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Vitamin d falls

David M Mosen, Matthew P Banegas, Nicole Friedman, Elizabeth Shuster, Neon Brooks
More than 3 million older US adults injure themselves by falling each year. Falls are a major cause of morbidity and mortality for this population, and account for nearly $30 billion in Medicare expenditures annually. Falls have been linked to frailty and vitamin D deficiency, both of which are linked to low nutrient intake and food insecurity. This retrospective, observational study is the first the authors know of to directly assess the relationship between food insecurity and falls. The study sample consisted of 26,525 Medicare Advantage members at Kaiser Permanente Northwest, a group model health maintenance organization, who had completed a quality of care survey between April 2013 and March 2017 and who maintained continuous enrollment in the 12 months prior to the survey date...
March 21, 2019: Population Health Management
Hiroyasu Mori, Yasunobu Tokuda
BACKGROUND AND OBJECTIVES: Sarcopenia and frailty result in loss of function and independence. Sarcopenia may be a risk factor for frailty; however, risk factors for sarcopenia with frailty, and associated incidence of falls and poor quality of life remain unclear. We investigated the clinical characteristics and relevant factors for sarcopenia with frailty in older community-dwelling Japanese. METHODS AND STUDY DESIGN: This cross-sectional study included 331 Japanese community-dwelling adults aged ≥60 years...
2019: Asia Pacific Journal of Clinical Nutrition
Terry J Aspray, Tom R Hill
Osteoporosis is a "skeletal disorder characterized by compromised bone strength predisposing a person to an increased risk of fracture" which, in light of demographic change, is becoming an increasing burden on health care worldwide. Increasing age and female gender are associated with the condition, although a wider range of clinical risk factors are being used increasingly to identify those at risk of osteoporosis and its most important sequelae, fracture.While osteoporosis and fracture have long been associated with women in the post-menopausal age, fracture incidence increases because of the ageing of our population...
2019: Sub-cellular Biochemistry
Meghan McGee
Vitamin D is a prohormone that is essential to good health. As very few foods (fish, egg yolks, milk) are rich in vitamin D, the main source of the vitamin is synthesized in the skin in the presence of ultraviolet B rays from sunlight. However, due to Canada's northern latitude, sufficient amounts of vitamin D cannot be synthesized using sunlight during the fall and winter months and, consequently, there is a concern that many Canadians are not achieving adequate levels of vitamin D. A wide array of inconsistent evidence derived from serum and dietary assessments has been published and the results are inconclusive...
March 13, 2019: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
Ashish Sharma, Rahul Janak Sinha, Vishwajeet Singh, Gaurav Garg, Samarth Agarwal, Siddharth Pandey
OBJECTIVE: Maintaining the optimum bone health is one of the important concerns in patients with prostate cancer, but it usually remains neglected. Failure to screen these patients is detrimental to both the length and the quality of life. The estimation of bone mineral density (BMD) and more recently the World Health Organization's fracture risk assessment (FRAX) algorithm in appropriate patients is recommended by several specialty organizations/associations at the time of instituting androgen deprivation therapy (ADT) for metastatic and high-risk individuals...
February 20, 2019: Turkish Journal of Urology
Francine Monique Ducharme, Megan Jensen, Geneviève Mailhot, Nathalie Alos, John White, Elizabeth Rousseau, Sze Man Tse, Ali Khamessan, Benjamin Vinet
BACKGROUND: New evidence supports the use of supplemental vitamin D in the prevention of exacerbation of asthma; however, the optimal posology to sufficiently raise serum levels while maximising adherence is unclear. The objective was to ascertain the efficacy of high-dose vitamin D3 in increasing serum vitamin D in preschoolers with asthma and provide preliminary data on safety and efficacy outcomes. METHODS: We conducted a 7-month, triple-blind, randomised, placebo-controlled, pilot trial of children aged 1-5 years with viral-induced asthma...
February 18, 2019: Trials
Melissa Dang, Cat Shore-Lorenti, Lachlan B McMillan, Jakub Mesinovic, Alan Hayes, Peter R Ebeling, David Scott
Low vitamin D status commonly accompanies obesity, and both vitamin D deficiency and obesity have been associated with falls and fracture risk in older adults. We aimed to determine the associations of serum 25-hydroxyvitamin D (25(OH)D) concentrations with physical performance and bone health in community-dwelling, overweight and obese older men and women. Serum 25(OH)D concentrations were measured in 84 participants with body mass index ≥25 kg/m² (mean ± SD age 62.4 ± 7.9 years; 55% women). Physical function was determined by short physical performance battery, hand grip and quadriceps strength, and stair climb power tests...
