Beatrice Foglia, Salvatore Sutti, Stefania Cannito, Chiara Rosso, Marina Maggiora, Alice Casalino, Claudia Bocca, Erica Novo, Francesca Protopapa, Naresh Naik Ramavath, Alessia Provera, Alessandro Gambella, Elisabetta Bugianesi, Frank Tacke, Emanuele Albano, Maurizio Parola
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously non-alcoholic fatty liver disease (NAFLD), is a leading cause of chronic liver disease worldwide. In 20%-30% of MASLD patients, the disease progresses to metabolic dysfunction-associated steatohepatitis (MASH, previously NASH) which can lead to fibrosis/cirrhosis, liver failure as well as hepatocellular carcinoma (HCC). Here we investigated the role of histidine-rich glycoprotein (HRG), a plasma protein produced by hepatocytes, in MASLD/MASH progression and HCC development...
2024: Frontiers in Immunology