keyword
https://read.qxmd.com/read/38534035/adverse-jaw-outcomes-from-immune-checkpoint-inhibitors-for-head-and-neck-cancer-case-reports
#1
JOURNAL ARTICLE
Gayathri Subramanian, Vincent Yeung, Soly Baredes, Sung Kim, Tessa Bergsbaken, Samuel Quek
Radiation treatment plays a mainstream role in the management of head and neck squamous cell carcinomas (HNSCCs). Adverse effects from radiation therapy include osteoradionecrosis of the jaw, and rarely, pathologic fracture. Immune checkpoint inhibitors (ICI) such as pembrolizumab are of growing relevance to the management of metastatic and recurrent HNSCCs. Adverse impacts on bone secondary to medications such as pembrolizumab and nivolumab have been sporadically documented in the literature. The objective of this manuscript is to raise awareness of possible increase in risk for adverse jaw outcomes in patients with HNSCCs exposed to both radiation treatment to the jaws and ICI therapy...
March 27, 2024: Quintessence International
https://read.qxmd.com/read/38530966/response-to-the-letter-to-the-editor-osteonecrosis-of-the-jaws-in-patients-under-osteoporosis-treatment-nine-year-experience-report
#2
JOURNAL ARTICLE
Daniela Cia Penoni, João Vitor S Canellas, Flávia Sader, Gonçalo Sobreira Pimentel Neto, Anna Thereza Thomé Leão
None.
March 25, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38530965/osteonecrosis-of-the-jaws-in-patients-under-osteoporosis-treatment-a-nine-year-experience-report
#3
JOURNAL ARTICLE
Efsun Somay
None.
March 25, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38527729/assessing-the-potential-role-of-artificial-intelligence-in-medication-related-osteonecrosis-of-the-jaw-information-sharing
#4
JOURNAL ARTICLE
Elif Çoban, Berkan Altay
BACKGROUND: Artificial Intelligence, by answering questions about disease prevention strategies, can contribute to making diseases more treatable in their early stages. PURPOSE: This study aims to evaluate the quality of patient information by assessing the responses of the Chat Generative Pretrained Transformer (ChatGPT, Open AI, USA) artificial intelligence model to questions related to medication-related osteonecrosis of the jaw (MRONJ). STUDY DESIGN, SETTING, SAMPLE: The study was prospective cross-sectional design...
March 9, 2024: Journal of Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38523198/ozone-infiltration-as-an-adjunctive-treatment-to-piezoelectric-surgery-in-the-management-of-medication-related-osteonecrosis-of-the-jaws-case-series-of-29-patients
#5
JOURNAL ARTICLE
Funda Goker, Girolamo Donati, Francesco Gallo, Antonella Sparaco, Vito Rania, Alberto Busa, Francesco Grecchi, Emma Grecchi, Gianluca Colapinto, Massimo Del Fabbro
PURPOSE: Medication-related osteonecrosis of the jaws has been reported to be associated with bisphosphonate and RANKL inhibitor medications. This prospective clinical study aimed to assess the outcomes of pre-operative ozone infiltration therapy in patients with established MRONJ. METHODS: The treatment protocol for ozone applications were designed as 20 applications ozone infiltration therapy followed by surgical interventions of necrotic tissue debridement using piezoelectric surgery instruments...
March 25, 2024: Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38523176/zoledronic-acid-accelerates-er-stress-mediated-inflammation-by-increasing-pde4b-expression-in-bisphosphonate-related-osteonecrosis-of-the-jaw
#6
JOURNAL ARTICLE
Qu Xz, Sun Zq, Liu L, Ong Hs
Long-term administration of bisphosphonates can lead to a significant side effect known as bisphosphonate-related osteonecrosis of the jaw (BRONJ). Although macrophage-mediated inflammation has been established as an important factor in BRONJ, the underlying mechanism remains elusive. In the current study, the roles of endoplasmic reticulum (ER) stress in zoledronic acid (ZOL)-induced inflammation were analyzed in macrophages, and the regulatory mechanism of ER stress activation was next investigated. An in vitro model of BRONJ was established by treating RAW264...
