Anna Stockbauer, Leonie Beyer, Maria Huber, Annika Kreuzer, Carla Palleis, Sabrina Katzdobler, Boris-Stephan Rauchmann, Silvia Morbelli, Andrea Chincarini, Rose Bruffaerts, Rik Vandenberghe, Milica G Kramberger, Maja Trost, Valentina Garibotto, Nicolas Nicastro, Aurélien Lathuilière, Afina W Lemstra, Bart N M van Berckel, Andrea Pilotto, Alessandro Padovani, Miguel A Ochoa-Figueroa, Anette Davidsson, Valle Camacho, Enrico Peira, Matteo Bauckneht, Matteo Pardini, Gianmario Sambuceti, Dag Aarsland, Flavio Nobili, Mattes Gross, Jonathan Vöglein, Robert Perneczky, Oliver Pogarell, Katharina Buerger, Nicolai Franzmeier, Adrian Danek, Johannes Levin, Günter U Höglinger, Peter Bartenstein, Paul Cumming, Axel Rominger, Matthias Brendel
PURPOSE: Metabolic network analysis of FDG-PET utilizes an index of inter-regional correlation of resting state glucose metabolism and has been proven to provide complementary information regarding the disease process in parkinsonian syndromes. The goals of this study were (i) to evaluate pattern similarities of glucose metabolism and network connectivity in dementia with Lewy bodies (DLB) subjects with subthreshold dopaminergic loss compared to advanced disease stages and to (ii) investigate metabolic network alterations of FDG-PET for discrimination of patients with early DLB from other neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, multiple system atrophy) at individual patient level via principal component analysis (PCA)...
November 16, 2023: European Journal of Nuclear Medicine and Molecular Imaging