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https://read.qxmd.com/read/30772168/imaging-assessment-of-cardioprotection-mediated-by-a-dodecafluoropentane-oxygen-carrier-administered-during-myocardial-infarction
#1
Zhonglin Liu, Christy Barber, Akash Gupta, Li Wan, Young-Wook Won, Lars R Furenlid, Qin Chen, Ankit A Desai, Ming Zhao, David A Bull, Evan C Unger, Diego R Martin
INTRODUCTION: The objective of this study was to investigate the cardioprotective effects of a dodecafluoropentane (DDFP)-based perfluorocarbon emulsion (DDFPe) as an artificial carrier for oxygen delivery to ischemic myocardium, using 99m Tc-duramycin SPECT imaging. METHODS: Rat hearts with Ischemia-reperfusion (I/R) was prepared by coronary ligation for 45-min followed by reperfusion. The feasibility of 99m Tc-duramycin in detecting myocardial I/R injury and its kinetic profile were first verified in the ischemic hearts with 2-h reperfusion (n = 6)...
January 17, 2019: Nuclear Medicine and Biology
https://read.qxmd.com/read/30772080/five-year-outcomes-after-first-and-second-generation-drug-eluting-stent-implantation-in-all-patients-undergoing-percutaneous-coronary-intervention
#2
Hideki Yano, Shigeo Horinaka, Manami Watahiki, Tomoko Watanabe, Toshihiko Ishimitsu
BACKGROUND: Use of the everolimus-eluting stent (EES) instead of the sirolimus-eluting stent (SES) has been shown to improve clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) out to 3 years. However, it is not known whether the differences in efficacy and safety outcomes remain constant throughout 5 years. METHODS: This was a retrospective, non-randomized, observational study. We followed 1460 consecutive patients undergoing PCI in our institutions from April 2005 to March 2012...
February 13, 2019: Journal of Cardiology
https://read.qxmd.com/read/30772013/tissue-characteristics-of-culprit-lesion-and-myocardial-tissue-level-perfusion-in-non-st-segment-elevation-acute-coronary-syndromes-the-early-myo-acs-study
#3
Gan Yang, Wei Wang, Xinchen Sheng, Fan Yang, Linchong Kong, Jie He, Song Ding, Peiren Shan, Yunpeng Shang, Jianchen Xiu, Yining Yang, Gary S Mintz, Jun Pu
OBJECTIVE: The impact of tissue characteristics of culprit lesion on myocardial tissue-level perfusion in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) remains unclear. EARLY-MYO-ACS study was a prospective observational study to investigate the relationship between pre-percutaneous coronary intervention (PCI) culprit plaque characteristics and post-PCI myocardial tissue-level perfusion with iMap intravascular ultrasound (IVUS) in NSTE-ACS patients. METHODS: A total of 408 patients with coronary artery disease (246 NSTE-ACS and 162 stable angina pectoris) undergoing coronary angiography, grayscale-IVUS and iMap-IVUS were enrolled...
February 8, 2019: International Journal of Cardiology
https://read.qxmd.com/read/30771861/relationship-between-optimism-and-outcomes-in-patients-with-chronic-angina-pectoris
#4
Alexander C Fanaroff, Kristi Prather, Amanda Brucker, Daniel Wojdyla, Linda Davidson-Ray, Daniel B Mark, Redford B Williams, John Barefoot, Giora Weisz, Ori Ben-Yehuda, Gregg W Stone, Erik Magnus Ohman, Karen P Alexander
Greater optimism regarding recovery from chronic illness is associated with improved quality of life and clinical outcomes. We performed a post-hoc analysis on the association between optimism and outcomes in Ranolazine in Patients with Incomplete Revascularization after Percutaneous Coronary Intervention (RIVER-PCI), a randomized trial in patients with chronic angina pectoris who had incomplete revascularization following percutaneous coronary intervention. At baseline, patients answered how much they agreed with the phrase, "I am optimistic about my future and returning to a normal lifestyle...
February 7, 2019: American Journal of Cardiology
https://read.qxmd.com/read/30771737/a-randomized-double-blind-placebo-controlled-trial-to-assess-the-efficacy-and-safety-of-trimetazidine-in-patients-with-angina-pectoris-having-been-treated-by-percutaneous-coronary-intervention-atpci-study-rationale-design-and-baseline-characteristics
#5
Roberto Ferrari, Ian Ford, Kim Fox, Mario Marzilli, Michal Tendera, Petr Widimský, Jean-Pascal Challeton, Nicolas Danchin
BACKGROUND: About 30% of angina patients have persisting symptoms despite successful revascularization and antianginal therapy. Moreover, in stable patients, percutaneous coronary intervention (PCI) does not improve survival as compared with medical therapy alone. Trimetazidine, an antianginal agent devoid of hemodynamic effect, may help reducing symptoms and improving outcomes after PCI. The ATPCI study is investigating the efficacy and safety of adding trimetazidine to standard-of-care in angina patients who had a recent PCI...
