keyword
https://read.qxmd.com/read/38537145/identification-of-two-novel-qtl-for-fusarium-head-blight-resistance-in-german-wheat-cultivar-centrum
#1
JOURNAL ARTICLE
Hui Ren, Xin Zhang, Yibo Zhang, Ziyang Zhang, Muzi Cheng, Lu Zhang, Xiangxue Zhang, Chunchun Li, Jiangli Duan, Chuanliang Zhang, Mingjie Xiang, Shengjie Liu, Chengzhi Jiang, Qingdong Zeng, Jianhui Wu, Zhensheng Kang, Zujun Yang, Chunlian Li, Shuo Huang, Dejun Han
Fusarium head blight (FHB) is a devastating disease that occurs in warm and humid environments. The German wheat Centrum has displayed moderate to high levels of FHB resistance in the field for many years. In this study, an F6:8 recombinant inbred line (RIL) population derived from cross Centrum × Xinong 979 was evaluated for FHB response following point inoculation in five environments. The population and parents were genotyped using the GenoBaits Wheat 16 K Panel. Stable quantitative trait loci (QTL) associated with FHB resistance in Centrum were mapped on chromosome arms 2DS and 5BS...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38535058/periportal-edema-as-an-extrarenal-manifestation-of-acute-pyelonephritis
#2
JOURNAL ARTICLE
Yu-Yun Chang, Kuei-Hong Kuo
Acute pyelonephritis is a common infection of the upper urinary tract that affects approximately 250,000 adults in the United States. Individuals with acute pyelonephritis require hospitalization and intravenous antimicrobial therapy. Diagnoses of acute pyelonephritis are made on the basis of clinical and laboratory findings. Individuals with complex or severe acute pyelonephritis undergo contrast-enhanced computed tomography (CT) for the diagnosis and assessment of perirenal abnormalities. However, extrarenal manifestations, such as periportal edema and gallbladder wall thickening, may complicate the diagnostic process...
March 18, 2024: Diagnostics
https://read.qxmd.com/read/38532775/discontinuous-translocation-of-a-luciferase-protein-beyond-graft-junction-in-tobacco
#3
JOURNAL ARTICLE
Taira Miyahara, Hitomi Ohkubo, Yukiko Umeyama, Taichi Oguchi, Takumi Ogawa, Daisaku Ohta, Tomofumi Mochizuki, Hiroaki Kodama
Transgrafting, a grafting technique that uses both genetically modified (GM) and non-GM plants, is a novel plant breeding technology that can be used to improve the efficiency of crop cultivation without introducing foreign genes into the edible parts of non-GM plants. This technique can facilitate the acquisition of disease resistance and/or increased yield. However, the translocation of low-molecular-weight compounds, ribonucleic acid (RNA), and proteins through graft junctions raises a potential safety risk for food crops...
March 2024: Food safety
https://read.qxmd.com/read/38532772/discontinuous-translocation-of-a-luciferase-protein-beyond-graft-junction-in-tobacco
#4
JOURNAL ARTICLE
Taira Miyahara, Hitomi Ohkubo, Yukiko Umeyama, Taichi Oguchi, Takumi Ogawa, Daisaku Ohta, Tomofumi Mochizuki, Hiroaki Kodama
Transgrafting, a grafting technique that uses both genetically modified (GM) and non-GM plants, is a novel plant breeding technology that can be used to improve the efficiency of crop cultivation without introducing foreign genes into the edible parts of non-GM plants. This technique can facilitate the acquisition of disease resistance and/or increased yield. However, the translocation of low-molecular-weight compounds, ribonucleic acid (RNA), and proteins through graft junctions raises a potential safety risk for food crops...