February 12, 2019: International Journal of Environmental Research and Public Health
Paul Lips, Kevin D Cashman, Cje Lamberg-Allardt, Heike Annette Bischoff-Ferrari, Barbara R Obermayer-Pietsch, Ml Bianchi, Jan Stepan, Ghada El-Hajj Fuleihan, Roger Bouillon
Vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) < 50 nmol/l or 20 ng/ml), is common in Europe and the Middle East. It occurs in < 20 % of the population in Northern Europe, in 30-60% in Western, Southern and Eastern Europe and up to 80 % in Middle East countries. Severe deficiency (serum 25(OH)D < 30 nmol/l or 12 ng/ml) is found in > 10 % of Europeans. The ECTS advises that the measurement of serum 25(OH)D be standardized e.g. by the Vitamin D Standardization Program. Risk groups include young children, adolescents, pregnant women, older people, especially the institutionalized, and non-western immigrants...
February 1, 2019: European Journal of Endocrinology
Alenka Gugger, Alex Marzel, E John Orav, Walter C Willett, Bess Dawson-Hughes, Robert Theiler, Gregor Freystätter, Andreas Egli, Heike A Bischoff-Ferrari
OBJECTIVES: To test the effect of monthly high-dose vitamin D supplementation on mental health in pre-frail older adults. DESIGN: Ancillary study of a 1-year double-blind randomized clinical trial conducted in Zurich, Switzerland. SETTING AND PARTICIPANTS: A total of 200 community-dwelling adults 70 years and older with a prior fall event in the last year. Participants were randomized to receive 24 000 IU vitamin D3 (considered standard of care), 60 000 IU vitamin D3 , or 24 000 IU vitamin D3 plus 300 μg calcifediol per month...
February 1, 2019: Journal of the American Geriatrics Society
Natasha Aparecida Grande de França, Lavanya Srinivasa Murthy, Steven Phu, Elizabeth Liberts, Sara Vogrin, Ligia Araujo Martini, Gustavo Duque
OBJECTIVES: A high level of parathyroid hormone (PTH) was recently identified as a risk factor for falling. As balance instability is one of the major risk factors for falls, we aimed to investigate whether high PTH concentrations are associated with poor balance in older persons. STUDY DESIGN: Cross-sectional study with 127 community-dwelling older adults (75% female), aged 65-96 years, at the Falls and Fracture Clinic, Western Health-Sunshine Hospital, Melbourne, Australia...
March 2019: Maturitas
Konstantinos Dretakis, Vasilios G Igoumenou
BACKGROUND: Fragility fractures of the hip are associated with high morbidity and mortality, and represent a rather devastating consequence of osteoporosis. Hip fractures are traditionally investigated as a whole, although it has been recently implied that distinct pathogenic mechanisms may lead either to trochanteric or subcapital fractures. AIMS: To investigate whether differences exist by hip fracture type with respect to serum 25(OH)D (vitamin D) and parathyroid hormone (PTH) levels, in addition to epidemiological and demographic data, including history of falls...
January 30, 2019: Aging Clinical and Experimental Research
John F Aloia, Rakhil Rubinova, Melissa Fazzari, Shahidul Islam, Mageda Mikhail, Louis Ragolia
BACKGROUND: Limited information is available on the influence of vitamin D on falls in older high-functioning black American women. Endocrine Society guidelines propose serum 25(OH)D levels over 30 ng/mL. OBJECTIVE: To determine if maintenance of serum 25(OH)D above 30 ng/mL protects against falls. DESIGN: The Physical Performance, Osteoporosis and Vitamin D in African American Women (PODA) trial had a prospective, randomized, placebo-controlled, double-dummy design with two arms: one with placebo and one with vitamin D3 adjusted to maintain serum 25(OH)D above 30 ng/mL...
January 30, 2019: Journal of the American Geriatrics Society
Christine Krull, Abramoff Benjamin, Jerome Mairin, Jessica Principe, Qingpo Cai, Yogita Tailor
BACKGROUND: Inadequate vitamin D is highly prevalent. Vitamin D deficiency (VDD) increases the risk of osteoporosis, falls, and fractures. Patients in acute inpatient rehabilitation have several risk factors for VDD, the adverse effects of which may hinder long-term functional gain. OBJECTIVE: To evaluate the prevalence of and risk factors for VDD in patients admitted to acute inpatient rehabilitation along with the efficacy of a standardized vitamin D screening and supplementation protocol...
January 27, 2019: PM & R: the Journal of Injury, Function, and Rehabilitation
Marina De Rui, Emine Meral Inelmen, Sabrina Pigozzo, Caterina Trevisan, Enzo Manzato, Giuseppe Sergi
The synchronic loss of bone mineral density and decrease in muscle mass, strength, and function defines the scenario of osteosarcopenia, which is associated with an increased risk of falls and fractures in older adults. An important role in preventing muscle and bone loss is played by nutritional factors, in particular the intake of proteins, calcium, magnesium and vitamin D. This review summarizes the available literature concerning the influence of protein intake and supplementation (vitamin D, Ca, Mg, branched-chain amino acids) on the decline of musculoskeletal integrity in healthy older adults...
