keyword
https://read.qxmd.com/read/38535199/structures-and-biological-activities-of-secondary-metabolites-from-xylaria-spp
#21
REVIEW
Weikang Chen, Miao Yu, Shiji Chen, Tianmi Gong, Linlin Xie, Jinqin Liu, Chang Bian, Guolei Huang, Caijuan Zheng
The fungus genus Xylaria is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary metabolites of Xylaria spp. from 1994 to January 2024 and their relevant biological activities. A total of 445 new compounds, including terpenoids, nitrogen-containing compounds, polyketides, lactones, and other classes, are presented in this review...
February 29, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38534974/protective-effects-of-propolis-and-chitosan-nanoparticles-against-ibuprofen-induced-hepatotoxicity-in-albino-rats
#22
JOURNAL ARTICLE
Fajer M AlKandari, Hussein S Mohamed, Sayed A Ahmed, Basant Mahmoud, Asmaa M Mahmoud
Post-marketing hepatotoxicity findings are more common or occur much later. NSAIDs (non-steroidal anti-inflammatory drugs) like ibuprofen are consumed in large quantities around the world. NSAIDs have a low incidence of hepatotoxicity but their wide use makes them a major contributor to drug-induced liver injury. Hepatitis is linked to systemic oxidative stress which results in cellular necrosis and fibrosis, as well as tissue lipoprotein peroxidation and glutathione depletion. Given the lack of safe and effective anti-hepatitis drugs in medicine today, natural substances appear to be a promising and safe alternative...
February 29, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534922/unlocking-the-potential-of-therapy-induced-cytokine-responses-illuminating-new-pathways-in-cancer-precision-medicine
#23
REVIEW
Dilip R Gunturu, Mohammed Hassan, Deepa Bedi, Pran Datta, Upender Manne, Temesgen Samuel
Precision cancer medicine primarily aims to identify individual patient genomic variations and exploit vulnerabilities in cancer cells to select suitable patients for specific drugs. These genomic features are commonly determined by gene sequencing prior to therapy, to identify individuals who would be most responsive. This precision approach in cancer therapeutics remains a powerful tool that benefits a smaller pool of patients, sparing others from unnecessary treatments. A limitation of this approach is that proteins, not genes, are the ultimate effectors of biological functions, and therefore the targets of therapeutics...
February 23, 2024: Current Oncology
https://read.qxmd.com/read/38534854/review-of-spider-silk-applications-in-biomedical-and-tissue-engineering
#24
REVIEW
Marija Branković, Fatima Zivic, Nenad Grujovic, Ivan Stojadinovic, Strahinja Milenkovic, Nikola Kotorcevic
This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems...
March 11, 2024: Biomimetics
https://read.qxmd.com/read/38534761/genetic-signatures-for-distinguishing-chemo-sensitive-from-chemo-resistant-responders-in-prostate-cancer-patients
#25
JOURNAL ARTICLE
Lemohang Gumenku, Mamello Sekhoacha, Beynon Abrahams, Samson Mashele, Aubrey Shoko, Ochuko L Erukainure
Prostate cancer remains a significant public health concern in sub-Saharan Africa, particularly impacting South Africa with high mortality rates. Despite many years of extensive research and significant financial expenditure, there has yet to be a definitive solution to prostate cancer. It is not just individuals who vary in their response to treatment, but even different nodules within the same tumor exhibit unique transcriptome patterns. These distinctions extend beyond mere differences in gene expression levels to encompass the control and networking of individual genes...
March 11, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534716/assessment-of-colistin-heteroresistance-among-multidrug-resistant-klebsiella-pneumoniae-isolated-from-intensive-care-patients-in-europe
#26
JOURNAL ARTICLE
Anouk J M M Braspenning, Sahaya Glingston Rajakani, Adwoa Sey, Mariem El Bounja, Christine Lammens, Youri Glupczynski, Surbhi Malhotra-Kumar
Heteroresistance (HR) to colistin is especially concerning in settings where multi-drug-resistant (MDR) K. pneumoniae are prevalent and empiric use of colistin might lead to treatment failures. This study aimed to assess the frequency of occurrence of colistin HR (CHR) among (MDR) K. pneumoniae ( n = 676) isolated from patients hospitalized in 13 intensive care units (ICUs) in six European countries in a clinical trial assessing the impact of decolonization strategies. All isolates were whole-genome-sequenced and studied for in vitro colistin susceptibility...