March 2024: Food safety
https://read.qxmd.com/read/38530900/structural-and-mechanistic-basis-of-the-central-energy-converting-methyltransferase-complex-of-methanogenesis
#5
JOURNAL ARTICLE
Iram Aziz, Kanwal Kayastha, Susann Kaltwasser, Janet Vonck, Sonja Welsch, Bonnie J Murphy, Jörg Kahnt, Di Wu, Tristan Wagner, Seigo Shima, Ulrich Ermler
Methanogenic archaea inhabiting anaerobic environments play a crucial role in the global biogeochemical material cycle. The most universal electrogenic reaction of their methane-producing energy metabolism is catalyzed by N     5 -methyl-tetrahydromethanopterin: coenzyme M methyltransferase (MtrABCDEFGH), which couples the vectorial Na+ transport with a methyl transfer between the one-carbon carriers tetrahydromethanopterin and coenzyme M via a vitamin B12 derivative (cobamide) as prosthetic group...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38530877/strongly-polarized-%C3%AF-extended-1-4-dihydropyrrolo-3-2-b-pyrroles-fused-with-tetrazolo-1-5-a-quinolines
#6
JOURNAL ARTICLE
Mohammad B Teimouri, Irena Deperasińska, Matt Rammo, Marzena Banasiewicz, Charles W Stark, Łukasz Dobrzycki, Michał K Cyrański, Aleksander Rebane, Daniel T Gryko
A straightforward route to 1,4-dihydropyrrolo[3,2- b ]pyrroles comprised of two electron-withdrawing quinoline or tetrazolo[1,5- a ]quinoline scaffolds has been developed. The versatile multicomponent reaction affording 1,4-dihydropyrrolo[3,2- b ]pyrroles combined with intramolecular direct arylation enables assembly of these products in just three steps from anilines with overall yields exceeding 30%. The planarized, ladder-type heteroacenes possess up to 14 conjugated rings. These nominally quadrupolar materials exhibit efficient fluorescence with wavelengths spanning most of the visible spectrum from green-yellow for the dyes possessing biaryl bridges and orange-red for the fully fused systems...
March 26, 2024: Journal of Organic Chemistry
https://read.qxmd.com/read/38530861/aminoglycoside-resistance-genes-in-early-members-of-the-acinetobacter-baumannii-st78a-smal-italian-clone-reside-in-an-is26-bounded-island-in-the-chromosome
#7
JOURNAL ARTICLE
Christopher J Harmer, Sarah M Cahill, Johanna J Kenyon, Ruth M Hall
BACKGROUND: The Acinetobacter baumannii isolate called SMAL, previously used to determine the structures of capsular polysaccharide and lipooligosaccharide, was recovered in Pavia, Italy in 2002 among the collection of aminoglycoside-resistant isolates designated as SMAL type. This type was later called the Italian clone, then ST78. ST78 isolates are now widely distributed. OBJECTIVES: To establish the resistance gene complement and the location and structure of acquired resistance regions in early members of the Italian/ST78 clone...
March 26, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38529880/mitochondrial-respiratory-supercomplexes-of-the-yeast-saccharomyces-cerevisiae
#8
REVIEW
Mazzen H Eldeeb, Lizeth J Camacho Lopez, Flavia Fontanesi
The functional and structural relationship among the individual components of the mitochondrial respiratory chain constitutes a central aspect of our understanding of aerobic catabolism. This interplay has been a subject of intense debate for over 50 years. It is well established that individual respiratory enzymes associate into higher-order structures known as respiratory supercomplexes, which represent the evolutionarily conserved organizing principle of the mitochondrial respiratory chain. In the yeast Saccharomyces cerevisiae, supercomplexes are formed by a complex III homodimer flanked by one or two complex IV monomers, and their high-resolution structures have been recently elucidated...
