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Si-Yuan Qiu, Kelvin K Ng, Tan-To Cheung, Chun-Hong Liu, Hong-Tao Zhu, Bang-Ren Xu, Ren Ji, Chung-Mau Lo
INTRODUCTION: Choledocholithiasis during pregnancy is relatively uncommon but it can be life-threatening. Therapeutic endoscopic retrograde cholangiopancreatography (ERCP) poses the risk of ionizing radiation exposure to the developing fetus. Other strategies are thus needed to tackle this problem. PRESENTATION OF CASE: A 38-year-old 8 weeks' pregnant lady presented with acute onset of right upper quadrant pain. Ultrasonography showed features of acute cholecystitis and choledocholithiasis, which was later confirmed by magnetic resonance cholangiogram...
April 8, 2019: International Journal of Surgery Case Reports
Francesca Comelli, Isabella Bettoni, Mariapia Colleoni, Gabriella Giagnoni, Barbara Costa
Neuropathy is the most common complication of diabetes and it is still considered to be relatively refractory to most of the analgesics. The aim of the present study was to explore the antinociceptive effect of a controlled cannabis extract (eCBD) in attenuating diabetic neuropathic pain. Repeated treatment with cannabis extract significantly relieved mechanical allodynia and restored the physiological thermal pain perception in streptozotocin (STZ)-induced diabetic rats without affecting hyperglycemia. In addition, the results showed that eCBD increased the reduced glutathione (GSH) content in the liver leading to a restoration of the defence mechanism and significantly decreased the liver lipid peroxidation suggesting that eCBD provides protection against oxidative damage in STZ-induced diabetes that also strongly contributes to the development of neuropathy...
December 2009: Phytotherapy Research: PTR
Duncan Ryan, Alison J Drysdale, Roger G Pertwee, Bettina Platt
We have shown previously that the plant cannabinoid cannabidiol (CBD) elevates intracellular calcium levels in both cultured hippocampal neurones and glia. Here, we investigated whether the main psychotropic constituent of cannabis, Delta(9)-tetrahydrocannabinol (THC) alone or in combination with other cannabis constituents can cause similar responses, and whether THC affects the responses induced by CBD. Our experiments were performed with 1 microM pure THC (pTHC), with 1 microM pure CBD (pCBD), with a high-THC, low CBD cannabis extract (eTHC), with a high-CBD, low THC cannabis extract (eCBD), with a mixture of eTHC and eCBD (THC:CBD=1:1) or with corresponding 'mock extracts' that contained only pTHC and pCBD mixed in the same proportion as in eTHC, eCBD or the 1:1 mixture of eTHC and eCBD...
November 20, 2006: Neuroscience Letters
Goodfellow, Thomas, Majeed, Johnson
AIMS: Cholecystectomy is a common operation. This study reviewed the changes in workload and practice in a teaching hospital over a 4-year period, during which a hepatobiliary subspecialist unit was developed. METHODS: Computerized demographic data, and details of operations and inpatient events were reviewed for all patients undergoing cholecystectomy in a single teaching hospital from 1993 to 1997. For statistical analysis the consultants were grouped into those with a hepatobiliary interest (n = 3) and those with other primary interests (n = 6); and the workload for the first 12 months of the study was compared with that of the last 12-month period...
March 2000: British Journal of Surgery
C T Faranisi, D Chimuka
A five-year study of patients treated for gall bladder disease in Harare was done. The aim of the study was to highlight the importance of the disease and its unusual presentation as compared to the typical European pattern. The disease is still relatively uncommon, seeing that only 54 patients were treated, while the total hospital admissions for the period was forty-one thousand eight hundred and ninety-one. The disease affects mainly house wives and mainly middle aged. The patients tend to present as semi-surgical emergencies with pain, 77...
February 1989: East African Medical Journal
C T Faranisi, D Chimuka
A five-year study of patients treated for gall bladder disease in Harare was done from 1984-1988. The aim of the study was to highlight the importance of the disease and its unusual presentation as compared to the typical European pattern. The disease is relatively uncommon since only 54 patients were treated while the total hospital admission for the period was 41,891. The disease affected mainly middle-aged housewives. The patients tend to present as semi surgical emergencies. Diagnosis was made most often by Ultrasound scan (U/S) and oral cholangiogram...
March 1990: Central African Journal of Medicine
M R Cox, I F Gunn, M C Eastman, R F Hunt, A W Heinz
Laparoscopic cholecystectomy is rapidly becoming accepted as the best method for the treatment of symptomatic cholelithiasis. Randomized clinical trials comparing laparoscopic cholecystectomy with open cholecystectomy are unlikely to be performed. In order to compare these two operations, surgeons need an historical control group of patients who have undergone a conventional open cholecystectomy. The aim of this study was to document a control group of patients having an open cholecystectomy and compare them with patients having a laparoscopic cholecystectomy...
October 1992: Australian and New Zealand Journal of Surgery
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