keyword
https://read.qxmd.com/read/38507902/high-throughput-mass-spectrometry-analysis-of-n-glycans-and-protein-markers-after-fut8-knockdown-in-the-syngeneic-sw480-sw620-colorectal-cancer-cell-model
#21
JOURNAL ARTICLE
Rubén López-Cortés, Laura Muinelo-Romay, Almudena Fernández-Briera, Emilio Gil Martín
Disruption of the glycosylation machinery is a common feature in many types of cancer, and colorectal cancer (CRC) is no exception. Core fucosylation is mediated by the enzyme fucosyltransferase 8 (FucT-8), which catalyzes the addition of α1,6-l-fucose to the innermost GlcNAc residue of N -glycans. We and others have documented the involvement of FucT-8 and core-fucosylated proteins in CRC progression, in which we addressed core fucosylation in the syngeneic CRC model formed by SW480 and SW620 tumor cell lines from the perspective of alterations in their N -glycosylation profile and protein expression as an effect of the knockdown of the FUT8 gene that encodes FucT-8...
March 20, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38506091/competitive-endogenous-rna-networks-decoding-the-role-of-long-non-coding-rnas-and-circular-rnas-in-colorectal-cancer-chemoresistance
#22
REVIEW
Ali Khalafizadeh, Seyedeh Donya Hashemizadegan, Fatemeh Shokri, Babak Bakhshinejad, Keyvan Jabbari, Mahsa Motavaf, Sadegh Babashah
Colorectal cancer (CRC) is recognized as one of the most common gastrointestinal malignancies across the globe. Despite significant progress in designing novel treatments for CRC, there is a pressing need for more effective therapeutic approaches. Unfortunately, many patients undergoing chemotherapy develop drug resistance, posing a significant challenge for cancer treatment. Non-coding RNAs (ncRNAs) have been found to play crucial roles in CRC development and its response to chemotherapy. However, there are still gaps in our understanding of interactions among various ncRNAs, such as long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs)...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38505918/increased-pkn2-and-m2-polarized-macrophages-promote-hct116-cell-invasion
#23
JOURNAL ARTICLE
Cheng He, Yimei Lin, Feng Qiu, Qingxin Zeng
Colorectal cancer is the third most common malignant tumor, with highly invasive and metastatic potential in the later stage. This study investigated the role of PKN2 overexpression and M2-polarized macrophages in dictating the malignant phenotype of colorectal cancer cells. HCT116 colorectal cancer cell line with PKN2 overexpression was generated to investigate the functional role of PKN2. THP-1 cells were polarized into M2-like macrophages, and the co-culture system of THP-1/M2 cells and HCT116 cells was established to examine the impacts of M2-polairzed macrophages on the malignant phenotype of colorectal cancer cells...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/38505308/expression-profile-of-serum-lncrnas-malat-1-and-ccat-1-and-their-correlation-with-mayo-severity-score-in-ulcerative-colitis-patients-can-diagnose-and-predict-the-prognosis-of-the-disease
#24
JOURNAL ARTICLE
Marwa A Ali, Olfat G Shaker, El Shimaa Gomaa Ali, Eman M Ezzat, Abeer A Khalifa, Essam A Hassan, Marwa A Habib, Heba Mostafa Ahmed, Asmaa F A Dawood, Esam Ali Mohamed
BACKGROUND: Ulcerative colitis (UC) has emerged as an accelerated-incidence chronic condition. UC has been identified as a precancerous lesion for colorectal cancer. Up-to-date genomic research revealed the value of many noncoding RNAs (ncRNAs) in UC pathogenesis, diagnosis, and prognosis. AIM: The present study was aimed at measuring both MALAT-1 and CCAT-1 in the sera of UC patients as diagnostic and prognostic biomarkers and correlating them with the Mayo score which is a novel predictive indicator of malignant transformation as well as with clinicopathological characteristics of the disease...