March 26, 2024: IUBMB Life
https://read.qxmd.com/read/38525130/toxicity-of-a-novel-antifungal-agent-atb1651-gel-in-yucatan-minipigs-sus-scrofa-following-4%C3%A2-weeks-of-daily-dermal-administration
#9
JOURNAL ARTICLE
Hyung-Sun Kim, Goo-Hwa Kang, Mi-Jin Yang, Yun-Jeong Joo, Dong-Gi Lee, Han-Seung Lee, Jong-Seung Lee, Jeong Ho Hwang
ATB1651 gel is an antifungal drug candidate that enhances antifungal activity through substitution of several aryl rings, alkyl chains, and methyl groups. To ensure safety of use of ATB1651 gel, assessment of its potentially toxic side effects is necessary. In this study, we examined the repeated-dose toxicity of ATB1651 gel to Yucatan minipigs (Sus scrofa) in accordance with the Good Laboratory Practice guidelines. Five doses of ATB1651 gel (0%, 0.2%, 0.5%, 1.0%, 3.0%) were administered dermally to the left and right flanks of 38 minipigs daily for 4 weeks...
April 2024: Toxicological Research
https://read.qxmd.com/read/38523579/wunderlich-syndrome-as-a-rare-complication-of-polyarteritis-nodosa-a-case-report
#10
JOURNAL ARTICLE
D Oliveira, A Martins, F Martins, M Rato, F Pinheiro, D Fonseca, C Vaz, E Mariz, L Costa
Spontaneous subcapsular and perirenal hemorrhage, known as Wunderlich syndrome (WS), is a rare clinical manifestation of polyarteritis nodosa (PAN). We report a case of a 48-year-old male with a history of recurrent episodes of leg muscle tenderness and dysesthesia, bilateral flank pain, painful nodular skin lesions in the lower limbs, weight loss, and difficult-to-control arterial hypertension. The abdominopelvic computed tomography angiography showed a large left perirenal hematoma, leading to the patient's admission to the intensive care unit...
March 22, 2024: Reumatismo
https://read.qxmd.com/read/38522681/targeting-proto-oncogene-b-myb-g-quadruplex-with-a-nucleic-acid-based-fluorescent-probe
#11
JOURNAL ARTICLE
Pedro Lourenço, André Miranda, Maria Paula Cabral Campello, António Paulo, Jean Louis-Mergny, Carla Cruz
The B-MYB gene encodes a transcription factor (B-Myb) that regulates cell growth and survival. Abnormal expression of B-MYB is frequently observed in lung cancer and poses challenges for targeted drug therapy. Oncogenes often contain DNA structures called G-quadruplexes (G4s) in their promoter regions, and B-MYB is no exception. These G4s play roles in genetic regulation and are potential cancer treatment targets. In this study, a probe was designed to specifically identify a G4 within the promoter region of the B-MYB gene...
March 22, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38522664/cdx1-and-gsc-distinctly-regulate-the-transcription-of-bmp4-target-gene-ventx3-2-by-directly-binding-to-the-proximal-promoter-region-in-xenopus-gastrulae
#12
JOURNAL ARTICLE
Ravi Shankar Goutam, Vijay Kumar, Unjoo Lee, Jaebong Kim
A comprehensive regulatory network of transcription factors controls the dorsoventral patterning of the body axis in developing vertebrate embryos. Bone morphogenetic protein signaling is essential for activating the Ventx family of homeodomain transcription factors, which regulates embryonic patterning and germ layer identity during Xenopus gastrulation. Although Ventx1.1 and Ventx2.1 of the Xenopus Ventx family have been extensively investigated, Ventx3.2 remains largely understudied. Therefore, this study aimed to investigate the transcriptional regulation of ventx3...
March 22, 2024: Molecules and Cells
https://read.qxmd.com/read/38522119/performance-and-characterization-of-94-identity-informative-snps-in-northern-han-chinese-using-forenseq-%C3%A2-dna-signature-prep-kit
#13
JOURNAL ARTICLE
Fei Guo, Ze Liu, Guannan Long, Biao Zhang, Dahua Liu, Shaobo Yu
Target and flanking region (FR) variation at 94 identity-informative SNPs (iSNPs) are investigated in 635 Northern Han Chinese using the ForenSeq DNA Signature Prep Kit on the MiSeq FGx Forensic Genomics System. The dataset presents the following performance characteristics (average values): ≥60% bases with a quality score of 20 or higher (%≥ Q20); >700 × of depth of coverage (DoC) from both Sample Details Reports and Flanking Region Reports; >80% of effective reads; ≥60% of allele coverage ratio (ACR); and ≥70% of inter-locus balance, while some stable low-performance characteristics are also observed: low DoC at rs1736442, rs1031825, rs7041158, rs338882, rs2920816, rs1493232, rs719366, and rs2342747; high noise at rs891700; and imbalanced ACR at rs6955448 and rs338882...