January 15, 2019: American Heart Journal
https://read.qxmd.com/read/30771449/effect-of-cancer-history-on-post-resuscitation-treatments-in-out-of-hospital-cardiac-arrest
#6
Saee Byel Kang, So Yeon Kong, Sang Do Shin, Young Sun Ro, Kyoung Jun Song, Ki Jeong Hong, Tae Han Kim
OBJECTIVES: There is growing evidence that optimal post-resuscitation treatment is a significant factor for overall survival and neurological outcomes in out-of-hospital cardiac arrest (OHCA). However, there is also growing evidence of disparities in treatments in vulnerable populations such as elderly individuals or patients with underlying diseases, including cancer. AIM: The aim of this study was to evaluate the influence of cancer status on post-resuscitation therapies among OHCA patients...
February 13, 2019: Resuscitation
https://read.qxmd.com/read/30771094/frailty-score-for-elderly-patients-is-associated-with-short-term-clinical-outcomes-in-patients-with-st-segment-elevated-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention
#7
M P J Hermans, D C Eindhoven, L A M van Winden, G J de Grooth, G J Blauw, M Muller, M J Schalij
OBJECTIVE: Consistent with the aging population in the Western world, there is a growing number of elderly patients with ST-segment elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention (PCI) is the recommended reperfusion strategy in elderly patients; risk models to determine which of these patients are prone to have poor clinical outcomes are, however, essential. The purpose of this study was to assess the association between frailty and short-term mortality and PCI-related serious adverse events (SAE) in elderly patients...
February 15, 2019: Netherlands Heart Journal
https://read.qxmd.com/read/30771036/impact-of-smoking-on-cardiac-magnetic-resonance-infarct-characteristics-and-clinical-outcome-in-patients-with-non-st-elevation-myocardial-infarction
#8
Hans-Josef Feistritzer, Ingo Eitel, Alexander Jobs, Suzanne de Waha-Thiele, Thomas Stiermaier, Mohamed Abdel-Wahab, Philipp Lurz, Sebastian J Reinstadler, Martin Reindl, Gert Klug, Bernhard Metzler, Steffen Desch, Holger Thiele
Data derived from several studies suggest a better survival in smokers with acute myocardial infarction, a phenomenon referred to as the 'smoker's paradox'. We aimed to investigate the association of smoking with cardiac magnetic resonance (CMR) imaging determined infarct severity and major adverse cardiac events (MACE) defined as the occurrence of death, reinfarction, and congestive heart failure at 12 months in patients with non-ST-elevation myocardial infarction (NSTEMI) reperfused by early percutaneous coronary intervention (PCI)...
February 15, 2019: International Journal of Cardiovascular Imaging
https://read.qxmd.com/read/30770671/i-do-not-want-to-go-to-the-hospital-again
#9
EDITORIAL
Samuel M Butman, Raelene Paris
Readmission after myocardial infarction is not uncommon. The likely readmission patient is by and large predictable. Coronary interventions appear to reduce the rate of readmissions.
February 15, 2019: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/30770662/branch-pulmonary-artery-stenting-in-children-by-using-premounted-stents-can-we-benefit-from-slenderization
#10
EDITORIAL
Dhaval R Parekh, Zvonimir Krajcer
Children with branch pulmonary artery stenosis represent a challenging cohort for stenting Premounted stent implantation provides immediate obstruction relief and hemodynamic improvement in infants Planned stent intervention is required to account for somatic growth and next stage palliation in children Continued slenderization of adult coronary and peripheral interventions, stent technology, and delivery systems may allow for more durable solutions in light of patient size.
February 15, 2019: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/30770658/treating-saphenous-vein-graft-lesions-drug-eluting-stents-are-not-the-answer
#11
EDITORIAL
Allison B Hall, Emmanouil S Brilakis
Saphenous vein graft (SVG) percutaneous coronary intervention carries high rates of acute (no reflow and periprocedural myocardial infarction) and long-term (restenosis and re-occlusion) complications. Long-term follow-up from the two largest trials of drug-eluting vs. bare metal stents in SVG lesions (The Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein graft Angioplasty and Is Drug-Eluting-Stenting Associated with Improved Results in Coronary Artery Bypass Grafts? Trial) definitely show no difference between the two stent types, suggesting that bare metal stents should be preferred given lower cost...
