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cholangiocarcinoma and hilar

F Rauchfuß, U Settmacher
No abstract text is available yet for this article.
February 13, 2019: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Jun Wang, Halmurat Obulkasim, Xiaoping Zou, Baorui Liu, Yafu Wu, Xingyu Wu, Yitao Ding
Hilar cholangiocarcinoma is a highly malignant tumor and is currently treated by surgical resection or liver transplantation; however, these treatments result in poor patient prognosis accompanied with high recurrence and low patient mortality rates. Neoadjuvant therapy with liver transplantation is a novel treatment that exhibits promising clinical application, with a reported 5-year survival rate of 82%. However, transplantation centers conducting research into this treatment are limited due to its length and complexity...
February 2019: Oncology Letters
Naoki Umezaki, Daisuke Hashimoto, Yo-Ichi Yamashita, Shigeki Nakagawa, Yousuke Nakao, Rumi Itoyama, Toshihiko Yusa, Takanobu Yamao, Hirohisa Okabe, Katsunori Imai, Hiromitsu Hayashi, Akira Chikamoto, Hideo Baba
Neuroendocrine tumors usually develop in the gastrointestinal tract, pancreas, and lung. Therefore, a neuroendocrine tumor of the bile duct is quite rare. We present a 59-year-old-male patient whose preoperative diagnosis was hilar cholangiocarcinoma. One month after embolization of the left branch and anterior branch of the portal vein, he underwent left hepatic trisegmentectomy and extrahepatic bile duct resection. Pathological examination revealed the neuroendocrine tumor in the submucosal layer of the hilar bile duct...
February 2019: Anticancer Research
Bing-Jie Lu, Xue-Dong Cao, Nong Yuan, Ning-Ning Liu, Nisma L Azami, Ming-Yu Sun
BACKGROUND: Infiltrative adenosquamous carcinoma (ASC) of the extrahepatic bile duct is reported infrequently, which is an unusual variant of the ordinary adenocarcinoma. The simultaneous development of ASC and cystadenocarcinoma in the extrahepatic biliary tree is rare. In addition, the accurate preoperative diagnosis of concomitant carcinoma in the multiple biliary trees at an early stage is often difficult. Thus, awareness of the risk of the multiplicity of biliary tumors is perhaps the most important factor in identifying these cases...
January 26, 2019: World Journal of Clinical Cases
Walid Elmoghazy, Jane Cowan, Nicolas Tabchouri, Pascale Tinguely, Mostefa Bennamoun, Candice Tubbax, Anthony Sarran, Marine Lefevre, Christian Lamer, Brice Gayet, David Fuks
BACKGROUND: Laparoscopic liver resection (LLR) has evolved over time, yet its role in extra-pancreatic biliary cancer has been limited due to several factors. We aimed to evaluate the short-term outcome of LLR in extra-pancreatic biliary tract cancer. METHODS: From January 2002 to 2016, all patients who underwent LLR for extra-pancreatic biliary tract cancer including gallbladder cancer (GBC), intra-hepatic cholangiocarcinoma (ICC), and peri-hilar cholangiocarcinoma (PHC) with curative intent (R0 or R1) at Institute Mutualiste Montsouris were identified from prospectively collected databases...
January 28, 2019: Surgical Endoscopy
Masako Akatsuka, Takayoshi Nakajima, Shinichi Ikuta, Tsukasa Aihara, Kurando Kusunoki, Yu Kitamura, Noriko Ichise, Ikumi Hamano, Ryo Okamoto, Yoshihiko Nakamoto, Fumihiko Kimura, Hidenori Yanagi, Ayako Kakuno, Naoki Yamanaka
A 74-year-old man was admitted to a local hospital with liver dysfunction. Imaging modalities revealed bile duct stenosis at the bifurcation of the anterior and posterior trunk. Exfoliative cytology of the bile and brushing cytology of the bile duct both revealed Class Ⅴ, and biopsy from the stenotic bile duct showed well differentiated adenocarcinoma. We diagnosed the patient with hilar cholangiocarcinoma and performed extended right bisectionectomy and biliary reconstruction after percuta- neous transhepatic right portal vein embolization(PTPE)...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Dingzhong Peng, Jiong Lu, Haijie Hu, Bei Li, Xiwen Ye, Nansheng Cheng
BACKGROUND: The objective of our research was to investigate the value of the lymphocyte to monocyte ratio (LMR) and its dynamic changes (LMRc) in predicting tumor resectability and early recurrence of radiologically resectable type IV hilar cholangiocarcinoma (HC). METHODS: A total of 411 patients with radiologically resectable type IV HC were included. Data on their clinicopathologic characteristics, perioperative features, and survival outcomes were analyzed...