March 21, 2024: Journal of Forensic and Legal Medicine
https://read.qxmd.com/read/38522068/homozygous-missense-variants-in-ykt6-result-in-loss-of-function-and-are-associated-with-developmental-delay-with-or-without-severe-infantile-liver-disease-and-risk-for-hepatocellular-carcinoma
#14
JOURNAL ARTICLE
Mengqi Ma, Mythily Ganapathi, Yiming Zheng, Kai-Li Tan, Oguz Kanca, Kevin E Bove, Norma Quintanilla, Sebnem O Sag, Sehime G Temel, Charles A LeDuc, Amanda J McPartland, Elaine M Pereira, Yufeng Shen, Jacob Hagen, Christie P Thomas, Nhu Thao Nguyen Galván, Xueyang Pan, Shenzhao Lu, Jill A Rosenfeld, Daniel G Calame, Michael F Wangler, James R Lupski, Davut Pehlivan, Paula M Hertel, Wendy K Chung, Hugo J Bellen
PURPOSE: YKT6 plays important roles in multiple intracellular vesicle trafficking events but has not been associated with Mendelian diseases. METHODS: We report three unrelated individuals with rare homozygous missense variants in YKT6 who exhibited neurological disease with or without a progressive infantile liver disease. We modeled the variants in Drosophila. We generated wild-type and variant genomic rescue constructs (GRs) of the fly ortholog dYkt6 and compared their ability in rescuing the loss-of-function phenotypes in mutant flies...
March 21, 2024: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://read.qxmd.com/read/38511954/first-report-of-multidrug-resistant-carbapenemase-producing-aeromonas-caviae-co-harboring-mcr-3-43-and-mcr-7-2
#15
JOURNAL ARTICLE
Tingting Xu, Jingjie Song, Jialong Liu, Lili Huang, Zhao Li, Kai Zhou
Hospital sewage serves as a crucial reservoir for antibiotic resistance genes. As colistin and carbapenems are the last-resort antibiotics, the emergence of their resistance genes has become a significant concern in clinical settings. In this study, we found that two novel mcr alleles ( mcr-3 .43 and mcr-7 .2) with two carbapenemase genes ( bla NDM-1 and bla KPC-2 ) were encoded in a single Aeromonas caviae strain isolated from hospital sewage. Our phylogenetic analysis revealed that the mcr-3.43 gene clustered with mcr-3...
March 21, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38511874/ewing-sarcoma-related-protein-1-recognizes-r-loops-by-binding-dna-forks
#16
JOURNAL ARTICLE
Michelle A Lay, Valery F Thompson, Ajibola D Adelakun, Jacob C Schwartz
EWSR1 (Ewing Sarcoma Related protein 1) is an RNA binding protein that is ubiquitously expressed across cell lines and involved in multiple parts of RNA processing, such as transcription, splicing, and mRNA transport. EWSR1 has also been implicated in cellular mechanisms to control formation of R-loops, a three-stranded nucleic acid structure consisting of a DNA:RNA hybrid and a displaced single-stranded DNA strand. Unscheduled R-loops result in genomic and transcription stress. Loss of function of EWSR1 functions commonly found in Ewing Sarcoma correlates with high abundance of R-loops...
