Shohei Takaoka, Akiko Yanagiya, Haytham Mohamed Aly Mohamed, Rei Higa, Takaya Abe, Ken-Ichi Inoue, Akinori Takahashi, Patrick Stoney, Tadashi Yamamoto
Control of mRNA stability and degradation is essential for appropriate gene expression, and its dysregulation causes various disorders, including cancer, neurodegenerative diseases, diabetes, and obesity. The 5'-3' exoribonuclease XRN1 executes the last step of RNA decay, but its physiological impact is not well understood. To address this, forebrain-specific Xrn1 conditional knockout mice ( Xrn1 -cKO) were generated, as Xrn 1 null mice were embryonic lethal. Xrn1 -cKO mice exhibited obesity with leptin resistance, hyperglycemia, hyperphagia, and decreased energy expenditure...
October 22, 2021: IScience