March 20, 2024: Antibiotics
https://read.qxmd.com/read/38534706/antimicrobial-action-mechanisms-of-natural-compounds-isolated-from-endophytic-microorganisms
#27
REVIEW
Farkhod Eshboev, Nilufar Mamadalieva, Pavel A Nazarov, Hidayat Hussain, Vladimir Katanaev, Dilfuza Egamberdieva, Shakhnoz Azimova
Infectious diseases are a significant challenge to global healthcare, especially in the face of increasing antibiotic resistance. This urgent issue requires the continuous exploration and development of new antimicrobial drugs. In this regard, the secondary metabolites derived from endophytic microorganisms stand out as promising sources for finding antimicrobials. Endophytic microorganisms, residing within the internal tissues of plants, have demonstrated the capacity to produce diverse bioactive compounds with substantial pharmacological potential...
March 18, 2024: Antibiotics
https://read.qxmd.com/read/38534606/hydrogels-in-cutaneous-wound-healing-insights-into-characterization-properties-formulation-and-therapeutic-potential
#28
REVIEW
Mariana Ribeiro, Marco Simões, Carla Vitorino, Filipa Mascarenhas-Melo
Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements of an ideal wound dressing, making them promising for wound care. These features include, among others, the ability to absorb and retain large amounts of water and the capacity to closely mimic native structures, such as the extracellular matrix, facilitating various cellular processes like proliferation and differentiation. The polymers used in hydrogel formulations exhibit a broad spectrum of properties, allowing them to be classified into two main categories: natural polymers like collagen and chitosan, and synthetic polymers such as polyurethane and polyethylene glycol...
March 8, 2024: Gels
https://read.qxmd.com/read/38534592/advancements-in-cellulose-based-superabsorbent-hydrogels-sustainable-solutions-across-industries
#29
REVIEW
Hossein Omidian, Arnavaz Akhzarmehr, Sumana Dey Chowdhury
The development of superabsorbent hydrogels is experiencing a transformative era across industries. While traditional synthetic hydrogels have found broad utility, their non-biodegradable nature has raised environmental concerns, driving the search for eco-friendlier alternatives. Cellulose-based superabsorbents, derived from sustainable sources, are gaining prominence. Innovations include biodegradable polymer hydrogels, natural cellulose-chitosan variants, and cassava starch-based alternatives. These materials are reshaping agriculture by enhancing soil fertility and water retention, serving as potent hemostatic agents in medicine, contributing to pollution control, and providing eco-friendly construction materials...
February 29, 2024: Gels
https://read.qxmd.com/read/38534583/agar-graft-modification-with-acrylic-and-methacrylic-acid-for-the-preparation-of-ph-sensitive-nanogels-for-5-fluorouracil-delivery
#30
JOURNAL ARTICLE
Ivelina Ivanova, Marta Slavkova, Teodora Popova, Borislav Tzankov, Denitsa Stefanova, Virginia Tzankova, Diana Tzankova, Ivanka Spassova, Daniela Kovacheva, Christina Voycheva
Agar, a naturally occurring polysaccharide, has been modified by grafting it with acrylic (AcA) and methacrylic (McA) acid monomers, resulting in acrylic or methacrylic acid grafted polymer (AA-g-AcA or AA-g-McA) with pH-sensitive swelling behavior. Different ratios between agar, monomers, and initiator were applied. The synthesized grades of both new polymer series were characterized using FTIR spectroscopy, NMR, TGA, DSC, and XRD to ascertain the intended grafting. The percentage of grafting (% G), grafting efficiency (% GE), and % conversion (% C) were calculated, and models with optimal characteristics were further characterized...
February 23, 2024: Gels
https://read.qxmd.com/read/38534575/disulfide-cross-linked-polymeric-redox-responsive-nanocarrier-based-on-heparin-chitosan-and-lipoic-acid-improved-drug-accumulation-increased-cytotoxicity-and-selectivity-to-leukemia-cells-by-tumor-targeting-via-aikido-principle
#31
JOURNAL ARTICLE
Igor D Zlotnikov, Alexander A Ezhov, Natalia V Dobryakova, Elena V Kudryashova
We have developed a micellar formulation of anticancer drugs based on chitosan and heparin grafted with lipoic and oleic acids that can release the cytotoxic cargo (doxorubicin) in response to external stimuli, such as increased glutathione concentration-a hallmark of cancer. Natural polysaccharides (heparin and chitosan) provide the pH sensitivity of the nanocarrier: the release of doxorubicin (Dox) is enhanced in a slightly acidic environment (tumor microenvironment). Fatty acid residues are necessary for the formation of nanoparticles (micelles) and solubilization of cytostatics in a hydrophobic core...