March 25, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38519674/medication-related-osteonecrosis-of-the-jaw-in-a-paediatric-patient-taking-denosumab-a-case-report
#7
REVIEW
Dominic Innes-Taylor, Vicky Adams
Medication-related osteonecrosis of the jaw (MRONJ) is a known complication of antiresorptive and anti-angiogenic therapies in adults. Increasingly, these drugs are being prescribed for children with a variety of conditions, such as osteogenesis imperfecta and cancers of the bone. Review of the literature, however, reveals no reported paediatric MRONJ cases to date. We present such a case in a nine-year-old female patient with a vertebral aneurysmal bone cyst, who received dental extractions subsequent to denosumab therapy...
March 2024: British Dental Journal
https://read.qxmd.com/read/38515001/visualising-cervical-lymph-nodes-in-jaw-osteonecrosis-using-diffusion-weighted-imaging
#8
JOURNAL ARTICLE
Hirotaka Muraoka, Takashi Kaneda, Takumi Kondo, Kohei Otsuka, Satoshi Tokunaga
OBJECTIVES: This study aimed to apply diffusion-weighted imaging to the evaluation of cervical lymph nodes affected by medication-related osteonecrosis of the jaw (MRONJ). METHODS: This retrospective study analysed the diffusion-weighted imaging data of 70 patients with or without MRONJ (Stages 0-3). The mean apparent diffusion coefficient (ADC) values of the submandibular (level IB) and superior internal jugular (level IIA) nodes in the control and MRONJ groups were calculated, and differences were analysed using the Mann-Whitney test...
March 21, 2024: Oral Diseases
https://read.qxmd.com/read/38514433/medical-and-dental-professions-varying-levels-of-awareness-regarding-medication-related-osteonecrosis-of-the-jaw-in-saudi-arabia-a-cross-sectional-study
#9
JOURNAL ARTICLE
Marwan Hamed Aljohani, Abdulbari Saleh Aljohani, Riyadh Mohammed Aljohani, Wahab Khalifah Alsharif, Ibrahim Nourwali, Shadia A Elsayed
AIMS: This study aimed to assess the awareness of the risk of medication-related osteonecrosis of the jaw (MRONJ) among general dental practitioners (GDPs) and primary care physicians (PCPs), focusing on the clinical implications and coordination of treating or identifying high-risk patients. MATERIALS AND METHODS: Two Google Forms electronic questionnaires were distributed to 724 GDPs and 617 PCPs in primary care settings. One for PCPs with eight multiple choice questions and the other for GDPs with 10 multiple choice questions...
January 1, 2024: Journal of Contemporary Dental Practice
https://read.qxmd.com/read/38481370/bone-pattern-changes-in-post-liver-transplant-patients-using-bisphosphonates
#10
JOURNAL ARTICLE
Marcus Vinícius Bueno, Luciana Munhoz, Karem L Ortega, Maria Paula Siqueira de Melo Peres, Juliana Bertoldi Franco
OBJECTIVE: To identify radiographic findings suggestive of drug-induced osteonecrosis and evaluate radiomorphometric patterns indicative of changes in bone mineral density in individuals transplanted for liver disorders using bisphosphonates. STUDY DESIGN: The study group included panoramic x-rays of liver transplant patients who are being monitored and who present a clinical status of osteoporosis and use bisphosphonates. The control group was made up of liver transplant patients who did not have osteoporosis...
March 14, 2024: Special Care in Dentistry
https://read.qxmd.com/read/38470273/-adverse-drug-reactions-in-the-oral-cavity
#11
JOURNAL ARTICLE
Ylva Böttiger, Emma Ekenstråle
Adverse drug reactions commonly occur in the oral cavity, and although these reactions are seldom life threatening, they may severely affect quality of life, as well as the nutritional status of the patient. Hyposalivation is often caused by antidepressants, antihistamines, and diuretics, and the risk increases with polypharmacy. A dry mouth may in turn lead to oral candidosis, which may also be caused by treatment with antibiotics, immunosuppressants or corticosteroids. Other possible adverse drug reactions that may be seen in the oral cavity include gingival hyperplasia, ulcerations, allergic mucosal reactions, changes in sensibility or taste, as well as discoloration of saliva and/or the oral mucosa...