February 15, 2019: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/30770090/effect-of-perioperative-antiplatelet-therapy-on-outcomes-in-patients-with-drug-eluting-stents-undergoing-elective-noncardiac-surgery
#12
Sung-Jin Hong, Min-Ji Kim, Jung-Sun Kim, Eun Hwa Kim, Jinae Lee, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
We investigated the association of perioperative antiplatelet therapy (APT) and outcomes in patients with drug-eluting stent (DES) placement for noncardiac surgery (NCS). In consecutive 23,358 patients who underwent percutaneous coronary interventions between 2005 and 2016, total of 2,179 patients that required 2,179 elective NCS after DES placement were retrospectively analyzed. A net adverse clinical event (NACE), composite of death, myocardial infarction, stent thrombosis, and major bleeding, was assessed at 30 days...
February 7, 2019: American Journal of Cardiology
https://read.qxmd.com/read/30770037/one-year-clinical-outcomes-of-ticagrelor-compared-with-clopidogrel-after-percutaneous-coronary-intervention-in-patients-with-acute-myocardial-infarction-from-korean-health-insurance-review-and-assessment-data
#13
Choongki Kim, Dong-Ho Shin, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Juhee Park, Hyeyeong Lee, Dong-Sook Kim, Sang-Kwon Oh, Yangsoo Jang
BACKGROUND: Ticagrelor has been widely accepted in clinical practice for treatment of acute myocardial infarction (AMI), however its clinical safety and efficacy have not been revealed sufficiently in Asian populations. METHODS AND RESULTS: Among a total 20,270 patients (age <75 years) with AMI undergoing percutaneous coronary intervention who received dual antiplatelet therapy for at least 30 days, clinical outcomes at 1 year were assessed from the database of Health Insurance Review and Assessment Service in Korea between 2013 and 2014...
March 2019: Journal of Cardiology
https://read.qxmd.com/read/30769125/impact-of-right-ventricular-dysfunction-on-mortality-in-adults-with-cardiac-arrest-undergoing-coronary-angiogram
#14
Jignesh K Patel, Andrew Figueroa, Rian Shah, Haasitha Korlipara, Puja B Parikh
OBJECTIVE: We sought to identify the impact of echocardiographic right ventricular (RV) systolic dysfunction on mortality in adults with cardiac arrest (CA). METHODS: The study population included 147 adults hospitalized with CA who underwent both echocardiogram and coronary angiogram at an academic tertiary medical center. The primary outcome of interest was all-cause in-hospital mortality. RESULTS: Of the 147 patients studied, 20 (13.6%) had evidence of RV systolic dysfunction while 127 (86...
February 12, 2019: Resuscitation
https://read.qxmd.com/read/30769059/routine-postoperative-cardiac-testing-is-unnecessary-following-carotid-endarterectomy
#15
Arthelma C Tyson, Shailraj Parikh, Kuldeep Singh, Saqib Zia, Jonathan S Deitch, Jonathan A Schor
BACKGROUND: Routine laboratory testing to rule out myocardial infarction (MI) after carotid endarterectomy (CEA) is common in many centers. Its utility in this patient population has not been thoroughly investigated. We hypothesize that routine testing for MI in post-CEA patients is of low-yield and not cost-effective. METHODS: A retrospective review of 291 consecutive CEAs from February, 2011 to July, 2015 was performed. Two patients were excluded: one for postoperative non-cardiac death and one for preoperative MI...
February 12, 2019: Annals of Vascular Surgery
https://read.qxmd.com/read/30768364/obesogenic-diet-in-aging-mice-disrupts-gut-microbe-composition-and-alters-neutrophil-lymphocyte-ratio-leading-to-inflamed-milieu-in-acute-heart-failure
#16
Vasundhara Kain, William Van Der Pol, Nithya Mariappan, Aftab Ahmad, Peter Eipers, Deanna L Gibson, Cecile Gladine, Claire Vigor, Thierry Durand, Casey Morrow, Ganesh V Halade
Calorie-dense obesogenic diet (OBD) is a prime risk factor for cardiovascular disease in aging. However, increasing age coupled with changes in the diet can affect the interaction of intestinal microbiota influencing the immune system, which can lead to chronic inflammation. How age and calorie-enriched OBD interact with microbial flora and impact leukocyte profiling is currently under investigated. Here, we tested the interorgan hypothesis to determine whether OBD in young and aging mice alters the gut microbe composition and the splenic leukocyte profile in acute heart failure (HF)...
