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Multiple sclerosis related fatigue

Arthur R Chaves, Liam P Kelly, Craig S Moore, Mark Stefanelli, Michelle Ploughman
OBJECTIVE: Poor fitness among people with Multiple Sclerosis (MS) aggravates disease symptoms. Whether low fitness levels accompany brain functioning changes is unknown. METHODS: MS patients (n = 82) completed a graded maximal exercise test, blood was drawn, and transcranial magnetic stimulation determined resting and active motor thresholds, motor evoked potential latency, and cortical silent period (CSP). RESULTS: Sixty-two percent of participants had fitness levels ranked below 10th percentile...
February 4, 2019: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Christopher C Hemond, Bonnie I Glanz, Rohit Bakshi, Tanuja Chitnis, Brian C Healy
BACKGROUND: Serum hematological indices such as the neutrophil-lymphocyte ratio (NLR) or monocyte-lymphocyte ratio (MLR) have been used as biomarkers of pathogenic inflammation and prognostication in multiple areas of medicine; recent evidence shows correlation with psychological parameters as well. OBJECTIVES/AIMS: To characterize clinical, neuroimaging, and psycho-neuro-immunological associations with NLR and MLR in persons with multiple sclerosis (MS). METHODS: We identified a large cohort of clinically well-defined patients from our longitudinal database that included MS-related outcomes, disease-modifying therapy, patient-reported outcome (PRO) measures, and quantified cerebral MRI at 1...
February 12, 2019: BMC Neurology
Terry L Wahls, Catherine A Chenard, Linda G Snetselaar
The precise etiology of multiple sclerosis (MS) is unknown but epidemiologic evidence suggests this immune-mediated, neurodegenerative condition is the result of a complex interaction between genes and lifetime environmental exposures. Diet choices are modifiable environmental factors that may influence MS disease activity. Two diets promoted for MS, low saturated fat Swank and modified Paleolithic Wahls Elimination (WahlsElim), are currently being investigated for their effect on MS-related fatigue and quality of life (NCT02914964)...
February 7, 2019: Nutrients
Jennifer Eriksson, Gisela Kobelt, Mia Gannedahl, Jenny Berg
OBJECTIVES: To assess the association between fatigue, cognition, domains of the EuroQol five-dimensional questionnaire (EQ-5D-3L), disability, and utilities estimated with several Western European value sets in patients with multiple sclerosis (MS). METHODS: Data from a multinational, cross-sectional, observational study of patients with MS (N = 16,808) conducted in 16 European countries were used. Health-related quality of life data were collected through the EQ-5D-3L, and fatigue and cognitive difficulties were self-assessed on a 10-point visual analogue scale...
February 2019: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Georgia K Chaseling, Dustin R Allen, Steve Vucic, Michael Barnett, Elliot Frohman, Scott L Davis, Ollie Jay
PURPOSE: To reassess the notion that people with multiple sclerosis (MS) do not demonstrate an elevated resting core temperature when measured using best-practice precision thermometry. METHOD: Across two international data collection sites (Australia and USA), twenty-eight relapsing-remitting MS patients and 27 aged-matched controls (CON) were exposed to either 30 °C, 30% relative humidity (RH) (Sydney) or 25 °C, 30% RH (Dallas). Resting rectal (Tre ) and esophageal (Teso ) temperature and resting oxygen consumption (VO2 ) was measured in MS (n = 28) and CON (n = 27) groups who completed the 25 °C and 30 °C trials...
January 4, 2019: Multiple Sclerosis and related Disorders
Gisela Kobelt, Vanessa Teich, Marcela Cavalcanti, Ana Maria Canzonieri
BACKGROUND: The objective of this study was to estimate costs to society and patients' quality of life (QoL) at all levels of disease severity (measured with the Expanded Disability Status Scale, EDSS) in Brazil. METHODS: The study was part of an international, cross-sectional burden-of-illness study carried out in collaboration with national MS patient organizations. All information was collected directly from patients using a validated questionnaire. Direct costs were estimated both from societal and payer perspectives, while total costs are presented as societal costs...
2019: PloS One
Tanja Grubić Kezele, Matea Babić, Dinko Štimac
PURPOSE: To evaluate the feasibility of a combined upper limb and breathing exercise for a home-based program and to explore its effect on primary fatigue and quality of life in ambulatory and non-ambulatory individuals with multiple sclerosis (MS) in a short time. METHOD: Nineteen individuals with MS were assigned into semi-controlled pre-post feasibility study based on Expanded Disability Status Scale (EDSS) status and divided into two groups: exercise (five ambulatory, five non-ambulatory; EDSS 1...