June 2024: Non-Coding RNA Research
https://read.qxmd.com/read/38503254/automated-classification-pipeline-for-real-time-in-vivo-examination-of-colorectal-tissue-using-raman-spectroscopy
#25
JOURNAL ARTICLE
Jan Vališ, Markéta Fousková, Daniela Janstová, Lucie Habartová, Jaromír Petrtýl, Luboš Petruželka, Alla Synytsya, Vladimír Setnička
Colorectal cancer is the third most common malignancy worldwide and one of the leading causes of death in oncological patients with its diagnosis typically involving confirmation by tissue biopsy. In vivo Raman spectroscopy, an experimental diagnostic method less invasive than a biopsy, has shown great potential to discriminate between normal and cancerous tissue. However, the complex and often manual processing of Raman spectra along with the absence of a suitable instant classifier are the main obstacles to its adoption in clinical practice...
March 13, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38499636/prognosis-significance-and-potential-association-between-aldoa-and-akt-expression-in-colorectal-cancer
#26
JOURNAL ARTICLE
Menglin Xu, Shihang Xi, Haoran Li, Yong Xia, Guangliang Mei, Zhengwu Cheng
Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract and a leading cause of cancer-related death worldwide. Since many CRC patients are diagnosed already in the advanced stage, and traditional chemoradiotherapy is prone to drug resistance, it is important to find new therapeutic targets. In this study, the expression levels of ALDOA and p-AKT were detected in cancer tissues and paired normal tissues, and it was found that they were significantly increased in CRC tissues, and their high expression indicated poor prognosis...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38499197/comparative-evaluation-of-a-language-model-and-human-specialists-in-the-application-of-ecco-guidelines-for-the-management-of-inflammatory-bowel-diseases-and-malignancies
#27
JOURNAL ARTICLE
Itai Ghersin, Roni Weisshof, Eduard Koifman, Haggai Bar-Yoseph, Dana Ben Hur, Itay Maza, Erez Hasnis, Roni Nasser, Baruch Ovadia, Dikla Dror Zur, Matti Waterman, Yuri Gorelik
BACKGROUND AND AIMS: Societal guidelines on colorectal dysplasia screening, surveillance and endoscopic management in inflammatory bowel diseases are rather complex, and physician adherence to them is suboptimal. We aimed to evaluate the use of ChatGPT, a large language model, in generating accurate guideline-based recommendations for colorectal dysplasia screening, surveillance and endoscopic management in inflammatory bowel diseases in line with European Crohn's and Colitis Organization (ECCO) guidelines...
March 18, 2024: Endoscopy
https://read.qxmd.com/read/38499079/understanding-the-role-of-dna-methylation-in-colorectal-cancer-mechanisms-detection-and-clinical-significance
#28
REVIEW
Ningning Zhao, Chuanxi Lai, Yunfei Wang, Sheng Dai, Hongcang Gu
Colorectal cancer (CRC) is one of the deadliest malignancies worldwide, ranking third in incidence and second in mortality. Remarkably, early stage localized CRC has a 5-year survival rate of over 90%; in stark contrast, the corresponding 5-year survival rate for metastatic CRC (mCRC) is only 14%. Compounding this problem is the staggering lack of effective therapeutic strategies. Beyond genetic mutations, which have been identified as critical instigators of CRC initiation and progression, the importance of epigenetic modifications, particularly DNA methylation (DNAm), cannot be underestimated, given that DNAm can be used for diagnosis, treatment monitoring and prognostic evaluation...
March 16, 2024: Biochimica et Biophysica Acta. Reviews on Cancer
https://read.qxmd.com/read/38498328/layer-by-layer-nanoparticle-encapsulating-all-trans-retinoic-acid-and-cpg-as-a-mucosal-adjuvant-targeting-colorectal-cancer
#29
JOURNAL ARTICLE
Shiwei Mi, Wei Li, Yixing Wen, Chen Yang, Shuai Liu, Jingjiao Li, Xingdi Cheng, Yuanyuan Zhao, Haonan Huo, Haowei Zu, Xueguang Lu
Colorectal cancer (CRC) ranks among the most prevalent cancers globally, demanding innovative therapeutic strategies. Immunotherapy, a promising avenue, employs cancer vaccines to activate the immune system against tumors. However, conventional approaches fall short of eliciting robust responses within the gastrointestinal (GI) tract, where CRC originates. Harnessing the potential of all-trans retinoic acid (ATRA) and cytosine-phosphorothioate-guanine (CpG), we developed layered nanoparticles using a layer-by-layer assembly method to co-deliver these agents...
