donor candidates...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38462876/procalcitonin-to-albumin-ratio-as-a-biomarker-for-predicting-mortality-in-sepsis
#39
JOURNAL ARTICLE
Adem Keskin, Recai Aci
OBJECTIVE: To investigate the ability of the procalcitonin to albumin ratio to predict mortality in patients with sepsis. STUDY DESIGN: Observational study. PLACE AND DURATION OF STUDY: Department of Intensive care, Samsun Training and Research Hospital, Samsun, Turkiye, from September to December 2022. METHODOLOGY: Patients diagnosed with sepsis admitted to the intensive care unit were included in the study. They were divided into two groups based on their prognosis (expiry/survival)...
March 2024: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://read.qxmd.com/read/38460714/neurofilament-light-chain-but-not-glial-fibrillary-acidic-protein-is-a-potential-biomarker-of-overt-hepatic-encephalopathy-in-patients-with-cirrhosis
#40
JOURNAL ARTICLE
Koos de Wit, Diederick J van Doorn, Bregje Mol, Lonneke A van Vught, Frederik Nevens, Ulrich Beuers, Cyriel Y Ponsioen, Charlotte E Teunissen, R Bart Takkenberg
INTRODUCTION AND OBJECTIVES: Hepatic encephalopathy (HE) is a frequent complication of cirrhosis and may cause cerebral damage. Neurodegenerative diseases can induce the release of neuroproteins like neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in body fluids, including blood plasma. We investigated whether NfL and GFAP could serve as potential diagnostic plasma biomarkers for overt HE (oHE). MATERIALS AND METHODS: We included 85 patients from three prospective cohorts with different stages of liver disease and HE severity...
March 7, 2024: Annals of Hepatology
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