January 22, 2019: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Anjelica Hodgson, Zuhoor Almansouri, Oyedele Adeyi, Sandra E Fischer
Liver transplantation is a surgical option with curative intent used in the management of some cases of hepatocellular carcinoma and cholangiocarcinoma (hilar, rarely intrahepatic). A number of different therapeutic modalities including ablative techniques, arterially directed therapies, radiation and chemotherapy are used in the neoadjuvant setting prior to liver transplantation with the goals of preventing tumour progression, decreasing post-transplant recurrence and possibly downstaging patients with tumour burden beyond what is acceptable by current transplant criteria...
February 2019: Journal of Clinical Pathology
D Y Zhang, W L Sun, X Ma, Z Lu, B Q Wu, H Wu, D D Wang, Z Liu, P Y Cui
Objective: To study the experience of preoperative evaluation, surgical planning and postoperative treatment of hilar cholangiocarcinoma (HCC) in our center. Method: The clinical data of 70 patients with HCC who underwent resection at the First Affiliated Hospital of Bengbu Medical College, from January 2011 to December 2017 were analyzed retrospectively. The treatment experience of HCC from the aspects of preoperative evaluation and treatment, surgical methods, postoperative recovery and prognosis were discussed...
January 22, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Chara Stavraka, Hannah Rush, Paul Ross
Combined hepatocellular cholangiocarcinoma (CC) is a rare and aggressive primary hepatic malignancy with significant histological and biological heterogeneity. It presents with more aggressive behavior and worse survival outcomes than either hepatocellular carcinoma or CC and remains a diagnostic challenge. An accurate diagnosis is crucial for its optimal management. Major hepatectomy with hilar node resection remains the mainstay of treatment in operable cases. Advances in the genetic and molecular characterization of this tumor will contribute to the better understanding of its pathogenesis and shape its future management...
2019: Journal of Hepatocellular Carcinoma
Prakriti Gupta, Shashi Dhawan, Vivek Mangla, Siddharth Mehrotra, Shailendra Lalwani, Naimish N Mehta, Samiran Nundy
Obstructive jaundice in the setting of a hilar mass raises strong suspicion of a cholangiocarcinoma, with diagnosis usually made on imaging. Jaundice, when present in patients with hepatocellular carcinoma, is mostly related to underlying liver disease (i.e. cirrhosis) and only rarely to diffuse tumor infiltration of liver parenchyma or hilar invasion. We report here the good outcome of a 67 year-old patient who presented with obstructive jaundice, underwent surgery and was given a diagnosis of hepatocellular carcinoma, which was made only at histopathological examination of resected specimen...
December 28, 2018: Journal of Clinical and Translational Hepatology
D Zhou, Y Yang, Z H Tang, W Gong, J D Wang, Z W Quan
Hilar cholangiocarcinoma is one of the most difficult malignant tumors to treat in the biliary system. In Japan, 5-year survival rate of the disease has increased from 32.5% to 67.1% during the past 30 years. The impressive progress reflects the solid efforts in preoperative endoscopic diagnosis, innovation in surgery such as PTPE as well as hepato-pancreatoduodenectomy and perioperative treatment including replacement of the bile and synbiotic treatment, which have finally formed a set of standardized diagnosis and treatment systems...
January 1, 2019: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Aldo Fafaj, Federico N Aucejo, Erica Savage, Toms Augustin
Xanthogranulomatous cholecystitis (XGC) is difficult to diagnose preoperatively because it often mimics gallbladder cancer. We present a case of a 64-year-old Caucasian male who presented with multiple intrahepatic abscesses, left portal vein and segmental right hepatic arterial thrombosis suspicious for extrahepatic cholangiocarcinoma who ultimately underwent an extended left hepatectomy and was noted to have XGC on final pathology. This case presents a new challenge in diagnosing XGC prior to final pathology results given the unique left portal vein, and later, right anterior portal vein thrombosis and occlusion...
December 2018: Journal of Surgical Case Reports
YouJin Lee, DongWook Choi, Sunjong Han, In Woong Han, Jin Seok Heo, Seong Ho Choi
Backgrounds/Aims: Several studies report worse prognosis after left-side compared to right-side liver resection in patients with perihilar cholangiocarcinoma. In this study, we compared outcomes of left-side and right-side resections for Bismuth type III hilar cholangiocarcinoma and analyzed factors affecting survival. Methods: From May 1995 to December 2012, 179 patients underwent surgery at Samsung Medical Center for type III hilar cholangiocarcinoma. Among these patients, 138 received hepatectomies for adenocarcinoma with curative intent: 103 had right-side resections (IIIa group) and 35 had left-side resections (IIIb group)...