February 20, 2024: Gels
https://read.qxmd.com/read/38534574/functional-hydrogels-for-delivery-of-the-proteolytic-enzyme-serratiopeptidase
#32
JOURNAL ARTICLE
Katya Kamenova, Anna Prancheva, Stiliyana Stoyanova, Lyubomira Radeva, Ivanka Pencheva-El Tibi, Krassimira Yoncheva, Martin A Ravutsov, Maya K Marinova, Svilen P Simeonov, Simona Mitova, Rumyana Eneva, Maya M Zaharieva, Hristo Najdenski, Petar D Petrov
Hydrogels are superior wound dressings because they can provide protection and hydration of the wound, as well as the controlled release of therapeutic substances to aid tissue regeneration and the healing process. Hydrogels obtained from natural precursors are preferred because of their low cost, biocompatibility, and biodegradability. We describe the synthesis of novel functional hydrogels based on two natural products-citric acid (CA) and pentane-1,2,5-triol (PT, a product from lignocellulose processing) and poly(ethylene glycol) (PEG-600)-via an environment friendly approach...
February 20, 2024: Gels
https://read.qxmd.com/read/38534423/research-progress-of-nanomaterials-acting-on-nk-cells-in-tumor-immunotherapy-and-imaging
#33
REVIEW
Yachan Feng, Haojie Zhang, Jiangtao Shao, Chao Du, Xiaolei Zhou, Xueling Guo, Yingze Wang
The prognosis for cancer patients has declined dramatically in recent years due to the challenges in treating malignant tumors. Tumor immunotherapy, which includes immune target inhibition and chimeric antigen receptor cell treatment, is currently evolving quickly. Among them, natural killer (NK) cells are gradually becoming another preferred cell immunotherapy after T cell immunotherapy due to their unique killing effects in innate and adaptive immunity. NK cell therapy has shown encouraging outcomes in clinical studies; however, there are still some problems, including limited efficacy in solid tumors, inadequate NK cell penetration, and expensive treatment expenses...
February 27, 2024: Biology
https://read.qxmd.com/read/38534126/genetic-activity-and-cytotoxic-effect-of-silybum-marianum-extract-in-comparison-with-the-impact-of-antitumor-drugs-etoposide-and-methotrexate-a-study-on-drosophila-melanogaster
#34
JOURNAL ARTICLE
Olga Nikolaevna Antosyuk, Elena Aleksandrovna Sharova, Anastasiya Konstantinovna Verbitskaya
One of the most important directions in medical practice involves the exploration of protectors and adaptogens to mitigate side effects associated with the use of antitumor and potent medications. The extracts of medicinal plants are actively tested as protectors. In connection with this, the aim of the research was to determine the effectiveness of the protective properties of Silybum marianum extract against the drugs 'etoposide' and 'methotrexate' at concentrations of 800 μg/kg using the model object Drosophila melanogaster ...
March 27, 2024: Natural Product Research
https://read.qxmd.com/read/38533624/a-review-on-topical-ophthalmic-drug-delivery-system-reference-to-viscosity-enhancer
#35
REVIEW
Pravin Kondiba Pawar, Raju Dubaji Rathod, Satyajeet Ramesh Jagadale
The eye is the most accessible site for topical drug delivery. Drug's ocular bioavailability is quite low when administered topically as eye drops. Viscosity enhancers are used to increase ocular bioavailability by extending the precorneal residence time of the drug at the ocular site. Cellulose, polyalcohol and polyacrylic acid are examples of hydrophilic viscosity enhancers. The addition of viscosity modifiers increases the amount of time the drug is in contact with the ocular surface. Several polysaccharides have been studied as excipients and viscosity boosters for ocular formulations, including cellulose derivatives such as chitosan (CS), xyloglucan and arabinogalactan (methylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose (HPMC), and sodium carboxymethylcellulose)...