February 15, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/30768153/association-of-the-coronary-artery-disease-risk-gene-gucy1a3-with-ischaemic-events-after-coronary-intervention
#17
Thorsten Kessler, Bernhard Wolf, Niclas Eriksson, Daniel Kofink, Bakhtawar K Mahmoodi, Himanshu Rai, Vinicius Tragante, Axel Åkerblom, Richard C Becker, Isabell Bernlochner, Roman Bopp, Stefan James, Hugo A Katus, Katharina Mayer, Matthias Munz, Francesco Nordio, Michelle L O'Donoghue, Hendrik B Sager, Dirk Sibbing, Linda Solakov, Robert F Storey, Jana Wobst, Folkert W Asselbergs, Robert A Byrne, Jeanette Erdmann, Wolfgang Koenig, Karl-Ludwig Laugwitz, Jurrien M Ten Berg, Lars Wallentin, Adnan Kastrati, Heribert Schunkert
AIM: A common genetic variant at the GUCY1A3 coronary artery disease locus has been shown to influence platelet aggregation. The risk of ischaemic events including stent thrombosis varies with the efficacy of aspirin to inhibit platelet reactivity. This study sought to investigate whether homozygous GUCY1A3 (rs7692387) risk allele carriers display higher on-aspirin platelet reactivity and risk of ischaemic events early after coronary intervention. METHODS AND RESULTS: The association of GUCY1A3 genotype and on-aspirin platelet reactivity was analysed in the genetics substudy of the ISAR-ASPI registry (n = 1678) using impedance aggregometry...
February 14, 2019: Cardiovascular Research
https://read.qxmd.com/read/30767663/safety-and-efficacy-of-polymer-free-drug-eluting-stents
#18
Mauro Chiarito, Gennaro Sardella, Antonio Colombo, Carlo Briguori, Luca Testa, Francesco Bedogni, Franco Fabbiocchi, Anita Paggi, Altin Palloshi, Corrado Tamburino, Alberto Margonato, Carlo Andrea Pivato, Usman Baber, Simone Calcagno, Arturo Giordano, Cosmo Godino, Giulio G Stefanini
Background Polymer-free drug-eluting stents are based on different technologies for drug binding and release without the use of polymer coatings. It is unknown whether different polymer-free drug-eluting stents are comparable in terms of safety and efficacy profiles. Methods and Results Polymer-free BioFreedom biolimus-eluting stents (BES) and polymer-free Cre8 amphilimus-eluting stents (AES) were investigated in 2 recent multicenter registries including 2320 all-comer patients undergoing percutaneous coronary interventions at 22 Italian centers...
February 2019: Circulation. Cardiovascular Interventions
https://read.qxmd.com/read/30767166/a-randomised-investigator-initiated-clinical-trial-of-the-effects-of-fentanyl-on-p2y12-receptor-inhibition-in-patients-with-st-elevation-myocardial-infarction-who-are-pre-treated-with-crushed-ticagrelor-rationale-and-design-of-the-opioids-and-crushed-ticagrelor
#19
A H Tavenier, R S Hermanides, J P Ottervanger, S Rasoul, R J Slingerland, R Tolsma, S van Workum, E Kedhi, A W J van 't Hof
BACKGROUND: Fast and accurate platelet inhibition is an important therapeutic goal in the acute treatment of patients with ST-elevation myocardial infarction (STEMI). Platelet inhibitory effects induced by oral P2Y12-receptor antagonists are delayed in STEMI patients undergoing primary percutaneous coronary intervention (PCI) due to haemodynamic changes and delayed gastro-intestinal absorption. Concomitant use of opioids, although recommended in the American College of Cardiology/American Heart Association and European Society of Cardiology STEMI guidelines, further delays gastro-intestinal absorption...
February 14, 2019: Netherlands Heart Journal
https://read.qxmd.com/read/30767111/full-metal-jacket-technique-using-second-generation-drug-eluting-stent-clinical-and-angiographic-follow-up-in-2-years
#20
Goro Yoshioka, Nehiro Kuriyama, Nozomi Watanabe, Keiichi Ashikaga, Yoshisato Shibata, Koichi Node
The aims of this study are to evaluate the efficacy of percutaneous coronary intervention (PCI) using full-metal jacket (FMJ) with second-generation drug-eluting stents (DES). A single-center, non-randomized, retrospective study was performed from May 2005 to February 2014 at Miyazaki Medical Association Hospital, Japan. PCI using FMJ with DES was performed to treat 240 very long lesions (> 60 mm) in 240 patients. Subjects were divided into a first-generation or second-generation DES group. The primary endpoint was the incidence of major adverse cardiac events (MACE) at 2 years...
February 14, 2019: Cardiovascular Intervention and Therapeutics
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