Jun-Hui Long, Pu-Jun Wang, Li Xuan, Yao Juan, Guang-Yan Wu, Jun-Fei Teng, Jian-Feng Sui, Ya-Min Li, Liu Yang, Hong-Li Li, Shu-Lei Liu
Itch is one of the most common clinical symptoms in patients with diseases of the skin, liver, or kidney, and it strongly triggers aversive emotion and scratching behavior. Previous studies have confirmed the role of the prelimbic cortex (Prl) and the nucleus accumbens core (NAcC), which are reward and motivation regulatory centers, in the regulation of itch. However, it is currently unclear whether the Prl-NAcC projection, an important pathway connecting these two brain regions, is involved in the regulation of itch and its associated negative emotions...
April 12, 2024: Behavioural Brain Research