March 21, 2024: Biopolymers
https://read.qxmd.com/read/38511293/evaluation-of-the-analgesic-efficacy-of-grapiprant-compared-with-robenacoxib-in-cats-undergoing-elective-ovariohysterectomy-in-a-prospective-randomized-masked-non-inferiority-clinical-trial
#17
JOURNAL ARTICLE
Elizabeth K Pisack, Stephanie A Kleine, Chiara E Hampton, Christopher K Smith, Jennifer Weisent, Rebecca DeBolt, Cambrie Schumacher, Genevieve Bussières, Reza Seddighi
OBJECTIVES: The main objective of this study was to compare the postoperative analgesic effects of grapiprant with those of robenacoxib in cats undergoing ovariohysterectomy (OVH). METHODS: In total, 37 female cats (age range 4 months-10 years, weighing ⩾2.5 kg) were enrolled in a prospective, randomized, masked, non-inferiority (NI) clinical trial. Cats received oral robenacoxib (1 mg/kg) or grapiprant (2 mg/kg) 2 h before OVH. Analgesia was assessed via the Feline Grimace Scale (FGS), the Glasgow Composite Measure Pain Scale-Feline (CMPS-F), von Frey monofilaments (vFFs) and pressure algometry (ALG) 2 h before treatment administration, at extubation, and 2, 4, 6, 8, 18 and 24 hours after extubation...
March 2024: Journal of Feline Medicine and Surgery
https://read.qxmd.com/read/38511232/immune-checkpoint-inhibitor-monotherapy-is-sufficient-to-promote-microenvironmental-normalization-via-the-type-i%C3%A2-interferon-pathway-in-pd-l1-expressing-head-and-neck-cancer
#18
JOURNAL ARTICLE
Jeon Yeob Jang, Bok-Soon Lee, Mei Huang, Chorong Seo, Ji-Hye Choi, Yoo Seob Shin, Hyun Goo Woo, Chul-Ho Kim
Immune checkpoint blockers (ICBs) targeting programmed cell death protein 1 (PD-1) have been proven to be an effective first-line therapy against programmed cell death 1 ligand 1 (PD-L1; also known as CD274 molecule)-expressing head and neck squamous cell carcinoma (HNSCC) in recent KEYNOTE-048 trial. However, associated changes in the tumor microenvironment (TME) and underlying mechanisms remain elusive. Oral tumors in C57/BL6 mice were induced by administering 7,12-dimethylbenzanthracene into the buccal mucosa...
March 21, 2024: Molecular Oncology
https://read.qxmd.com/read/38510096/a-case-of-successful-revascularization-and-renal-recovery-after-6%C3%A2-days-of-renal-artery-occlusion
#19
Muner M B Mohamed, Khalid M G Mohammed, MoetazBellah S A Kadoura, W Charles Sternbergh, Juan Carlos Q Velez
A 72-year-old man with peripheral arterial disease, an atrophic left kidney, and prior right renal chimney stent as part of a complex endovascular abdominal aortic aneurysm repair presented to our emergency department with right flank pain and anuria resulting from right artery occlusion. His serum creatinine on admission was 7.5 mg/dL. Computed tomography angiography 6 days after the onset of his symptoms revealed complete occlusion of the right renal artery stent. Percutaneous thrombectomy was performed restored renal blood flow...
June 2024: Journal of Vascular Surgery Cases and Innovative Techniques
https://read.qxmd.com/read/38508534/robotic-flexible-ureteroscopy-a-step-by-step-video-by-using-roboflex-avicenna-tm-platform
#20
Rifat Burak Ergül, Mehmet Gurcan, Ahmet Baris Aydin, İsmet Nane, Faruk Özcan, Tzevat Tefik
BACKGROUND: The management of kidney stones, particularly those in the renal pelvis, is a critical aspect of urology. The European Association of Urology guidelines recommend Extracorporeal Shock Wave Lithotripsy or Endourology methods, encompassing Percutaneous Nephrolithotomy and Ureterorenoscopy (URS), for stones ranging from 10-20 mm. Robotic-assisted urological procedures have gained prominence in recent years, promising enhanced precision, and safety. OBJECTIVES: This article aims to provide a detailed account of the technical aspects and outcomes of a robotic URS (robo-URS) procedure in a 63-year-old male patient with a 15 mm renal pelvis stone, serving as a reference for urologists considering this approach...
March 18, 2024: Urology
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