Wangpeng Gu, Jia Zhang, Qing Li, Yaguang Zhang, Xuan Lin, Bingbing Wu, Qi Yin, Jinqiao Sun, Yulan Lu, Xiaoyu Sun, Caiwei Jia, Chuanyin Li, Yu Zhang, Meng Wang, Xidi Yin, Su Wang, Jiefang Xu, Ran Wang, Songling Zhu, Shipeng Cheng, Shuangfeng Chen, Lian Liu, Lin Zhu, Chenghua Yan, Chunyan Yi, Xuezhen Li, Qiaoshi Lian, Guomei Lin, Zhiyang Ling, Liyan Ma, Min Zhou, Kuanlin Xiao, Haiming Wei, Ronggui Hu, Wenhao Zhou, Lilin Ye, Haikun Wang, Jinsong Li, Bing Sun
The Mulibrey (Muscle-liver-brain-eye) nanism caused by loss-of-function variants in TRIM37 gene is an autosomal recessive disorder characterized by severe growth failure and constrictive pericarditis. These patients also suffer from severe respiratory infections, co-incident with an increased mortality rate. Here, we revealed that TRIM37 variants were associated with recurrent infection. Trim37 FINmajor (a representative variant of Mulibrey nanism patients) and Trim37 knockout mice were susceptible to influenza virus infection...
August 1, 2023: Cell Discovery