March 18, 2024: Biomaterials Science
https://read.qxmd.com/read/38497584/mapping-the-intellectual-structure-and-landscape-of-colorectal-cancer-immunotherapy-a-bibliometric-analysis
#30
JOURNAL ARTICLE
Qin Ling Ou, Yong Long Chang, Jin Hui Liu, Hai Xia Yan, Lin Zi Chen, Duan Yang Guo, Si Fang Zhang
Immunotherapy, particularly immune checkpoint inhibitor (ICIs) therapy, stands as an innovative therapeutic approach currently garnering substantial attention in cancer treatment. It has become a focal point of numerous studies, showcasing significant potential in treating malignancies, including lung cancer and melanoma. The objective of this research is to analyze publications regarding immunotherapy for colorectal cancer (CRC), investigating their attributes and identifying the current areas of interest and cutting-edge advancements...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38495263/chemoembolization-beyond-hepatocellular-carcinoma-what-tumors-can-we-treat-and-when
#31
REVIEW
Daniel M DePietro, Xin Li, Susan M Shamimi-Noori
Liver metastases are the most common malignancy found in the liver and are 20 to 40 times more common than primary hepatic tumors, including hepatocellular carcinoma. Patients with liver metastases often present with advanced disease and are not eligible for curative-intent surgery or ablative techniques. The unique hepatic arterial blood supply of liver metastases allows interventional radiologists to target these tumors with transarterial therapies. Transarterial chemoembolization (TACE) has been studied in the treatment of liver metastases originating from a variety of primary malignancies and has demonstrated benefits in terms of hepatic progression-free survival, overall survival, and symptomatic relief, among other benefits...
February 2024: Seminars in Interventional Radiology
https://read.qxmd.com/read/38495181/holistic-exploration-of-chga-and-hsa-mir-137-in-colorectal-cancer-via-multi-omic-data-integration
#32
JOURNAL ARTICLE
Hossein Safarpour, Javad Ranjbaran, Nafiseh Erfanian, Samira Nomiri, Afshin Derakhshani, Casimiro Gerarduzzi, Adib Miraki Feriz, Edris HosseiniGol, Samira Saghafi, Nicola Silvestris
Colorectal cancer (CRC) ranks among the most widespread malignancies globally, with early detection significantly influencing prognosis. Employing a systems biology approach, we aimed to unravel the intricate mRNA-miRNA network linked to CRC pathogenesis, potentially yielding diagnostic biomarkers. Through an integrative analysis of microarray, Bulk RNA-seq, and single-cell RNA-seq data, we explored CRC-related transcriptomes comprehensively. Differential gene expression analysis uncovered crucial genes, while Weighted Gene Co-expression Network Analysis (WGCNA) identified key modules closely linked to CRC...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38494866/targeted-inhibition-of-colorectal-cancer-proliferation-the%C3%A2-dual-modulatory-role-of-2-4-dtbp-on-anti-apoptotic-bcl-2-and-survivin-proteins
#33
JOURNAL ARTICLE
Partha Saha, Mangala Hegde, Kanak Chakraborty, Achinta Singha, Nobendu Mukerjee, Deepshikha Ghosh, Ajaikumar B Kunnumakkara, Mohd Shahnawaz Khan, Md Irshad Ahmad, Arabinda Ghosh, Ajoy Kumer, Samir Kumar Sil
The anti-apoptotic proteins, Bcl-2 and Survivin, are consistently overexpressed in numerous human malignancies, notably in colorectal cancer. 2,4-Di-tert-butylphenol (2,4-DTBP) is a naturally occurring phenolic compound known for its diverse biological activities, including anti-cancer properties. The mechanism behind 2,4-DTBP-induced inhibition of cell proliferation and apoptosis in human colorectal cancer cells, specifically regarding Bcl-2 and Survivin, remains to be elucidated. In this study, we employed both in silico and in vitro methodologies to underpin this interaction at the molecular level...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38494600/tumor-suppressive-role-of-the-epigenetic-master-regulator-brd3-in-colorectal-cancer
