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Blood cancers

Kotaro Yamashita, Shinji Mine, Tasuku Toihata, Ian Fukudome, Akihiko Okamura, Masami Yuda, Masaru Hayami, Yu Imamura, Masayuki Watanabe
BACKGROUND: The three-dimensional video-assisted (3D-VA) system is known to provide depth perception and the precise measurement of anatomical spaces, unlike the two-dimensional video-assisted (2D-VA) system. However, the advantages of the 3D-VA system in thoracoscopic esophagectomy remains unclear. METHODS: We retrospectively analyzed data from 104 patients who underwent thoracoscopic esophagectomy for esophageal cancer from 2016 to 2017. We performed thoracic esophagectomy using either the 2D-VA or 3D-VA system during this period...
March 19, 2019: Esophagus: Official Journal of the Japan Esophageal Society
Hiroyuki Kanao, Koji Matsuo, Yoichi Aoki, Terumi Tanigawa, Hidetaka Nomura, Sanshiro Okamoto, Nobuhiro Takeshima
OBJECTIVES: Intraoperative tumor manipulation and dissemination may possibly compromise survival of women with early-stage cervical cancer who undergo minimally-invasive radical hysterectomy (RH). The objective of the study was to examine survival related to minimally-invasive RH with a "no-look no-touch" technique for clinical stage IB1 cervical cancer. METHODS: This retrospective study compared patients who underwent total laparoscopic radical hysterectomy (TLRH) with no-look no-touch technique (n=80) to those who underwent an abdominal radical hysterectomy (ARH; n=83) for stage IB1 (≤4 cm) cervical cancer...
May 2019: Journal of Gynecologic Oncology
Wawaimuli Arozal, Wenny Trias Ramadanty, Melva Louisa, Regina Puspa Utami Satyana, Gaviota Hartono, Serlie Fatrin, Sigit Purbadi, Ari Estuningtyas, Instiaty Instiaty
BACKGROUND: Curcumin is a natural diphenolic compound that is currently being investigated for various cancers, including ovarian cancer. Clinical application of curcumin has been limited due to its low solubility and bioavailability and rapid metabolism and degradation at physiological pH. Particle size is one factor that can affect the absorption process, which thus increases compound solubility and transport across the membrane. This study was conducted to determine the effects of modifying the particle size of curcumin on its pharmacokinetic parameters in blood and other organs...
March 18, 2019: Drug Research
Leili Pourafkari, Aidin Baghbani-Oskouei, Safa Savadi-Oskouei, Samad Ghaffari, Raziye Parizad, Arezou Tajlil, Nader D Nader
BACKGROUND AND OBJECTIVE: The use and range of indications for anticoagulation therapy are steadily growing. The objective of this study was to develop a scoring model to predict the occurrence of significant bleeding in patients taking warfarin with a supra-therapeutic international normalized ratio. METHODS: Data were collected from the medical records of patients taking warfarin with an international normalized ratio > 3.5. The characteristics of bleeding episodes and the need for transfusion of blood products were recorded...
March 18, 2019: Clinical Drug Investigation
Damrongsak Faroongsarng, Somkiat Sunpaweravong, Achara Raksawong
Cancerous invasion yields unusual metabolisms providing a significant amount of peptide albuminomes that modulate albumin stability via binding. The study aimed at the investigation of the thermal stability of human plasma albumin with breast cancer of various stages by means of differential scanning calorimetry (DSC). Blood plasma was drawn from 11 female breast cancer patients and 50 healthy volunteers of homogeneous demographics. Plasma samples and their albumin-enriched fractions were subjected to DSC scanning between 37 and 90°C at 5°C/min rate...
March 18, 2019: AAPS PharmSciTech
Lei Gu, Yidong Xu, Wangyan Xu, Meng Li, Hui Su, Cong Li, Zhongchen Liu
Colorectal cancer (CRC) is the most frequently encountered malignancy associated with the rectum or colon, and accumulating evidences have implicated intestinal dysbacteriosis (IDB, disruption of gut microbiome) and exosomes in the pathology of CRC. We aimed to investigate the effect of IDB on exosome secretion in a CRC xenograft mouse model. An IDB mouse model was established and was inoculated with the CRC cell line SW480 as a xenograft tumor. Tumor growth was monitored for 15 days in sham and IDB mice, after which blood was collected to assess serum exosome secretion...
March 19, 2019: Investigational New Drugs
Jin Gao, Huimin Hu, Xuesong Wang
BACKGROUND: Angiogenesis, the formation of blood vessel, is required for invasive tumor growth and metastasis. In this study, the effects of lidocaine, an amide-link local anesthetic, on angiogenesis and tumor growth were investigated. METHODS: In vitro angiogenesis assays were conducted using human umbilical vascular endothelial cell (HUVEC). Essential molecules involved in vascular endothelial growth factor (VEGF) signaling were analyzed. Tumor angiogenesis was analyzed using in vivo mouse tumor model...