January 18, 2019: Neurological Sciences
Scott Rooney, Les Wood, Fiona Moffat, Lorna Paul
BACKGROUND: Fatigue is a complex and disabling symptom of Multiple Sclerosis (MS); however, there is conflicting evidence of the relationship between fatigue and clinical features of MS. Furthermore, few studies have considered these relationships specifically in a progressive MS population. AIMS: (1) estimate the prevalence of self-reported fatigue in people with MS; (2) evaluate the relationship between fatigue severity/impact and clinical features of MS; (3) compare the prevalence of fatigue, and the strength of relationship between fatigue severity/impact and clinical features of MS in progressive and non-progressive forms of MS...
January 3, 2019: Multiple Sclerosis and related Disorders
Turhan Kahraman, Asiye Tuba Özdoğar, Özge Ertekin, Serkan Özakbaş
BACKGROUND: Although there is accumulating evidence on neuropathic pain in persons with multiple sclerosis (pwMS), little is known about musculoskeletal pain. The aim was to examine the frequency, type, distribution of pain and related factors in pwMS. METHODS: This cross-sectional study included 223 pwMS. The Nordic Musculoskeletal Questionnaire and painDETECT Questionnaire were used to assess pain. Depression, fatigue, sleepiness, and health-related quality of life were assessed...
January 3, 2019: Multiple Sclerosis and related Disorders
Miguel A Sánchez-Lastra, Daniel Martínez-Aldao, Antonio J Molina, Carlos Ayán
BACKGROUND: Pilates can be an interesting rehabilitation strategy for people with multiple sclerosis (MS), since is a low-cost and attractive physical exercise modality that has shown to have beneficial effects in other neurological pathologies. For prescribing Pilates to this population, health professionals should be aware of its potential benefits, a goal that can be achieved by making available updated scientific evidence in this regard. Therefore, the purpose of this study was to conduct a systematic review and a meta-analysis aimed at identifying the characteristics and methodological quality of the investigations that have studied the effects of Pilates in people affected with MS...
January 3, 2019: Multiple Sclerosis and related Disorders
Alon Kalron, Shay Menascu, Lior Frid, Roy Aloni, Anat Achiron
PURPOSE: To clarify the relationship between leisure-time physical activity, perceived fatigue, and energy expenditure while walking in people with multiple sclerosis. METHODS: Sixty-six people afflicted with multiple sclerosis (MS) (32 women) with a mild neurological disability, participated in this study. Energy expenditure was separately measured at rest, during comfortable walking and during fast walking via a portable metabolic device using breath-by-breath technology (COSMED K5, COSMED Srl, Rome, Italy)...
January 8, 2019: Disability and Rehabilitation
Martin Heine, Rosie Richards, Bibi Geurtz, Felicia Los, Marc Rietberg, Jaap Harlaar, Karin Gerrits, Heleen Beckerman, Vincent de Groot
BACKGROUND: Patients with multiple sclerosis (pwMS) often experience a decline in motor function and performance during prolonged walking, which potentially is associated with reduced ankle push-off power and might be alleviated through structured exercise. The objectives of this pilot study were to assess ankle push-off power and walking performance in pwMS and healthy controls, and the preliminary effectiveness of a sequential exercise program (resistance training followed by walking-specific endurance training) on ankle push-off power and walking performance...
December 29, 2018: Clinical Biomechanics
Anna L Kratz, Susan L Murphy, Tiffany J Braley, Neil Basu, Shubhangi Kulkarni, Jenna Russell, Noelle E Carlozzi
PURPOSE: Perceived fatigability, reflective of changes in fatigue intensity in the context of activity, has emerged as a potentially important clinical outcome and quality of life indicator. Unfortunately, the nature of perceived fatigability is not well characterized. The aim of this study is to define the characteristics of fatigability through the development of a conceptual model informed by input from key stakeholders who experience fatigability, including the general population, individuals with multiple sclerosis (MS), and individuals with fibromyalgia (FM)...