#34
JOURNAL ARTICLE
Masahiro Hashimoto, Takaaki Masuda, Yusuke Nakano, Taro Tobo, Hideyuki Saito, Kensuke Koike, Junichi Takahashi, Tadashi Abe, Yuki Ando, Yuki Ozato, Kiyotaka Hosoda, Satoshi Higuchi, Yuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Tsuyoshi Hata, Mamoru Uemura, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori, Koshi Mimori
Bromodomain and extraterminal domain (BET) family proteins are epigenetic master regulators of gene expression via recognition of acetylated histones and recruitment of transcription factors and co-activators to chromatin. Hence, BET family proteins have emerged as promising therapeutic targets in cancer. In this study, we examined the functional role of bromodomain containing 3 (BRD3), a BET family protein, in colorectal cancer (CRC). In vitro and vivo analyses using BRD3-knockdown or BRD3-overexpressing CRC cells showed that BRD3 suppressed tumor growth and cell cycle G1/S transition and induced p21 expression...
March 17, 2024: Cancer Science
https://read.qxmd.com/read/38494579/molecular-engineering-of-a-spheroid-penetrating-phage-nanovector-for-photodynamic-treatment-of-colon-cancer-cells
#35
JOURNAL ARTICLE
Eleonora Turrini, Luca Ulfo, Paolo Emidio Costantini, Roberto Saporetti, Matteo Di Giosia, Michela Nigro, Annapaola Petrosino, Lucia Pappagallo, Alena Kaltenbrunner, Andrea Cantelli, Valentina Pellicioni, Elena Catanzaro, Carmela Fimognari, Matteo Calvaresi, Alberto Danielli
Photodynamic therapy (PDT) represents an emerging strategy to treat various malignancies, including colorectal cancer (CC), the third most common cancer type. This work presents an engineered M13 phage retargeted towards CC cells through pentavalent display of a disulfide-constrained peptide nonamer. The M13CC nanovector was conjugated with the photosensitizer Rose Bengal (RB), and the photodynamic anticancer effects of the resulting M13CC -RB bioconjugate were investigated on CC cells. We show that upon irradiation M13CC -RB is able to impair CC cell viability, and that this effect depends on i) photosensitizer concentration and ii) targeting efficiency towards CC cell lines, proving the specificity of the vector compared to unmodified M13 phage...
March 17, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38493666/selenium-levels-in-colorectal-cancer-a-systematic-review-and-meta-analysis-of-serum-plasma-and-colorectal-specimens
#36
JOURNAL ARTICLE
Amit Pal, Aninda Dhar, Muhammad Aaqib Shamim, Isha Rani, Ram Rattan Negi, Aaina Sharma, Namrata Chatterjee, Anmol Goyal, Sadashiv, Bandhan Kaur, Vincenzo Tondolo, Mauro Rongioletti, Subha Ranjan Samantaray, Mehboob Hoque, Anil Pawar, Kalyan Goswami, Rosanna Squitti
BACKGROUND: Colorectal cancer (CRC) is a growing public health problem. Several clinical studies have shown a potentially protective effect of selenium (Se), but the reports are inconsistent. The objective of the study was to examine the evidence for relation between serum/tissue Se status and CRC. METHOD AND MATERIALS: In this Systematic Review and Meta-Analysis, we searched Cochrane Library, EBSCOhost, EMBASE, ProQuest, PubMed/MEDLINE, Scopus, and Web of Science for studies reporting serum/plasma/whole blood/tissue Se concentrations in CRC patients and controls for articles published till August 2023...