March 12, 2024: Läkartidningen
https://read.qxmd.com/read/38452783/duration-of-fracture-prevention-after-zoledronate-treatment-in-women-with-osteopenia-observational-follow-up-of-a-6-year-randomised-controlled-trial-to-10-years
#12
JOURNAL ARTICLE
Ian R Reid, Anne M Horne, Borislav Mihov, Usha Bava, Angela Stewart, Gregory D Gamble
BACKGROUND: We previously identified that zoledronate administered at 18-month intervals reduced fragility fractures by a third in a 6-year trial of women older than 65 years with osteopenia. This extension aims to identify the persistence of these effects. METHODS: Of the 2000 ambulant, community dwelling, postmenopausal women older than 65 years recruited in Auckland, New Zealand, with T-scores at the total hip or femoral neck in the range -1·0 to -2·5, we invited participants who received four doses of intravenous zoledronate, completed follow-up to year 6 of the core trial, did not have metabolic bone disease (other than osteoporosis), and were not using bone-active drugs into this 4-year observational study extension, during which further treatment was at the discretion of their own doctors...
March 4, 2024: Lancet Diabetes & Endocrinology
https://read.qxmd.com/read/38448748/biomechanical-analysis-of-alveolar-bones-with-compromised-quality-supporting-a-4-unit-implant-bridge-a-possible-association-with-implant-related-sequestration-irs
#13
JOURNAL ARTICLE
Youngjae Yoon, Inyeong Kang, Gunwoo Noh, Yong-Dae Kwon
OBJECTIVES: This study aimed to investigate the strain in the bone surrounding dental implants supporting a 4-unit bridge and assess the role of excessive strain as a possible risk factor for implant related sequestration (IRS) or peri-implant medication-related osteonecrosis of the jaw (PI-MRONJ). MATERIALS AND METHODS: A 3D-mandibular model was constructed using computed tomography and segmented it into cortical and cancellous bones. The 4-unit implant-supported bridges replacing the mandibular posteriors were constructed, and each featuring two, three, and four implants, respectively...
March 7, 2024: Clinical Oral Investigations
https://read.qxmd.com/read/38443942/stability-of-standardized-uptake-values-for-quantitative-bone-spect-for-jawbone-lesions-a-single-center-cross-sectional-study
#14
JOURNAL ARTICLE
Hironobu Hata, Satoshi Shimomura, Kenji Imamachi, Jun Sato, Takuya Asaka, Kenji Hirata, Kyousuke Funayama, Yoichi Mori, Masashi Matsuzaka, Toshikazu Nambu, Yoshimasa Kitagawa
BACKGROUND: The long time required for bone uptake of radiopharmaceutical material after injection for bone scintigraphy is a burden for patients with poor health. Thus, to assess whether the uptake time could be reduced for single-photon emission computed tomography (SPECT) of the jawbone, this study evaluated differences in maximum standardized uptake values (SUVmax) within patients using SPECT imaging at 2 and 3 hours after radiopharmaceutical injection. METHODS: A total of 33 patients undergoing treatment or in post-treatment follow-up for medication-related osteonecrosis of the jaw, who visited our hospital between July 2020 and August 2021 and could receive SPECT twice on the same day, were enrolled in the study...
March 5, 2024: BMC Oral Health
https://read.qxmd.com/read/38443685/medication-related-osteonecrosis-of-the-jaw-evolving-research-for-multimodality-medical-management
#15
REVIEW
Ali Abdolrahmani, Joel B Epstein, Firoozeh Samim
PURPOSE: Medication-related osteonecrosis of the jaw (MRONJ) is a debilitating side effect of antiresorptive and antiangiogenic agents that can lead to progressive bone destruction in the maxillofacial region. Dental surgery, including tooth extractions, commonly trigger the onset of MRONJ. While guidelines suggest avoiding extraction when possible, complete avoidance is not always feasible, as necrosis can develop from dental and periodontal disease without dental procedures. The goal of this article is to provide an update review of current preventive and therapeutic approaches for MRONJ...