January 23, 2019: Aging Clinical and Experimental Research
Marina S Oliveira, Natasha Y Matsunaga, Marina L E Rodrigues, André M Morcillo, Maria A G de Oliveira Ribeiro, Antônio F Ribeiro, Maria de Fátima C P Servidoni, Roberto José N Nogueira, Monica Corso Pereira, José Dirceu Ribeiro, Adyléia Aparecida D C Toro
INTRODUCTION: Vitamin D acts on the immune system and lung response. Patients with cystic fibrosis (CF) may be deficient in this vitamin. The aims of the study were to evaluate vitamin D levels and severity of lung disease in infants and preschoolers diagnosed with CF, and to compare them to a group of children without pancreatic insufficiency (PI). METHODS: Patients with CF up to 4 years old were included, and compared to an age-matched group of children without diagnosis of CF...
January 20, 2019: Pediatric Pulmonology
R Durazo-Arvizu, F Ahmed, J Berry, E Cavalier, E Gunter, G Jones, J Jones, C Sempos, P J Twomey, E L Williams, G D Carter
The External Quality Assessment (EQA) scheme for vitamin D metabolites (DEQAS) distributes human serum samples to laboratories across the world to assess their performance in measuring serum total 25-hydroxyvitamin D [25(OH)D], i.e. the sum of the concentrations of serum 25(OH)D2 and 25(OH)D3 . In 2013 DEQAS, in collaboration with the Vitamin D Standardization Program (VDSP), became an accuracy-based EQAS when the National Institute for Standards and Technology (NIST) began assigning 25(OH)D target values to DEQAS serum samples using their Joint Committee for Traceability in Laboratory Medicine (JCTLM) approved reference measurement procedure (RMP)...
January 9, 2019: Journal of Steroid Biochemistry and Molecular Biology
David N Bernstein, Jacob T Davis, Carson Fairbanks, Kindra McWilliam-Ross, David Ring, Hugo B Sanchez
Background: A better understanding of how bone mineral density and vitamin D levels are associated with femoral neck and intertrochanteric hip fractures may help inform healthcare providers. We asked: 1) In patients age ≥ 55 years, is there a difference in quantitative ultrasound of the heel (QUS) t-score between patients with fractures of the femoral neck and those with fractures of the intertrochanteric region, accounting for other factors 2) In patients age ≥ 55 years, is there a difference in vitamin D level between those with fractures of the femoral neck and those with fractures of the intertrochanteric region, accounting for other factors? 3) Is there an association between vitamin D level and QUS t-score? Methods: In this retrospective cohort study, 1,030 patients were identified using CPT codes for fixation of hip fractures between December 2010 and September 2013...
November 2018: Archives of Bone and Joint Surgery
Elizabeth Manias, Andrea Maier, Gopika Krishnamurthy
BACKGROUND: Oldest old patients aged 85 years and over are at risk of experiencing potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs) across transitions of care. Geriatricians also face enormous challenges in prescribing medications for these patients. METHODS: A mixed-methods, sequential explanatory design was undertaken of electronic medical records and semi-structured interviews with geriatricians at a public teaching hospital...
January 10, 2019: Aging Clinical and Experimental Research
Elisabeth Stamm, Anna Acchini, Alexandre Da Costa, Sarah Besse, Foteini Christou, Cyrille Launay, Philippe Balmer, Marc Humbert, Sylvain Nguyen, Kristof Major, Wanda Bosshard, Christophe Büla
In 2018, new recommendations about the prevention of falls and fractures emphasized the benefits from exercise and from multimodal prevention programs but did not endorse any more vitamin D supplementation for falls prevention. Results were contrasted for several studies testing exercise (negative) and cognitive training (mixed results) in the management of older patients suffering from neurocognitive disorders. The new direct oral anticoagulants are increasingly prescribed in older patients despite the paucity of data...
January 9, 2019: Revue Médicale Suisse
Terry J Aspray, Thomas Chadwick, Roger M Francis, Elaine McColl, Elaine Stamp, Ann Prentice, Alexander von Wilamowitz-Moellendorff, Inez Schoenmakers
Background: Vitamin D insufficiency is common in older people and may lead to increased bone resorption, bone loss, and increased falls and fractures. However, clinical trials assessing the effect of vitamin D supplementation on bone mineral density (BMD) have yielded conflicting results. Objectives: This study examined the effect of vitamin D supplementation on BMD at the hip, using dual-energy X-ray absorptiometry. Methods: A total of 379 adults aged ≥70 y (48% women; mean age: 75 y) from the northeast of England were randomly allocated to 1 of 3 doses of vitamin D3 [12,000 international units (IU), 24,000 IU, or 48,000 IU] given once a month...
January 8, 2019: American Journal of Clinical Nutrition
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