March 12, 2024: Journal of Trace Elements in Medicine and Biology
https://read.qxmd.com/read/38492205/liquid-biopsy-for-breast-cancer-and-other-solid-tumors-a-review-of-recent-advances
#37
JOURNAL ARTICLE
Hirofumi Ohmura, Fumiyasu Hanamura, Yuta Okumura, Yuki Ando, Takaaki Masuda, Koshi Mimori, Koichi Akashi, Eishi Baba
Liquid biopsy using circulating tumor DNA (ctDNA) has been reported to be less invasive and effective for comprehensive genetic analysis of heterogeneous solid tumors, including decision-making for therapeutic strategies, predicting recurrence, and detecting genetic factors related to treatment resistance in various types of cancers. Breast cancer, colorectal cancer, and lung cancer are among the most prevalent malignancies worldwide, and clinical studies of liquid biopsy for these cancers are ongoing. Liquid biopsy has been used as a companion diagnostic tool in clinical settings, and research findings have accumulated, especially in cases of colorectal cancer after curative resection and non-small cell lung cancer (NSCLC) after curative chemoradiotherapy, in which ctDNA detection helps predict eligibility for adjuvant chemotherapy...
March 16, 2024: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/38492158/abnormal-upregulation-of-nubp2-contributes-to-cancer-progression-in-colorectal-cancer
#38
JOURNAL ARTICLE
Danfeng Lan, Junyu Wang, Guishun Sun, Lixia Jiang, Qiyun Chen, Sha Li, Haiyan Qu, Yibo Wang, Bian Wu
Colorectal cancer (CRC), a digestive tract malignancy with high mortality and morbidity, lacks effective biomarkers for clinical prognosis due to its complex molecular pathogenesis. Nucleotide binding protein 2 (NUBP2) plays a vital role in the assembly of cytosolic Fe/S protein and has been implicated in cancer progression. In this study, we found that NUBP2 was highly expressed in CRC by TCGA database analysis. Subsequently, we verified the expression of NUBP2 in CRC tumor tissues and para-carcinoma tissues using IHC staining, and further investigated its association with clinicopathological parameters...
March 16, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38492056/use-of-tryptic-peptide-maldi-mass-spectrometry-imaging-to-identify-the-spatial-proteomic-landscape-of-colorectal-cancer-liver-metastases
#39
JOURNAL ARTICLE
Celine Man Ying Li, Matthew T Briggs, Yea-Rin Lee, Teresa Tin, Clifford Young, John Pierides, Gurjeet Kaur, Paul Drew, Guy J Maddern, Peter Hoffmann, Manuela Klingler-Hoffmann, Kevin Fenix
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. CRC liver metastases (CRLM) are often resistant to conventional treatments, with high rates of recurrence. Therefore, it is crucial to identify biomarkers for CRLM patients that predict cancer progression. This study utilised matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to spatially map the CRLM tumour proteome...
March 16, 2024: Clinical and Experimental Medicine
https://read.qxmd.com/read/38491898/national-survey-of-barriers-to-colorectal-cancer-screening-in-jordan
#40
JOURNAL ARTICLE
Zaid Ali Abdulelah, Ahmed Ali Abdulelah, Mohammad Alqaisieh, Asim N Khanfar, Nouran Husam Hammad, Eyad Bassam Al Masoud, Qusai B Odeh, Mohammad Ali Alshrouf, Rahaf Maher Abuaisheh, Haitham Mohammed Abd-Alrahman, Amer Khatib
BACKGROUND: Colorectal cancer is among the leading malignancies globally and in Jordan. It causes significant morbidity and mortality. It can be detected early, but uptake of colorectal cancer screening in Jordan is substantially low. AIM: To determine the underlying barriers to the uptake of colorectal cancer screening in Jordan. METHODS: A cross-sectional study was conducted in the northern, central and southern regions of Jordan using selfadministered questionnaire that evaluated the barriers and attitudes towards colorectal cancer screening among adults aged 45 years and above living in Jordan...
February 25, 2024: Eastern Mediterranean Health Journal
keyword
keyword
162699
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.