Karla Deysiree Alcântara Silva, João Paulo Silva Nunes, Pauline Andrieux, Pauline Brochet, Rafael Ribeiro Almeida, Andréia Cristina Kazue Kuramoto Takara, Natalia Bueno Pereira, Laurent Abel, Aurelie Cobat, Ricardo Costa Fernandes Zaniratto, Débora Levy, Sergio Paulo Bydlowski, Ivan Cecconello, Francisco Carlos Bernal da Costa Seguro, Jorge Kalil, Christophe Chevillard, Edecio Cunha-Neto
Chagas disease (CD), caused by the protozoan parasite Trypanosoma cruzi , affects 8 million people, and around 1/3 develop chronic cardiac (CCC) or digestive disease (megaesophagus/megacolon), while the majority remain asymptomatic, in the indeterminate form of Chagas disease (ASY). Most CCC cases in families with multiple Chagas disease patients carry damaging mutations in mitochondrial genes. We searched for exonic mutations associated to chagasic megaesophagus (CME) in genes essential to mitochondrial processes...
September 7, 2022: Biomedicines