March 5, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38443234/is-maxillary-sinusitis-and-radiographic-maxillary-sinus-opacification-associated-with-an-altered-microbiology-of-mronj
#16
JOURNAL ARTICLE
Matthew W Hershberger, Puhan He, Kevin Francois, David Lerner, Adam Bear, Nithin Adappa, Neeraj Panchal
OBJECTIVE: Maxillary sinusitis can be a sequela of medication-related osteonecrosis of the jaw (MRONJ). This study aims to characterize the microbiome of maxillary MRONJ with concurrent maxillary sinusitis and radiographic maxillary sinus opacification to determine if there is a relationship between the microbiome of MRONJ and sinus disease. STUDY DESIGN: This retrospective case series was conducted using electronic health records from the University of Pennsylvania and affiliated hospitals...
December 9, 2023: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://read.qxmd.com/read/38427111/treatment-of-bone-metastases-from-solid-tumors-with-bone-modifying-agents-a-web-survey-of-italian-oncologists-investigating-patterns-of-practice-drug-prescription-and-prevention-of-side-effects
#17
JOURNAL ARTICLE
Vittorio Fusco, Massimo Di Maio, Anna Amela Valsecchi, Daniele Santini, Marcello Tucci, Ugo De Giorgi, Paolo Bossi, Toni Ibrahim, Luigi Cavanna, Gaetano Lanzetta, Maura Rossi, Giorgia Rossetti, Mario Airoldi, Alessandro Comandone, Saverio Cinieri
PURPOSE: Optimal use of bone-modifying agents (BMAs) in patients with bone metastases from solid tumors is uncertain in some aspects: the drug choice; the planned treatment duration and long-term therapy; the prevention and management of possible side effects, including renal toxicity, hypocalcaemia, and medication-related osteonecrosis of the jaw (MRONJ). METHODS: Italian oncologists were invited to fulfil a 24-question web survey about prescription of BMAs for bone metastases of breast cancer, prostate cancer, and other solid tumors...
March 1, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38418702/surgical-and-conservative-treatment-outcomes-of-medication-related-osteonecrosis-of-the-jaw-located-at-tori-a-retrospective-study
#18
JOURNAL ARTICLE
Hameda Amin, Sanne Werner Moeller Andersen, Simon Storgård Jensen, Thomas Kofod
PURPOSE: Tori and exostoses are considered risk factors for the development of medication-related osteonecrosis of the jaw (MRONJ). The aims of this study were to present the prevalence of MRONJ located at tori in the Copenhagen ONJ Cohort, evaluate the surgical treatment of MRONJ located at tori and explore trauma to tori as an additional risk factor in patients on antiresorptive medication. METHODS: Data from a consecutive series of 506 patients with MRONJ (Copenhagen ONJ Cohort) were reviewed for the presence of tori and MRONJ located at tori...
February 29, 2024: Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38417990/inflammatory-lesions-of-the-jaws
#19
REVIEW
Galal Omami, Richard H Wiggins
This article defines the fascial and spatial anatomy of the suprahyoid neck region, delineates the role of CT and MR imaging, discusses the inflammatory conditions of the jaws and adjacent spaces and their clinical symptomatology, and illustrates the appearance of these conditions.
April 2024: Dental Clinics of North America
https://read.qxmd.com/read/38406100/awareness-of-medication-related-osteonecrosis-of-the-jaws-amongst-patients-on-antiresorptive-and-antiangiogenic-medications
#20
JOURNAL ARTICLE
Ahmad S Assari, Yosef Alanazi, Elaf Mubarak Algharbi, Abdulmajeed Abuhabsha, Basel Alshammry, Ali Alzahrani, Abdulrahaman Alduhaim, Reem Abuhaimed
Background Medication-related osteonecrosis of the jaws (MRONJ) is a rare but severe condition that has garnered increasing attention in recent years. It primarily affects individuals undergoing treatment with antiresorptive and antiangiogenic medications, such as bisphosphonates and denosumab, commonly prescribed for osteoporosis and cancer-related bone metastases. Therefore, the present study aimed to assess awareness and understanding of MRONJ among patients receiving antiresorptive and antiangiogenic medications...
January 2024: Curēus
keyword
keyword
162644
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.