March 18, 2019: Cancer Chemotherapy and Pharmacology
Ingrid Poláková, Ondřej Pelák, Daniel Thürner, Barbora Pokrývková, Ruth Tachezy, Tomáš Kalina, Michal Šmahel
Monitoring immune responses to solid cancers may be a better prognostic tool than conventional staging criteria, and it can also serve as an important criterion for the selection of individualized therapy. Multiparametric phenotyping by mass cytometry extended possibilities for immunoprofiling. However, careful optimization of each step of such method is necessary for obtaining reliable results. Also, with respect to procedure length and costs, sample preparation, staining, and storage should be optimized. Here, we designed a panel of 31 antibodies which allows for identification of several subpopulations of lymphoid and myeloid cells in a solid tumor and peripheral blood simultaneously...
2019: Journal of Immunology Research
Vyshak Alva Venur, Justine V Cohen, Priscilla K Brastianos
The discovery and clinical application of agents targeting pivotal molecular pathways in malignancies such as lung, breast, renal cell carcinoma, and melanoma have led to impressive improvements in clinical outcomes. Mutations in epidermal growth factor receptor ( EGFR ), and rearrangements of anaplastic lymphoma kinase ( ALK ) are targetable in lung cancer, while BRAF mutations have been successfully targeted in metastatic melanoma. Targeting estrogen receptors, cyclin dependent kinases, and HER2 (Human Epidermal Receptor) have resulted in improvement in survival in breast cancer...
2019: Frontiers in Oncology
Yuanxin Chen, Xiujie Liu, Hengfeng Yuan, Zhaogang Yang, Christina A von Roemeling, Yaqing Qie, Hai Zhao, Yifan Wang, Wen Jiang, Betty Y S Kim
A major challenge in the development of cancer nanomedicine is the inability for nanomaterials to efficiently penetrate and deliver therapeutic agents into solid tumors. Previous studies have shown that tumor vasculature and extracellular matrix regulate the transvascular and interstitial transport of nanoparticles, both critical for successfully delivering nanomedicine into solid tumors. Within the malignant tumor microenvironment, blood vessels are morphologically abnormal and functionally exhibit substantial permeability...
March 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Jingxin Shao, Imke A B Pijpers, Shoupeng Cao, David S Williams, Xuehai Yan, Junbai Li, Loai K E A Abdelmohsen, Jan C M van Hest
Morphologically discrete nanoarchitectures, which mimic the structural complexity of biological systems, are an increasingly popular design paradigm in the development of new nanomedical technologies. Herein, engineered polymeric stomatocytes are presented as a structural and functional mimic of red blood cells (RBCs) with multifunctional therapeutic features. Stomatocytes, comprising biodegradable poly(ethylene glycol)- block -poly(D,L-lactide), possess an oblate-like morphology reminiscent of RBCs. This unique dual-compartmentalized structure is augmented via encapsulation of multifunctional cargo (oxygen-binding hemoglobin and the photosensitizer chlorin e6)...
March 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Toshihisa Fujiyoshi, Ryoji Miyahara, Kohei Funasaka, Kazuhiro Furukawa, Tsunaki Sawada, Keiko Maeda, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Masato Nakaguro, Masahiro Nakatochi, Yoshiki Hirooka
BACKGROUND: Linked color imaging (LCI) is a method of endoscopic imaging that emphasizes slight differences in red mucosal color. AIM: To evaluate LCI in diagnostic endoscopy of early gastric cancer and to compare LCI and pathological findings. METHODS: Endoscopic images were obtained for 39 patients (43 lesions) with early gastric cancer. Three endoscopists evaluated lesion recognition with white light imaging (WLI) and LCI. Color values in Commission Internationale de l'Eclairage (CIE) 1976 L*a*b* color space were used to calculate the color difference (ΔE) between cancer lesions and non-cancer areas...
March 14, 2019: World Journal of Gastroenterology: WJG
Amin Aalipour, Hui-Yen Chuang, Surya Murty, Aloma L D'Souza, Seung-Min Park, Gunsagar S Gulati, Chirag B Patel, Corinne Beinat, Federico Simonetta, Ivana Martinić, Gayatri Gowrishankar, Elise R Robinson, Eamon Aalipour, Zahra Zhian, Sanjiv S Gambhir
Endogenous biomarkers remain at the forefront of early disease detection efforts, but many lack the sensitivities and specificities necessary to influence disease management. Here, we describe a cell-based in vivo sensor for highly sensitive early cancer detection. We engineer macrophages to produce a synthetic reporter on adopting an M2 tumor-associated metabolic profile by coupling luciferase expression to activation of the arginase-1 promoter. After adoptive transfer in colorectal and breast mouse tumor models, the engineered macrophages migrated to the tumors and activated arginase-1 so that they could be detected by bioluminescence imaging and luciferase measured in the blood...
March 18, 2019: Nature Biotechnology
Jine Li, Jun Lei, Liyun He, Xiude Fan, Fengming Yi, Wenxiong Zhang
BACKGROUND This systematic review of the literature and meta-analysis aimed to review the evaluation and monitoring of superoxide dismutase (SOD) activity and its clinical significance in gastric cancer. MATERIAL AND METHODS Systematic review involved searching the PubMed, Embase, Ovid, and the China National Knowledge Infrastructure (CNKI) databases. Search terms included 'superoxide dismutase,' and 'gastric cancer.' Studies that included measurements of SOD activity in peripheral blood samples in patients with SOD activity compared with healthy controls...