January 2, 2019: Quality of Life Research
Jessica F Baird, Robert W Motl
Multiple sclerosis (MS) is a heterogeneous disease, both in its pathology and symptomology. This poses a challenge for the medical management and rehabilitation of MS; however, physical activity and exercise training are rehabilitation approaches that have demonstrated beneficial effects on many of the burdensome consequences of MS such as mobility impairment and fatigue. Given the heterogeneous course of MS, it is possible that outcomes of physical activity and exercise training interventions demonstrate heterogeneity both in the magnitude and pattern of change, but there has been little focus on response heterogeneity with these interventions among persons with MS...
December 26, 2018: Neurorehabilitation and Neural Repair
Catherine F Siengsukon, Mohammed Alshehri, Mayis Aldughmi
Background: Nearly 70% of individuals with multiple sclerosis report sleep disturbances or poor sleep quality. Sleep disturbances may exacerbate or complicate the management of multiple sclerosis-related symptoms. While sleep variability has been associated with several health outcomes, it is unclear how sleep variability is associated with multiple sclerosis-related symptoms. Objective: The purpose of this study was to determine how total sleep time variability combined with self-reported sleep quality is associated with fatigue, depression, and anxiety in individuals with multiple sclerosis...
October 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Alon Kalron, Roy Aloni, Uri Givon, Shay Menascu
BACKGROUND: There is a consensus that physical activity is imperative for people with MS (PwMS). However, regardless of the benefits, many PwMS do not participate in any meaningful physical activity. AIM: To examine the relationship between leisure-time physical activity with clinical characteristics and common symptoms in PwMS. METHODS: The sample included 190 PwMS (107 women), mean age 40.8 (S.D = 13.1) and mean disease duration of 6...
September 2018: Gait & Posture
Luis Carlos Nacul, Kathleen Mudie, Caroline C Kingdon, Taane G Clark, Eliana Mattos Lacerda
Background: The diagnosis of myalgic encephalomyelitis (ME/CFS) in research and clinical practice has largely relied on clinical history, which can be subjective in nature. Clinical signs are often subtle, overlap with other conditions, and are not formally included as part of diagnostic workup. The characterization of clinical signs and biomarkers is needed for better diagnosis and classification of patients and to monitor treatment response. Hand grip strength (HGS) has been used as an objective measure of muscle strength and fatigue, which is a primary symptom of ME/CFS...
2018: Frontiers in Neurology
James S Krause, Clara E Dismuke-Greer, Melinda Jarnecke, Chao Li, Karla S Reed, Phillip Rumrill
OBJECTIVE: To identify demographic, educational, and disease-related characteristics associated with the odds of employment and earnings among participants with multiple sclerosis (MS). DESIGN: Cross-sectional using self-report assessment obtained by mail or online SETTING: Medical University in the southeastern United States. PARTICIPANT: Participants with MS (n = 1059) were enrolled from a specialty hospital in the southeastern United States...
December 6, 2018: Archives of Physical Medicine and Rehabilitation
Anne Katrine Andreasen, Pernille Iversen, Lisbet Marstrand, Volkert Siersma, Hartwig Roman Siebner, Finn Sellebjerg
BACKGROUND: Fatigue in multiple sclerosis (MS) is a debilitating symptom and experienced by most patients. In recent studies investigating this phenomenon, the majority of patients had a relapsing-remitting disease course. METHODS: Patients with progressive MS participating in one of three treatment trials during a period from 2010 to 2014 were included. Fatigue was assessed with the Fatigue Scale for Motor and Cognitive Functions (FSMC) and patients were further examined with a cognitive test battery, including Symbol Digit Modalities Test (SDMT), and 3 T MRI with subsequent quantitative analyses of 13 cortical regions of interest, deep grey matter and lesion volume...
December 4, 2018: Neurological Research
Fabio Basta, Domenico Paolo Emanuele Margiotta, Carmen Mazzuca, Veronica Batani, Giulio Dolcini, Patrizio Moras, Marta Vadacca, Antonella Afeltra
To assess clinical and psychosocial factors related to alexithymia in systemic sclerosis (SSc). We enrolled 40 consecutive SSc patients in a cross-sectional study evaluating alexithymia with Toronto Alexithymia scale (TAS-20). We measured Beck Depression inventory (BDI), Hamilton Anxiety rating scale (HAM-H), 36-Items Short-Form Healthy Survey (SF-36), Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue, Visual Analog Scale (VAS) pain, Pittsburgh Sleep Quality Index (PSQI), Satisfaction with Appearance Scale (SWAP), and Mouth Handicap in Systemic Sclerosis (MHISS)...
November 29, 2018: Rheumatology International
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