November 2018: Annals of Hepato-Biliary-Pancreatic Surgery
Thuy B Tran, Cecilia G Ethun, Timothy M Pawlik, Carl Schmidt, Eliza W Beal, Ryan C Fields, Bradley Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Kamran Idrees, Chelsea A Isom, Ioannis Hatzaras, Rivfka Shenoy, Shishir K Maithel, George A Poultsides
BACKGROUND: The prevalence and characteristics of actual 5-year survivors after surgical treatment of hilar cholangiocarcinoma (HC) have not been described previously. METHODS: Patients who underwent resection for HC from 2000 to 2015 were analyzed through a multi-institutional registry from 10 U.S. academic medical centers. The clinicopathologic characteristics and both the perioperative and long-term outcomes for actual 5-year survivors were compared with those for non-survivors (patients who died within 5 years after surgery)...
December 11, 2018: Annals of Surgical Oncology
Ryusei Matsuyama, Daisuke Morioka, Ryutaro Mori, Yasuhiro Yabushita, Seigo Hiratani, Yohei Ota, Takafumi Kumamoto, Itaru Endo
BACKGROUND: The concept of "borderline resectable" was recently introduced to the field of surgery for pancreatic cancer, and surgical outcomes for this disease with extremely dismal prognosis have improved since the introduction of this concept. However, no such concept has yet been introduced to the field of surgery for hilar cholangiocarcinoma (HCca). AIM: To determine a definition and criteria for "borderline resectable" in the field of surgery for HCca...
December 7, 2018: World Journal of Surgery
Yu A Kovalenko, Yu O Zharikov, I A Kukeev, V A Vishnevsky, A V Chzhao
AIM: To determine significant predictors of long-term outcomes of surgery for portal cholangiocarcinoma. MATERIAL AND METHODS: Analysis included 49 out of 84 patients who were operated at the Vishnevsky Institute of Surgery in 2003-2016. Morphological examination (2011-2016) revealed great percentage of following positive variables: micro- (42.9%) and lymphovascular invasion (11.8%), positive resection margin (59.2%), perineural invasion (83.3%), depth of invasion - (83...
2018: Khirurgiia
Ryusei Yamamoto, Yasuji Mokuno, Hideo Matsubara, Hirokazu Kaneko, Yozo Sato, Shinsuke Iyomasa
BACKGROUND: Chylothorax is the accumulation of chyle within the pleural space. Chylothorax can occur as a complication after multiple different types of surgery, most frequently after thoracic surgery, albeit with an incidence rate of less than 1%. Chylothorax after abdominal surgery is extremely rare, and there are only a few case reports. CASE PRESENTATION: A 74-year-old Japanese woman presented with jaundice. She was diagnosed as having hilar cholangiocarcinoma and underwent right hepatectomy, caudate lobectomy, extrahepatic bile duct resection, and lymph node dissection after preoperative percutaneous transhepatic portal vein embolization...
November 26, 2018: Journal of Medical Case Reports
Ming-Liang Wang, Zhang-Yan Ke, Shuai Yin, Chen-Hai Liu, Qiang Huang
BACKGROUND: The benefit of adjuvant chemotherapy for resectable cholangiocarcinoma remains unclear due to the lack of randomized control studies. This study aimed to investigate the possible benefit of postoperative adjuvant chemotherapy for resectable cholangiocarcinoma. DATA SOURCES: Relevant research articles published before 1st March 2018 in PubMed, Embase and the Cochrane library databases were retrieved. Published data were extracted and analyzed by RevMan 5...
November 14, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Sven Jonas, Felix Krenzien, Georgi Atanasov, Hans-Michael Hau, Matthias Gawlitza, Michael Moche, Georg Wiltberger, Johann Pratschke, Moritz Schmelzle
Background: A right trisectionectomy with portal vein resection represents the conventional approach for hilar cholangiocarcinoma. Here, we present a technical modification of hilar en bloc resection in order to increase the remnant volume by partially preserving liver segment 4. Methods: The caudal parenchymal dissection line starts centrally between the left lateral and left medial segments. Cranially, the resection line switches to the right towards Cantlie's line and turns again upwards perpendicularly...
2018: European Surgery: ACA: Acta Chirurgica Austriaca
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