March 19, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Hannah M Phelps, Josephine M Ndolo, Kyle J Van Arendonk, Heidi Chen, Hannah L Dietrich, Katherine D Watson, Melissa A Hilmes, Dai H Chung, Harold N Lovvorn
BACKGROUND: The current neuroblastoma (NBL) staging system employs image-defined risk factors (IDRFs) to assess numerous anatomic features, but the impact of IDRFs on surgical and oncologic outcomes is unclear. METHODS: The Vanderbilt Cancer Registry identified children treated for NBL from 2002 to 2017. Tumor volume (TV) and IDRFs were measured radiographically at diagnosis and before resection. Perioperative and oncologic outcomes were evaluated. RESULTS: At diagnosis of 106 NBL, 61% were IDRF positive...
March 1, 2019: Journal of Pediatric Surgery
Chris Hurt, Rajeswari Ramaraj, Angela Farr, Meleri Morgan, Namor Williams, Ceri J Philips, Geraint T Williams, Georgina Gardner, Catherine Porter, Julian Sampson, Sharon Hillier, Hayley Heard, Sunil Dolwani
BACKGROUND: Most post-colonoscopy interval colorectal cancers are proximal; serrated polyps are often precursors to these cancers and are considered difficult to detect. We assessed the safety, feasibility, and economic effect of chromocolonoscopy on detection of proximal serrated neoplasia. METHODS: We did an open-label, multicentre, randomised, controlled non-inferiority trial including patients from Bowel Screening Wales centres. Participants who tested positive for faecal occult blood and who were eligible for and considered fit to have colonoscopy (patients with known cases of polyposis syndromes, Lynch syndrome, and chronic inflammatory disease were excluded) were randomly assigned (1:1; with the use of minimisation, stratified by centre with an 80:20 random element) to either standard white light colonoscopy (standard group) or chromocolonoscopy (indigo carmine dye [0·2%]; chromocolonoscopy group) using a secure, internet-based, computerised, randomisation system that used centralised, dynamic allocation...
March 15, 2019: Lancet. Gastroenterology & Hepatology
Yun L Miao, Qing Qing Xu
OBJECTIVES: MET amplification or MET exon 14 skipping site mutation can be treated with crizotinib in non-small cell lung cancer patients. Y1003 is a binding site for E3 ubiquitin ligase, which is critical for MET degradation. Here we show an adenocarcinoma patient with Y1003S mutation and she got tumor remission after crizotinib treatment. MATERIALS AND METHODS: A 61-year-old never-smoking female was admitted to our hospital due to increased carcino-embryonicantigen...
April 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Tao Jiang, Yuchen Bai, Fei Zhou, Wei Li, Guanghui Gao, Chunxia Su, Shengxiang Ren, Xiaoxia Chen, Caicun Zhou
INTRODUCTION: There is unmet need to explore the predictive biomarkers of PD-1/PD-L1 inhibitors in patients with non-small-cell lung cancer (NSCLC). Here, we aimed to investigate the predictive and prognostic value of blood neutrophil-to-lymphocyte ratio (NLR) in NSCLC patients treated with PD-1/PD-L1 inhibitors. METHODS: We performed a comprehensive online search to explore the association between blood NLR and overall survival (OS) or progression-free survival (PFS) in NSCLC patients received PD-1/PD-L1 inhibitors...
April 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Thomas Muley, Ying He, Vinzent Rolny, Birgit Wehnl, Achim Escherich, Arne Warth, Christa Stolp, Marc A Schneider, Michael Meister, Felix J Herth, Farshid Dayyani
OBJECTIVES: The biomarkers cytokeratin 19 fragment (CYFRA 21-1) and human epididymis protein 4 (HE4) are useful in the diagnosis, prognosis, and monitoring of non-small cell lung cancer (NSCLC), but their combination has not been investigated yet. The objective of this analysis was to evaluate the ability of CYFRA 21-1 and HE4 to predict recurrence as part of follow-up monitoring in patients with adenocarcinoma (ADC) of the lung. MATERIALS AND METHODS: Serum samples were collected from patients with stage I-IIIA ADC preoperatively and during follow-up at 3, 6, 12, 18, and 24 months and then every 6-12 months up to 5 years post-R0 resection...
April 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Ararat Chakhoyan, Catalina Raymond, Jason Chen, Jodi Goldman, Jingwen Yao, Tania B Kaprealian, Nader Pouratian, Benjamin M Ellingson
PURPOSE: To identify clinically relevant magnetic resonance imaging (MRI) features of different types of metastatic brain lesions, including standard anatomical, diffusion weighted imaging (DWI) and dynamic susceptibility contrast (DSC) perfusion MRI. METHODS: MRI imaging was retrospectively assessed on one hundred and fourteen (N = 114) brain metastases including breast (n = 27), non-small cell lung cancer (NSCLC, n = 43) and 'other' primary tumors (n = 44)...
March 18, 2019: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
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