March 27, 2024: Polimery W Medycynie
https://read.qxmd.com/read/38533260/redirecting-pantoprazole-as-a-metallo-beta-lactamase-inhibitor-in-carbapenem-resistant-klebsiella-pneumoniae
#36
JOURNAL ARTICLE
Wesam H Abdulaal, Nabil A Alhakamy, Amer H Asseri, Mohamed F Radwan, Tarek S Ibrahim, Solomon Z Okbazghi, Hisham A Abbas, Basem Mansour, Aly A Shoun, Wael A H Hegazy, Mahmoud Saad Abdel-Halim
The development of resistance to carbapenems in Klebsiella pneumoniae due to the production of metallo-β-lactamases (MBLs) is a critical public health problem because carbapenems are the last-resort drugs used for treating severe infections of extended-spectrum β-lactamases (ESBLs) producing K. pneumoniae . Restoring the activity of carbapenems by the inhibition of metallo-β-lactamases is a valuable approach to combat carbapenem resistance. In this study, two well-characterized clinical multidrug and carbapenem-resistant K...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38533170/keto-clarity-a-comprehensive-systematic-review-exploring-the-efficacy-safety-and-mechanisms-of-ketogenic-diet-in-pediatric-epilepsy
#37
REVIEW
Youmna Faheem, Amisha Jaiswal, Kainaat Shergill, Kusalik Boppana, Naiela E Almansouri, Saloni Bakkannavar, Ann Kashmer Yu
Epilepsy, a widespread neurological disorder characterized by recurrent seizures, affects millions globally, with a significant impact on the pediatric population. Antiepileptic drugs (AEDs) constitute the primary treatment; however, drug-resistant epilepsy (DRE), especially in children, poses a therapeutic challenge. Alternative interventions, such as surgery, vagus nerve stimulation, and the ketogenic diet (KD), have been explored. This systematic review aims to investigate various types of KDs, their distinctions, their effectiveness, and their safety concerning the reduction of seizure frequency, achieving seizure freedom, and the occurrence of adverse events...
February 2024: Curēus
https://read.qxmd.com/read/38533051/therapeutic-potential-of-clinically-proven-natural-products-in-the-management-of-dementia
#38
REVIEW
Farzana Ansari, Md Sohel, Md Mahfujul Haque Haidary, Md Saqline Mostaq, Shamima Akter, Asrafun Nahar, Fatematuz Zohora Labony, Arman Ahmed, Mohammed Shamim Hasan, Mohammad Hasem Babu, Mohammad Nurul Amin
Dementia is a common neurodegenerative disorder connected to damage to nerve cells in the brain. Although some conventional drugs are available for dementia treatments and are still sanctified for dementia patients, their short- and long-term side effects and other limitations make treating patients more challenging. The authors aimed to explain novel options for treating dementia with natural products and unravel some clinically proven natural products. This article systematically reviewed recent studies that have investigated the role of natural products and their bioactive compounds for dementia...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533040/comprehensive-single-cell-analysis-reveals-heterogeneity-of-fibroblast-subpopulations-in-ovarian-cancer-tissue-microenvironment
#39
JOURNAL ARTICLE
Bo Ding, Zheng Ye, Han Yin, Xin-Yi Hong, Song-Wei Feng, Jing-Yun Xu, Yang Shen
BACKGROUND: Ovarian cancer, as a highly malignant tumor, features the critical involvement of tumor-associated fibroblasts in the ovarian cancer tissue microenvironment. However, due to the apparent heterogeneity within fibroblast subpopulations, the specific functions of these subpopulations in the ovarian cancer tissue microenvironment remain insufficiently elucidated. METHODS: In this study, we integrated single-cell sequencing data from 32 ovarian cancer samples derived from four distinct cohorts and 3226 bulk RNA-seq data from GEO and TCGA-OV cohorts...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533033/elucidating-the-anti-cancer-potential-of-cinnamomum-tamala-essential-oil-against-non-small-cell-lung-cancer-a-multifaceted-approach-involving-gc-ms-profiling-network-pharmacology-and-molecular-dynamics-simulations
#40
JOURNAL ARTICLE
Debajani Mohanty, Sucheesmita Padhee, Arpita Priyadarshini, Bibhuti Bhusan Champati, Prabhat Kumar Das, Sudipta Jena, Ambika Sahoo, Pratap Chandra Panda, Sanghamitra Nayak, Asit Ray
Cinnamomum tamala (Buch.-Ham.) T.Nees & Eberm., or Indian Bay Leaf, is a well-known traditional ayurvedic medicine used to treat various ailments. However, the molecular mechanism of action of Cinnamomum tamala essential oil (CTEO) against non-small cell lung cancer (NSCLC) remains elusive. The present study aims to decipher the molecular targets and mechanism of CTEO in treating NSCLC. GC-MS analysis detected 49 constituents; 44 successfully passed the drug-likeness screening and were identified as active compounds...
March 30, 2024: Heliyon
keyword
keyword
162604
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.